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  1. Article: E-cigarettes and nicotine abstinence

    Hanewinkel, Reiner / Niederberger, Kathrin / Pedersen, Anya / Unger, Jennifer B. / Galimov, Artur

    European Respiratory Review

    A meta-analysis of randomised controlled trials

    2022  Volume 31, Issue 163, Page(s) No

    Abstract: Objectives: To determine the effects of electronic cigarettes (e-cigarettes) as a therapeutic ... in which nicotine e-cigarettes were compared to NRT among current cigarette users. The primary outcome was ... abstaining from all nicotine-delivery devices. Secondary outcomes were 1) allocated product use (e-cigarettes ...

    Title translation E-Zigaretten und Nikotinabstinenz: eine Metaanalyse randomisierter kontrollierter Studien
    Abstract Objectives: To determine the effects of electronic cigarettes (e-cigarettes) as a therapeutic intervention compared to nicotine replacement therapy (NRT) on nicotine abstinence. Methods: Two authors independently searched the PubMed, Embase, Psyclnfo and Cochrane Central Register of Controlled Trials databases for articles published up to and including 10 July 2021. We included randomised controlled trials (RCTs) in which nicotine e-cigarettes were compared to NRT among current cigarette users. The primary outcome was abstaining from all nicotine-delivery devices. Secondary outcomes were 1) allocated product use (e-cigarettes or NRT) among successful cigarette quitters and 2) quitting cigarettes at the end of the trial using fixed-effect Mantel-Haenszel models. Results: We included four RCTs representing 1598 adult participants (51.0% females). The mean age of participants in these studies ranged from 41 to 54 years, while average baseline smoking ranged from 14 to 21 cigarettes per day. Compared to NRT, e-cigarette use was associated with lower nicotine abstinence rates at the longest follow-up (risk ratio 0.50 (95% CI 0.32-0.77)). Among successful cigarette quitters, the risk of allocated product use by the end of the observational time was higher for e-cigarette users compared to NRT (risk ratio 8.94 (95% CI 3.98-20.07)). E-cigarette users had higher cigarette smoking cessation rates compared to NRT users (risk ratio 1.58 (95% CI 1.20-2.08)). Conclusions: The use of e-cigarettes as a therapeutic intervention for smoking cessation may lead to permanent nicotine dependence.
    Keywords Drogeninhalation ; Electronic Cigarettes ; Elektronische Zigaretten ; Nicotine Withdrawal ; Nikotinentzug ; Randomisierte kontrollierte Studien ; Randomized Controlled Trials ; Rauchen ; Rauchentwöhnung ; Smoking Cessation ; Tobacco Smoking ; Vaping
    Language English
    Document type Article
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0215-2021
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  2. Article ; Online: E-cigarettes and nicotine abstinence: a meta-analysis of randomised controlled trials.

    Hanewinkel, Reiner / Niederberger, Kathrin / Pedersen, Anya / Unger, Jennifer B / Galimov, Artur

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 163

    Abstract: Objectives: To determine the effects of electronic cigarettes (e-cigarettes) as a therapeutic ... in which nicotine e-cigarettes were compared to NRT among current cigarette users. The primary outcome was ... abstaining from all nicotine-delivery devices. Secondary outcomes were 1) allocated product use (e-cigarettes ...

