LIVIVO - Search results -

Search results

Result 1 - 10 of total 10

Search options

Article ; Online: Sex, the aging immune system, and chronic disease.

Gubbels Bupp, Melanie R

2015 Volume 294, Issue 2, Page(s) 102–110

Abstract: The immune systems of men and women differ in significant ways, especially after puberty. In particular, females are generally more prone to autoimmunity, but experience lower rates of infections and chronic inflammatory disease. Sex hormones, genes ... ...

Abstract	The immune systems of men and women differ in significant ways, especially after puberty. In particular, females are generally more prone to autoimmunity, but experience lower rates of infections and chronic inflammatory disease. Sex hormones, genes encoded on the sex chromosomes, and gender-specific behaviors likely contribute to these differences. The aging process is associated with changes in the composition and function of the immune system and these changes may occur at an accelerated rate in men as compared to women. Moreover, after the age of menopause, the incidence of chronic inflammatory disease in women approaches or exceeds that observed in males. At the same time, the incidence of autoimmunity in post-menopausal women is decreased or equivalent to the rates observed in similarly-aged men. Additional studies addressing the influence of sex on the pathogenesis of chronic and autoimmune diseases in the aged are warranted.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/immunology ; Androgens/blood ; Autoimmune Diseases/immunology ; B-Lymphocytes/immunology ; Estrogens/blood ; Female ; Gonadal Steroid Hormones/immunology ; Humans ; Inflammation/epidemiology ; Inflammation/immunology ; Macrophages/immunology ; Male ; Neutrophils/immunology ; Postmenopause/immunology ; Sex Characteristics ; T-Lymphocytes/immunology
Chemical Substances	Androgens ; Estrogens ; Gonadal Steroid Hormones
Language	English
Publishing date	2015-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2015.02.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 417: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Setting Up an Undergraduate Immunology Lab: Resources and Examples.

Garrison, Keith E / Gubbels Bupp, Melanie R

Frontiers in immunology

2019 Volume 10, Page(s) 2027

Abstract: Laboratory courses in immunology require a different skill set for their development than lecture courses. They vary widely in their form based on factors like institutional budget and class size, and also in the prioritization of learning goals centered ...

Abstract	Laboratory courses in immunology require a different skill set for their development than lecture courses. They vary widely in their form based on factors like institutional budget and class size, and also in the prioritization of learning goals centered around reinforcing lecture concepts and/or building fundamental skills in the field of immunology. Lab activities can come from a variety of sources including published research protocols, commercial kits, computer-based tools or simulations, and case studies. Each has their own strengths, which will be explored here. There are also important decisions to make about how students will report their data, and what level of guidance in interpreting data is best to enhance student learning and growth. Finally, methods like use of rubrics can help ensure fair and efficient grading, especially with skills-based learning goals. Periodic assessment is important to ensure that activities contribute effectively to student learning and to guide improvements to the lab course over time.
MeSH term(s)	Allergy and Immunology ; Flow Cytometry ; Health Resources ; Humans ; Laboratories/standards ; Laboratories/supply & distribution ; Universities
Language	English
Publishing date	2019-08-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02027
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Androgen-Induced Immunosuppression.

Gubbels Bupp, Melanie R / Jorgensen, Trine N

Frontiers in immunology

2018 Volume 9, Page(s) 794

Abstract: In addition to determining biological sex, sex hormones are known to influence health and ... ...

Abstract	In addition to determining biological sex, sex hormones are known to influence health and disease
MeSH term(s)	Androgens/immunology ; Animals ; Autoimmune Diseases/immunology ; Autoimmunity/immunology ; Female ; Humans ; Immune Tolerance/immunology ; Male ; Sex Characteristics
Chemical Substances	Androgens
Language	English
Publishing date	2018-04-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.00794
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The Confluence of Sex Hormones and Aging on Immunity.

Gubbels Bupp, Melanie R / Potluri, Tanvi / Fink, Ashley L / Klein, Sabra L

Frontiers in immunology

2018 Volume 9, Page(s) 1269

Abstract: The immune systems of post-pubescent males and females differ significantly with profound consequences to health and disease. In many cases, sex-specific differences in the immune responses of young adults are also apparent in aged men and women. ... ...

