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  1. Book ; Conference proceedings: Molecular and cellular endocrinology of the testis

    Verhoeven, Guido

    [8th European Workshop on Molecular and Cellular Endocrinology of the Testis, held in De Panne, Belgium, from 27 - 31 March 1994]

    (Ernst Schering Research Foundation workshop : Supplement ; 1)

    1994  

    Event/congress European Workshop on Molecular and Cellular Endocrinology of the Testis (8, 1994, DePanne)
    Author's details G. Verhoeven ... ed
    Series title Ernst Schering Research Foundation workshop : Supplement ; 1
    Ernst Schering Research Foundation workshop
    Ernst Schering Research Foundation workshop ; Supplement
    Collection Ernst Schering Research Foundation workshop
    Ernst Schering Research Foundation workshop ; Supplement
    Keywords Leydig-Zwischenzelle ; Endokrine Regulation
    Subject Hormonale Regulation ; Hormonelle Regulation ; Hormonregulation ; Innersekretorische Regulation ; Hormonsystem ; Hodenzwischenzelle ; Leydig-Zelle
    Language English
    Size XIV, 298 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT006575251
    ISBN 3-540-58337-8 ; 0-387-58337-8 ; 978-3-540-58337-0 ; 978-0-387-58337-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 7968 order for loan Magazin

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  2. Article: Alfapump

    Weil-Verhoeven, Delphine / Di Martino, Vincent / Stirnimann, Guido / Cervoni, Jean Paul / Nguyen-Khac, Eric / Thévenot, Thierry

    World journal of hepatology

    2022  Volume 14, Issue 7, Page(s) 1344–1356

    Abstract: Refractory ascites (RA) is a frequent and life-threatening complication of cirrhosis. In selected patients with RA, transjugular intrahepatic portosystemic shunt (TIPS) placement and liver transplantation (LT) are currently considered the best ... ...

    Abstract Refractory ascites (RA) is a frequent and life-threatening complication of cirrhosis. In selected patients with RA, transjugular intrahepatic portosystemic shunt (TIPS) placement and liver transplantation (LT) are currently considered the best therapeutic alternatives to repeated large volume paracentesis. In patients with a contraindication to TIPS or LT, the alfapump
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v14.i7.1344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical Performance of the Low Profile Zenith Alpha Abdominal Endovascular Graft: 2 Year Results from the ZEPHYR Registry.

    Hatzl, Johannes / van Basten Batenburg, Michiel / Yeung, Kak K / Fioole, Bram / Verhoeven, Eric / Lauwers, Geert / Kölbel, Tilo / Wever, Jan J / Scheinert, Dierk / Van den Eynde, Wouter / Rouhani, Guido / Mees, Barend M E / Vermassen, Frank / Schelzig, Hubert / Böckler, Dittmar / Cuypers, Philippe W M

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2024  

    Abstract: Objective: The midterm outcomes of the low profile Zenith Alpha Abdominal Endovascular Graft from the ZEnith alPHa for aneurYsm Repair (ZEPHYR) registry are reported.: Methods: The ZEPHYR registry is a physician initiated, multicentre, non-randomised, ...

    Abstract Objective: The midterm outcomes of the low profile Zenith Alpha Abdominal Endovascular Graft from the ZEnith alPHa for aneurYsm Repair (ZEPHYR) registry are reported.
    Methods: The ZEPHYR registry is a physician initiated, multicentre, non-randomised, core laboratory controlled, prospective registry. Inclusion criteria were patients with a non-ruptured abdominal aortic aneurysm with a maximum diameter ≥ 50 mm or enlargement > 5 mm within 6 months, with a site reported infrarenal neck length of ≥ 10 mm and with the intention to electively implant the Zenith Alpha abdominal endograft. Patients from 14 sites across Germany, Belgium, and the Netherlands were included. The primary endpoint was treatment success, defined as technical success and clinical success. Technical success was defined as successful delivery and deployment of the endograft in the planned position without unintentional coverage of internal iliac or renal arteries, with successful removal of the delivery system. Clinical success was defined as freedom from aneurysm sac expansion > 5 mm, type I or type III endoleaks, aneurysm rupture, stent graft migration > 10 mm, open conversion, and stent graft occlusion.
    Results: Three hundred and forty-seven patients were included in the ZEPHYR registry. The median clinical follow up was 743 days (interquartile range [IQR] 657, 806) with a median imaging follow up of 725 days (IQR 408, 788). Treatment success at 6 months, 1, and 2 years was 92.5%, 90.4%, and 85.3%, respectively. Freedom from secondary intervention was 94.3%, 93.4%, and 86.9%, respectively. The predominant reason for secondary intervention was limb complications. Freedom from limb occlusion (per patient) at 6 months, 1, and 2 years was 97.2%, 95.8%, and 92.5%, respectively. Univariable and multivariable Cox regression analyses could not identify any independent predictor for limb complications.
    Conclusion: While treatment success is comparable with other commercially available grafts, the rate of limb complications at 2 years is of concern. The manufacturer's instructions for use should be followed closely. Further studies are necessary to investigate the root cause of the increased rate of limb complications with the Zenith Alpha Abdominal Endovascular Graft.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2024.03.004
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    Zs.MO 381: Show issues

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  4. Article ; Online: Correction to "Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues".