    Abstract Objectives: To determine the effects of electronic cigarettes (e-cigarettes) as a therapeutic intervention compared to nicotine replacement therapy (NRT) on nicotine abstinence.
    Methods: Two authors independently searched the PubMed, Embase, PsycInfo and Cochrane Central Register of Controlled Trials databases for articles published up to and including 10 July 2021. We included randomised controlled trials (RCTs) in which nicotine e-cigarettes were compared to NRT among current cigarette users. The primary outcome was abstaining from all nicotine-delivery devices. Secondary outcomes were 1) allocated product use (e-cigarettes or NRT) among successful cigarette quitters and 2) quitting cigarettes at the end of the trial using fixed-effect Mantel-Haenszel models.
    Results: We included four RCTs representing 1598 adult participants (51.0% females). The mean age of participants in these studies ranged from 41 to 54 years, while average baseline smoking ranged from 14 to 21 cigarettes per day. Compared to NRT, e-cigarette use was associated with lower nicotine abstinence rates at the longest follow-up (risk ratio 0.50 (95% CI 0.32-0.77)). Among successful cigarette quitters, the risk of allocated product use by the end of the observational time was higher for e-cigarette users compared to NRT (risk ratio 8.94 (95% CI 3.98-20.07)). E-cigarette users had higher cigarette smoking cessation rates compared to NRT users (risk ratio 1.58 (95% CI 1.20-2.08)).
    Conclusions: The use of e-cigarettes as a therapeutic intervention for smoking cessation may lead to permanent nicotine dependence.
    MeSH term(s) Adult ; Electronic Nicotine Delivery Systems ; Female ; Humans ; Male ; Middle Aged ; Nicotine/adverse effects ; Randomized Controlled Trials as Topic ; Smoking Cessation ; Tobacco Use Cessation Devices/adverse effects ; Vaping/adverse effects
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0215-2021
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  3. Article ; Online: Allergen-Immuntherapie in der aktuellen COVID-19-Pandemie – ein Positionspapier von ARIA, EAACI, AeDA, GPA und DGAKI (Kurzversion) – Positionspapier der deutschen ARIA-GruppeA in Kooperation mit der österreichischen ARIA-GruppeB, der schweizerischen ARIA-GruppeC, dem Ärzteverband Deutscher Allergologen (AeDA)D, der Deutschen Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)E und der Gesellschaft für Pädiatrische Allergologie (GPA)F in Kooperation mit der AG Klinische Immunologie, Allergologie und Umweltmedizin der DGHNO-KHCG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H.

    Pfaar, O / Klimek, L / Worm, M / Bergmann, K-C / Bieber, T / Buhl, R / Buters, J / Darsow, U / Keil, T / Kleine-Tebbe, J / Lau, S / Maurer, M / Merk, H / Mösges, R / Saloga, J / Staubach, P / Stute, P / Rabe, K / Rabe, U /
    Vogelmeier, C / Biedermann, T / Jung, K / Schlenter, W / Ring, J / Chaker, A / Wehrmann, W / Becker, S / Mülleneisen, N / Nemat, K / Czech, W / Wrede, H / Brehler, R / Fuchs, T / Tomazic, P-V / Aberer, W / Fink-Wagner, A / Horak, F / Wöhrl, S / Niederberger-Leppin, V / Pali-Schöll, I / Pohl, W / Roller-Wirnsberger, R / Spranger, O / Valenta, R / Akdis, M / Akdis, C / Hoffmann-Sommergruber, K / Jutel, M / Matricardi, P / Spertini, F / Khaltaev, N / Michel, J-P / Nicod, L / Schmid-Grendelmeier, P / Hamelmann, E / Jakob, T / Werfel, T / Wagenmann, M / Taube, C / Gerstlauer, M / Vogelberg, C / Bousquet, J / Zuberbier, T

    Laryngo- rhino- otologie

    2020  Volume 99, Issue 10, Page(s) 676–679

    Title translation Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI-AeDA-GPA-DGAKI Position Paper (Pocket-Guide).
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Desensitization, Immunologic ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language German
    Publishing date 2020-08-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/a-1170-8426
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  4. Article ; Online: Novel Insights into Molecular Mechanisms of Chronic Pain.

    Niederberger, Ellen

    Cells

    2020  Volume 9, Issue 10

    Abstract: Pain is the most frequent cause triggering patients to visit a physician. The worldwide incidence of chronic pain is in the range of 20% of adults, and chronic pain conditions are frequently associated with several comorbidities and a drastic decrease in ...

    Abstract Pain is the most frequent cause triggering patients to visit a physician. The worldwide incidence of chronic pain is in the range of 20% of adults, and chronic pain conditions are frequently associated with several comorbidities and a drastic decrease in patients' quality of life. Although several approved analgesics are available, such therapy is often not satisfying due to insufficient efficacy and/or severe side effects. Therefore, novel strategies for the development of safe and highly efficacious pain killers are urgently needed. To reach this goal, it is necessary to clarify the causes and signal transduction cascades underlying the onset and progression of the different types of chronic pain. The papers in this Special Issue cover a wide variety of mechanisms involved in different pain types such as inflammatory, neuropathic or cancer pain. Therefore, the results summarized here might contribute to a better understanding of the mechanisms in chronic pain and thereby to the development of novel therapeutic strategies for pain patients.
    MeSH term(s) Adult ; Chronic Pain/metabolism ; Humans ; Quality of Life/psychology
    Language English
    Publishing date 2020-10-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9102220
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  5. Article ; Online: Follicle-stimulating hormone treatment for male factor infertility.

