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Article ; Online: An incentive circuit for memory dynamics in the mushroom body of

Gkanias, Evripidis / McCurdy, Li Yan / Nitabach, Michael N / Webb, Barbara

2022 Volume 11

Abstract: Insects adapt their response to stimuli, such as odours, according to their pairing with positive or negative reinforcements, such as sugar or shock. Recent electrophysiological and imaging findings ... ...

Abstract	Insects adapt their response to stimuli, such as odours, according to their pairing with positive or negative reinforcements, such as sugar or shock. Recent electrophysiological and imaging findings in
MeSH term(s)	Animals ; Drosophila melanogaster/physiology ; Memory/physiology ; Motivation ; Mushroom Bodies/physiology ; Odorants
Language	English
Publishing date	2022-04-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.75611
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Article ; Online: A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use.

McCurdy, Li Yan / Kong, Grace / Krishnan-Sarin, Suchitra / Kiluk, Brian D / Potenza, Marc N

PloS one

2023 Volume 18, Issue 10, Page(s) e0292293

Abstract: Introduction: Connecting individuals to recovery support services such as recovery community centers and mutual help organizations can be crucial for sustaining recovery from addiction. However, there may be barriers to engagement with recovery support ... ...

Abstract	Introduction: Connecting individuals to recovery support services such as recovery community centers and mutual help organizations can be crucial for sustaining recovery from addiction. However, there may be barriers to engagement with recovery support services on individual (e.g., limited motivation) and structural (e.g., limited information on recovery resources) levels. This pilot study will determine the feasibility and acceptability of a novel online social support intervention (Let's Do Addiction Recovery Together!, abbreviated as LDART) that uses pre-recorded videos created by members from several recovery support services to help individuals in early recovery from hazardous alcohol use sustain motivation during recovery and introduce them to freely available recovery support services in the community. Methods and analysis: This will be a non-randomized mixed-method pilot study. We will recruit 30 adults who engaged in past-year hazardous alcohol use and have some desire to cut down or quit to use LDART every night for a month. A subset of these participants will be invited to participate in a semi-structured qualitative interview after completing the study. Primary outcomes will be feasibility parameters such as recruitment and retention rates, and acceptability measures such as frequency of intervention use. Secondary outcomes will include self-reported changes in alcohol use, engagement in recovery support services, and quality of life at one-month post-intervention relative to baseline. Discussion: Results of this pilot study will inform a randomized controlled trial to examine efficacy of this intervention, with the goal of creating an accessible and scalable intervention that has direct benefits on individuals who want to cut down or quit problematic alcohol use. Trial registration: ClinicalTrials.gov ID: NCT06022107.
MeSH term(s)	Adult ; Humans ; Pilot Projects ; Quality of Life ; Social Support ; Non-Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0292293
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Article ; Online: Intravenous versus oral acetaminophen for pain and quality of recovery after ambulatory spine surgery: a randomized controlled trial.

Schwenk, Eric S / Ferd, Polina / Torjman, Marc C / Li, Chris J / Charlton, Alex R / Yan, Vivian Z / McCurdy, Michael A / Kepler, Christopher K / Schroeder, Gregory D / Fleischman, Andrew N / Issa, Tariq

Regional anesthesia and pain medicine

2024

Abstract: Introduction: As ambulatory spine surgery increases, efficient recovery and discharge become essential. Multimodal analgesia is superior to opioids alone. Acetaminophen is a central component of multimodal protocols and both intravenous and oral forms ... ...

