Article ; Online: Enhanced delivery of quercetin and doxorubicin using β-cyclodextrin polymer to overcome P-glycoprotein mediated multidrug resistance.
International journal of pharmaceutics
2023 Volume 635, Page(s) 122763
Abstract: ... doxorubicin (DOX) nanocarrier (β-CDP/QD NCs) by freeze-dried method to combat P-glycoprotein (P-gp) mediated ...
Abstract | In this study, we prepared a β-cyclodextrin polymer (β-CDP) co-loaded quercetin (QCT) and doxorubicin (DOX) nanocarrier (β-CDP/QD NCs) by freeze-dried method to combat P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in KB-Ch |
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MeSH term(s) | Humans ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Quercetin/pharmacology ; Polymers/pharmacology ; Molecular Docking Simulation ; Drug Resistance, Neoplasm ; Doxorubicin/pharmacology ; Doxorubicin/chemistry ; Drug Resistance, Multiple ; ATP Binding Cassette Transporter, Subfamily B ; MCF-7 Cells ; Cell Line, Tumor |
Chemical Substances | ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antineoplastic Agents ; cyclodextrin polymer ; Quercetin (9IKM0I5T1E) ; Polymers ; Doxorubicin (80168379AG) ; ATP Binding Cassette Transporter, Subfamily B |
Language | English |
Publishing date | 2023-02-21 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 428962-6 |
ISSN | 1873-3476 ; 0378-5173 |
ISSN (online) | 1873-3476 |
ISSN | 0378-5173 |
DOI | 10.1016/j.ijpharm.2023.122763 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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