    Caroppo, Ettore / Niederberger, Craig S

    Fertility and sterility

    2022  Volume 119, Issue 2, Page(s) 173–179

    Abstract: Follicle-stimulating hormone (FSH) treatment has been proven effective in stimulating spermatogenesis and improving the reproductive ability of men with hypogonadotropic hypogonadism, while the usefulness of such a treatment in infertile patients with ... ...

    Abstract Follicle-stimulating hormone (FSH) treatment has been proven effective in stimulating spermatogenesis and improving the reproductive ability of men with hypogonadotropic hypogonadism, while the usefulness of such a treatment in infertile patients with normal pituitary function is restricted to a subgroup of responders that, however, cannot be identified by the current diagnostic tools before treatment. In this review we summarize the role played by FSH in the modulation of spermatogenesis, the effect of FSH treatment at a standard replacement dose and at higher dose on sperm parameters, spontaneous and in vitro fertilization pregnancy rates, and the efforts made to identify possible responders to FSH treatment.
    MeSH term(s) Female ; Male ; Humans ; Pregnancy ; Follicle Stimulating Hormone/pharmacology ; Semen ; Infertility, Male/diagnosis ; Infertility, Male/drug therapy ; Follicle Stimulating Hormone, Human/therapeutic use ; Hypogonadism/diagnosis ; Hypogonadism/drug therapy ; Spermatogenesis
    Chemical Substances Follicle Stimulating Hormone (9002-68-0) ; Follicle Stimulating Hormone, Human
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2022.09.362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Allergen-Immuntherapie in der aktuellen COVID-19-Pandemie – ein Positionspapier von ARIA, EAACI, AeDA, GPA und DGAKI (Kurzversion) – Positionspapier der deutschen ARIA-GruppeA in Kooperation mit der österreichischen ARIA-GruppeB, der schweizerischen ARIA-GruppeC, dem Ärzteverband Deutscher Allergologen (AeDA)D, der Deutschen Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)E und der Gesellschaft für Pädiatrische Allergologie (GPA)F in Kooperation mit der AG Klinische Immunologie, Allergologie und Umweltmedizin der DGHNO-KHCG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H

    Pfaar, O. / Klimek, L. / Worm, M. / Bergmann, K.-C. / Bieber, T. / Buhl, R. / Buters, J. / Darsow, U. / Keil, T. / Kleine-Tebbe, J. / Lau, S. / Maurer, M. / Merk, H. / Mösges, R. / Saloga, J. / Staubach, P. / Stute, P. / Rabe, K. / Rabe, U. /
    Vogelmeier, C. / Biedermann, T. / Jung, K. / Schlenter, W. / Ring, J. / Chaker, A. / Wehrmann, W. / Becker, S. / Mülleneisen, N. / Nemat, K. / Czech, W. / Wrede, H. / Brehler, R. / Fuchs, T. / Tomazic, P.-V. / Aberer, W. / Fink-Wagner, A. / Horak, F. / Wöhrl, S. / Niederberger-Leppin, V. / Pali-Schöll, I. / Pohl, W. / Roller-Wirnsberger, R. / Spranger, O. / Valenta, R. / Akdis, M. / Akdis, C. / Hoffmann-Sommergruber, K. / Jutel, M. / Matricardi, P. / Spertini, F. / Khaltaev, N. / Michel, J.-P. / Nicod, L. / Schmid-Grendelmeier, P. / Hamelmann, E. / Jakob, T. / Werfel, T. / Wagenmann, M. / Taube, C. / Gerstlauer, M. / Vogelberg, C. / Bousquet, J. / Zuberbier, T.