Abstract	Introduction: As ambulatory spine surgery increases, efficient recovery and discharge become essential. Multimodal analgesia is superior to opioids alone. Acetaminophen is a central component of multimodal protocols and both intravenous and oral forms are used. While some advantages for intravenous acetaminophen have been touted, prospective studies with patient-centered outcomes are lacking in ambulatory spine surgery. A substantial cost difference exists. We hypothesized that intravenous acetaminophen would be associated with fewer opioids and better recovery. Methods: Patients undergoing ambulatory spine surgery were randomized to preoperative oral placebo and intraoperative intravenous acetaminophen or preoperative oral acetaminophen. All patients received general anesthesia and multimodal analgesia. The primary outcome was 24-hour opioid use in intravenous morphine milligram equivalents (MMEs), beginning with arrival to the postanesthesia care unit (PACU). Secondary outcomes included pain, Quality of Recovery (QoR)-15 scores, postoperative nausea and vomiting, recovery time, and correlations between pain catastrophizing, QoR-15, and pain. Results: A total of 82 patients were included in final analyses. Demographics were similar between groups. For the primary outcome, the median 24-hour MMEs did not differ between groups (12.6 (4.0, 27.1) vs 12.0 (4.0, 29.5) mg, p=0.893). Postoperative pain ratings, PACU MMEs, QoR-15 scores, and recovery time showed no differences. Spearman's correlation showed a moderate negative correlation between postoperative opioid use and QoR-15. Conclusion: Intravenous acetaminophen was not superior to the oral form in ambulatory spine surgery patients. This does not support routine use of the more expensive intravenous form to improve recovery and accelerate discharge. Trial registration number: NCT04574778.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2024-105386
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Article ; Online: A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila.

Sareen, Preeti F / McCurdy, Li Yan / Nitabach, Michael N

Nature communications

2021 Volume 12, Issue 1, Page(s) 4131

Abstract: Feeding decisions are fundamental to survival, and decision making is often disrupted in disease. Here, we show that neural activity in a small population of neurons projecting to the fan-shaped body higher-order central brain region of Drosophila ... ...

Abstract	Feeding decisions are fundamental to survival, and decision making is often disrupted in disease. Here, we show that neural activity in a small population of neurons projecting to the fan-shaped body higher-order central brain region of Drosophila represents food choice during sensory conflict. We found that food deprived flies made tradeoffs between appetitive and aversive values of food. We identified an upstream neuropeptidergic and dopaminergic network that relays internal state and other decision-relevant information to a specific subset of fan-shaped body neurons. These neurons were strongly inhibited by the taste of the rejected food choice, suggesting that they encode behavioral food choice. Our findings reveal that fan-shaped body taste responses to food choices are determined not only by taste quality, but also by previous experience (including choice outcome) and hunger state, which are integrated in the fan-shaped body to encode the decision before relay to downstream motor circuits for behavioral implementation.
MeSH term(s)	Animals ; Brain/metabolism ; Decision Making ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Feeding Behavior/physiology ; Food Preferences ; Hunger/physiology ; Neurons/metabolism ; Taste/physiology ; Taste Perception
Chemical Substances	Drosophila Proteins
Language	English
Publishing date	2021-07-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-24423-y
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Article: Smartphone Apps for Problem Gambling: A Review of Content and Quality.

McCurdy, Li Yan / Loya, Jennifer M / Hart-Derrick, Victoria R / Young, Griffin C / Kiluk, Brian D / Potenza, Marc N

Current addiction reports

2023 Volume 10, Issue 2, Page(s) 178–186

Abstract: Purpose of review: Problem gambling can have profound consequences for affected individuals, yet only a small proportion of people with problem gambling seek treatment. Mobile phone applications (apps) may provide an effective and scalable therapeutic ... ...

Abstract	Purpose of review: Problem gambling can have profound consequences for affected individuals, yet only a small proportion of people with problem gambling seek treatment. Mobile phone applications (apps) may provide an effective and scalable therapeutic option. The purpose of this study was to evaluate publicly available mobile apps aimed at improving problematic gambling behavior. Recent findings: To date, there are no published studies that have evaluated the quality of publicly available smartphone apps for problem gambling in the US. There is thus a significant gap in knowledge of existing apps for addressing problem gambling. Summary: This study included a review of 14 problem-gambling-specific apps. Apps that incorporated cognitive-behavioral therapy concepts and in-app communities were associated with better aesthetics and information quality scores. Additionally, in-app communities were associated with better engagement scores. Our results highlight the importance of evidence-based and engaging features in apps designed to help people with problem gambling.
Language	English
Publishing date	2023-05-02
Publishing country	Switzerland
Document type	Journal Article
ISSN	2196-2952
ISSN	2196-2952
DOI	10.1007/s40429-023-00479-2
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Article ; Online: Neural correlates of altered emotional responsivity to infant stimuli in mothers who use substances.

