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  1. Article ; Online: Papulopustular infantile acne treated with oral isotretinoin.

    Santos, Grasielle Silva / Ianhez, Mayra / Miot, Hélio Amante

    Anais brasileiros de dermatologia

    2023  Volume 98, Issue 3, Page(s) 400–402

    MeSH term(s) Humans ; Isotretinoin/therapeutic use ; Acne Vulgaris/drug therapy ; Administration, Oral ; Dermatologic Agents/therapeutic use
    Chemical Substances Isotretinoin (EH28UP18IF) ; Dermatologic Agents
    Language English
    Publishing date 2023-02-15
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2021.05.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Refractory pyoderma gangrenosum associated with rheumatoid arthritis successfully treated with upadacitinib. Comments on: "JAK inhibitors: a novel, safe, and efficacious therapy for pyoderma gangrenosum".

    Dos Santos, Mayra Rabelo / Ianhez, Mayra / Ribeiro, Bruno Nazeozeno / de Queiroz, Boaventura Braz / Miot, Helio Amante

    International journal of dermatology

    2023  Volume 62, Issue 11, Page(s) e595–e598

    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Eosinophilia and elevated IgE serum levels: a red flag: when your diagnosis is not a common atopic eczema or common allergy.

    Criado, Paulo Ricardo / Miot, Hélio Amante / Ianhez, Mayra

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2023  Volume 72, Issue 3, Page(s) 541–551

    Abstract: Objective and design: The hallmark of type 2 inflammation is eosinophilia and/or high IgE serum levels, mostly in atopic dermatitis. Nevertheless, many dermatoses may present similar findings. Our aim is to explore the biological and clinical spectrum ... ...

    Abstract Objective and design: The hallmark of type 2 inflammation is eosinophilia and/or high IgE serum levels, mostly in atopic dermatitis. Nevertheless, many dermatoses may present similar findings. Our aim is to explore the biological and clinical spectrum of cutaneous manifestations involving tissue and/or systemic eosinophilia, and distinct serum levels of IgE, where atopic dermatitis or other primary allergic eczema, not always is the definitive diagnosis.
    Materials/methods: A total of 37 scientific papers were enrolled in this narrative review.
    Results: A diagnostic approach for patients with elevated serum IgE level and a list of conditions not related to atopic dermatitis that runs through inborn errors of immunity, inflammatory disorders, lung disorders, malignancy, infections/infestations are displayed. Regarding to peripheral eosinophilia, differential diagnosis is also explored and clinical patterns of skin diseases associated with tissue eosinophilia are listed, to facilitate our diagnosis.
    Conclusions: We should maintain a high level of suspicion about other differential diagnosis involving eosinophilia and IgE dysregulation, especially in patients very young (when innate errors of the immunity may present) and in middle to elderly patients classified as having atopic dermatitis, due to the possibility of cutaneous hematological malignancies, paraneoplasia or autoimmune blistering diseases.
    MeSH term(s) Humans ; Aged ; Dermatitis, Atopic ; Immunoglobulin E ; Eosinophilia/diagnosis ; Eosinophilia/complications ; Eosinophilia/pathology ; Eosinophils ; Skin/pathology
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-023-01690-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Frequency of Complications of Aesthetic Facial Fillers in Brazil.

    Ianhez, Mayra / Souza, Marcela B / Miot, Hélio A

    Plastic and reconstructive surgery

    2022  Volume 149, Issue 3, Page(s) 599e–601e

    MeSH term(s) Brazil ; Cosmetic Techniques/adverse effects ; Dermal Fillers/adverse effects ; Face ; Humans
    Chemical Substances Dermal Fillers
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000008839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Persistent Dermatitis in an Infant.

    Carvalho, Maysa Martins / Bichuetti-Silva, Danielli Christinni / Ianhez, Mayra / Baptista da Costa, Bárbara Esper / Terra, Mariana Campos / Costa, Paulo Sucasas

    Dermatitis : contact, atopic, occupational, drug

    2024  

    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1089/derm.2024.0052
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  6. Article ; Online: Prurigo: review of its pathogenesis, diagnosis, and treatment.

    Criado, Paulo Ricardo / Ianhez, Mayra / Criado, Roberta Fachini Jardim / Nakano, Juliana / Lorenzini, Daniel / Miot, Hélio Amante

    Anais brasileiros de dermatologia

    2024  

    Abstract: Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and ... ...

    Abstract Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and underlying etiological factors. The immunology of chronic prurigo shows similarities with atopic dermatitis due to the involvement of IL-4 and IL-13, IL-22, and IL-31. Treatment includes antihistamines, topical steroids, dupilumab, and JAK inhibitors. Several conditions manifest clinically as prurigo-like lesions, and the correct clinical diagnosis must precede correct treatment. Furthermore, chronic prurigos represent a recalcitrant and distressing dermatosis, and at least 50% of these patients have atopic diathesis, the treatment of which may induce adverse effects, especially in the elderly. The quality of life is significantly compromised, and topical treatments are often unable to control symptoms and skin lesions. Systemic immunosuppressants, immunobiologicals, and JAK inhibitors, despite the cost and potential adverse effects, may be necessary to achieve clinical improvement and quality of life. This manuscript reviews the main types of prurigo, associated diseases, their immunological bases, diagnosis, and treatment.
    Language English
    Publishing date 2024-03-16
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2023.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Side effects of chronic systemic glucocorticoid therapy: what dermatologists should know.