    Laryngo-Rhino-Otologie

    2020  Volume 99, Issue 10, Page(s) 676–679

    Keywords Otorhinolaryngology ; covid19
    Language German
    Publisher Georg Thieme Verlag KG
    Publishing country de
    Document type Article ; Online
    ISSN 0935-8943
    DOI 10.1055/a-1170-8426
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Allergen-Immuntherapie in der aktuellen COVID-19-Pandemie – ein Positionspapier von ARIA, EAACI, AeDA, GPA und DGAKI (Kurzversion) – Positionspapier der deutschen ARIA-GruppeA in Kooperation mit der österreichischen ARIA-GruppeB, der schweizerischen ARIA-GruppeC, dem Ärzteverband Deutscher Allergologen (AeDA)D, der Deutschen Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)E und der Gesellschaft für Pädiatrische Allergologie (GPA)F in Kooperation mit der AG Klinische Immunologie, Allergologie und Umweltmedizin der DGHNO-KHCG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H

    Pfaar, O. / Klimek, L. / Worm, M. / Bergmann, K.-C. / Bieber, T. / Buhl, R. / Buters, J. / Darsow, U. / Keil, T. / Kleine-Tebbe, J. / Lau, S. / Maurer, M. / Merk, H. / Mösges, R. / Saloga, J. / Staubach, P. / Stute, P. / Rabe, K. / Rabe, U. /
    Vogelmeier, C. / Biedermann, T. / Jung, K. / Schlenter, W. / Ring, J. / Chaker, A. / Wehrmann, W. / Becker, S. / Mülleneisen, N. / Nemat, K. / Czech, W. / Wrede, H. / Brehler, R. / Fuchs, T. / Tomazic, P.-V. / Aberer, W. / Fink-Wagner, A. / Horak, F. / Wöhrl, S. / Niederberger-Leppin, V. / Pali-Schöll, I. / Pohl, W. / Roller-Wirnsberger, R. / Spranger, O. / Valenta, R. / Akdis, M. / Akdis, C. / Hoffmann-Sommergruber, K. / Jutel, M. / Matricardi, P. / Spertini, F. / Khaltaev, N. / Michel, J.-P. / Nicod, L. / Schmid-Grendelmeier, P. / Hamelmann, E. / Jakob, T. / Werfel, T. / Wagenmann, M. / Taube, C. / Gerstlauer, M. / Vogelberg, C. / Bousquet, J. / Zuberbier, T.

    Laryngo-Rhino-Otologie

    2020  Volume 99, Issue 10, Page(s) 676–679

    Language German
    Publishing date 2020-08-21
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/a-1170-8426
    Database Thieme publisher's database

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  8. Book ; Thesis: Lebens- und extremitätenbedrohende nekrotisierende Weichteilfunktionen

    Niederberger, Edith

    2000  

    Author's details vorgelegt von Edith Niederberger
    Language German
    Size 63 Bl.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 2000
    HBZ-ID HT013201592
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 E 3386 order for loan Magazin

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  9. Article ; Online: Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemie(a, b, c): Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H