McCurdy, Li Yan / Yip, Sarah W / Worhunsky, Patrick D / Zhai, Zu Wei / Kim, Sohye / Strathearn, Lane / Potenza, Marc N / Mayes, Linda C / Rutherford, Helena J V

Journal of psychiatric research

2024 Volume 171, Page(s) 126–133

Abstract: Mothers who use substances during pregnancy and postpartum may have altered maternal behavior towards their infants, which can have negative consequences on infant social-emotional development. Since maternal substance use has been associated with ... ...

Abstract	Mothers who use substances during pregnancy and postpartum may have altered maternal behavior towards their infants, which can have negative consequences on infant social-emotional development. Since maternal substance use has been associated with difficulties in recognizing and responding to infant emotional expressions, investigating mothers' subjective responses to emotional infant stimuli may provide insight into the neural and psychological processes underlying these differences in maternal behavior. In this study, 39 mothers who used substances during the perinatal period and 42 mothers who did not underwent functional magnetic resonance imaging while viewing infant faces and hearing infant cries. Afterwards, they rated the emotional intensity they thought each infant felt ('think'-rating), and how intensely they felt in response to each infant stimulus ('feel'-rating). Mothers who used substances had lower 'feel'-ratings of infant stimuli compared to mothers who did not. Brain regions implicated in affective processing (e.g., insula, inferior frontal gyrus) were less active in response to infant stimuli, and activity in these brain regions statistically predicted maternal substance-use status. Interestingly, 'think'-ratings and activation in brain regions related to cognitive processing (e.g., medial prefrontal cortex) were comparable between the two groups of mothers. Taken together, these results suggest specific neural and psychological processes related to emotional responsivity to infant stimuli may reflect differences in maternal affective processing and may contribute to differences in maternal behavior in mothers who use substances compared to mothers who do not. The findings suggest potential neural targets for increasing maternal emotional responsivity and improving child outcomes.
MeSH term(s)	Female ; Humans ; Infant ; Brain/diagnostic imaging ; Brain/physiology ; Emotions/physiology ; Magnetic Resonance Imaging ; Maternal Behavior/physiology ; Maternal Behavior/psychology ; Mother-Child Relations/psychology ; Mothers/psychology
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2024.01.024
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Article ; Online: A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila

Preeti F. Sareen / Li Yan McCurdy / Michael N. Nitabach

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 13

Abstract: The valence of information about food sources can be conflicting. Here, the authors show that activity in a small population of neurons projecting to the fan-shaped body of Drosophila represents food choice during sensory conflict. ...

Abstract	The valence of information about food sources can be conflicting. Here, the authors show that activity in a small population of neurons projecting to the fan-shaped body of Drosophila represents food choice during sensory conflict.
Keywords	Science ; Q
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster

Evripidis Gkanias / Li Yan McCurdy / Michael N Nitabach / Barbara Webb

eLife, Vol

2022 Volume 11

Abstract	Insects adapt their response to stimuli, such as odours, according to their pairing with positive or negative reinforcements, such as sugar or shock. Recent electrophysiological and imaging findings in Drosophila melanogaster allow detailed examination of the neural mechanisms supporting the acquisition, forgetting, and assimilation of memories. We propose that this data can be explained by the combination of a dopaminergic plasticity rule that supports a variety of synaptic strength change phenomena, and a circuit structure (derived from neuroanatomy) between dopaminergic and output neurons that creates different roles for specific neurons. Computational modelling shows that this circuit allows for rapid memory acquisition, transfer from short term to long term, and exploration/exploitation trade-off. The model can reproduce the observed changes in the activity of each of the identified neurons in conditioning paradigms and can be used for flexible behavioural control.
Keywords	computational model ; memory ; plasticity ; dopamine ; olfactory conditioning ; motivation ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use.

