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  1. Book: Androgens in women

    Wierman, Margaret E.

    too much, too little, just right

    (Endocrinology and metabolism clinics of North America ; volume 50, number 1 (March 2021))

    2021  

    Author's details editor Margaret E. Wierman
    Series title Endocrinology and metabolism clinics of North America ; volume 50, number 1 (March 2021)
    Collection
    Language English
    Size xvi, 165 Seiten, Illustrationen, Diagramme
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT020906523
    ISBN 978-0-323-77736-0 ; 0-323-77736-8
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Mitotane: a friend or a foe before cabozantinib treatment in adrenocortical cancer?

    Wierman, Margaret E

    The Lancet. Oncology

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(24)00151-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hyperandrogenic Anovulation: Differential Diagnosis and Evaluation.

    Wierman, Margaret E

    Endocrinology and metabolism clinics of North America

    2020  Volume 50, Issue 1, Page(s) 1–10

    Abstract: Hyperandrogenic anovulation refers to the constellation of disorders that present in women with irregular menses, hirsutism and/or acne across the lifespan. Understanding the clinical signs and symptoms of each diagnosis in the differential and ... ...

    Abstract Hyperandrogenic anovulation refers to the constellation of disorders that present in women with irregular menses, hirsutism and/or acne across the lifespan. Understanding the clinical signs and symptoms of each diagnosis in the differential and laboratory testing to confirm or exclude a diagnosis allows a clinician to appropriately counsel and treat the patient.
    MeSH term(s) Anovulation/diagnosis ; Diagnosis, Differential ; Female ; Hirsutism/diagnosis ; Hirsutism/etiology ; Hirsutism/therapy ; Humans ; Hyperandrogenism/diagnosis ; Polycystic Ovary Syndrome/diagnosis
    Language English
    Publishing date 2020-12-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2020.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Why Focus on Androgens in Women?

    Wierman, Margaret E

    Endocrinology and metabolism clinics of North America

    2020  Volume 50, Issue 1, Page(s) xv–xvi

    MeSH term(s) Androgens ; Dehydroepiandrosterone ; Female ; Humans ; Testosterone
    Chemical Substances Androgens ; Testosterone (3XMK78S47O) ; Dehydroepiandrosterone (459AG36T1B)
    Language English
    Publishing date 2020-12-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2020.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Short term effects of intraarticular triamcinolone acetonide injection on serum testosterone, luteinizing hormone, and follicle stimulating hormone levels in male veterans: A prospective pilot study.

    Tahmasbi Sohi, Maryam / Cali, Malia / Forster, Jeri E / Kiseljak-Vassiliades, Katja / Wierman, Margaret E

    PM & R : the journal of injury, function, and rehabilitation

    2023  Volume 16, Issue 1, Page(s) 6–13

    Abstract: Background: Despite the common practice of intraarticular corticosteroid injections (ICSIs) for peripheral joint disease, little is known about their systemic effects on the hypothalamic-pituitary-gonadal axis.: Objective: To assess the short-term ... ...

