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Article ; Online: Effects of different primers and colouring solutions on orthodontic bonding: shear bond strength and colour change.

Eren, Hatice Kübra / Bilgiç Zortuk, Fundagül

2024 Volume 28, Issue 5, Page(s) 271

Abstract: Objectives: This in vitro study evaluated the effect of different colouring solutions and primer systems used in the bonding of brackets on enamel colour change and bond strength.: Materials and methods: 120 premolar teeth were divided into four main ...

Abstract	Objectives: This in vitro study evaluated the effect of different colouring solutions and primer systems used in the bonding of brackets on enamel colour change and bond strength. Materials and methods: 120 premolar teeth were divided into four main groups; brackets were bonded with 37% orthophosphoric acid + Transbond XT Primer in Group 1, 3 M Single Bond Universal in Group 2, Transbond Plus SEP in Group 3, and G-Premio Bond in Group 4. Each group was divided into three subgroups, and the teeth were placed in a cup containing coffee and tea mixture, in a cup containing cola and in distilled water. A bond strength test was applied to all teeth. Colour measurements of all teeth were performed at 2 different times: before bonding and after the bond strength test. Results: The average bond strength of the 37% orthophosphoric acid group was higher than that of the other groups. The effect of primer and solution groups on colour change was statistically significant (p = 0.001 and p = 0.023, respectively). Conclusions: In this study, the bond strength was clinically sufficient in all primer groups. The highest colour change was observed when the tea-coffee solution and Transbond Plus SEP primer were used. Clinical relevance: This study has identified enamel discoloration and bond strength from different colouring solutions and primer systems used for bonding braces, which can be used to inform clinicians and patients to achieve better treatment results.
MeSH term(s)	Humans ; Shear Strength ; Dental Bonding/methods ; Orthodontic Brackets ; In Vitro Techniques ; Bicuspid ; Resin Cements/chemistry ; Color ; Coloring Agents ; Materials Testing ; Dental Enamel/chemistry ; Dental Stress Analysis ; Phosphoric Acids/chemistry ; Surface Properties ; Tea/chemistry ; Acid Etching, Dental ; Bisphenol A-Glycidyl Methacrylate
Chemical Substances	Resin Cements ; Coloring Agents ; Transbond XT ; single bond ; Phosphoric Acids ; phosphoric acid (E4GA8884NN) ; Tea ; Bisphenol A-Glycidyl Methacrylate (454I75YXY0)
Language	English
Publishing date	2024-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-024-05665-8
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Article ; Online: Digital Transformation Readiness Factors in Healthcare.

Bilgiç, Dudu / Camgöz Akdağ, Hatice

Hospital topics

2021 Volume 101, Issue 3, Page(s) 199–207

Abstract: Recently, technological transformation has led to critical innovations in the health sector. Hospitals can provide much better services via digital transformation. However, the desired result cannot be achieved due to the lack of organizational ... ...

Abstract	Recently, technological transformation has led to critical innovations in the health sector. Hospitals can provide much better services via digital transformation. However, the desired result cannot be achieved due to the lack of organizational preparation for digital transformation. This article has introduced criteria to measure the readiness for digital transformation, and the analysis of these criteria was performed using Explanatory and Confirmatory Factor analysis. The proposed structure includes 21 items under five factors: Management Support, Current Status Tracking, Corporate Culture, Resource Reservation and Service Management. Exploring the factors for Digital readiness will be a guide for researchers, hospitals and practitioners.
MeSH term(s)	Humans ; Hospitals ; Delivery of Health Care
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	604270-3
ISSN	1939-9278 ; 0018-5868
ISSN (online)	1939-9278
ISSN	0018-5868
DOI	10.1080/00185868.2021.2002745
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Article ; Online: Differential expression of Phlebotomus tobbi Adler, Theodor & Lourie, 1930 (Diptera: Psychodidae) genes under different environmental conditions

Oguz, Gizem / Bilgic, Hayriye Akel / Karaaslan, Cagatay / Mergen, Hatice / Kasap, Ozge Erisoz / Alten, Bulent

Acta Tropica. 2023 Mar., v. 239 p.106808-

2023

Abstract: Phlebotomus tobbi is a widely distributed sand fly species in Turkey and is the proven vector of Leishmania infantum and several Phleboviruses. Information regarding the genetic basis of phenotypic plasticity is crucial for managing vector-borne diseases, ...

