LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article: Honeysuckle (

    Yeh, Yuan-Chieh / Doan, Ly Hien / Huang, Zi-Yi / Chu, Li-Wei / Shi, Tzu-Hau / Lee, Ying-Ray / Wu, Cheng-Tao / Lin, Chao-Hsiung / Chiang, Shu-Tuan / Liu, Hui-Kang / Chuang, Tsung-Hsien / Ping, Yueh-Hsin / Liu, Hsiao-Sheng / Huang, Chi-Ying F

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 765553

    Abstract: COVID-19 is threatening human health worldwide but no effective treatment currently exists for this disease. Current therapeutic strategies focus on the inhibition of viral replication or using anti-inflammatory/immunomodulatory compounds to improve host ...

    Abstract COVID-19 is threatening human health worldwide but no effective treatment currently exists for this disease. Current therapeutic strategies focus on the inhibition of viral replication or using anti-inflammatory/immunomodulatory compounds to improve host immunity, but not both. Traditional Chinese medicine (TCM) compounds could be promising candidates due to their safety and minimal toxicity. In this study, we have developed a novel
    Language English
    Publishing date 2022-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.765553
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage.

    Shi, Tzu-Hau / Huang, Yi-Long / Chen, Chiao-Che / Pi, Wen-Chieh / Hsu, Yu-Ling / Lo, Lee-Chiang / Chen, Wei-Yi / Fu, Shu-Ling / Lin, Chao-Hsiung

    Biochemical and biophysical research communications

    2020  Volume 533, Issue 3, Page(s) 467–473

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively, utilization of old drugs or ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively, utilization of old drugs or available medicine that can suppress the viral activity or replication may provide an urgent solution to suppress the rapid spread of 2019-nCoV. Andrographolide is a highly abundant natural product of the medicinal plant, Andrographis paniculata, which has been clinically used for inflammatory diseases and anti-viral therapy. We herein demonstrate that both andrographolide and its fluorescent derivative, the nitrobenzoxadiazole-conjugated andrographolide (Andro- NBD), suppressed the main protease (M
    MeSH term(s) Betacoronavirus/enzymology ; Catalytic Domain ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/metabolism ; Diterpenes/chemistry ; Diterpenes/pharmacology ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacology ; Molecular Docking Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Protein Conformation ; Protein Multimerization ; Severe acute respiratory syndrome-related coronavirus/enzymology ; SARS-CoV-2 ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
    Chemical Substances Diterpenes ; Fluorescent Dyes ; Protease Inhibitors ; Viral Nonstructural Proteins ; andrographolide (410105JHGR) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.08.086
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage

    Shi, Tzu-Hau / Huang, Yi-Long / Chen, Chiao-Che / Pi, Wen-Chieh / Hsu, Yu-Ling / Lo, Lee-Chiang / Chen, Wei-Yi / Fu, Shu-Ling / Lin, Chao-Hsiung

    Biochemical and biophysical research communications. 2020 Dec. 10, v. 533, no. 3

    2020  

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively, utilization of old drugs or ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively, utilization of old drugs or available medicine that can suppress the viral activity or replication may provide an urgent solution to suppress the rapid spread of 2019-nCoV. Andrographolide is a highly abundant natural product of the medicinal plant, Andrographis paniculata, which has been clinically used for inflammatory diseases and anti-viral therapy. We herein demonstrate that both andrographolide and its fluorescent derivative, the nitrobenzoxadiazole-conjugated andrographolide (Andro- NBD), suppressed the main protease (Mᵖʳᵒ) activities of 2019-nCoV and severe acute respiratory syndrome coronavirus (SARS-CoV). Moreover, Andro-NBD was shown to covalently link its fluorescence to these proteases. Further mass spectrometry (MS) analysis suggests that andrographolide formed a covalent bond with the active site Cys¹⁴⁵ of either 2019-nCoV Mᵖʳᵒ or SARS-CoV Mᵖʳᵒ. Consistently, molecular modeling analysis supported the docking of andrographolide within the catalytic pockets of both viral Mᵖʳᵒs. Considering that andrographolide is used in clinical practice with acceptable safety and its diverse pharmacological activities that could be beneficial for attenuating COVID-19 symptoms, extensive investigation of andrographolide on the suppression of 2019-nCoV as well as its application in COVID-19 therapy is suggested.
    Keywords Andrographis paniculata ; COVID-19 infection ; Severe acute respiratory syndrome coronavirus ; Severe acute respiratory syndrome coronavirus 2 ; active sites ; andrographolide ; chemical bonding ; fluorescence ; mass spectrometry ; medicinal plants ; medicine ; pandemic ; proteinases ; research ; therapeutics
    Language English
    Dates of publication 2020-1210
    Size p. 467-473.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.08.086
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 71/706: Show issues
    Z 3.8: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage

