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  1. Article ; Online: Anatomising failure: there should be a statutory public inquiry into the UK Government's handling of COVID-19.

    Clift, Ashley Kieran

    Journal of the Royal Society of Medicine

    2020  Volume 113, Issue 6, Page(s) 230–231

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Empowerment ; Federal Government ; Government Regulation ; Humans ; Leadership ; Needs Assessment ; Pandemics/legislation & jurisprudence ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Right to Health/legislation & jurisprudence ; Right to Health/standards ; SARS-CoV-2 ; Social Responsibility ; United Kingdom
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1177/0141076820925778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anatomising failure

    Clift, Ashley Kieran

    Journal of the Royal Society of Medicine

    there should be a statutory public inquiry into the UK Government’s handling of COVID-19

    2020  Volume 113, Issue 6, Page(s) 230–231

    Keywords General Medicine ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1177/0141076820925778
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Developments in interventional management of hepatic metastases from neuroendocrine tumours.

    Clift, Ashley Kieran / Thomas, Robert / Frilling, Andrea

    Best practice & research. Clinical endocrinology & metabolism

    2023  Volume 37, Issue 5, Page(s) 101798

    Abstract: Neuroendocrine tumours commonly metastasise to the liver, particularly those arising from the intestinal tract and pancreas. Whilst surgery offers the only approach with intent to cure, the vast majority of patients with neuroendocrine liver metastases ... ...

    Abstract Neuroendocrine tumours commonly metastasise to the liver, particularly those arising from the intestinal tract and pancreas. Whilst surgery offers the only approach with intent to cure, the vast majority of patients with neuroendocrine liver metastases are ineligible. Liver-directed interventional therapies seek to exploit the patho-anatomy of the blood supply of hepatic metastases to deliver therapy to liver deposits. This may involve percutaneous ablation, bland embolization, or the selective infusion of chemotherapeutics, targeted agents or radiolabelled embolic material. Retrospective case series evidence has characterised objective response rates, disease control rates, and longer-term outcomes associated with each approach. Recent advances in this field include ongoing comparative trials of different techniques, but more importantly, combinations of interventional liver-directed therapies and other systemic therapy in multimodal treatment concepts.
    MeSH term(s) Humans ; Neuroendocrine Tumors/therapy ; Retrospective Studies ; Liver Neoplasms/therapy ; Liver Neoplasms/secondary ; Antineoplastic Agents ; Embolization, Therapeutic/methods
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2023.101798
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  5. Article ; Online: The diagnostic odyssey in children and adolescents with X-linked hypophosphataemia: population-based, case-control study.

    Boardman-Pretty, Freya / Clift, Ashley Kieran / Mahon, Hadley / Sawoky, Nadine / Mughal, M Zulf

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: X-linked hypophosphataemia (XLH) is a rare genetic disorder causing renal phosphate wasting, which predicates musculoskeletal manifestations such as rickets. Diagnosis is often delayed.: Objective: To explore the recording of clinical ... ...

    Abstract Context: X-linked hypophosphataemia (XLH) is a rare genetic disorder causing renal phosphate wasting, which predicates musculoskeletal manifestations such as rickets. Diagnosis is often delayed.
    Objective: To explore the recording of clinical features, and the diagnostic odyssey of children and adolescents with XLH in primary care electronic healthcare records (EHR) in the United Kingdom.
    Methods: Using the Optimum Patient Care Research Database, individuals aged 20 years or younger after 1st Jan 2000 at date of recorded XLH diagnosis were identified using SNOMED/Read codes, and age-matched to 100 controls. Recording of XLH-related clinical features was summarised, then compared between cases and controls using Chi-squared or Fisher's exact tests.
    Results: 261 XLH cases were identified; 99 met inclusion criteria. Of these, 84/99 had at least 1 XLH-related clinical feature recorded in their primary care EHR. Clinical codes for rickets, genu varum and low phosphate were recorded prior to XLH diagnosis in under 20% of cases (median of 1, 1, and 3 years prior, respectively). Rickets, genu varum, low phosphate, nephrocalcinosis and growth delay were significantly more likely to be recorded in cases.
    Conclusion: This characterisation of the EHR phenotypes of children and adolescents with XLH may inform future case-finding approaches to expedite diagnosis in primary care.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Combining radiolabelled therapies for neuroendocrine neoplasms.