Abstract	The immune systems of post-pubescent males and females differ significantly with profound consequences to health and disease. In many cases, sex-specific differences in the immune responses of young adults are also apparent in aged men and women. Moreover, as in young adults, aged women develop several late-adult onset autoimmune conditions more frequently than do men, while aged men continue to develop many cancers to a greater extent than aged women. However, sex differences in the immune systems of aged individuals have not been extensively investigated and data addressing the effectiveness of vaccinations and immunotherapies in aged men and women are scarce. In this review, we evaluate age- and sex hormone-related changes to innate and adaptive immunity, with consideration about how this impacts age- and sex-associated changes in the incidence and pathogenesis of autoimmunity and cancer as well as the efficacy of vaccination and cancer immunotherapy. We conclude that future preclinical and clinical studies should consider age and sex to better understand the ways in which these characteristics intersect with immune function and the resulting consequences for autoimmunity, cancer, and therapeutic interventions.
MeSH term(s)	Adaptive Immunity ; Aging/immunology ; Aging/metabolism ; Animals ; Autoimmunity ; Gonadal Steroid Hormones/metabolism ; Host-Pathogen Interactions/immunology ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immunity ; Immunity, Innate ; Immunologic Surveillance ; Sex Factors
Chemical Substances	Gonadal Steroid Hormones
Language	English
Publishing date	2018-06-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.01269
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral T cell pool during malnourishment.

Murphy, Sarah / Patrick, Kristin / Thoner, Timothy / Edwards, Regina W / Gubbels Bupp, Melanie R

Biochemistry and biophysics reports

2016 Volume 7, Page(s) 164–172

Abstract: The following study was undertaken to better understand the mechanisms that relate the homeostatic set point of the peripheral T cell population to energy availability in mice. We report that the total number of peripheral naïve and memory CD4+ and CD8+T ...

Abstract	The following study was undertaken to better understand the mechanisms that relate the homeostatic set point of the peripheral T cell population to energy availability in mice. We report that the total number of peripheral naïve and memory CD4+ and CD8+T cells notably declined after one week of malnourishment, a time period too short to be entirely due to malnutrition-induced thymic involution. Peripheral malnourished T cells expressed higher levels of the IL-7 receptor component, CD127, and were less sensitive to death-by-neglect as compared to control T cells. Overall levels of IL-7 were similar in malnourished and control mice. Adoptive transfer studies revealed that CD127 expression did not correlate with increased survival
Language	English
Publishing date	2016-06-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2016.06.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation.

Rao, Rajesh R / Li, Qingsheng / Gubbels Bupp, Melanie R / Shrikant, Protul A

Immunity

2012 Volume 36, Issue 3, Page(s) 374–387

Abstract: The evolutionary conserved Foxo transcription factors are important regulators of quiescence and longevity. Although, Foxo1 is known to be important in regulating CD8(+) T cell trafficking and homeostasis, its role in functional differentiation of ... ...

Abstract	The evolutionary conserved Foxo transcription factors are important regulators of quiescence and longevity. Although, Foxo1 is known to be important in regulating CD8(+) T cell trafficking and homeostasis, its role in functional differentiation of antigen-stimulated CD8(+) T cells is unclear. Herein, we demonstrate that inactivation of Foxo1 was essential for instructing T-bet transcription factor-mediated effector differentiation of CD8(+) T cells. The Foxo1 inactivation was dependent on mTORC1 kinase, given that blockade of mTORC1 abrogated mTORC2-mediated Akt (Ser473) kinase phosphorylation, resulting in Foxo1-dependent switch from T-bet to Eomesodermin transcription factor activation and increase in memory precursors. Silencing Foxo1 ablated interleukin-12- and rapamycin-enhanced CD8(+) T cell memory responses and restored T-bet-mediated effector functions. These results demonstrate an essential role of Foxo1 in actively repressing effector or terminal differentiation processes to promote memory CD8(+) T cell development and identify the functionally diverse mechanisms utilized by Foxo1 to promote quiescence and longevity.
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation/immunology ; Forkhead Box Protein O1 ; Forkhead Transcription Factors/antagonists & inhibitors ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/immunology ; Immunologic Memory ; Interleukin-12/pharmacology ; Mechanistic Target of Rapamycin Complex 1 ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Multiprotein Complexes ; Proteins/antagonists & inhibitors ; Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Sirolimus/pharmacology ; T-Box Domain Proteins/immunology ; TOR Serine-Threonine Kinases ; Trans-Activators/metabolism ; Transcription Factors
Chemical Substances	Crtc2 protein, mouse ; Forkhead Box Protein O1 ; Forkhead Transcription Factors ; Foxo1 protein, mouse ; Multiprotein Complexes ; Proteins ; T-Box Domain Proteins ; T-box transcription factor TBX21 ; Trans-Activators ; Transcription Factors ; Interleukin-12 (187348-17-0) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2012-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2012.01.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: T cells require Foxo1 to populate the peripheral lymphoid organs.

Gubbels Bupp, Melanie R / Edwards, Bonnie / Guo, Caiying / Wei, Datsen / Chen, Gang / Wong, Brian / Masteller, Emma / Peng, Stanford L

European journal of immunology

2009 Volume 39, Issue 11, Page(s) 2991–2999

Abstract: Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of Foxo1, we generated mice that selectively lack Foxo1 in T cells (Foxo1(flox/flox) Lck.cre(+)conditional knockout mice (cKO)). ... ...