    Jouffroy, Lucile / Verhoeven, Jonas / Brambilla, Marta / Verniest, Guido / Kong, Hanchu / Zhao, Yongbin / Wang, Wenbin / Meerpoel, Lieven / Thuring, Jan Willem / Winne, Johan M

    Organic letters

    2022  Volume 24, Issue 2, Page(s) 798

    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Published Erratum
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c04263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synthesis and Reactivity of Spirocarbocycles as Scaffolds for Nucleoside Analogues.

    Verhoeven, Jonas / Deraet, Xavier / Pande, Vineet / Sun, Weimei / Alonso, Mercedes / De Proft, Frank / Meerpoel, Lieven / Thuring, Jan Willem / Verniest, Guido

    The Journal of organic chemistry

    2020  Volume 85, Issue 23, Page(s) 14989–15005

    Abstract: A novel class of substituted spiro[3.4]octanes can be accessed via a [2 + 2]-cycloaddition of dichloroketene on a readily ... ...

    Abstract A novel class of substituted spiro[3.4]octanes can be accessed via a [2 + 2]-cycloaddition of dichloroketene on a readily prepared
    MeSH term(s) Cycloaddition Reaction ; Cyclopentanes ; Nucleosides
    Chemical Substances Cyclopentanes ; Nucleosides
    Language English
    Publishing date 2020-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.0c01825
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  6. Article: Synthesis of Cyclopropyl Pinacol Boronic Esters from Dibromo­cyclopropanes

    Neouchy, Zeina / Hullaert, Jan / Verhoeven, Jonas / Meerpoel, Lieven / Thuring, Jan-Willem / Verniest, Guido / Winne, Johan

    Synlett

    2022  Volume 33, Issue 08, Page(s) 759–766

    Abstract: The synthesis of cyclopropyl pinacol boronic esters from dibromocyclopropanes via Matteson–Pasto rearrangement is reported. The method is readily scalable and shows limited levels of stereoinduction, with a selectivity that is in part complementary to ... ...

    Abstract The synthesis of cyclopropyl pinacol boronic esters from dibromocyclopropanes via Matteson–Pasto rearrangement is reported. The method is readily scalable and shows limited levels of stereoinduction, with a selectivity that is in part complementary to that observed in existing stereoselective borylcyclopropanation strategies. The method can be used to rapidly access borylcyclopropanes as interesting building blocks for diversely functionalized cyclopropanes.
    Keywords olefins ; dibromocyclopropanes ; borylcyclopropanes ; pinacolborane ; Matteson–Pasto rearrangement
    Language English
    Publishing date 2022-04-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-0037-1610794
    Database Thieme publisher's database

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  7. Article ; Online: The Impact of Structured and Standardized Documentation on Documentation Quality; a Multicenter, Retrospective Study.

    Ebbers, Tom / Kool, Rudolf B / Smeele, Ludi E / Dirven, Richard / den Besten, Chrisje A / Karssemakers, Luc H E / Verhoeven, Tim / Herruer, Jasmijn M / van den Broek, Guido B / Takes, Robert P

    Journal of medical systems

    2022  Volume 46, Issue 7, Page(s) 46

    Abstract: The reuse of healthcare data for various purposes will become increasingly important in the future. To enable the reuse of clinical data, structured and standardized documentation is conditional. However, the primary purpose of clinical documentation is ... ...