Abstract	Phlebotomus tobbi is a widely distributed sand fly species in Turkey and is the proven vector of Leishmania infantum and several Phleboviruses. Information regarding the genetic basis of phenotypic plasticity is crucial for managing vector-borne diseases, as the changing environmental conditions have consequences for the survival of arthropods and the disease agents they transmit. However, limited data is available on the impacts of environmental conditions on the traits associated with sand fly survival, reproduction, and vectorial competence. The present study aimed to reveal the changes in the expression levels of three selected P. tobbi genes using laboratory-reared and wild-caught populations. A nervous system protein, Cacophony (PtCac), related to the life history traits of sand flies, and two sand fly salivary protein genes, PtSP32 and PtSP38, influence the infection of the vertebrate hosts, were assessed. Sand flies were maintained at 23 °C and 27 °C in the laboratory to evaluate the relationship between temperature and the expressed phenotypes. Field collections were carried out in three climatically distinct regions of Turkey to establish the regional differences in the gene expression levels of natural P. tobbi populations. In the laboratory, PtCac expression increased with the temperature. However, PtCac expression was negatively correlated with local temperature and humidity conditions. No differences were detected in the PtSP32 gene expression levels of both laboratory-reared and wild-caught females, but a negative correlation was observed with relative humidity in natural populations. Although the expression levels of PtSP38 did not differ among the females collected from distinct regions, a positive correlation was detected in the laboratory-reared colony. The findings indicated that changes in environmental conditions could drive the expression levels of P. tobbi genes, which influence population dynamics and the transmission risk of the disease.
Keywords	Leishmania infantum ; Phlebotomus ; gene expression ; gene expression regulation ; laboratory rearing ; life history ; nervous system ; phenotypic plasticity ; population dynamics ; relative humidity ; reproduction ; risk ; sand ; temperature ; vector competence ; vertebrates ; Phlebotomus tobbi ; Humidity ; Cacophony ; Salivary gland proteins
Language	English
Dates of publication	2023-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2022.106808
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Differential expression of Phlebotomus tobbi Adler, Theodor & Lourie, 1930 (Diptera: Psychodidae) genes under different environmental conditions.

Oguz, Gizem / Bilgic, Hayriye Akel / Karaaslan, Cagatay / Mergen, Hatice / Kasap, Ozge Erisoz / Alten, Bulent

Acta tropica

2022 Volume 239, Page(s) 106808

Abstract	Phlebotomus tobbi is a widely distributed sand fly species in Turkey and is the proven vector of Leishmania infantum and several Phleboviruses. Information regarding the genetic basis of phenotypic plasticity is crucial for managing vector-borne diseases, as the changing environmental conditions have consequences for the survival of arthropods and the disease agents they transmit. However, limited data is available on the impacts of environmental conditions on the traits associated with sand fly survival, reproduction, and vectorial competence. The present study aimed to reveal the changes in the expression levels of three selected P. tobbi genes using laboratory-reared and wild-caught populations. A nervous system protein, Cacophony (PtCac), related to the life history traits of sand flies, and two sand fly salivary protein genes, PtSP32 and PtSP38, influence the infection of the vertebrate hosts, were assessed. Sand flies were maintained at 23 °C and 27 °C in the laboratory to evaluate the relationship between temperature and the expressed phenotypes. Field collections were carried out in three climatically distinct regions of Turkey to establish the regional differences in the gene expression levels of natural P. tobbi populations. In the laboratory, PtCac expression increased with the temperature. However, PtCac expression was negatively correlated with local temperature and humidity conditions. No differences were detected in the PtSP32 gene expression levels of both laboratory-reared and wild-caught females, but a negative correlation was observed with relative humidity in natural populations. Although the expression levels of PtSP38 did not differ among the females collected from distinct regions, a positive correlation was detected in the laboratory-reared colony. The findings indicated that changes in environmental conditions could drive the expression levels of P. tobbi genes, which influence population dynamics and the transmission risk of the disease.
MeSH term(s)	Animals ; Female ; Phlebotomus/genetics ; Psychodidae/genetics ; Turkey ; Leishmania infantum/genetics ; Temperature
Language	English
Publishing date	2022-12-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2022.106808
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Article ; Online: Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.

Demirci, Ufuk / Orenay-Boyacioglu, Seda / Kasap, Elmas / Gerçeker, Emre / Bilgiç, Fahri / Yüceyar, Hakan / Yildirim, Hatice / Baykan, Ahmed Ramiz / Ellidokuz, Ender Berat / Korkmaz, Mehmet

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

2023 Volume 24, Issue 2, Page(s) 91–97

Abstract: Background and study aims: Intestinal metaplasia (IM), and Helicobacter pylori (HP) infection can be shown as risk factors in the development of gastric cancer (GC). WNT signaling pathway plays a critical role in carcinogenesis. However, the literature ... ...