    Frilling, Andrea / Clift, Ashley Kieran

    Nature reviews. Endocrinology

    2020  Volume 16, Issue 7, Page(s) 347–348

    MeSH term(s) Holmium ; Humans ; Liver Neoplasms ; Lutetium ; Neuroendocrine Tumors ; Radioisotopes
    Chemical Substances Holmium-166 ; Radioisotopes ; Lutetium (5H0DOZ21UJ) ; Lutetium-177 (BRH40Y9V1Q) ; Holmium (W1XX32SQN1)
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-020-0367-3
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  7. Article ; Online: Liver-Directed Therapies for Neuroendocrine Neoplasms.

    Clift, Ashley Kieran / Frilling, Andrea

    Current oncology reports

    2021  Volume 23, Issue 4, Page(s) 44

    Abstract: Purpose of review: To comprehensively synthesise and appraise the available evidence regarding therapies for metastatic neuroendocrine neoplasms that exploit the hepatic vasculature to deliver therapy to liver metastases.: Recent findings: Various ... ...

    Abstract Purpose of review: To comprehensively synthesise and appraise the available evidence regarding therapies for metastatic neuroendocrine neoplasms that exploit the hepatic vasculature to deliver therapy to liver metastases.
    Recent findings: Various techniques including transarterial embolisation/chemoembolisation (TAE/TACE) and selective internal radiotherapy (SIRT, also termed radioembolisation [RE]) have been examined in patents with neuroendocrine liver metastases. Variations in the radioactive agents for selective internal radiotherapy (SIRT) have been explored, such as the use of Holmium-166, in addition to more established agents such as Yttrium-90. Recent trials have examined the safety and efficacy of combining liver-targeted therapy with systemic treatments, such as peptide receptor radionuclide therapy. More retrospective case series of liver-directed modalities will not provide additional knowledge. Randomised clinical trials have begun to compare the efficacy of different forms of liver-directed therapies, and also their combination with systemic treatment. Their results are expected to guide optimal treatment sequencing within multimodal concepts.
    MeSH term(s) Chemoembolization, Therapeutic ; Clinical Trials as Topic ; Holmium ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Neuroendocrine Tumors/pathology ; Radioisotopes ; Radiotherapy ; Yttrium Radioisotopes
    Chemical Substances Holmium-166 ; Radioisotopes ; Yttrium Radioisotopes ; Yttrium-90 (1K8M7UR6O1) ; Holmium (W1XX32SQN1)
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-021-01030-0
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    Zs.A 5521: Show issues Location:
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  8. Article: Long-Term Outcomes of Liver Transplantation for the Management of Neuroendocrine Neoplasms: A Systematic Review.

    Palaniappan, Varun / Li, Chun Hei / Frilling, Andrea / Clift, Ashley Kieran

    Journal of personalized medicine

    2023  Volume 13, Issue 10

    Abstract: Liver transplantation is an uncommonly used, controversially debated therapeutic approach for highly selected individuals with neuroendocrine liver metastases. Synthesising evidence regarding outcomes from this approach is crucial to understand its ... ...

    Abstract Liver transplantation is an uncommonly used, controversially debated therapeutic approach for highly selected individuals with neuroendocrine liver metastases. Synthesising evidence regarding outcomes from this approach is crucial to understand its position within the broad neuroendocrine liver metastases armamentarium. In this narrative systematic review of studies published in PubMed, Scopus and OVID until 1 July 2021, we summarise and critically appraise the existing literature regarding this modality, with a special focus on long-term outcomes data where possible. Fourteen studies were identified that reported outcomes from the use of liver transplantation for metastatic neuroendocrine neoplasms. No randomised trials were identified. Generally, indications and selection criteria were poorly articulated, with the notable exception of studies using the Milan criteria. The median 5-year overall survival was 65% (ranging from 36% to 97.2%, 11 studies), and the median 10-year overall survival was 50% (ranging from 46.1% to 88.8%, 3 studies). One additional study focussed on treatments and outcomes following post-transplant recurrence. No studies reported outcomes past 10 years. Further follow-up of the largest series with explicit selection criteria will deepen our understanding of the role that transplantation has to play in this setting.
    Language English
    Publishing date 2023-09-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13101428
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  9. Article ; Online: Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998-2017.