Abstract	Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of Foxo1, we generated mice that selectively lack Foxo1 in T cells (Foxo1(flox/flox) Lck.cre(+)conditional knockout mice (cKO)). Although thymocyte development appeared relatively normal, Foxo1 cKO mice harbored significantly increased percentages of mature single positive T cells in the thymus as compared with WT mice, yet possessed smaller lymph nodes and spleens that contained fewer T cells. Foxo1 cKO T cells were not more prone to apoptosis, but instead were characterized by a CD62L(lo) CCR7(lo) CD44(hi) surface phenotype, a poorly populated lymphoid compartment in the periphery, and were relatively refractory to TCR stimulation, all of which were associated with reduced expression of Sell, Klf2, Ccr7, and S1pr1. Thus, Foxo1 is critical for naïve T cells to populate the peripheral lymphoid organs by coordinating a molecular program that maintains homeostasis and regulates trafficking.
MeSH term(s)	Animals ; Apoptosis/immunology ; Cell Proliferation ; Chemotaxis, Leukocyte/immunology ; Flow Cytometry ; Forkhead Box Protein O1 ; Forkhead Transcription Factors/immunology ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Mice ; Mice, Knockout ; Phenotype ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Chemical Substances	Forkhead Box Protein O1 ; Forkhead Transcription Factors ; Foxo1 protein, mouse
Language	English
Publishing date	2009-08-05
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.200939427
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

Order via subito

Details ▾

Article: T cells require Foxo1 to populate the peripheral lymphoid organs

Gubbels Bupp, Melanie R / Edwards, Bonnie / Guo, Caiying / Wei, Datsen / Chen, Gang / Wong, Brian / Masteller, Emma / Peng, Stanford L

European journal of immunology. 2009 Nov., v. 39, no. 11

2009

Abstract: Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of Foxo1, we generated mice that selectively lack Foxo1 in T cells (Foxo1flox/flox Lck.cre⁺conditional knockout mice (cKO)). ... ...

Abstract	Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of Foxo1, we generated mice that selectively lack Foxo1 in T cells (Foxo1flox/flox Lck.cre⁺conditional knockout mice (cKO)). Although thymocyte development appeared relatively normal, Foxo1 cKO mice harbored significantly increased percentages of mature single positive T cells in the thymus as compared with WT mice, yet possessed smaller lymph nodes and spleens that contained fewer T cells. Foxo1 cKO T cells were not more prone to apoptosis, but instead were characterized by a CD62Llo CCR7lo CD44hi surface phenotype, a poorly populated lymphoid compartment in the periphery, and were relatively refractory to TCR stimulation, all of which were associated with reduced expression of Sell, Klf2, Ccr7, and S1pr1. Thus, Foxo1 is critical for naïve T cells to populate the peripheral lymphoid organs by coordinating a molecular program that maintains homeostasis and regulates trafficking.
Language	English
Dates of publication	2009-11
Size	p. 2991-2999.
Publishing place	Wiley-VCH Verlag
Document type	Article
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.200939427
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2005/701: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus.

Jørgensen, Trine N / Alfaro, Jennifer / Enriquez, Hilda L / Jiang, Chao / Loo, William M / Atencio, Stephanie / Bupp, Melanie R Gubbels / Mailloux, Christina M / Metzger, Troy / Flannery, Shannon / Rozzo, Stephen J / Kotzin, Brian L / Rosemblatt, Mario / Bono, María Rosa / Erickson, Loren D

Journal of immunology (Baltimore, Md. : 1950)

2009 Volume 184, Issue 2, Page(s) 775–786

Abstract: Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to ... ...