    Abstract Background: Despite the common practice of intraarticular corticosteroid injections (ICSIs) for peripheral joint disease, little is known about their systemic effects on the hypothalamic-pituitary-gonadal axis.
    Objective: To assess the short-term effects of ICSIs on serum testosterone (T), luteinizing hormone (LH), and follicle stimulating hormone (FSH) levels together with changes in Shoulder Pain and Disability Index (SPADI) scores in a veteran population.
    Design: Prospective pilot study.
    Setting: Outpatient musculoskeletal clinic.
    Participants: Thirty male veterans, median age 50 (range 30-69) years.
    Interventions: Ultrasound-guided glenohumeral joint injection using 3 mL of 1% lidocaine HCl and 1 mL of 40 mg triamcinolone acetonide (Kenalog).
    Outcome measure(s): Serum T, FSH, and LH levels, Quantitative Androgen Deficiency in the Aging Male (qADAM), and SPADI questionnaires at baseline, 1, and 4 week(s) post procedure.
    Results: At 1 week post injection, serum T levels decreased by 56.8 ng/dL (95% confidence interval (CI): 91.8, 21.7, p = .002) compared with baseline. Between 1 and 4 weeks post injection, serum T levels increased by 63.9 ng/dL (95% CI: 26.5, 101.2, p = .001), recovering to near baseline levels. SPADI scores were reduced at 1 week (-18.3, 95% CI: -24.4, -12.1, p < .001) and 4 weeks (-14.5, 95% CI -21.1, -7.9, p < .001).
    Conclusions: A single ICSI can temporarily suppress the male gonadal axis. Future studies are needed to evaluate for long-term effects of multiple injections at a single setting and/or higher corticosteroid doses on male reproductive axis function.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Luteinizing Hormone ; Triamcinolone Acetonide ; Follicle Stimulating Hormone ; Pilot Projects ; Veterans ; Prospective Studies ; Testosterone ; Adrenal Cortex Hormones
    Chemical Substances Luteinizing Hormone (9002-67-9) ; Triamcinolone Acetonide (F446C597KA) ; Follicle Stimulating Hormone (9002-68-0) ; Testosterone (3XMK78S47O) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2608988-9
    ISSN 1934-1563 ; 1934-1482
    ISSN (online) 1934-1563
    ISSN 1934-1482
    DOI 10.1002/pmrj.13001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Do Women Need Androgens Like a Fish Needs a Bicycle? A Review of the Literature and Clinical Guidelines.

    Santoro, Nanette / Wierman, Margaret E

    Clinical obstetrics and gynecology

    2021  Volume 64, Issue 4, Page(s) 784–792

    Abstract: Biopotent androgens such as testosterone circulate in low levels in women. However, androgen precursors, such as dehyroepiandrosterone, are among the most abundant hormones produced in both men and women. While testosterone exerts obvious phenotypic ... ...

    Abstract Biopotent androgens such as testosterone circulate in low levels in women. However, androgen precursors, such as dehyroepiandrosterone, are among the most abundant hormones produced in both men and women. While testosterone exerts obvious phenotypic effects in men and is essential for male sexual function, considerable debate and controversy abounds over the role of androgens in women and whether androgens exert an analogous role in women as they do in men. This piece reviews androgen economy in women and the clinical case for and against androgen treatment for women for specific indications.
    MeSH term(s) Androgens ; Animals ; Bicycling ; Female ; Humans ; Male ; Testosterone
    Chemical Substances Androgens ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0000000000000658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dual Aldosterone- and Cortisol-Secreting Adrenal Cortical Carcinoma: Pre- and Perioperative Evaluation and Management.

    Rosenberg, Rebecca / Raeburn, Christopher D / Clay, Michael R / Wierman, Margaret E

    JCEM case reports

    2023  Volume 1, Issue 4, Page(s) luad073

    Abstract: Adrenal cortical carcinoma (ACC) is a rare cancer (1-2/million) that presents with hormone overproduction in 60% of cases. Presentation of ACC with multiple hormone syndromes from different adrenal zones is rare. We present a case of dual-secreting ACC ... ...

    Abstract Adrenal cortical carcinoma (ACC) is a rare cancer (1-2/million) that presents with hormone overproduction in 60% of cases. Presentation of ACC with multiple hormone syndromes from different adrenal zones is rare. We present a case of dual-secreting ACC with hyperaldosteronism and cortisol excess. The previously healthy patient was noted to have new-onset hypertension and hypokalemia during a primary care visit. On hormonal evaluation, he was found to have evidence of hyperaldosteronism and adrenocorticotropic hormone (ACTH)-independent cortisol excess. Imaging revealed a 2.7 × 3.1 × 3.5 cm left adrenal mass with indeterminant computed tomography characteristics. He underwent laparoscopic adrenalectomy and required glucocorticoid replacement for adrenal insufficiency postoperatively. Pathology revealed stage T2N0M0 ACC. His hypokalemia resolved and glucocorticoids were stopped within a month. This case stresses the importance of routine screening for cortisol excess in all adrenal masses detected on imaging. Avoidance of postoperative adrenal insufficiency in patients with cortisol excess without overt Cushing syndrome is paramount.
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Should Dehydroepiandrosterone Be Administered to Women?