Abstract	Background and study aims: Intestinal metaplasia (IM), and Helicobacter pylori (HP) infection can be shown as risk factors in the development of gastric cancer (GC). WNT signaling pathway plays a critical role in carcinogenesis. However, the literature studies are limited on the significance of this pathway for the transition from IM to GC. Patients and methods: We aimed to investigate the importance of the genes of WNT signaling pathways diagnostic and prognostic markers in the presence and absence of HP in conversion from IM to GC. 104 patients, (GC group n = 35, IM group n = 45, control group n = 25) were included in this case-control study. Expression of genes in WNT signalling were searched in study groups with qRT-PCR array and qRT-PCR method. Data were analysed using PCR array data analysis software. Results: Statistically significant overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes was detected in the GC and IM groups compared to the control group (p < 0.05). Statistically significant overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes was observed in patients with metastatic GC compared to patients with GC without metastasis (p < 0.05). It was found that the RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes were statistically significantly over-expressed in diffuse GC patients compared to non-diffuse GC patients (p < 0.05). Statistically significant overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes was detected in HP positive IM patients compared to HP negative IM patients (p < 0.05). Conclusion: Overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes in IM may suggest that these genes are important markers in the development of IM and inflammation with HP. In addition, these genes are linked to tumor burden in the GC group. Consequently, we can conclude that these genes are poor prognosis biomarkers for GC and have the potential to be used as markers for future treatment monitoring.
MeSH term(s)	Humans ; Stomach Neoplasms/pathology ; Gastric Mucosa/metabolism ; Helicobacter pylori ; Case-Control Studies ; Risk Factors ; Helicobacter Infections/complications ; Helicobacter Infections/genetics ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism ; Low Density Lipoprotein Receptor-Related Protein-5/genetics ; Low Density Lipoprotein Receptor-Related Protein-5/metabolism ; Dishevelled Proteins/metabolism
Chemical Substances	RHOA protein, human (124671-05-2) ; rhoA GTP-Binding Protein (EC 3.6.5.2) ; LRP5 protein, human ; Low Density Lipoprotein Receptor-Related Protein-5 ; DVL2 protein, human ; Dishevelled Proteins
Language	English
Publishing date	2023-01-29
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2502114-X
ISSN	2090-2387 ; 1687-1979
ISSN (online)	2090-2387
ISSN	1687-1979
DOI	10.1016/j.ajg.2023.01.004
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Article ; Online: Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride‑induced experimental Alzheimer's disease.

Bilgic, Yasemin / Demir, Enver Ahmet / Bilgic, Nilufer / Dogan, Hatice / Tutuk, Okan / Tumer, Cemil

Acta neurobiologiae experimentalis

2019 Volume 78, Issue 4, Page(s) 322–331

Abstract: Polyphenols and omega‑3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the ... ...

Abstract	Polyphenols and omega‑3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum‑induced Alzheimer's disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open‑field, elevated plus maze, Porsolt's forced swim, and Morris' water maze, to evaluate anxiety‑ and depression‑like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer's‑related anxiety, whereas depression‑like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment. Rather, cognitive performance in chia‑pretreated animals was remarkably worse as compared to their non‑treated disease‑induced counterparts. Hippocampal concentrations of amyloid-β42, amyloid precursor protein, and total tau protein were similarly increased in all disease‑induced animals (despite chia supplementation), as compared to the controls. Based on these findings, chia supplementation during the progression of Alzheimer's disease may exacerbate the disease. Although the results presented here emerge from an experimental/preclinical study, we suggest cautious and careful use of chia, especially in early‑stage Alzheimer's patients, until future research in different experimental settings is conducted.
MeSH term(s)	Aluminum Chloride/pharmacology ; Alzheimer Disease/chemically induced ; Alzheimer Disease/drug therapy ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Anxiety/drug therapy ; Cognition/drug effects ; Cognition/physiology ; Male ; Memory/drug effects ; Memory/physiology ; Plant Extracts/pharmacology ; Rats, Wistar ; Salvia ; Salvia miltiorrhiza
Chemical Substances	Amyloid beta-Protein Precursor ; Plant Extracts ; Aluminum Chloride (3CYT62D3GA)
Language	English
Publishing date	2019-01-09
Publishing country	Poland
Document type	Journal Article
ZDB-ID	184409-x
ISSN	1689-0035 ; 0065-1400
ISSN (online)	1689-0035
ISSN	0065-1400
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Article ; Online: Treatment Emergent Central Sleep Apnea

Sebahat Genç / Hatice Kayım Bilgiç / Özge Oral Tapan

Türk Uyku Tıbbı Dergisi, Vol 3, Iss 2, Pp 48-

Should We Repeat Titration?

2016 Volume 50

Abstract: Most patients with Obstructive sleep apnea syndrome are treated with continuous positive airway pressure (CPAP). However, in some patients central apnea arises during CPAP titration. This clinical condition is defined as treatment-emergent central sleep ... ...

