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  1. Article ; Online: Adrenal-Permissive HSD3B1 Genotype-An Invisible Stimulator of Prostate Cancer Mortality.

    Schiffer, Lina / Sharifi, Nima

    JAMA network open

    2024  Volume 7, Issue 3, Page(s) e243402

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/genetics ; Prostate ; Genotype ; Multienzyme Complexes
    Chemical Substances Multienzyme Complexes
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.3402
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  2. Article ; Online: Kicking the dirt in the hunt for discoveries: pursuing a career in biomedical science.

    Sharifi, Nima

    Nature reviews. Urology

    2021  Volume 18, Issue 3, Page(s) 129–130

    MeSH term(s) Biomedical Research ; Career Choice ; Humans
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-021-00433-9
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    Zs.A 6030: Show issues Location:
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  3. Article ; Online: Homozygous HSD3B1(1245C) inheritance and poor outcomes in metastatic castration-resistant prostate cancer with abiraterone or enzalutamide: what does it mean?

    Sharifi, Nima

    Annals of oncology : official journal of the European Society for Medical Oncology

    2020  Volume 31, Issue 9, Page(s) 1103–1105

    MeSH term(s) Androstenes ; Germ Cells ; Humans ; Male ; Multienzyme Complexes ; Phenylthiohydantoin/analogs & derivatives ; Prospective Studies ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics
    Chemical Substances Androstenes ; Multienzyme Complexes ; Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU) ; abiraterone (G819A456D0)
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2020.06.009
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    Zs.A 2862: Show issues Location:
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  4. Article ; Online: 3βHSD activity saturates at physiological substrate concentrations in intact cells.

    McManus, Jeffrey M / Chung, Yoon-Mi / Sharifi, Nima

    The Prostate

    2023  Volume 83, Issue 13, Page(s) 1306–1309

    Abstract: Background: Conversion of adrenally produced dehydroepiandrosterone (DHEA) to the potent androgen dihydrotestosterone (DHT) is an important mechanism by which prostate cancer reaches castration resistance. At the start of this pathway is a branch point ... ...

    Abstract Background: Conversion of adrenally produced dehydroepiandrosterone (DHEA) to the potent androgen dihydrotestosterone (DHT) is an important mechanism by which prostate cancer reaches castration resistance. At the start of this pathway is a branch point at which DHEA can be converted to Δ
    Methods: Prostate cancer cells (LNCaP cell line) were incubated with steroids (DHEA and Δ
    Results: The two reactions displayed very different saturation profiles, with only the 3βHSD-catalyzed reaction beginning to saturate within a physiological substrate concentration range. Strikingly, incubating LNCaP cells with low (in the ~10 nM range) concentrations of DHEA resulted in a large majority of the DHEA undergoing 3βHSD-catalyzed conversion to Δ
    Conclusion: Contrary to expectations from previous studies that used purified enzyme, cellular metabolism of DHEA by 3βHSD begins to saturate in the physiological concentration range, suggesting that fluctuations in DHEA concentrations could be buffered at the downstream active androgen level.
    MeSH term(s) Humans ; Male ; Androgens ; Androstenediols ; Androstenedione/metabolism ; Cell Line, Tumor ; Dehydroepiandrosterone/metabolism ; Prostatic Neoplasms/pathology
    Chemical Substances Androgens ; Androstenediols ; Androstenedione (409J2J96VR) ; Dehydroepiandrosterone (459AG36T1B)
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.24587
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    Zs.A 1608: Show issues Location:
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  5. Article ; Online: Targeting the Androgen Signaling Axis in Prostate Cancer.

    Dai, Charles / Dehm, Scott M / Sharifi, Nima

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 26, Page(s) 4267–4278

    Abstract: Activation of the androgen receptor (AR) and AR-driven transcriptional programs is central to the pathophysiology of prostate cancer. Despite successful translational efforts in targeting AR, therapeutic resistance often occurs as a result of molecular ... ...

    Abstract Activation of the androgen receptor (AR) and AR-driven transcriptional programs is central to the pathophysiology of prostate cancer. Despite successful translational efforts in targeting AR, therapeutic resistance often occurs as a result of molecular alterations in the androgen signaling axis. The efficacy of next-generation AR-directed therapies for castration-resistant prostate cancer has provided crucial clinical validation for the continued dependence on AR signaling and introduced a range of new treatment options for men with both castration-resistant and castration-sensitive disease. Despite this, however, metastatic prostate cancer largely remains an incurable disease, highlighting the need to better understand the diverse mechanisms by which tumors thwart AR-directed therapies, which may inform new therapeutic avenues. In this review, we revisit concepts in AR signaling and current understandings of AR signaling-dependent resistance mechanisms as well as the next frontier of AR targeting in prostate cancer.
    MeSH term(s) Male ; Humans ; Androgens/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Receptors, Androgen/genetics ; Signal Transduction
    Chemical Substances Androgens ; Receptors, Androgen
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00433
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    Zs.MO 650: Show issues

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  6. Article ; Online: Approaches to assessing 3β-hydroxysteroid dehydrogenase-1.

