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  1. Article ; Online: Reduced postabsorptive interoception of nutrients in obesity: cause or consequence?

    Berthoud, Hans-Rudolf

    The American journal of clinical nutrition

    2023  Volume 118, Issue 3, Page(s) 496–497

    MeSH term(s) Humans ; Interoception ; Nutrients ; Obesity
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1016/j.ajcnut.2023.07.015
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  2. Article ; Online: Corrigendum to "Functional anatomy of the vagus system: How does the polyvagal theory comply?" [Biological Psychology 174 (2022) 108425].

    Neuhuber, Winfried L / Berthoud, Hans-Rudolf

    Biological psychology

    2023  Volume 179, Page(s) 108554

    Language English
    Publishing date 2023-04-12
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2023.108554
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  3. Article ; Online: Functional anatomy of the vagus system: How does the polyvagal theory comply?

    Neuhuber, Winfried L / Berthoud, Hans-Rudolf

    Biological psychology

    2022  Volume 174, Page(s) 108425

    Abstract: Due to its pivotal role in autonomic networks and interoception, the vagus attracts continued interest from both basic scientists and therapists of various clinical disciplines. In particular, the widespread use of heart rate variability as an index of ... ...

    Abstract Due to its pivotal role in autonomic networks and interoception, the vagus attracts continued interest from both basic scientists and therapists of various clinical disciplines. In particular, the widespread use of heart rate variability as an index of autonomic cardiac control and a proposed central role of the vagus in biopsychological concepts, e.g., the polyvagal theory, provide a good opportunity to recall basic features of vagal anatomy. In addition to the "classical" vagal brainstem nuclei, i.e., dorsal motor nucleus, nucleus ambiguus and nucleus tractus solitarii, the spinal trigeminal and paratrigeminal nuclei come into play as targets of vagal afferents. On the other hand, the nucleus of the solitary tract receives and integrates not only visceral but also somatic afferents.
    MeSH term(s) Autonomic Nervous System ; Heart Rate ; Humans ; Solitary Nucleus ; Vagus Nerve
    Language English
    Publishing date 2022-09-12
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2022.108425
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  4. Article ; Online: Hepatic interoception in health and disease.

    Berthoud, Hans-Rudolf / Münzberg, Heike / Morrison, Christopher D / Neuhuber, Winfried L

    Autonomic neuroscience : basic & clinical

    2024  Volume 253, Page(s) 103174

    Abstract: The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. ...

    Abstract The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific sensory and motor components of both vagal and spinal access pathways to the hepatic parenchyma is missing. Lack of progress largely owes to controversies regarding selectivity of vagal access pathways and extent of hepatocyte innervation. In contrast, there is considerable evidence for glucose sensors in the wall of the hepatic portal vein and their importance for glucose handling by the liver and the brain and the systemic response to hypoglycemia. As liver diseases are on the rise globally, and there are intriguing associations between liver diseases and mental illnesses, it will be important to further dissect and identify both neural and humoral pathways that mediate hepatocyte-specific signals to relevant brain areas. The question of whether and how sensations from the liver contribute to interoceptive self-awareness has not yet been explored.
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2024.103174
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  5. Article ; Online: Sensory spinal interoceptive pathways and energy balance regulation.

    Münzberg, Heike / Berthoud, Hans-Rudolf / Neuhuber, Winfried L

    Molecular metabolism

    2023  Volume 78, Page(s) 101817

    Abstract: Interoception plays an important role in homeostatic regulation of energy intake and metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain signaling via vagal sensory nerves and hormones, such as leptin. However, ... ...