    Clift, Ashley Kieran / Coupland, Carol Ac / Hippisley-Cox, Julia

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2021  Volume 71, Issue 703, Page(s) e157–e165

    Abstract: Background: Prostate cancer is a leading cause of cancer- related death. Interpreting the results from trials of screening with prostate-specific antigen (PSA) is complex in terms of defining optimal prostate cancer screening policy.: Aim: To assess ... ...

    Abstract Background: Prostate cancer is a leading cause of cancer- related death. Interpreting the results from trials of screening with prostate-specific antigen (PSA) is complex in terms of defining optimal prostate cancer screening policy.
    Aim: To assess the rates of, and factors associated with, the uptake of PSA testing and opportunistic screening (that is, a PSA test in the absence of any symptoms) in England between 1998 and 2017, and to estimate the likely rates of pre-randomisation screening and contamination (that is, unscheduled screening in the 'control' arm) of the UK-based Cluster Randomised Trial of PSA Testing for Prostate Cancer (CAP).
    Design and setting: Open cohort study of men in England aged 40-75 years at cohort entry (1998-2017), undertaken using the QResearch database.
    Method: Eligible men were followed for up to 19 years. Rates of PSA testing and opportunistic PSA screening were calculated; Cox regression was used to estimate associations.
    Results: The cohort comprised 2 808 477 men, of whom 631 426 had a total of 1 720 855 PSA tests. The authors identified that 410 724 men had opportunistic PSA screening. Cumulative proportions of uptake of opportunistic screening in the cohort were 9.96% at 5 years', 22.71% at 10 years', and 44.13% at 19 years' follow-up. The potential rate of contamination in the CAP control arm was estimated at 24.50%.
    Conclusion: A substantial number of men in England opt in to opportunistic prostate cancer screening, despite uncertainty regarding its efficacy and harms. The rate of opportunistic prostate cancer screening in the population is likely to have contaminated the CAP trial, making it difficult to interpret the results.
    MeSH term(s) Adult ; Aged ; Cohort Studies ; Early Detection of Cancer ; England/epidemiology ; Humans ; Male ; Mass Screening ; Middle Aged ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp20X713957
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  10. Article ; Online: Surgical Approaches to the Management of Neuroendocrine Liver Metastases.

    Frilling, Andrea / Clift, Ashley Kieran

    Endocrinology and metabolism clinics of North America

    2018  Volume 47, Issue 3, Page(s) 627–643

    Abstract: Surgical approaches to hepatic metastases occupy an important role in the management of patients with neuroendocrine neoplasms and may have curative or palliative intentions. Resection of hepatic disease with curative intent is the only modality offering ...

    Abstract Surgical approaches to hepatic metastases occupy an important role in the management of patients with neuroendocrine neoplasms and may have curative or palliative intentions. Resection of hepatic disease with curative intent is the only modality offering potential cure for patients with liver metastases; however, only a minority of patients are eligible. Regardless of resection margin, disease recurrence almost invariably occurs and novel adjuvant/neoadjuvant therapies are mandated to be included within multimodal treatment concepts. Liver transplantation in meticulously selected patients may be associated with excellent outcomes, but unfortunately demands on donated organs limit the wider utilization of this approach.
    MeSH term(s) Combined Modality Therapy ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Liver Transplantation ; Neoadjuvant Therapy ; Neuroendocrine Tumors/pathology ; Neuroendocrine Tumors/surgery
    Language English
    Publishing date 2018-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2018.04.001
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