    Alyamani, Mohammad / McManus, Jeff / Patel, Mona / Sharifi, Nima

    Methods in enzymology

    2023  Volume 689, Page(s) 89–119

    Abstract: The enzyme 3β-hydroxysteroid dehydrogenase-1 (3βHSD1), encoded by the gene HSD3B1, plays an essential role in the peripheral conversion of 3β-OH, ... ...

    Abstract The enzyme 3β-hydroxysteroid dehydrogenase-1 (3βHSD1), encoded by the gene HSD3B1, plays an essential role in the peripheral conversion of 3β-OH, Δ
    MeSH term(s) Humans ; Androgens/metabolism ; Estrogens ; Multienzyme Complexes/metabolism ; Dehydroepiandrosterone/metabolism ; Steroids
    Chemical Substances Androgens ; Estrogens ; Multienzyme Complexes ; Dehydroepiandrosterone (459AG36T1B) ; Steroids
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2023.04.002
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  7. Article ; Online: ASO Author Reflections: Inheritance of Adrenal Permissive HSD3B1 Genotype Negatively Impacts Outcomes in Hormone Receptor-Positive Postmenopausal Breast Cancer.

    Flanagan, Meghan R / Sharifi, Nima / Gadi, Vijayakrishna K

    Annals of surgical oncology

    2022  Volume 29, Issue 11, Page(s) 7202–7203

    MeSH term(s) Breast ; Breast Neoplasms/genetics ; Female ; Genotype ; Humans ; Multienzyme Complexes/genetics ; Postmenopause
    Chemical Substances Multienzyme Complexes
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12091-1
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    Zs.A 4042: Show issues Location:
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  8. Article ; Online: Targeting Glucocorticoid Metabolism in Prostate Cancer.

    Valle, Shelley / Sharifi, Nima

    Endocrinology

    2021  Volume 162, Issue 9

    Abstract: In the treatment of metastatic prostate cancer, resistance to hormonal therapy is a major obstacle. With antiandrogen therapies that suppress androgen signaling through the androgen receptor (AR), the primary driver of prostate cancer, some malignancies ... ...

    Abstract In the treatment of metastatic prostate cancer, resistance to hormonal therapy is a major obstacle. With antiandrogen therapies that suppress androgen signaling through the androgen receptor (AR), the primary driver of prostate cancer, some malignancies are able take advantage of the closely related glucocorticoid receptor (GR). Escape from AR dependency often involves a simple functional switch from 1 steroid receptor to another. Recent research efforts have outlined the mechanism enabling this switch, which involves alterations in glucocorticoid metabolism that occur with antiandrogen therapy to increase tumor tissue glucocorticoids and enable GR signaling. Targeting this mechanism pharmacologically by blocking hexose-6-phosphate dehydrogenase shows promise in normalizing glucocorticoid metabolism and restoring responsiveness to antiandrogen therapy. This perspective reviews what we have learned about this resistance mechanism, examines potential implications, and considers how this knowledge might be harnessed for therapeutic benefit.
    MeSH term(s) Androgen Antagonists/therapeutic use ; Animals ; Antineoplastic Agents/therapeutic use ; Glucocorticoids/metabolism ; Humans ; Male ; Metabolic Networks and Pathways/drug effects ; Metabolic Networks and Pathways/genetics ; Molecular Targeted Therapy/methods ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism
    Chemical Substances Androgen Antagonists ; Antineoplastic Agents ; Glucocorticoids
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqab132
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    Uh III Zs.72: Show issues Location:
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  9. Article ; Online: Response to "Letter to the Editor From Penning and Deltefsen "5-hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells".

    Hardaway, Aimalie L / Goodarzi, Maryam / Berk, Michael / Li, Jianneng / Chung, Yoon-Mi / Sharifi, Nima

    Endocrinology

    2023  Volume 164, Issue 5

    MeSH term(s) Humans ; Androgens/pharmacology ; Hydroxyeicosatetraenoic Acids ; Epithelial Cells
    Chemical Substances 5-hydroxy-6,8,11,14-eicosatetraenoic acid (467RNW8T91) ; Androgens ; Hydroxyeicosatetraenoic Acids
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqad053
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  10. Article ; Online: Androgen hazards with COVID-19.

    Sharifi, Nima / Ryan, Charles J

    Endocrine-related cancer

    2020  Volume 27, Issue 6, Page(s) E1–E3

    MeSH term(s) Androgens/immunology ; Androgens/metabolism ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Serine Endopeptidases/biosynthesis ; Sex Factors ; Virus Internalization
    Chemical Substances Androgens ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-20-0133
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    Zs.A 4192: Show issues Location:
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