    Klimek, Ludger / Pfaar, Oliver / Worm, Margitta / Eiwegger, Thomas / Hagemann, Jan / Ollert, Markus / Untersmayr, Eva / Hoffmann-Sommergruber, Karin / Vultaggio, Alessandra / Agache, Ioana / Bavbek, Sevim / Bossios, Apostolos / Casper, Ingrid / Chan, Susan / Chatzipetrou, Alexia / Vogelberg, Christian / Firinu, Davide / Kauppi, Paula / Kolios, Antonios /
    Kothari, Akash / Matucci, Andrea / Palomares, Oscar / Szépfalusi, Zsolt / Pohl, Wolfgang / Hötzenecker, Wolfram / Rosenkranz, Alexander / Bergmann, Karl-Christian / Bieber, Thomas / Buhl, Roland / Buters, Jeroen / Darsow, Ulf / Keil, Thomas / Kleine-Tebbe, Jörg / Lau, Susanne / Maurer, Marcus / Merk, Hans / Mösges, Ralph / Saloga, Joachim / Staubach, Petra / Jappe, Uta / Rabe, Claus / Rabe, Uta / Vogelmeier, Claus / Biedermann, Tilo / Jung, Kirsten / Schlenter, Wolfgang / Ring, Johannes / Chaker, Adam / Wehrmann, Wolfgang / Becker, Sven / Freudelsperger, Laura / Mülleneisen, Norbert / Nemat, Katja / Czech, Wolfgang / Wrede, Holger / Brehler, Randolf / Fuchs, Thomas / Tomazic, Peter-Valentin / Aberer, Werner / Fink Wagner, Antje / Horak, Fritz / Wöhrl, Stefan / Niederberger-Leppin, Verena / Pali-Schöll, Isabella / Roller-Wirnsberger, Regina / Spranger, Otto / Valenta, Rudolf / Akdis, Mübecell / Matricardi, Paolo M. / Spertini, François / Khaltaev, Nikolai / Michel, Jean-Pierre / Nicod, Larent / Schmid-Grendelmeier, Peter / Idzko, Marco / Hamelmann, Eckard / Jakob, Thilo / Werfel, Thomas / Wagenmann, Martin / Taube, Christian / Jensen-Jarolim, Erika / Korn, Stephanie / Hentges, Francois / Schwarze, Jürgen / O´Mahony, Liam / Knol, Edward / del Giacco, Stefano / Chivato, Tomás / Bousquet, Jean / Zuberbier, Torsten / Akdis, Cezmi / Jutel, Marek

    Allergo J

    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/s15007-020-2553-y
    Database COVID19

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  10. Article ; Online: Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemiea, b, c ; Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H

    Klimek, Ludger / Pfaar, Oliver / Worm, Margitta / Eiwegger, Thomas / Hagemann, Jan / Ollert, Markus / Untersmayr, Eva / Hoffmann-Sommergruber, Karin / Vultaggio, Alessandra / Agache, Ioana / Bavbek, Sevim / Bossios, Apostolos / Casper, Ingrid / Chan, Susan / Chatzipetrou, Alexia / Vogelberg, Christian / Firinu, Davide / Kauppi, Paula / Kolios, Antonios /
    Kothari, Akash / Matucci, Andrea / Palomares, Oscar / Szépfalusi, Zsolt / Pohl, Wolfgang / Hötzenecker, Wolfram / Rosenkranz, Alexander / Bergmann, Karl-Christian / Bieber, Thomas / Buhl, Roland / Buters, Jeroen / Darsow, Ulf / Keil, Thomas / Kleine-Tebbe, Jörg / Lau, Susanne / Maurer, Marcus / Merk, Hans / Mösges, Ralph / Saloga, Joachim / Staubach, Petra / Jappe, Uta / Rabe, Claus / Rabe, Uta / Vogelmeier, Claus / Biedermann, Tilo / Jung, Kirsten / Schlenter, Wolfgang / Ring, Johannes / Chaker, Adam / Wehrmann, Wolfgang / Becker, Sven / Freudelsperger, Laura / Mülleneisen, Norbert / Nemat, Katja / Czech, Wolfgang / Wrede, Holger / Brehler, Randolf / Fuchs, Thomas / Tomazic, Peter-Valentin / Aberer, Werner / Fink Wagner, Antje / Horak, Fritz / Wöhrl, Stefan / Niederberger-Leppin, Verena / Pali-Schöll, Isabella / Roller-Wirnsberger, Regina / Spranger, Otto / Valenta, Rudolf / Akdis, Mübecell / Matricardi, Paolo M. / Spertini, François / Khaltaev, Nikolai / Michel, Jean-Pierre / Nicod, Larent / Schmid-Grendelmeier, Peter / Idzko, Marco / Hamelmann, Eckard / Jakob, Thilo / Werfel, Thomas / Wagenmann, Martin / Taube, Christian / Jensen-Jarolim, Erika / Korn, Stephanie / Hentges, Francois / Schwarze, Jürgen / O´Mahony, Liam / Knol, Edward / del Giacco, Stefano / Chivato, Tomás / Bousquet, Jean / Zuberbier, Torsten / Akdis, Cezmi / Jutel, Marek

    Allergo Journal

    2020  Volume 29, Issue 4, Page(s) 14–27

    Keywords Immunology and Allergy ; covid19
    Language German
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-020-2553-y
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