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Article ; Online: The promising effects of BMP2 transfected mesenchymal stem cells on human osteosarcoma.

Sari, Ahmet Sinan / Demirçay, Emre / Öztürk, Ahmet / Terzi, Ayşen / Karaöz, Erdal

Turkish journal of biology = Turk biyoloji dergisi

2021 Volume 45, Issue 3, Page(s) 301–313

Abstract: Selective targeting of transfected mesenchymal stem cells (MSCs) carrying specific antioncogenes to the tumor was suggested as a treatment option. Bone morphogenetic protein-2 (BMP2) was shown to inhibit the proliferation and aggressiveness of ... ...

Abstract	Selective targeting of transfected mesenchymal stem cells (MSCs) carrying specific antioncogenes to the tumor was suggested as a treatment option. Bone morphogenetic protein-2 (BMP2) was shown to inhibit the proliferation and aggressiveness of osteosarcoma (OS) cells. Here, we aimed to assess the homing efficiency of intraperitoneally administered hMSCs transfected with
Language	English
Publishing date	2021-06-23
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2046470-8
ISSN	1303-6092 ; 1300-0152
ISSN (online)	1303-6092
ISSN	1300-0152
DOI	10.3906/biy-2101-50
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Review of management of unstable elbow fractures.

Ozel, Omer / Demircay, Emre

World journal of orthopedics

2016 Volume 7, Issue 1, Page(s) 50–54

Abstract: Stable and painless elbow motion is essential for activities of daily living. The elbow joint is the second most commonly dislocated joint in adults. The goals of treatment are to perform a stable fixation of all fractures, to achieve concentric and ... ...

Abstract	Stable and painless elbow motion is essential for activities of daily living. The elbow joint is the second most commonly dislocated joint in adults. The goals of treatment are to perform a stable fixation of all fractures, to achieve concentric and stable reduction of the elbow and to provide early motion. The treatment modality for complex elbow instability is almost always surgical. The treatment objectives are anatomic reduction, stable fixation, and early rehabilitation of the elbow. The common complications of these unstable fractures include recurrent instability, stiffness, myositis ossifications, heterotopic calcification, and neurovascular dysfunction. We analyzed the management of complex elbow fractures and instabilities on the basis of recent literature and suggested possible guidelines for the treatment in this paper. In conclusion, recognition of the injury pattern and restoration of the joint stability are the prerequisites for any successful treatment of an unstable elbow injury.
Language	English
Publishing date	2016-01-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2649712-8
ISSN	2218-5836
ISSN	2218-5836
DOI	10.5312/wjo.v7.i1.50
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Article ; Online: Radiofrequency Thermocoagulation of the Ganglion Impar for Coccydynia Management: Long-Term Effects.

Kırcelli, Atilla / Demirçay, Emre / Özel, Ömer / Çöven, Ilker / Işık, Semra / Civelek, Erdinç / Kabataş, Serdar

Pain practice : the official journal of World Institute of Pain

2018 Volume 19, Issue 1, Page(s) 9–15

Abstract: Objective: To investigate the short- and long-term effects of ganglion impar radiofrequency thermocoagulation (RFT) treatment in patients with chronic coccydynia.: Methods: We retrospectively analyzed the medical records of patients who underwent RFT ...