    Wierman, Margaret E / Kiseljak-Vassiliades, Katja

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 6, Page(s) 1679–1685

    Abstract: Context: Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects ... ...

    Abstract Context: Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in normal women and those with DHEA-deficient states.
    Evidence acquisition: A review of the literature from 1985 to 2021 on the potential benefits and risks of androgen prohormones in women.
    Evidence synthesis: Studies have examined the potential benefit of DHEA therapy for anti-aging, sexual dysfunction, infertility, metabolic bone health, cognition, and wellbeing in hormone-deficient states such as primary adrenal insufficiency, hypopituitarism, and anorexia as well as administration to normal women across the lifespan.
    Conclusions: Data support small benefits in quality of life and mood but not for anxiety or sexual function in women with primary or secondary adrenal insufficiency or anorexia. No consistent beneficial effects of DHEA administration have been observed for menopausal symptoms, sexual function, cognition, or overall wellbeing in normal women. Local administration of DHEA shows benefit in vulvovaginal atrophy. Use of DHEA to improve induction of ovulation response in women with diminished ovarian reserve is not recommended. Risks of high physiologic or pharmacologic use of DHEA include androgenic and estrogenic side effects which are of concern for long-term administration.
    Clinical case: A 49-year-old woman with Addison's disease who is on low dose estrogen with cyclic progesterone therapy for menopausal symptoms returns for follow-up. She is on a stable glucocorticoid replacement strategy of hydrocortisone 10 mg in the morning and 5 mg in the early afternoon and fludrocortisone 0.05 mg each morning. She has read on the internet that additional therapy with DHEA may help her overall quality of life and libido. She asks whether she should add this therapy to her regimen and at what dose.
    MeSH term(s) Androgens ; Anorexia/chemically induced ; Anorexia/drug therapy ; Dehydroepiandrosterone/adverse effects ; Estrogens ; Female ; Hormone Replacement Therapy/adverse effects ; Humans ; Middle Aged ; Quality of Life
    Chemical Substances Androgens ; Estrogens ; Dehydroepiandrosterone (459AG36T1B)
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function.

    Libby, Andrew E / Solt, Claudia / Jackman, Matthew / Sherk, Vanessa / Foright, Rebecca M / Johnson, Ginger C / Nguyen, Thi-Tina / Breit, Matthew / Hulett, Nicholas / Rudolph, Michael / Roberson, Paul A / Wellberg, Elizabeth / Jambal, Purevsuren / Scalzo, Rebecca L / Higgins, Janine / Kumar, T Rajendra / Wierman, Margaret E / Pan, Zhaoxing / Shankar, Kartik /
    Klemm, Dwight J / Moreau, Kerrie L / Kohrt, Wendy M / MacLean, Paul S

    American journal of physiology. Endocrinology and metabolism

    2024  

    Abstract: ... These effects are largely attributed to decreased estradiol (E ...

    Abstract Loss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00400.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Risks of Different Testosterone Preparations: Too Much, Too Little, Just Right.

    Wierman, Margaret E

    JAMA internal medicine

    2015  Volume 175, Issue 7, Page(s) 1197–1198

    MeSH term(s) Androgens/administration & dosage ; Androgens/adverse effects ; Cardiovascular Diseases/chemically induced ; Humans ; Male ; Testosterone/administration & dosage ; Testosterone/adverse effects
    Chemical Substances Androgens ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2015.1580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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