Abstract	Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to antinuclear Ab production. To identify gene intervals within Nba2 that control the development of autoantibody-producing B cells and to determine the cellular components through which Nba2 genes accomplish this, we generated congenic mice expressing various Nba2 intervals where genes for the FcgammaR, SLAM, and IFN-inducible families are encoded. Analysis of congenic strains demonstrated that the FcgammaR and SLAM intervals independently controlled the severity of autoantibody production and renal disease, yet are both required for lupus susceptibility. Deregulated homeostasis of terminally differentiated B cells was found to be controlled by the FcgammaR interval where FcgammaRIIb-mediated apoptosis of germinal center B cells and plasma cells was impaired. Increased numbers of activated plasmacytoid dendritic cells that were distinctly CD19+ and promoted plasma cell differentiation via the proinflammatory cytokines IL-10 and IFNalpha were linked to the SLAM interval. These findings suggest that SLAM and FcgammaR intervals act cooperatively to influence the clinical course of disease through supporting the differentiation and survival of autoantibody-producing cells.
MeSH term(s)	Animals ; Antigens, CD/genetics ; Apoptosis ; Autoantibodies/biosynthesis ; B-Lymphocytes/pathology ; Cell Differentiation ; Cytokines/physiology ; Disease Progression ; Genetic Predisposition to Disease/genetics ; Kidney Diseases ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/pathology ; Mice ; Mice, Congenic ; Plasma Cells/pathology ; Receptors, Cell Surface/genetics ; Receptors, IgG/genetics ; Signaling Lymphocytic Activation Molecule Family Member 1
Chemical Substances	Antigens, CD ; Autoantibodies ; Cytokines ; Receptors, Cell Surface ; Receptors, IgG ; Signaling Lymphocytic Activation Molecule Family Member 1 (169535-43-7)
Language	English
Publishing date	2009-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.0901322
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval.

Panchanathan, Ravichandran / Shen, Hui / Bupp, Melanie Gubbels / Gould, Karen A / Choubey, Divaker

Journal of immunology (Baltimore, Md. : 1950)

2009 Volume 183, Issue 11, Page(s) 7031–7038

Abstract: Increased expression of IFN-inducible Ifi202 gene in certain strains of female mice is associated with susceptibility to systemic lupus erythematosus (SLE). Although, the development of SLE is known to have a strong sex bias, the molecular mechanisms ... ...

Abstract	Increased expression of IFN-inducible Ifi202 gene in certain strains of female mice is associated with susceptibility to systemic lupus erythematosus (SLE). Although, the development of SLE is known to have a strong sex bias, the molecular mechanisms remain unknown. Here we report that in vivo treatment of orchiectomized (NZB x NZW)F(1) male mice with the female sex hormone 17beta-estradiol significantly increased steady-state levels of Ifi202 mRNA in splenic cells, whereas treatment with the male hormone dihydrotestosterone decreased the levels. Moreover, increased expression of Ifi202 in B6.Nba2 B cells and reduced expression in T cells were associated with increased levels of estrogen receptor-alpha (ERalpha) and androgen receptor, respectively. Furthermore, the steady-state levels of Ifi202 mRNA were higher in splenic cells from C57BL/6, B6.Nba2, NZB, and (NZB x NZW)F(1) female mice as compared with males. 17beta-estradiol treatment of B cells and WT276 cells increased Ifi202 mRNA levels, whereas treatment with dihydrotestosterone decreased the levels. Interestingly, overexpression of ERalpha in WT276 cells increased the expression of Ifi202 and stimulated the activity of the 202-luc-reporter through the c-Jun/AP-1 DNA-binding site. Accordingly, ERalpha preferentially associated with the regulatory region of the Ifi202 gene in female B6.Nba2 B cells than in males. Furthermore, Ifi202 mRNA levels were detectable in splenic cells of wild-type (Esr1(+/+)), but not null (Esr1(-/-)), (NZB x NZW)F(1) female mice. Collectively, our observations demonstrate that the female and male sex hormones differentially regulate the expression of Ifi202, thus providing support for the role of Ifi202 in sex bias in SLE.
MeSH term(s)	Androgens/metabolism ; Androgens/pharmacology ; Animals ; B-Lymphocytes/drug effects ; B-Lymphocytes/metabolism ; Blotting, Western ; Chromatin Immunoprecipitation ; Dihydrotestosterone/pharmacology ; Estradiol/pharmacology ; Estrogen Receptor alpha/biosynthesis ; Estrogen Receptor alpha/drug effects ; Estrogens/metabolism ; Estrogens/pharmacology ; Female ; Gene Expression ; Gene Expression Regulation/drug effects ; Genetic Predisposition to Disease ; Gonadal Steroid Hormones/metabolism ; Gonadal Steroid Hormones/pharmacology ; Intracellular Signaling Peptides and Proteins/drug effects ; Intracellular Signaling Peptides and Proteins/genetics ; Lupus Erythematosus, Systemic/genetics ; Male ; Mice ; Mice, Inbred NZB ; Orchiectomy ; RNA, Messenger/drug effects ; Receptors, Androgen/biosynthesis ; Receptors, Androgen/drug effects ; Reverse Transcriptase Polymerase Chain Reaction ; Sex Characteristics ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism
Chemical Substances	Androgens ; Estrogen Receptor alpha ; Estrogens ; Gonadal Steroid Hormones ; Ifi202b protein, mouse ; Intracellular Signaling Peptides and Proteins ; RNA, Messenger ; Receptors, Androgen ; Dihydrotestosterone (08J2K08A3Y) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2009-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.0802665
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito