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  1. Article ; Online: And now for something completely different: from 2019-nCoV and COVID-19 to 2020-nMan.

    Froes, F

    Pulmonology

    2020  Volume 26, Issue 2, Page(s) 114–115

    MeSH term(s) COVID-19 ; Communicable Diseases, Emerging ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Disease Outbreaks ; Global Health ; History ; Humans ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Social Conditions ; Vaccines
    Chemical Substances Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-03-06
    Publishing country Spain
    Document type Editorial
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2020.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What do we know about macrolides immunomodulatory therapeutic potential in respiratory disease in 2023.

    Godinho, Daniela / Freixa, Marta / Froes, Filipe

    Pulmonology

    2024  

    Language English
    Publishing date 2024-02-23
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2024.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: And now for something completely different

    Froes, F.

    Pulmonology

    from 2019-nCoV and COVID-19 to 2020-nMan

    2020  Volume 26, Issue 2, Page(s) 114–115

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2531-0437
    DOI 10.1016/j.pulmoe.2020.02.010
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: TRALI: A differential diagnosis to keep in mind.

    Cavaco, M J / Santos, M J / Paula, F / Froes, F

    Pulmonology

    2023  

    Language English
    Publishing date 2023-12-20
    Publishing country Spain
    Document type Letter
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2023.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 Vaccination in the Portuguese Medical Community: An Unprecedented Campaign Coordinated by the Portuguese Medical Association.

    Guimarães, Miguel / Correia, Rubina / Vargas, Susana / Froes, Filipe

    Acta medica portuguesa

    2023  Volume 36, Issue 3, Page(s) 149–152

    MeSH term(s) Humans ; COVID-19 ; Portugal ; COVID-19 Vaccines ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-01
    Publishing country Portugal
    Document type Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.19709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2343: Show issues Location:
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  7. Article ; Online: Há Artefactos e Artefactos.

    Baptista, Diogo / Froes, Filipe

    Acta medica portuguesa

    2021  Volume 34, Issue 11, Page(s) 798–799

    Title translation Some Artifacts Matter More Than Others.
    MeSH term(s) Artifacts ; Humans ; Medical History Taking ; Radiography, Thoracic ; Tomography, X-Ray Computed
    Language Portuguese
    Publishing date 2021-11-02
    Publishing country Portugal
    Document type Letter
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.17056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2343: Show issues Location:
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  8. Article ; Online: A Mechanism of Action of Metformin in the Brain: Prevention of Methylglyoxal-Induced Glutamatergic Impairment in Acute Hippocampal Slices.

    Vizuete, Adriana Fernanda K / Fróes, Fernanda / Seady, Marina / Hansen, Fernanda / Ligabue-Braun, Rodrigo / Gonçalves, Carlos-Alberto / Souza, Diogo O

    Molecular neurobiology

    2023  

    Abstract: Metformin, a biguanide compound (N-1,1-dimethylbiguanide), is widely prescribed for diabetes mellitus type 2 (T2D) treatment. It also presents a plethora of properties, such as anti-oxidant, anti-inflammatory, anti-apoptosis, anti-tumorigenic, and anti- ... ...

    Abstract Metformin, a biguanide compound (N-1,1-dimethylbiguanide), is widely prescribed for diabetes mellitus type 2 (T2D) treatment. It also presents a plethora of properties, such as anti-oxidant, anti-inflammatory, anti-apoptosis, anti-tumorigenic, and anti-AGE formation activity. However, the precise mechanism of action of metformin in the central nervous system (CNS) needs to be clarified. Herein, we investigated the neuroprotective role of metformin in acute hippocampal slices exposed to methylglyoxal (MG), a highly reactive dicarbonyl compound and a key molecule in T2D developmental pathophysiology. Metformin protected acute hippocampal slices from MG-induced glutamatergic neurotoxicity and neuroinflammation by reducing IL-1β synthesis and secretion and RAGE protein expression. The drug also improved astrocyte function, particularly with regard to the glutamatergic system, increasing glutamate uptake. Moreover, we observed a direct effect of metformin on glutamate transporters, where the compound prevented glycation, by facilitating enzymatic phosphorylation close to Lys residues, suggesting a new neuroprotective role of metformin via PKC ζ in preventing dysfunction in glutamatergic system induced by MG. Proposed neuroprotection role of metformin in acute hippocampal slices against impairment in glutamatergic system induced in a model of methylglyoxal glycotoxicity. Metformin reversed methylglyoxal (MG)-induced neuroinflammation by reducing pro-inflammatory IL-1β synthesis and secretion and RAGE protein expression. Metformin did not alter the effect of MG on S100B secretion (1). Both MG and metformin also influenced astrocyte function in hippocampal slices. Metformin did not reverse the elevation in GLO1 activity induced by glycotoxicity; however, it abrogated the high GSH level and the expression of the co-factor of GLO1 (2). Both treatments per se changed bioenergetic metabolism and increased glucose uptake, extracellular lactate content, and pyruvate kinase (PK) activity. The increment in glucose uptake and lactate levels ceased during the co-incubation of MG with metformin. Metformin reversed the elevation of hexokinase activity by MG (3). We suggest a new role of metformin in the glutamate system, whereby it protects the hippocampus against the derangements of the glutamatergic system induced by MG, possibly by phosphorylation via PKC ζ (4). The neuroprotective action of metformin may be mediated by the phosphorylation of specific amino acid residues (Lysine) of the glutamate transporters (GLAST and GLT-1), since metformin activated the PKC ζ signaling and promoted cascades of phosphorylation in p38 MAPK and Akt proteins. The transporter protein phosphorylation prevented the Lys-glycation and the impairment of glutamate uptake induced by MG (5).
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03774-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Palmitic acid, but not other long-chain saturated fatty acids, increases S100B protein and TNF-α secretion by astrocytes.