    Abstract The reuse of healthcare data for various purposes will become increasingly important in the future. To enable the reuse of clinical data, structured and standardized documentation is conditional. However, the primary purpose of clinical documentation is to support high-quality patient care. Therefore, this study investigated the effect of increased structured and standardized documentation on the quality of notes in the Electronic Health Record. A multicenter, retrospective design was used to assess the difference in note quality between 144 unstructured and 144 structured notes. Independent reviewers measured note quality by scoring the notes with the Qnote instrument. This instrument rates all note elements independently using and results in a grand mean score on a 0-100 scale. The mean quality score for unstructured notes was 64.35 (95% CI 61.30-67.35). Structured and standardized documentation improved the Qnote quality score to 77.2 (95% CI 74.18-80.21), a 12.8 point difference (p < 0.001). Furthermore, results showed that structured notes were significantly longer than unstructured notes. Nevertheless, structured notes were more clear and concise. Structured documentation led to a significant increase in note quality. Moreover, considering the benefits of structured data recording in terms of data reuse, implementing structured and standardized documentation into the EHR is recommended.
    MeSH term(s) Documentation ; Electronic Health Records ; Humans ; Quality of Health Care ; Retrospective Studies
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-022-01837-9
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    Zs.A 1426: Show issues Location:
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  8. Article ; Online: Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues.

    Jouffroy, Lucile / Verhoeven, Jonas / Brambilla, Marta / Verniest, Guido / Kong, Hanchu / Zhao, Yongbin / Wang, Wenbin / Meerpoel, Lieven / Thuring, Jan Willem / Winne, Johan M

    Organic letters

    2021  Volume 23, Issue 22, Page(s) 8828–8833

    Abstract: Novel C-4',C-5' cyclobutane-fused spirocyclic ribonucleoside analogues were prepared. Thermal [2 + 2] cycloaddition between dichloroketene and readily derived 4'- ...

    Abstract Novel C-4',C-5' cyclobutane-fused spirocyclic ribonucleoside analogues were prepared. Thermal [2 + 2] cycloaddition between dichloroketene and readily derived 4'-
    MeSH term(s) Adenosine
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c03334
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  9. Article: Synthesis and transformations of pyrrolo[1,2-a][1,3,5]-triazines

    Verhoeven, Jonas / B. Narendraprasad Reddy / Lieven Meerpoel / Jan Willem Thuring / Guido Verniest

    Tetrahedron letters. 2018 Dec. 26, v. 59, no. 52

    2018  

    Abstract: Pyrrolotriazines and related fused azaheterocycles have high potential for the synthesis of bioactive compounds, especially as a purine base isoster in carbon linked nucleosides. Although many structurally related compounds have already been synthesized ... ...

    Abstract Pyrrolotriazines and related fused azaheterocycles have high potential for the synthesis of bioactive compounds, especially as a purine base isoster in carbon linked nucleosides. Although many structurally related compounds have already been synthesized and used in medicinal chemistry, pyrrolo[1,3,5]triazines have barely been described. The present work describes the synthesis of such heterocycles via condensation of 2-amino-3-ethoxycarbonylpyrrole with ethoxycarbonyliso(thio)cyanate. In a brief reactivity study of the obtained fused pyrroles, O- and S-alkylation, ester hydrolysis as well as regioselective bromination at the 6-position was demonstrated.
    Keywords alkylation ; bioactive compounds ; bromination ; carbon ; chemical structure ; cyanates ; hydrolysis ; nucleosides ; purines ; pyrroles ; regioselectivity ; triazines
    Language English
    Dates of publication 2018-1226
    Size p. 4537-4539.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2018.11.002
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2837: Show issues Location:
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  10. Article ; Online: Stereodivergent Synthesis of Biologically Active Spironucleoside Scaffolds via Catalytic Cyclopropanation of 4-

    Neouchy, Zeina / Verhoeven, Jonas / Kong, Hanchu / Zhao, Yongbin / Wang, Wenbin / Brambilla, Marta / Van Hecke, Kristof / Meerpoel, Lieven / Thuring, Jan Willem / Verniest, Guido / Winne, Johan

    The Journal of organic chemistry

    2021  Volume 86, Issue 23, Page(s) 17344–17361

    Abstract: Cyclopropane fusion of the only rotatable carbon-carbon bond in furanosyl nucleosides (i.e., exocyclic 4'-5') is a powerful design strategy to arrive at conformationally constrained analogues. Herein, we report a direct stereodivergent route toward the ... ...

    Abstract Cyclopropane fusion of the only rotatable carbon-carbon bond in furanosyl nucleosides (i.e., exocyclic 4'-5') is a powerful design strategy to arrive at conformationally constrained analogues. Herein, we report a direct stereodivergent route toward the synthesis of the four possible configurations of 4-spirocyclopropane furanoses, which have been transformed into the corresponding 4'-spirocyclic adenosine analogues. The latter showed differential inhibition of the protein methyltransferase PRMT5-MEP50 complex, with one analogue inhibiting more effectively than adenosine itself, demonstrating the utility of rationally probing 4'-5' side chain orientations.
    MeSH term(s) Adenosine ; Catalysis ; Nucleosides
    Chemical Substances Nucleosides ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2021-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c01611
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