Abstract	Objective: To investigate the short- and long-term effects of ganglion impar radiofrequency thermocoagulation (RFT) treatment in patients with chronic coccydynia. Methods: We retrospectively analyzed the medical records of patients who underwent RFT of the ganglion impar between 2009 and 2011. Pain intensity visual numeric scale (VNS) scores and Euroqol 5D (EQ-5D) index scores were recorded pre-intervention and post-intervention at the first, sixth, and twelfth months. The differences between pre-procedural VNS scores and post-procedural VNS scores at the first, sixth, and twelfth months were evaluated. The success of the intervention was recorded as the percentage difference between the pre-intervention VNS scores and post-intervention VNS scores at the first, sixth, and twelfth months. Results: The mean age of the patients, including 11 females (55%) and 8 males (45%), was 48.7 ± 14.3 years. The average follow-up duration was 17.3 ± 2.9 months. Statistically significant differences were observed between the pre- and post-procedure VNS scores (P < 0.0001). Improvements in VNS scores were correlated with improvements in EQ-5D index scores. Mid-term (sixth month) and long-term (twelfth month) evaluations after the intervention revealed that 67.4% and 61.1% of the patients had successful outcomes, respectively. Conclusion: Our data suggested that RFT of the ganglion impar in patients with chronic coccydynia resulted in effective outcomes, and patients who responded to RFT had significantly lower post-RFT pain scores.
MeSH term(s)	Adult ; Electrocoagulation/methods ; Female ; Ganglia, Sympathetic/surgery ; Humans ; Low Back Pain/surgery ; Male ; Middle Aged ; Pain Management/methods ; Retrospective Studies ; Sacrococcygeal Region
Language	English
Publishing date	2018-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2151272-3
ISSN	1533-2500 ; 1530-7085
ISSN (online)	1533-2500
ISSN	1530-7085
DOI	10.1111/papr.12698
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Zs.A 5928: Show issues

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Article ; Online: Solitary spinous process metastasis: a case report.

Demirçay, Emre / Civelek, Erdinç / Demiralay, Ebru

Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery

2013 Volume 24, Issue 1, Page(s) 58–61

Abstract: Vertebral column is a common site for bony metastases in patients with systemic malignancy. Patients with metastatic spinal tumors usually present with pain. Some tumors are asymptomatic and can be detected during screening examinations. Magnetic ... ...

Abstract	Vertebral column is a common site for bony metastases in patients with systemic malignancy. Patients with metastatic spinal tumors usually present with pain. Some tumors are asymptomatic and can be detected during screening examinations. Magnetic resonance imaging (MRI) of the vertebral column with the panel of available imagining methods and the clinical findings should be used for the diagnosis of spinal metastasis. A 45-year-old man was admitted with low back pain. With a history of rectum surgery and radiotherapy, he was on chemotherapy for rectum adenocarcinoma. F18 sodium fluoride positron emission tomography scan which was performed three weeks ago showed no abnormalities other than the primary surgical site. Magnetic resonance imaging of the lumbar vertebrae spine revealed a lesion on the tip of L4 spinous process. Excisional biopsy of L4 spinous process was performed. Histologic examination revealed mucinous adenocarcinoma. He had no low back pain at two-months follow-up. We could not find any solitary spinous process metastasis reported in English literature. Patients with nonspecific spinal pain with a previous cancer history should be carefully evaluated for a spinal metastasis. Even a solitary spinous process lesion may turn out to be the initial manifestation of a spinal metastasis.
MeSH term(s)	Adenocarcinoma, Mucinous/pathology ; Diagnosis, Differential ; Humans ; Low Back Pain/etiology ; Lumbar Vertebrae ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Metastasis ; Positron-Emission Tomography ; Rectal Neoplasms/pathology ; Spinal Neoplasms/complications ; Spinal Neoplasms/diagnosis ; Spinal Neoplasms/secondary ; Spinal Neoplasms/surgery
Language	English
Publishing date	2013
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ISSN	1309-0313
ISSN (online)	1309-0313
DOI	10.5606/ehc.2013.14
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Article ; Online: Atypical Presentation of an Epidural Hematoma in a Patient Receiving Rivaroxaban After Total Hip Arthroplasty.

Ozel, Omer / Demircay, Emre / Kircelli, Atilla / Cansever, Tufan

Orthopedics

2016 Volume 39, Issue 3, Page(s) e558–60

Abstract: The authors report a case of a 69-year-old woman who presented with a spontaneous spinal epidural hematoma (SSEH) 10 days after a total hip arthroplasty. The patient had been receiving 10 mg/d of rivaroxaban for 5 days for venous thromboembolism ... ...