    Abstract Interoception plays an important role in homeostatic regulation of energy intake and metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain signaling via vagal sensory nerves and hormones, such as leptin. However, signaling via spinal sensory neurons is rapidly emerging as an additional important signaling pathway. Here we provide an in-depth review of the known anatomy and functions of spinal sensory pathways and discuss potential mechanisms relevant for energy balance homeostasis in health and disease. Because sensory innervation by dorsal root ganglia (DRG) neurons goes far beyond vagally innervated viscera and includes adipose tissue, skeletal muscle, and skin, it is in a position to provide much more complete metabolic information to the brain. Molecular and anatomical identification of function specific DRG neurons will be important steps in designing pharmacological and neuromodulation approaches to affect energy balance regulation in disease states such as obesity, diabetes, and cancer.
    MeSH term(s) Humans ; Sensory Receptor Cells/metabolism ; Vagus Nerve/metabolism ; Obesity/metabolism ; Adipose Tissue/metabolism ; Ganglia, Spinal/metabolism
    Language English
    Publishing date 2023-10-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2023.101817
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  6. Article ; Online: Sensory spinal interoceptive pathways and energy balance regulation

    Heike Münzberg / Hans-Rudolf Berthoud / Winfried L. Neuhuber

    Molecular Metabolism, Vol 78, Iss , Pp 101817- (2023)

    2023  

    Abstract: Interoception plays an important role in homeostatic regulation of energy intake and metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain signaling via vagal sensory nerves and hormones, such as leptin. However, ... ...

    Abstract Interoception plays an important role in homeostatic regulation of energy intake and metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain signaling via vagal sensory nerves and hormones, such as leptin. However, signaling via spinal sensory neurons is rapidly emerging as an additional important signaling pathway. Here we provide an in-depth review of the known anatomy and functions of spinal sensory pathways and discuss potential mechanisms relevant for energy balance homeostasis in health and disease. Because sensory innervation by dorsal root ganglia (DRG) neurons goes far beyond vagally innervated viscera and includes adipose tissue, skeletal muscle, and skin, it is in a position to provide much more complete metabolic information to the brain. Molecular and anatomical identification of function specific DRG neurons will be important steps in designing pharmacological and neuromodulation approaches to affect energy balance regulation in disease states such as obesity, diabetes, and cancer.
    Keywords Interoception ; Food intake ; Energy expenditure ; Obesity ; Diabetes ; Gut-brain communication ; Internal medicine ; RC31-1245
    Subject code 571
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Functional anatomy of the vagus system - Emphasis on the somato-visceral interface.

    Neuhuber, Winfried L / Berthoud, Hans-Rudolf

    Autonomic neuroscience : basic & clinical

    2021  Volume 236, Page(s) 102887

    Abstract: Due to its pivotal role in autonomic networks, the vagus attracts continuous interest from both basic scientists and clinicians. In particular, recent advances in vagus nerve stimulation strategies and their application to pathological conditions beyond ... ...

    Abstract Due to its pivotal role in autonomic networks, the vagus attracts continuous interest from both basic scientists and clinicians. In particular, recent advances in vagus nerve stimulation strategies and their application to pathological conditions beyond epilepsy provide a good opportunity to recall basic features of vagal peripheral and central anatomy. In addition to the "classical" vagal brainstem nuclei, i.e., dorsal motor nucleus, nucleus ambiguus and nucleus tractus solitarii, the spinal trigeminal and paratrigeminal nuclei come into play as targets of vagal afferents. On the other hand, the nucleus of the solitary tract receives and integrates not only visceral but also somatic afferents. Thus, the vagus system participates significantly in what may be defined as "somato-visceral interface".
    MeSH term(s) Autonomic Nervous System ; Brain Stem ; Solitary Nucleus ; Vagus Nerve ; Vagus Nerve Stimulation
    Language English
    Publishing date 2021-09-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2021.102887
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1533: Show issues Location:
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  8. Book: Neural and metabolic control of macronutrient intake