Abstract	Most patients with Obstructive sleep apnea syndrome are treated with continuous positive airway pressure (CPAP). However, in some patients central apnea arises during CPAP titration. This clinical condition is defined as treatment-emergent central sleep apnea (CSA). Here, we would like to present a case who was diagnosed with treatment-emergent CSA during the first titration study, however CSA was lost in the second titration. Before the diagnosis of treatment-emergent CSA, factors of titration should be reviewed and if it is not found satisfactory, procedure should be repeated. In most cases CPAP therapy eliminates CSA. However, in some cases bilevel positive airway pressure- spontaneous/timed or adaptive servo ventilator is needed. Repeated titration could be useful tool to predict whether the patient needs CPAP or advanced therapies.
Keywords	Central sleep apnea ; continuous positive airway pressure ; adaptive servo ventilator ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
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Article ; Online: Cutaneous findings in patients with acromegaly and its relationship with concomitant endocrinopathies.

An, İsa / Kahraman, Filiz Cebeci / Bilgiç, Aslı / Aktürk, Aysun Şikar / Albayrak, Hülya / Kartal, Demet / Çınar, Salih Levent / Solak, Sezgi Sarıkaya / Uslu, Meltem / Şanlı, Hatice Erdi / Yıldızhan, İncilay Kalay / Şahin, Mustafa Turhan / Zindanci, İlkin / Savaş, Sevil / Ayhan, Erhan / Cinel, Murat / Ataş, Elif Nazlı Serin / Aydemir, Mustafa / Selek, Alev /

Elbüken, Gülşah / Zuhur, Sayid Shafi / Karaca, Züleyha / Bülbül, Buket Yılmaz / Ünübol, Mustafa / Demir, Özgür / Hekimsoy, Zeliha / Tuna, Mazhar / Asilsoy, Miray / Çetin, Sedat

Clinical endocrinology

2024

Abstract: Objectives: Skin changes in acromegaly are often the first sign of the disease. The aim of this study was to describe the cutaneous findings in patients with acromegaly. In addition, a secondary aim was to investigate the possible association of these ... ...

Abstract	Objectives: Skin changes in acromegaly are often the first sign of the disease. The aim of this study was to describe the cutaneous findings in patients with acromegaly. In addition, a secondary aim was to investigate the possible association of these findings with remission status and concomitant endocrinopathies. Design, patients, and measurements: In this prospective multicenter study, 278 patients over the age of 18 years with acromegaly who were followed up in 14 different tertiary healthcare institutions were included. These patients, who were followed up by the Endocrinology Department, were then referred to a dermatologist for dermatological examination. The frequency of skin lesions was investigated by detailed dermatologic examination. Dermatological diagnosis is reached by clinical, dermatological and/or dermoscopic examination, and rarely skin punch biopsy examinations in suspicious cases. The possible association of the skin findings between remitted and nonremitted patients and with concomitant endocrinopathies were evaluated. Results: The most common skin findings in patients with acromegaly in our study were skin tags (52.5%), cherry angiomas (47.4%), seborrhoea (37%), varicose veins (33%), acneiform lesions (28.8%), hyperhidrosis (26.9%) and hypertrichosis (18.3%). Hypertrichosis was significantly more prevalent in patients nonremitted (p: .001), while xerosis cutis was significantly more prevalent in patients remitted (p: .001). The frequency of diabetes mellitus and hypothyroidism was significantly higher in patients with varicose veins and seborrhoeic keratosis than those without. Additionally, the coexistence of hypothyroidism, hyperthyroidism and galactorrhea was significantly higher in patients with Cherry angioma than in those without Cherry angioma (p-values: .024, .034 and .027, respectively). The frequency of hypogonadism in those with xerosis cutis was significantly higher than in those without (p: .035). Conclusions: Cutaneous androgenization findings such as skin tag, seborrhoea, acne and acanthosis nigricans are common in patients with acromegaly. Clinicians should be aware that skin findings associated with insulin resistance may develop in these patients. It can be said that the remission state in acromegaly has no curative effect on cutaneous findings. Only patients in remission were less likely to have hypertrichosis. This may allow earlier review of the follow-up and treatment of acromegaly patients presenting with complaints of hypertrichosis. Additionally, it can be said that patients with skin findings such as cherry angioma may be predisposed to a second endocrinopathy, especially hypothyroidism. Including dermatology in a multidisciplinary perspective in acromegaly patient management would be beneficial to detect cutaneous findings earlier.
Language	English
Publishing date	2024-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.15071
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Article ; Online: Response to the letter to the editor.

Journal of infection and public health

2021 Volume 15, Issue 1, Page(s) 65–67

Language	English
Publishing date	2021-12-11
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2021.12.007
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Article ; Online: Response to the letter to the editor

Journal of Infection and Public Health, Vol 15, Iss 1, Pp 65-

2022 Volume 67

Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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