    Tavares, Lucas Campos Prudente / Caetano, Lívia de Vasconcelos Nasser / Ianhez, Mayra

    Anais brasileiros de dermatologia

    2023  Volume 99, Issue 2, Page(s) 259–268

    Abstract: In dermatologists' clinical practice, the use of systemic glucocorticoids is recurrent for the management of different comorbidities that require chronic immunosuppression. The prescription of this medication requires caution and basic clinical knowledge ...

    Abstract In dermatologists' clinical practice, the use of systemic glucocorticoids is recurrent for the management of different comorbidities that require chronic immunosuppression. The prescription of this medication requires caution and basic clinical knowledge due to the several adverse effects inherent to the treatment. However, different doubts may arise or inappropriate conduct may be adopted due to the lack of objective and specific guidelines for the screening, prophylaxis and management of complications from chronic corticosteroid therapy. Considering this problem, the authors carried out a narrative review of the literature to gather up-to-date data on adverse effects secondary to the chronic use of systemic glucocorticoids. The broad approach to this topic made it possible to review the pathophysiology and risk factors for these complications, as well as to develop updated orientation that can be used as a learning tool and quick reference for dermatologists during their clinical practice with glucocorticoids.
    MeSH term(s) Humans ; Glucocorticoids/adverse effects ; Dermatologists ; Risk Factors
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-11-24
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2023.05.005
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  8. Article ; Online: Dermal Filler Injections in Patients with Autoimmune and Immune-Mediated Diseases: A Survey with Dermatologists.

    Ianhez, Mayra / Luz, Allana Rodrigues César Araújo / Palermo, Eliandre Costa / Miot, Hélio Amante

    Aesthetic plastic surgery

    2023  

    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Letter
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-023-03639-x
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  9. Article ; Online: Neutralizing Antibodies to Botulinum Toxin Type A Are Rare Following Aesthetic Indications.

    Ianhez, Mayra / Peres, Gabriel / Miot, Hélio Amante

    Aesthetic surgery journal

    2021  Volume 41, Issue 11, Page(s) NP1800–NP1801

    MeSH term(s) Antibodies, Neutralizing ; Botulinum Toxins, Type A/adverse effects ; Esthetics ; Humans ; Neuromuscular Agents/adverse effects
    Chemical Substances Antibodies, Neutralizing ; Neuromuscular Agents ; Botulinum Toxins, Type A (EC 3.4.24.69)
    Language English
    Publishing date 2021-09-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2087022-X
    ISSN 1527-330X ; 1090-820X ; 1084-0761
    ISSN (online) 1527-330X
    ISSN 1090-820X ; 1084-0761
    DOI 10.1093/asj/sjab289
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  10. Article: Case Report: A Case Series of Immunobiological Therapy (Anti-TNF-α) for Patients With Erythema Nodosum Leprosum.

    Mendes, Ana Flávia Moura / Gomes, Ciro Martins / Kurizky, Patrícia Shu / Ianhez, Mayra

    Frontiers in medicine

    2022  Volume 9, Page(s) 879527

    Abstract: Patients with leprosy may experience a chronic and severe type II leprosy reaction (ENL) erythema nodosum leprosum that may not respond to thalidomide and systemic immunosuppressants or may even cause serious adverse events. We here present four patients ...

    Abstract Patients with leprosy may experience a chronic and severe type II leprosy reaction (ENL) erythema nodosum leprosum that may not respond to thalidomide and systemic immunosuppressants or may even cause serious adverse events. We here present four patients in whom anti-TNF-α therapy was used with successful results and compare our findings with other published cases. Four patients with chronic and severe ENL who did not respond to, at least, thalidomide and steroids (high doses) were followed up at two reference centers in Brazil. A thorough laboratory investigation was performed to exclude tuberculosis and other diseases before the start of immunobiological medication. Three patients were started on etanercept, and one patient was started on adalimumab. Of all patients, three developed severe adverse events resulting from the use of classical immunosuppressants for ENL (cataracts, deep vein thrombosis, diabetes, and osteoporosis). In all cases, a reduction in the number of ENL and, at least half of the immunosuppressant dose between 6 months and 2 years, were observed. Long-term follow-up of one patient revealed a dramatic reduction in hospital admissions due to ENL, from 12 instances in 1 year (before biologic therapy) to none (after biologic therapy), along with an improvement in condyloma acuminatum. In addition, no direct adverse events were observed with biologics. Treatment with anti-TNF-α therapy may be used as an alternative in patients with chronic and severe ENL who do not respond to traditional treatment (e.g., thalidomide, steroids, and other immunosuppressants). This treatment can help reduce the frequency of ENL, the immunosuppressive burden, and the number of hospital admissions.
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.879527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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