Li Yan McCurdy / Grace Kong / Suchitra Krishnan-Sarin / Brian D Kiluk / Marc N Potenza

PLoS ONE, Vol 18, Iss 10, p e

2023 Volume 0292293

Abstract: Introduction Connecting individuals to recovery support services such as recovery community centers and mutual help organizations can be crucial for sustaining recovery from addiction. However, there may be barriers to engagement with recovery support ... ...

Abstract	Introduction Connecting individuals to recovery support services such as recovery community centers and mutual help organizations can be crucial for sustaining recovery from addiction. However, there may be barriers to engagement with recovery support services on individual (e.g., limited motivation) and structural (e.g., limited information on recovery resources) levels. This pilot study will determine the feasibility and acceptability of a novel online social support intervention (Let's Do Addiction Recovery Together!, abbreviated as LDART) that uses pre-recorded videos created by members from several recovery support services to help individuals in early recovery from hazardous alcohol use sustain motivation during recovery and introduce them to freely available recovery support services in the community. Methods and analysis This will be a non-randomized mixed-method pilot study. We will recruit 30 adults who engaged in past-year hazardous alcohol use and have some desire to cut down or quit to use LDART every night for a month. A subset of these participants will be invited to participate in a semi-structured qualitative interview after completing the study. Primary outcomes will be feasibility parameters such as recruitment and retention rates, and acceptability measures such as frequency of intervention use. Secondary outcomes will include self-reported changes in alcohol use, engagement in recovery support services, and quality of life at one-month post-intervention relative to baseline. Discussion Results of this pilot study will inform a randomized controlled trial to examine efficacy of this intervention, with the goal of creating an accessible and scalable intervention that has direct benefits on individuals who want to cut down or quit problematic alcohol use. Trial registration ClinicalTrials.gov ID: NCT06022107.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila.

McCurdy, Li Yan / Sareen, Preeti / Davoudian, Pasha A / Nitabach, Michael N

Nature communications

2021 Volume 12, Issue 1, Page(s) 1115

Abstract: Animals form and update learned associations between otherwise neutral sensory cues and aversive outcomes (i.e., punishment) to predict and avoid danger in changing environments. When a cue later occurs without punishment, this unexpected omission of ... ...

Abstract	Animals form and update learned associations between otherwise neutral sensory cues and aversive outcomes (i.e., punishment) to predict and avoid danger in changing environments. When a cue later occurs without punishment, this unexpected omission of aversive outcome is encoded as reward via activation of reward-encoding dopaminergic neurons. How such activation occurs remains unknown. Using real-time in vivo functional imaging, optogenetics, behavioral analysis and synaptic reconstruction from electron microscopy data, we identify the neural circuit mechanism through which Drosophila reward-encoding dopaminergic neurons are activated when an olfactory cue is unexpectedly no longer paired with electric shock punishment. Reduced activation of punishment-encoding dopaminergic neurons relieves depression of olfactory synaptic inputs to cholinergic neurons. Synaptic excitation by these cholinergic neurons of reward-encoding dopaminergic neurons increases their odor response, thus decreasing aversiveness of the odor. These studies reveal how an excitatory cholinergic relay from punishment- to reward-encoding dopaminergic neurons encodes the absence of punishment as reward, revealing a general circuit motif for updating aversive memories that could be present in mammals.
MeSH term(s)	Animals ; Avoidance Learning/physiology ; Conditioning, Classical ; Dopamine/metabolism ; Dopaminergic Neurons/physiology ; Drosophila melanogaster/physiology ; Memory/physiology ; Punishment ; Reversal Learning ; Reward ; Smell/physiology ; Synapses/physiology
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-21388-w
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