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Article ; Online: Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage.

Xue, Dao-Jin / Zhen, Zheng / Wang, Ke-Xin / Zhao, Jia-Lin / Gao, Yao / Chen, Yu-Peng / Shen, You-Bi / Peng, Zi-Zhuang / Guan, Dao-Gang / Huang, Tao

BMC complementary medicine and therapies

2022 Volume 22, Issue 1, Page(s) 103

Abstract: ... by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used ...

Abstract	Background: Chinese herbal medicine (CHM) is characterized by "multi- compounds, multi-targets and multi-pathway", which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacology is a hot cross research area based on system biology, mathematics and poly-pharmacology. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. Methods: Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network analysis and node importance calculation. Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. Results: The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. Conclusions: Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the molecular mechanism of prescriptions in treating complex diseases of CHM.
MeSH term(s)	Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional/methods ; Reproducibility of Results
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-022-03577-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage

Xue, Dao-jin / Zhen, Zheng / Wang, Ke-xin / Zhao, Jialin / Gao, Yao / Chen, Yu-peng / Shen, You-bi / Peng, Zi-zhuang / Guan, Dao-gang / Huang, Tao

BMC Complement Med Ther. 2022 Dec., v. 22, no. 1 p.103-103

2022

Abstract: ... by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used ...

Abstract	BACKGROUND: Chinese herbal medicine (CHM) is characterized by “multi- compounds, multi-targets and multi-pathway”, which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacology is a hot cross research area based on system biology, mathematics and poly-pharmacology. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. METHODS: Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network analysis and node importance calculation. Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. RESULTS: The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. CONCLUSIONS: Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the molecular mechanism of prescriptions in treating complex diseases of CHM.
Keywords	complement ; death ; genes ; hemorrhage ; herbal medicines ; mathematics ; models ; mortality ; pharmacology ; therapeutics
Language	English
Dates of publication	2022-12
Size	p. 103.
Publishing place	BioMed Central
Document type	Article ; Online
ISSN	2662-7671
DOI	10.1186/s12906-022-03577-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage

Dao-jin Xue / Zheng Zhen / Ke-xin Wang / Jia-lin Zhao / Yao Gao / Yu-peng Chen / You-bi Shen / Zi-zhuang Peng / Dao-gang Guan / Tao Huang

BMC Complementary Medicine and Therapies, Vol 22, Iss 1, Pp 1-

2022 Volume 21

Abstract: ... by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used ...

Abstract	Abstract Background Chinese herbal medicine (CHM) is characterized by “multi- compounds, multi-targets and multi-pathway”, which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacology is a hot cross research area based on system biology, mathematics and poly-pharmacology. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. Methods Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network analysis and node importance calculation. Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. Results The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. Conclusions Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the molecular mechanism of prescriptions in treating complex diseases of CHM.
Keywords	Chinese herbal medicine (CHM) ; Intracerebral Hemorrhage (ICH) ; Important gene network model ; Mechanism ; Integrated pharmacology ; Other systems of medicine ; RZ201-999
Subject code	540
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice.

Wang, Anlu / Guan, Baoyi / Shao, Chang / Zhao, Lin / Li, Qiuyi / Hao, Haiping / Gao, Zhuye / Chen, Keji / Hou, Yuanlong / Xu, Hao

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 103, Page(s) 154220

Abstract: ... characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction ...

Abstract	Background: Atherosclerosis (AS) is a key pathological factor in cardiovascular disease (CVD) and is characterized by high mortality and morbidity worldwide. Metabolic disorders, including pathoglycemia and dyslipidemia that lead to chronic inflammation, represent the prominent pathological characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically proven to be effective for patients with CVD. However, the underlying mechanisms have not been completely elucidated. Purpose: To investigate the protective effects of QXJYG against AS and its potential mechanisms. Methods: QXJYG was orally administered at doses of 1.664 and 4.992 g·kg Results: QXJYG retarded HFD-induced weight gain and reduced the increased serum levels of total cholesterol, triglycerides, and low-density lipoprotein-cholesterol, whereas high-dose QXJYG increased the serum level of high-density lipoprotein-cholesterol in HFD-fed ApoE-/- mice. Meanwhile, QXJYG reduced the serum levels, as well as aortas mRNA levels of the inflammatory cytokines, IL-1β and IL-6, which indicates that QXJYG is effective against metaflammation. Mechanistically, QXJYG reshaped the gut microbiota and its associated bile acids (BAs) metabolomic phenotype, partly by increasing the levels of BA synthesis enzymes, hepatic CYP7A1, and CYP27A1, while decreasing ileal FGF15 and β-Klotho mRNA expression, favoring facilitated de novo BAs synthesis and thereby driving cholesterol catabolic excretion. Conclusion: Our findings indicate that QXJYG is effective against HFD-triggered chronic inflammation, and contributes to the alleviation of AS development, and the antiatherogenic properties of QXJYG may be partly due to the remodeling of the gut microbiota and BA metabolism. Although the results are encouraging, further clinical studies of anti-AS herbal medicines are required to elucidate the full potential of the gut microbiota and BA metabolism.
MeSH term(s)	Animals ; Apolipoproteins E ; Atherosclerosis/metabolism ; Cholesterol/metabolism ; Diet, High-Fat/adverse effects ; Drugs, Chinese Herbal ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; Inflammation/metabolism ; Liver ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; RNA, Ribosomal, 16S
Chemical Substances	Apolipoproteins E ; Drugs, Chinese Herbal ; RNA, Messenger ; RNA, Ribosomal, 16S ; qing-xin-jie-yu granules ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-06-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154220
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamics and diversity of microbial community succession during fermentation of Suan yu, a Chinese traditional fermented fish, determined by high throughput sequencing.

Zang, Jinhong / Xu, Yanshun / Xia, Wenshui / Yu, Dawei / Gao, Pei / Jiang, Qixing / Yang, Fang

Food research international (Ottawa, Ont.)

2018 Volume 111, Page(s) 565–573

Abstract: ... community present during the preparation of Suan yu (fermented fish), with and without starter cultures ... with food spoilage and contributed to the improvement of the quality of Suan yu products. ...

Abstract	The main goal of this study was to investigate the dynamics, diversity and succession of microbial community present during the preparation of Suan yu (fermented fish), with and without starter cultures by high-throughput sequencing of 16S rRNA and ITS1 genes. Firmicutes and Ascomycota were the predominant phyla of bacteria and fungi, respectively, in all samples. At the genus level, Lactobacillus, Macrococcus and Staphylococcus were the predominating bacteria throughout the fermentation process, regardless of the inclusion of starter cultures. Saccharomyces was the predominating fungal genus in the early-fermentation stage of samples that inoculated starter cultures (MS), while the final product was dominated by Candida and Wickerhamomyces. Compared with naturally-fermented samples (NS; no starter cultures), Lactococcus, Leuconostoc, Enterococcus, Vibrio, Fusicolla and Torulaspora were inhibited and Aureobasidium emerged in samples inoculated with starter cultures (P < .05). Unweighted pair-group and principal component analyses of bacterial and fungal compositions revealed that microbiota structures differed between NS and MS samples. Redundancy analysis indicated that water content and pH might be important factors influencing the dominant bacterial and fungal community. Results indicated that microbial community were dynamic during fermentation process and the inoculation of mixed starter culture inhibited the growth of many organisms associated with food spoilage and contributed to the improvement of the quality of Suan yu products.
MeSH term(s)	Animals ; Bacteria/classification ; Bacteria/isolation & purification ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; DNA, Fungal/genetics ; DNA, Fungal/isolation & purification ; Fermentation ; Fermented Foods ; Fish Products/microbiology ; Fishes/microbiology ; Food Microbiology ; Fungi/classification ; Fungi/isolation & purification ; High-Throughput Nucleotide Sequencing ; Microbiota ; Principal Component Analysis ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/isolation & purification
Chemical Substances	DNA, Bacterial ; DNA, Fungal ; RNA, Ribosomal, 16S
Language	English
Publishing date	2018-06-01
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2018.05.076
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice

Wang, Anlu / Guan, Baoyi / Shao, Chang / Zhao, Lin / Li, Qiuyi / Hao, Haiping / Gao, Zhuye / Chen, Keji / Hou, Yuanlong / Xu, Hao

Phytomedicine. 2022 Aug., v. 103

2022

Abstract: ... of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically ...

Abstract	Atherosclerosis (AS) is a key pathological factor in cardiovascular disease (CVD) and is characterized by high mortality and morbidity worldwide. Metabolic disorders, including pathoglycemia and dyslipidemia that lead to chronic inflammation, represent the prominent pathological characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically proven to be effective for patients with CVD. However, the underlying mechanisms have not been completely elucidated. To investigate the protective effects of QXJYG against AS and its potential mechanisms. QXJYG was orally administered at doses of 1.664 and 4.992 g·kg⁻¹·d⁻¹ in a high-fat diet (HFD)-induced AS model using ApoE-/- mice. Histopathological and immunohistochemical analyses, ELISA, untargeted and targeted metabolomics analysis, 16S rRNA analysis, and RT-qPCR were performed to identify the therapeutic effects and mechanisms of QXJYG in treating HFD-induced AS. QXJYG retarded HFD-induced weight gain and reduced the increased serum levels of total cholesterol, triglycerides, and low-density lipoprotein-cholesterol, whereas high-dose QXJYG increased the serum level of high-density lipoprotein-cholesterol in HFD-fed ApoE-/- mice. Meanwhile, QXJYG reduced the serum levels, as well as aortas mRNA levels of the inflammatory cytokines, IL-1β and IL-6, which indicates that QXJYG is effective against metaflammation. Mechanistically, QXJYG reshaped the gut microbiota and its associated bile acids (BAs) metabolomic phenotype, partly by increasing the levels of BA synthesis enzymes, hepatic CYP7A1, and CYP27A1, while decreasing ileal FGF15 and β-Klotho mRNA expression, favoring facilitated de novo BAs synthesis and thereby driving cholesterol catabolic excretion. Our findings indicate that QXJYG is effective against HFD-triggered chronic inflammation, and contributes to the alleviation of AS development, and the antiatherogenic properties of QXJYG may be partly due to the remodeling of the gut microbiota and BA metabolism. Although the results are encouraging, further clinical studies of anti-AS herbal medicines are required to elucidate the full potential of the gut microbiota and BA metabolism.
Keywords	atherosclerosis ; bile ; blood serum ; excretion ; gene expression ; high fat diet ; histopathology ; homeostasis ; hyperlipidemia ; ileum ; immunohistochemistry ; inflammation ; interleukin-6 ; intestinal microorganisms ; metabolism ; metabolomics ; morbidity ; mortality ; phenotype ; weight gain
Language	English
Dates of publication	2022-08
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154220
Database	NAL-Catalogue (AGRICOLA)

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Article: A network pharmacology-based study on Alzheimer disease prevention and treatment of Qiong Yu Gao.

You, Jie-Shu / Li, Chen-Yue / Chen, Wei / Wu, Xia-Lin / Huang, Li-Jie / Li, Ren-Kai / Gao, Fei / Zhang, Ming-Yue / Liu, Huan-Lan / Qu, Wei-Ling

BioData mining

2020 Volume 13, Page(s) 2

Abstract: ... the bioactive compounds and potential mechanisms of Qiong Yu Gao (QYG) for AD prevention and treatment ...

Abstract	Background and objective: As the pathological mechanisms of AD are complex, increasing evidence have demonstrated Chinese Medicine with multi-ingredients and multi-targets may be more suitable for the treatment of diseases with complex pathogenesis. Therefore, the study was to preliminarily decipher the bioactive compounds and potential mechanisms of Qiong Yu Gao (QYG) for AD prevention and treatment by an integrated network pharmacology approach. Methods: Putative ingredients of QYG and significant genes of AD were retrieved from public database after screening. Then QYG ingredients target proteins/genes were obtained by target fishing. Compound-target-disease network was constructed using Cytoscape to decipher the mechanism of QYG for AD. KEGG pathway and GO enrichment analysis were performed to investigate the molecular mechanisms and pathways related to QYG for AD treatments. Results: Finally, 70 compounds and 511 relative drug targets were collected. In which, 17 representative direct targets were found. Gene ontology enrichment analysis revealed that the adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway was the key biological processes and were regulated simultaneously by the 17 direct targets. The KEGG pathway enrichment analysis found that three signaling pathways were closely related to AD prevention and treatment by QYG, including PI3K-Akt signaling pathway, regulation of actin cytoskeleton pathway and insulin resistance pathway. Conclusion: This study demonstrated that QYG exerted the effect of preventing and treating AD by regulating multi-targets with multi-components. Furthermore, the study demonstrated that a network pharmacology-based approach was useful for elucidation of the interrelationship between complex diseases and interventions of Chinese herbal medicines.
Language	English
Publishing date	2020-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2438773-3
ISSN	1756-0381
ISSN	1756-0381
DOI	10.1186/s13040-020-00212-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Xue-Fu-Zhu-Yu capsule in the treatment of qi stagnation and blood stasis syndrome: a study protocol for a randomised controlled pilot and feasibility trial.

He, Haoqiang / Chen, Guang / Gao, Jialiang / Liu, Yu / Zhang, Chenhao / Liu, Chao / Li, Hongzheng / He, Qingyong / Li, Jun / Wang, Jie

Trials

2018 Volume 19, Issue 1, Page(s) 515

Abstract: ... hundred and twenty participants will be randomised to a treatment group (Xue-Fu-Zhu-Yu Capsule (XFZYC ...

Abstract	Background: Qi stagnation and blood stasis syndrome (QS&BSS) is one of the common Zhengs in traditional Chinese medicine (TCM), which manifests as various symptoms and signs, such as distending pain or a tingling sensation in a fixed position. In recent years, a number of clinical trials have focused on the effectiveness and safety of XFZYC in patients with a QS&BSS subtype disease, such as coronary heart disease, hyperlipidaemia, ischaemic cerebrovascular disease, gastritis, dysmenorrhoea, or arthritis, in terms of the outcomes of relevant diseases. However, there is lack of evidence of the effects of XFZYC in patients with QS&BSS with different diseases, focusing on the outcomes of Zhengs. Methods/design: A randomised, controlled, pilot and feasibility trial will be employed in this study, using a 7-week study period. Participants will be recruited from Guang'anmen Hospital, Huguosi TCM Hospital, Wangjing Hospital in China. One hundred and twenty participants will be randomised to a treatment group (Xue-Fu-Zhu-Yu Capsule (XFZYC)) and placebo group in a 1:1 ratio. Participants included in the study must be diagnosed with Qi stagnation and blood stasis syndrome criteria. The outcome measurements will include the traditional Chinese medicine patient-reported outcome (PRO) scale for QS&BSS, the single symptom and sign scale of QS&BSS, and the pain scale of QS&BSS. The clinical data management system ( http://www.tcmcec.net /) will be used to collect and manage the data. Quality control will be used, according to Good Clinical Practice (GCP). Discussion: Previous studies were expected to evaluate whether the addition of XFZYC to standard routine treatment would enhance the treatment effectiveness and improve the biomedical parameters pertaining to relevant disease. However, this trial is focused on the outcome of Zhengs, and we chose a range of outcome measurements to assess the improvement of relevant symptoms and signs. This trial is the first study designed to define and optimise the outcome measurements of Zhengs of XFZYC in the treatment of patients with QS&BSS. Trial registration: ClinicalTrials.gov, NCT03091634 . Registered on 12 August 2018. Release date 6 May 2017.
MeSH term(s)	Administration, Oral ; Blood Circulation/drug effects ; Capsules ; China ; Double-Blind Method ; Drugs, Chinese Herbal/administration & dosage ; Feasibility Studies ; Humans ; Multicenter Studies as Topic ; Pain/diagnosis ; Pain/drug therapy ; Pain/physiopathology ; Pilot Projects ; Prospective Studies ; Qi ; Randomized Controlled Trials as Topic ; Syndrome ; Time Factors ; Treatment Outcome
Chemical Substances	Capsules ; Drugs, Chinese Herbal ; Xue-Fu-Zhu-Yu decoction
Language	English
Publishing date	2018-09-21
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-018-2908-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry method based on a four-step analysis strategy to investigate metabolites of Qi-Yu-San-Long decoction in rat plasma.

