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  1. AU=Duro Raquel Pacheco
  2. AU="Rao, Carmelo Massimiliano"
  3. AU="Sung, Byungje"
  4. AU="Debbie Sherratt"
  5. AU="Zhen, Jimmy"
  6. AU=Haraj Nassim Essabah
  7. AU="Garabiles, Melissa R."
  8. AU="Jin-cai Hou"
  9. AU="Kolb, Jennifer M"
  10. AU=Kalra Paul R
  11. AU="Miller, Mona"
  12. AU="Tao Ming Sim"
  13. AU="Simen, Susanne"
  14. AU="Jole Costanza"
  15. AU="Paula, Camila S Y"
  16. AU="Azevedo, Helena S"
  17. AU=Molyneaux Phillip L.
  18. AU=Shimizu Kazuki
  19. AU=Pell Robert AU=Pell Robert
  20. AU="Aguiar, Liza"
  21. AU="Bahls, Christine"
  22. AU="Dongho Lee"
  23. AU=Houser Steven R.
  24. AU="Morgom M.M."
  25. AU="Jordana-Comajuncosa, Rosa"
  26. AU="Kaushansky, Alexis"
  27. AU="Bhatjiwale, Mohinish"
  28. AU="Velu, Chinavenmeni S"
  29. AU=Trayanova Natalia A
  30. AU=Jimeno-Gonzlez Silvia
  31. AU=Bussolino F
  32. AU="Almulla, Hanan"
  33. AU="Chen, Wenmei"
  34. AU=Zeng Weiqing

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  1. Artikel: Severe Tuberculosis Requiring Intensive Care: A Descriptive Analysis.

    Duro, Raquel Pacheco / Figueiredo Dias, Paulo / Ferreira, Alcina Azevedo / Xerinda, Sandra Margarida / Lima Alves, Carlos / Sarmento, António Carlos / Dos Santos, Lurdes Campos

    Critical care research and practice

    2017  Band 2017, Seite(n) 9535463

    Abstract: ... ...

    Abstract Background
    Sprache Englisch
    Erscheinungsdatum 2017-01-30
    Erscheinungsland Egypt
    Dokumenttyp Journal Article
    ZDB-ID 2573849-5
    ISSN 2090-1313 ; 2090-1305
    ISSN (online) 2090-1313
    ISSN 2090-1305
    DOI 10.1155/2017/9535463
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Anatomophysiologic basis of tetralogy of Fallot and its clinical implications.

    Duro, Raquel Pacheco / Moura, Cláudia / Leite-Moreira, Adelino

    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

    2010  Band 29, Heft 4, Seite(n) 591–630

    Abstract: Tetralogy of Fallot is the most frequent cyanotic congenital cardiopathy. Its physiopathology has been progressively described which has made better treatment possible. The four characteristic morphologic abnormalities are: interventricular communication, ...

    Abstract Tetralogy of Fallot is the most frequent cyanotic congenital cardiopathy. Its physiopathology has been progressively described which has made better treatment possible. The four characteristic morphologic abnormalities are: interventricular communication, subpulmonary stenosis, biventricular origin of the aortic valve and right ventricular hypertrophy, which are the direct result of the antero-cephalad deviation of the ventricular septal outlet and hypertrophy of the septoparietal trabeculations. These anatomic abnormalities result in decreased pulmonary blood flow, leading to hypoxia and cyanosis. The main determinants of pulmonary blood flow are the source of the blood flow to the lungs, the severity and functional behaviour of the subpulmonary obstruction, the right ventricular and arterial systemic pressures and the ductus arteriosus. The mechanism of cyanotic spells is not clear. Increases in infundibular contractility, peripheral vasodilatation and right ventricular mechanoreceptor stimulation are some of the proposed mechanisms. There are two surgical strategies in newborns/children: a staged approach (with a palliative procedure followed by the complete repair) or early complete repair. There are arguments for and against each of these strategies, and the debate about the ideal treatment continues. In conclusion, the correct understanding of this cardiopathy's physiopathology is essential to improving the child's treatment. This review is particularly contemporary and relevant issue because one must always bear in mind the physiopathology of the original disease in order to correctly follow-up a new patient population: adults with surgically corrected Tetralogy of Fallot.
    Mesh-Begriff(e) Child ; Child, Preschool ; Ductus Arteriosus/physiopathology ; Exercise ; Fetus/blood supply ; Heart Septal Defects, Ventricular/complications ; Heart Septal Defects, Ventricular/pathology ; Heart Septal Defects, Ventricular/physiopathology ; Humans ; Hypoxia/etiology ; Infant ; Infant, Newborn ; Oxygen/metabolism ; Posture ; Pulmonary Circulation ; Tetralogy of Fallot/complications ; Tetralogy of Fallot/pathology ; Tetralogy of Fallot/physiopathology ; Tetralogy of Fallot/surgery ; Ventricular Dysfunction, Right/etiology ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Outflow Obstruction/etiology ; Ventricular Outflow Obstruction/physiopathology
    Chemische Substanzen Oxygen (S88TT14065)
    Sprache Portugiesisch
    Erscheinungsdatum 2010-04
    Erscheinungsland Portugal
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632718-7
    ISSN 0870-2551 ; 0304-4750
    ISSN 0870-2551 ; 0304-4750
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  3. Artikel ; Online: Severe Tuberculosis Requiring Intensive Care