    Shi, Tzu-Hau / Huang, Yi-Long / Chen, Chiao-Che / Pi, Wen-Chieh / Hsu, Yu-Ling / Lo, Lee-Chiang / Chen, Wei-Yi / Fu, Shu-Ling / Lin, Chao-Hsiung

    Biochem Biophys Res Commun

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively, utilization of old drugs or ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively, utilization of old drugs or available medicine that can suppress the viral activity or replication may provide an urgent solution to suppress the rapid spread of 2019-nCoV. Andrographolide is a highly abundant natural product of the medicinal plant, Andrographis paniculata, which has been clinically used for inflammatory diseases and anti-viral therapy. We herein demonstrate that both andrographolide and its fluorescent derivative, the nitrobenzoxadiazole-conjugated andrographolide (Andro- NBD), suppressed the main protease (Mpro) activities of 2019-nCoV and severe acute respiratory syndrome coronavirus (SARS-CoV). Moreover, Andro-NBD was shown to covalently link its fluorescence to these proteases. Further mass spectrometry (MS) analysis suggests that andrographolide formed a covalent bond with the active site Cys145 of either 2019-nCoV Mpro or SARS-CoV Mpro. Consistently, molecular modeling analysis supported the docking of andrographolide within the catalytic pockets of both viral Mpros. Considering that andrographolide is used in clinical practice with acceptable safety and its diverse pharmacological activities that could be beneficial for attenuating COVID-19 symptoms, extensive investigation of andrographolide on the suppression of 2019-nCoV as well as its application in COVID-19 therapy is suggested.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #728447
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: The emissions from co-firing of biomass and torrefied biomass with coal in a chain-grate steam boiler.

    Chang, Chia-Chi / Chen, Yen-Hau / Chang, Wei-Ren / Wu, Chao-Hsiung / Chen, Yi-Hung / Chang, Ching-Yuan / Yuan, Min-Hao / Shie, Je-Lueng / Li, Yuan-Shen / Chiang, Sheng-Wei / Yang, Tzu-Yi / Lin, Far-Ching / Ko, Chun-Han / Liu, Bo-Liang / Liu, Kuang-Wei / Wang, Shi-Guan

    Journal of the Air & Waste Management Association (1995)

    2019  Volume 69, Issue 12, Page(s) 1467–1478

    Abstract: In this study, biomass of rice straw (RS) and wood (WD) and their torrefied biomass ( ... ...

    Abstract In this study, biomass of rice straw (RS) and wood (WD) and their torrefied biomass (RS
    MeSH term(s) Air Pollutants/chemistry ; Biomass ; Coal/analysis ; Gases ; Heating ; Incineration ; Oryza ; Particulate Matter/analysis ; Wood/chemistry
    Chemical Substances Air Pollutants ; Coal ; Gases ; Particulate Matter
    Language English
    Publishing date 2019-10-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003064-5
    ISSN 2162-2906 ; 0894-0630 ; 1047-3289 ; 1096-2247
    ISSN (online) 2162-2906
    ISSN 0894-0630 ; 1047-3289 ; 1096-2247
    DOI 10.1080/10962247.2019.1668871
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top