Abstract	The authors report a case of a 69-year-old woman who presented with a spontaneous spinal epidural hematoma (SSEH) 10 days after a total hip arthroplasty. The patient had been receiving 10 mg/d of rivaroxaban for 5 days for venous thromboembolism prophylaxis. She had a sudden onset of severe neck pain, followed by quadriplegia below C4. A dorsal SSEH was revealed by computed tomography. While preparing for the emergency evacuation of the SSEH, the neurological symptoms resolved spontaneously in 4 hours. The 1-month follow-up magnetic resonance imaging confirmed that the SSEH had completely resolved. The pathogenesis of SSEH is unclear, but anticoagulant therapy is a known risk factor. It is a relatively rare disorder. Only 1 case of SSEH has been reported, and that patient was receiving a nonsteroidal anti-inflammatory drug besides rivaroxaban, which is another known risk factor for bleeding disorders. [Orthopedics. 2016; 39(3):e558-e560.].
MeSH term(s)	Aged ; Anticoagulants/adverse effects ; Arthroplasty, Replacement, Hip/adverse effects ; Female ; Hematoma, Epidural, Spinal/chemically induced ; Hematoma, Epidural, Spinal/diagnosis ; Hematoma, Epidural, Spinal/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Neck Pain/etiology ; Rare Diseases/surgery ; Risk Factors ; Rivaroxaban/adverse effects ; Tomography, X-Ray Computed ; Venous Thromboembolism/prevention & control
Chemical Substances	Anticoagulants ; Rivaroxaban (9NDF7JZ4M3)
Language	English
Publishing date	2016-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	424447-3
ISSN	1938-2367 ; 0147-7447
ISSN (online)	1938-2367
ISSN	0147-7447
DOI	10.3928/01477447-20160414-01
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Zs.A 1487: Show issues

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Article ; Online: Comparison of Anteromedial and Transtibial ACL Reconstruction Using Expandable Fixation.

Ozel, Omer / Yucel, Bulent / Orman, Osman / Demircay, Emre / Mutlu, Serhat

Orthopedics

2017 Volume 40, Issue 3, Page(s) e532–e537

Abstract: The influence of anatomical or nonanatomical femoral tunnel position on tunnel widening and clinical outcomes in patients undergoing anterior cruciate ligament (ACL) reconstruction is not fully understood. This retrospective study examined the influence ... ...

Abstract	The influence of anatomical or nonanatomical femoral tunnel position on tunnel widening and clinical outcomes in patients undergoing anterior cruciate ligament (ACL) reconstruction is not fully understood. This retrospective study examined the influence of tunnel width and placement on anterior knee stability and clinical outcomes after ACL reconstruction using the AperFix System (Cayenne Medical Inc, Scottsdale, Arizona), a direct expandable fixation technique with autologous hamstring grafts. The records of 80 patients (79 men and 1 woman) who underwent ACL reconstruction were evaluated. In 38 patients, anatomical femoral tunnel placement was performed via an accessory medial portal (anteromedial group); in the remaining 42 patients, the femoral tunnel was positioned nonanatomically using a transtibial technique (transtibial group). Mean follow-up was 40.7 months (range, 27-60 months). Postoperative knee kinetics were measured, and clinical outcomes were assessed using International Knee Documentation Committee, Lysholm, and Tegner scores. Femoral tunnel widening was measured by comparing postoperative radiographs with final follow-up radiographs. Femoral tunnel width was significantly greater (P<.001) and anterior knee translation was significantly higher (P=.01) in the transtibial group. Lysholm and Tegner scores were not significantly different (P>.05) between the 2 groups. These findings suggest that femoral tunnel widening is associated with increased anterior joint laxity when a direct fixation technique is used for ACL reconstruction, particularly in nonanatomically positioned femoral tunnels. Anatomical femoral tunnel placement provides better anterior stability and less tunnel widening than transtibial tunnel placement; however, these benefits did not produce a detectable advantage in clinical outcomes measures. [Orthopedics. 2017; 40(3):e532-e537.].
Language	English
Publishing date	2017-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	424447-3
ISSN	1938-2367 ; 0147-7447
ISSN (online)	1938-2367
ISSN	0147-7447
DOI	10.3928/01477447-20170404-02
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Zs.A 1487: Show issues

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Article: Simultaneous bilateral ganglion cysts of the anterior cruciate ligaments.