    Raquel Pacheco Duro / Paulo Figueiredo Dias / Alcina Azevedo Ferreira / Sandra Margarida Xerinda / Carlos Lima Alves / António Carlos Sarmento / Lurdes Campos dos Santos

    Critical Care Research and Practice, Vol

    A Descriptive Analysis

    2017  Band 2017

    Abstract: Background. This study aims to describe the characteristics of tuberculosis (TB) patients requiring intensive care and to determine the in-hospital mortality and the associated predictive factors. Methods. Retrospective cohort study of all TB patients ... ...

    Abstract Background. This study aims to describe the characteristics of tuberculosis (TB) patients requiring intensive care and to determine the in-hospital mortality and the associated predictive factors. Methods. Retrospective cohort study of all TB patients admitted to the ICU of the Infectious Diseases Department of Centro Hospitalar de São João (Porto, Portugal) between January 2007 and July 2014. Comorbid diagnoses, clinical features, radiological and laboratory investigations, and outcomes were reviewed. Univariate analysis was performed to identify risk factors for death. Results. We included 39 patients: median age was 52.0 years and 74.4% were male. Twenty-one patients (53.8%) died during hospital stay (15 in the ICU). The diagnosis of isolated pulmonary TB, a positive smear for acid-fast-bacilli and a positive PCR for Mycobacterium tuberculosis in patients of pulmonary disease, severe sepsis/septic shock, acute renal failure and Multiple Organ Dysfunction Syndrome on admission, the need for mechanical ventilation or vasopressor support, hospital acquired infection, use of adjunctive corticotherapy, smoking, and alcohol abuse were significantly associated with mortality (p<0.05). Conclusion. This cohort of TB patients requiring intensive care presented a high mortality rate. Most risk factors for mortality were related to organ failure, but others could be attributed to delay in the diagnostic and therapeutic approach, important targets for intervention.
    Schlagwörter Internal medicine ; RC31-1245 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Environmental tobacco smoke in the early postnatal period induces impairment in brain myelination.

    Torres, Larissa H / Annoni, Raquel / Balestrin, Natalia T / Coleto, Priscila L / Duro, Stephanie O / Garcia, Raphael C T / Pacheco-Neto, Maurílio / Mauad, Thais / Camarini, Rosana / Britto, Luiz R G / Marcourakis, Tania

    Archives of toxicology

    2015  Band 89, Heft 11, Seite(n) 2051–2058

    Abstract: Environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in children. However, few studies focus on the brain development effects of ETS exposure. Myelination mainly occurs in the early years of life in humans and the ... ...

    Abstract Environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in children. However, few studies focus on the brain development effects of ETS exposure. Myelination mainly occurs in the early years of life in humans and the first three postnatal weeks in rodents and is sensitive to xenobiotics exposure. This study investigated the effects of early postnatal ETS exposure on myelination. BALB/c mice were exposed to ETS generated from 3R4F reference research cigarettes from the third to the fourteenth days of life. The myelination of nerve fibers in the optic nerve by morphometric analysis and the levels of Olig1 and myelin basic protein (MBP) were evaluated in the cerebellum, diencephalon, telencephalon, and brainstem in infancy, adolescence, and adulthood. Infant mice exposed to ETS showed a decrease in the percentage of myelinated fibers in the optic nerve, compared with controls. ETS induced a decrease in Olig1 protein levels in the cerebellum and brainstem and an increase in MBP levels in the cerebellum at infant. It was also found a decrease in MBP levels in the telencephalon and brainstem at adolescence and in the cerebellum and diencephalon at adulthood. The present study demonstrates that exposure to ETS, in a critical phase of development, affects the percentage of myelinated fibers and myelin-specific proteins in infant mice. Although we did not observe differences in the morphological analysis in adolescence and adulthood, there was a decrease in MBP levels in distinctive brain regions suggesting a delayed effect in adolescence and adulthood.
    Mesh-Begriff(e) Age Factors ; Animals ; Animals, Newborn ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Brain/pathology ; Environmental Exposure/adverse effects ; Mice ; Mice, Inbred BALB C ; Myelin Basic Protein/metabolism ; Myelin Sheath/pathology ; Optic Nerve/pathology ; Tobacco Smoke Pollution/adverse effects
    Chemische Substanzen Basic Helix-Loop-Helix Transcription Factors ; Myelin Basic Protein ; Olig1 protein, mouse ; Tobacco Smoke Pollution
    Sprache Englisch
    Erscheinungsdatum 2015-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-014-1343-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Uf I Zs.90: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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