    Fróes, Fernanda Telles / Da Ré, Carollina / Taday, Jéssica / Galland, Fabiana / Gonçalves, Carlos Alberto / Leite, Marina Concli

    Nutrition research (New York, N.Y.)

    2023  Volume 122, Page(s) 101–112

    Abstract: Obesity is a health problem that involves fat accumulation in adipose and other tissues and causes cell dysfunction. Long-chain saturated fatty acids can induce and propagate inflammation, which may also contribute to the brain alterations found in ... ...

    Abstract Obesity is a health problem that involves fat accumulation in adipose and other tissues and causes cell dysfunction. Long-chain saturated fatty acids can induce and propagate inflammation, which may also contribute to the brain alterations found in individuals with obesity. Fatty acids accumulate in astrocytes in situations of blood‒brain barrier disruption, such as inflammatory conditions. Furthermore, the increase in tumor necrosis factor-alpha (TNF-α) and S100 calcium-binding protein B (S100B) secretion is considered an essential component of the inflammatory response. We hypothesize that through their action on astrocytes, long-chain saturated fatty acids mediate some of the brain alterations observed in individuals with obesity. Here, we investigate the direct effect of long-chain fatty acids on astrocytes. Primary astrocyte cultures were incubated for 24 hours with myristic, palmitic, stearic, linoleic, or α-linolenic acids (25-100 µM). All saturated fatty acids tested led to an increase in TNF-α secretion, but only palmitic acid, one of the most common fatty acids, increased S100B secretion, indicating that S100B secretion is probably not caused in response to TNF-α release. Palmitic acid also caused nuclear migration of nuclear factor kappa B. Long-chain saturated fatty acids did not alter cell viability or redox status. In conclusion, long-chain saturated fatty acids can alter astrocytic homeostasis and may contribute to brain disorders associated with obesity, such as neuroinflammation.
    MeSH term(s) Humans ; Palmitic Acid/pharmacology ; Tumor Necrosis Factor-alpha/metabolism ; Astrocytes/metabolism ; Fatty Acids/pharmacology ; Fatty Acids/metabolism ; Obesity ; S100 Calcium Binding Protein beta Subunit/pharmacology
    Chemical Substances Palmitic Acid (2V16EO95H1) ; Tumor Necrosis Factor-alpha ; Fatty Acids ; S100B protein, human ; S100 Calcium Binding Protein beta Subunit
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 582432-1
    ISSN 1879-0739 ; 0271-5317
    ISSN (online) 1879-0739
    ISSN 0271-5317
    DOI 10.1016/j.nutres.2023.12.007
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    Zs.A 1686: Show issues Location:
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  10. Article ; Online: A rare but potentially fatal cause of hemoptysis.

    Durão, V / Simões, A / Paula, F / Mineiro, A / Lousada, N / Froes, F

    Pulmonology

    2022  Volume 28, Issue 5, Page(s) 406–408

    MeSH term(s) Hemoptysis/diagnosis ; Hemoptysis/etiology ; Humans ; Pulmonary Artery
    Language English
    Publishing date 2022-03-25
    Publishing country Spain
    Document type Letter
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2022.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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