Demircay, Emre / Ofluoglu, Demet / Ozel, Omer / Oztop, Pinar

Singapore medical journal

2015 Volume 56, Issue 4, Page(s) e59–61

Abstract: Intra-articular ganglion cysts of the anterior cruciate ligament (ACL) are rare, and bilateral ganglion cysts are even rarer. These cysts may cause intermittent or chronic nonspecific knee discomfort. Although three cases of bilateral ganglion cysts have ...

Abstract	Intra-articular ganglion cysts of the anterior cruciate ligament (ACL) are rare, and bilateral ganglion cysts are even rarer. These cysts may cause intermittent or chronic nonspecific knee discomfort. Although three cases of bilateral ganglion cysts have been reported in the literature, the knees were not simultaneously affected in those cases. Herein, we report the case of a 56-year-old woman who presented with simultaneous bilateral ganglion cysts of the ACL that were symptomatic. She was successfully treated with arthroscopic resection and debridement. We also present a brief review of the literature, highlighting the aetiology, diagnosis and management of ganglion cysts of the ACL. To the best of our knowledge, this is the first report of simultaneous bilateral intra-articular ganglion cysts of the ACL.
MeSH term(s)	Anterior Cruciate Ligament/pathology ; Anterior Cruciate Ligament/surgery ; Arthroscopy/methods ; Debridement/methods ; Delayed Diagnosis ; Female ; Ganglion Cysts/diagnosis ; Ganglion Cysts/surgery ; Humans ; Magnetic Resonance Imaging ; Middle Aged
Language	English
Publishing date	2015-04-27
Publishing country	Singapore
Document type	Case Reports ; Journal Article
ZDB-ID	604319-7
ISSN	0037-5675
ISSN	0037-5675
DOI	10.11622/smedj.2015062
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Zs.B 589: Show issues

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Conference proceedings: A Comparison of The Anteromedial and Transtibial Anterior Cruciate Ligament Reconstruction Using Expandable Fixation

Ozel, Omer / Yucel, Bulent / Orman, Osman / Demircay, Emre / Mutlu, Serhat

2016 , Page(s) IN12–627

Event/congress	Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2016
Keywords	Medizin, Gesundheit ; tunnel widening ; aperfix system ; direct graft fixation ; anatomic tunnel ; non-anatomic tunnel
Publishing date	2016-10-10
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/16dkou006
Database	German Medical Science

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Article ; Online: Malignant lymphoma of bone: a review of 119 patients.

Demircay, Emre / Hornicek, Francis John / Mankin, Henry J / Degroot, Henry

Clinical orthopaedics and related research

2013 Volume 471, Issue 8, Page(s) 2684–2690

Abstract: Background: Lymphoma of bone is uncommon. As a result of this, many aspects of primary lymphoma of bone (PLB) are controversial: the definition, treatment strategies, response criteria, and prognostic factors.: Questions/purposes: We sought to ... ...