    Berthoud, Hans-Rudolf

    2000  

    Author's details ed. by Hans-Rudolf Berthoud
    Keywords Nutrition ; Dietary Carbohydrates / metabolism ; Dietary Fats / metabolism ; Dietary Proteins / metabolism ; Food Preferences / physiology ; Food Preferences / psychology ; Biochemie ; Stoffwechsel ; Nahrungsaufnahme ; Regulation ; Lebensmittel ; Auswahl ; Ernährungsphysiologie ; Neurochemie ; Molekulargenetik ; Stoffwechselkrankheit ; Nervale Regulation
    Subject Neurale Regulation ; Neuroregulation ; Essen ; Nahrungsphysiologie ; Nahrungsmittel ; Nahrung für Menschen ; Stoffwechsel ; Stoffwechselerkrankung ; Molekulare Genetik ; Biochemische Genetik ; Biochemie ; Neurobiochemie ; Metabolismus ; Verstoffwechselung ; Metabolische Regulation ; Biologische Chemie
    Language English
    Size [12], 508 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT011217124
    ISBN 0-8493-2752-0 ; 978-0-8493-2752-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 A 703 order for loan Magazin

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  9. Book: Neural and metabolic control of macronutrient intake

    Berthoud, Hans-Rudolf

    2000  

    Author's details ed. by Hans-Rudolf Berthoud
    Keywords Nutrition ; Dietary Carbohydrates / metabolism ; Dietary Fats / metabolism ; Dietary Proteins / metabolism ; Food Preferences / physiology ; Food Preferences / psychology ; Biochemie ; Stoffwechsel ; Nahrungsaufnahme ; Regulation ; Lebensmittel ; Auswahl ; Ernährungsphysiologie ; Neurochemie ; Molekulargenetik ; Stoffwechselkrankheit ; Nervale Regulation
    Subject Neurale Regulation ; Neuroregulation ; Essen ; Nahrungsphysiologie ; Nahrungsmittel ; Nahrung für Menschen ; Stoffwechsel ; Stoffwechselerkrankung ; Molekulare Genetik ; Biochemische Genetik ; Biochemie ; Neurobiochemie ; Metabolismus ; Verstoffwechselung ; Metabolische Regulation ; Biologische Chemie
    Language English
    Size [12], 508 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT011217124
    ISBN 0-8493-2752-0 ; 978-0-8493-2752-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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    998/4092 available for loan (reading room) Freihandmagazin (U1)

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  10. Article ; Online: Gut-brain communication and obesity: understanding functions of the vagus nerve.

    Berthoud, Hans-Rudolf / Albaugh, Vance L / Neuhuber, Winfried L

    The Journal of clinical investigation

    2021  Volume 131, Issue 10

    Abstract: Given the crucial role of the gastrointestinal tract and associated organs in handling nutrient assimilation and metabolism, it has long been known that its communication with the brain is important for the control of ingestive behavior and body weight ... ...

    Abstract Given the crucial role of the gastrointestinal tract and associated organs in handling nutrient assimilation and metabolism, it has long been known that its communication with the brain is important for the control of ingestive behavior and body weight regulation. It is also clear that gut-brain communication is bidirectional and utilizes both rapid neural and slower humoral mechanisms and pathways. However, progress in understanding these mechanisms and leveraging them for the treatment of obesity and metabolic disease has been hindered by the enormous dimension of the gut mucosa, the complexity of the signaling systems, and lack of specific tools. With the ascent of modern neurobiological technology, our understanding of the role of vagal afferents in gut-brain communication has begun to change. The first function-specific populations of vagal afferents providing nutritional feedback as well as feed-forward signals have been identified with genetics-guided methodology, and it is hoped that extension of the methodology to other neural communication pathways will follow soon. Currently, efficient clinical leveraging of gut-brain communication to treat obesity and metabolic disease is limited to a few gut hormones, but a more complete understanding of function-specific and projection-specific neuronal populations should make it possible to develop selective and more effective neuromodulation approaches.
    MeSH term(s) Animals ; Brain/metabolism ; Brain/physiopathology ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/physiopathology ; Metabolic Diseases/metabolism ; Metabolic Diseases/physiopathology ; Obesity/metabolism ; Obesity/physiopathology ; Synaptic Transmission ; Vagus Nerve/metabolism ; Vagus Nerve/physiopathology
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI143770
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