Zhao, Yue / Chen, Yang / Li, Ruijuan / Zheng, Ting / Huang, Mengwen / Gao, Yating / Li, Zegeng / Wu, Huan

Rapid communications in mass spectrometry : RCM

2022 Volume 37, Issue 1, Page(s) e9419

Abstract: ... of traditional Chinese medicine. In clinic, Qi-Yu-San-Long decoction (QYSLD) has achieved good results in the treatment ...

Abstract	Metabolism is undoubtedly significantly correlated with the efficacy and safety of traditional Chinese medicine. In clinic, Qi-Yu-San-Long decoction (QYSLD) has achieved good results in the treatment of non-small-cell lung cancer (NSCLC). Nevertheless, a detailed understanding of the compounds (prototypes and metabolites) of QYSLD and its dynamic metabolic profile in plasma has not been revealed. Methods: In this study, a rapid and sensitive method based on ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF/MS Results: In all, 101 xenobiotics (41 prototypes and 60 QYSLD-related metabolites) were identified in rat plasma. The research uncovered metabolic profiles of alkaloids, saponins, flavonoids, iridoids, anthraquinones, and phenylpropanoids of QYSLD in rat plasma. The dynamic changes in these xenobiotics were also observed at different time intervals. At 0.5 h after oral administration, only 15 prototypes and 11 metabolites were detected. Within 24 h, 4 prototypes and 20 metabolites can still be detected. Four prototypes and 10 metabolites had the phenomenon of emergence-disappearance-reappearance in vivo. Conclusion: In rat plasma, 101 xenobiotics of QYSLD were identified and their dynamic metabolic profiles were systematically delineated, which laid a material basis for further research of the pharmacodynamic substances of QYSLD inhibiting NSCLC.
MeSH term(s)	Rats ; Animals ; Tandem Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Carcinoma, Non-Small-Cell Lung ; Rats, Sprague-Dawley ; Lung Neoplasms ; Chromatography, Liquid ; Xenobiotics ; Administration, Oral
Chemical Substances	Drugs, Chinese Herbal ; Xenobiotics
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	58731-x
ISSN	1097-0231 ; 0951-4198
ISSN (online)	1097-0231
ISSN	0951-4198
DOI	10.1002/rcm.9419
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Book: Han yu jiao xue yu yan jiu

Gao, Xiaofang

(Jiang shan yu yan xue cong shu ; di 2 qi)

2013

Author's details	Gao xiao fang
Series title	Jiang shan yu yan xue cong shu ; di 2 qi
Keywords	Chinese language/Study and teaching
Language	Chinese
Size	2, 259 p, 21 cm
Edition	Di 1 ban
Publisher	Shang hai ren min chu ban she
Publishing place	Shang hai
Document type	Book
ISBN	7208111448 ; 9787208111448
Database	Former special subject collection: coastal and deep sea fishing

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