Abstract	Background: Lymphoma of bone is uncommon. As a result of this, many aspects of primary lymphoma of bone (PLB) are controversial: the definition, treatment strategies, response criteria, and prognostic factors. Questions/purposes: We sought to determine the following in an analysis from a single center over a four-decade period: (1) 5-year disease-free survival of patients with PLB as well as those with systemic lymphoma with bone involvement; and (2) whether prognostic factors (sex, site of tumor, age) were associated with 5-year survival. Methods: A total of 119 patients with lymphoma involving the musculoskeletal system were retrospectively evaluated. Among these, 94 patients who had a minimum followup of 6 months (mean, 67 months; range, 6 months to 34 years) were further analyzed for the skeletal site of involvement, the orthopaedic intervention(s) needed, and survival. The overall median age was 45 years (range, 7-87 years). The female-to-male ratio was 1:1.53. There were 70 (65 unifocal, five multifocal) patients with PLB. The femur was the most frequent site involved. Appendicular skeleton involvement was substantially higher in patients with PLB. Thirty-four (36%) patients had at least one surgical intervention. Fourteen patients (41%) needed more than one major surgical intervention. Results: The disease-free 5-year survival for patients with PLB was 81% and for the patients with systemic lymphoma with bone involvement, it was 44%. The disease-free 5-year survival of the patients with PLB younger than 60 years old and 60 years old or older was 90% and 62%, respectively. Age was the only prognostic factor on survival of patients with PLB. Conclusions: Orthopaedic intervention was usually needed for pathologic fractures, avascular necrosis, spinal cord compression, or for the lesions of the weightbearing bones compromising stability or joint motion. The potential for long-term survival suggests the use of implants and techniques that have the best chance of long-term success.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Bone Neoplasms/complications ; Bone Neoplasms/mortality ; Bone Neoplasms/pathology ; Bone Neoplasms/surgery ; Child ; Disease-Free Survival ; Female ; Humans ; Lymphoma/complications ; Lymphoma/mortality ; Lymphoma/pathology ; Lymphoma/surgery ; Male ; Middle Aged ; Neoplasm Invasiveness ; Orthopedic Procedures ; Reoperation ; Retrospective Studies ; Risk Factors ; Survival Analysis ; Time Factors ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2013-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80301-7
ISSN	1528-1132 ; 0009-921X
ISSN (online)	1528-1132
ISSN	0009-921X
DOI	10.1007/s11999-013-2991-x
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Uk I Zs.188: Show issues

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Article ; Online: Plantar fascia coronal length: a new parameter for plantar fascia assessment.

Sari, Ahmet Sinan / Demircay, Emre / Cakmak, Gokhan / Sahin, M Sukru / Tuncay, I Cengiz / Altun, Suleyman

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

2015 Volume 54, Issue 3, Page(s) 445–448

Abstract: The effects of gender and various anthropometric variables were previously reported as significant predictors of plantar fascia thickness. Although a strong correlation between either the body weight or body mass index (BMI) and plantar fascia thickness ... ...

Abstract	The effects of gender and various anthropometric variables were previously reported as significant predictors of plantar fascia thickness. Although a strong correlation between either the body weight or body mass index (BMI) and plantar fascia thickness were not demonstrated, a moderate relation was stated. We retrospectively investigated the role of gender, height, weight, and body mass index on plantar fascia thickness at the calcaneal origin (PFCO) and 1 cm distal from the calcaneal origin (PF1cm) and the coronal length of the plantar fascia at the calcaneal origin (CLPF) in healthy subjects. The PFCO, PF1cm, and CLPF were retrospectively measured from magnetic resonance images of 100 healthy subjects. The gender, height, weight, and body mass index of the participants were also noted. Gender was a predictive factor for the length of the CLPF. The subjects with a BMI >25 kg/m(2) had a significantly greater PFCO, PF1cm, and CLPF. Height was mildly and BMI and weight were moderately related to the PFCO. However the CLPF showed a better correlation with height, BMI, and weight than that of plantar fascia thickness. CLPF better reflected the role of weight, BMI, and height than its thickness. It is a new parameter that could be valuable in the evaluation of plantar fascia disorders.
MeSH term(s)	Adult ; Body Mass Index ; Body Weight ; Body Weights and Measures ; Fascia/anatomy & histology ; Female ; Heel ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Reference Values ; Retrospective Studies ; Sex Factors ; Young Adult
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146972-9
ISSN	1542-2224 ; 1067-2516
ISSN (online)	1542-2224
ISSN	1067-2516
DOI	10.1053/j.jfas.2014.11.002
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