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Article: Alkyl chain interaction at the surface of room temperature ionic liquids: systematic variation of alkyl chain length (R = C(1)-C(4), C(8)) in both cation and anion of [RMIM][R-OSO(3)] by sum frequency generation and surface tension.

Santos, Cherry S / Baldelli, Steven

The journal of physical chemistry. B

2009 Volume 113, Issue 4, Page(s) 923–933

Abstract: The gas-liquid interface of halide-free 1,3-dialkylimidazolium alkyl sulfates [RMIM][R-OSO(3 ... with R chain length from C(1)-C(4) and C(8) has been studied systematically using the surface-specific ...

Abstract	The gas-liquid interface of halide-free 1,3-dialkylimidazolium alkyl sulfates [RMIM][R-OSO(3)] with R chain length from C(1)-C(4) and C(8) has been studied systematically using the surface-specific sum frequency generation (SFG) vibrational spectroscopy and surface tension measurements. From the SFG spectra, vibrational modes from the methyl group of both cation and anion are observed for all ionic liquid samples considered in the present study. These results suggest the presence of both ions at the gas-liquid interface, which is further supported by surface tension measurements. Surface tension data show a decreasing trend as the alkyl chain in the imidazolium cation is varied from methyl to butyl chain, with a specific anion. A similar trend is observed when the alkyl chain of the anion is modified and the cation is fixed.
Language	English
Publishing date	2009-01-29
Publishing country	United States
Document type	Journal Article
ISSN	1520-6106
ISSN	1520-6106
DOI	10.1021/jp807924g
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Article ; Online: Characterization of selected dietary fibers microparticles and application of the optimized formulation as a fat replacer in hazelnut spreads.

Silva Zamora, Rocio / Baldelli, Alberto / Pratap-Singh, Anubhav

Food research international (Ottawa, Ont.)

2023 Volume 165, Page(s) 112466

Abstract: The present work demonstrates the application of the spray drying technique to produce microparticulates of different dietary fibers with particle sizes<10 µm. It examines their role as potential fat replacers for hazelnut spread creams. Optimization of ... ...

Abstract	The present work demonstrates the application of the spray drying technique to produce microparticulates of different dietary fibers with particle sizes<10 µm. It examines their role as potential fat replacers for hazelnut spread creams. Optimization of a dietary fiber formulation containing inulin, glucomannan, psyllium husk, and chia mucilage to obtain high viscosity, water holding capacity, and oil holding capacity was conducted. Microparticles containing 46.1, 46.2, and 7.6 weight percentages of chia seed mucilage, konjac glucomannan, and psyllium husk showed a spraying yield of 83.45 %, a solubility of 84.63 %, and viscosity of 40.49 Pas. When applied to hazelnut spread creams, microparticles substituted palm oil by 100 %; they produced a product with a total unsaturated and saturated fat reduction of 41 and 77 %, respectively. An increase in dietary fibers of 4 % and a decrease in total calories of 80 % were also induced when compared with the original formulation. Hazelnut spread with dietary fiber microparticles were preferred by 73.13 % of the panelist in the sensory study due to an enhancement in brightness. The demonstrated technique could be used to increase the fiber content while decreasing the fat content in some commercial products, such as peanut butter or chocolate cream.
MeSH term(s)	Dietary Fiber ; Corylus ; Psyllium ; Cacao
Chemical Substances	Dietary Fiber ; Psyllium (8063-16-9) ; Salvia hispanica seed extract
Language	English
Publishing date	2023-01-07
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.112466
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Article: Selective up-regulation of P- and R-type Ca2+ channels in rat embryo motoneurons by BDNF.

Baldelli, P / Magnelli, V / Carbone, E

The European journal of neuroscience

1999 Volume 11, Issue 4, Page(s) 1127–1133

Abstract: ... and P-type channels, E15 rat motoneurons also express high densities of R-type channels. We have ... previously shown that the P-type channel is nearly absent in 60% of these cells, while the R-type contributes ... regulation of the P- and R-type current density available after blocking N- and L-type channels, with no ...

Abstract	Cultured spinal cord motoneurons from day 15 rat embryos (E15) represent a useful model to study Ca2+ channel diversities and their regulation by neurotrophins. Besides the previously identified L-, N- and P-type channels, E15 rat motoneurons also express high densities of R-type channels. We have previously shown that the P-type channel is nearly absent in 60% of these cells, while the R-type contributes to approximately 35% of the total current. Here, we show that chronic preincubation of cultured rat motoneurons with high concentrations (20-100 ng/mL) of brain-derived neurotrophic factor (BDNF) caused a selective up-regulation of the P- and R-type current density available after blocking N- and L-type channels, with no changes to cell membrane capacitance. N- and L-type channels were either not affected or slightly down-modulated by the neurotrophin. The onset of BDNF up-regulation of P/R-type currents had a half-time of 12 h and reached maximal values of approximately 80%. High concentrations of nerve growth factor (NGF; 50-100 ng/mL) had no effect on P/R currents, while BDNF action was prevented by the kinase inhibitor K252a and by the protein synthesis inhibitor anisomycin. These results suggest that chronic applications of BDNF selectively up-regulates the Ca2+ channel types which are most likely to be involved in the control of neurotransmitter release in mammalian neuromuscular junctions. The signal transduction mechanism is probably mediated by TrkB receptors and involves the synthesis of newly functionally active P- and R-type channels. Our data furnish a rationale for a number of recent observations in other laboratories, in which prolonged applications of neurotrophins were shown to potentiate the presynaptic response in developing synapses.
MeSH term(s)	Animals ; Brain-Derived Neurotrophic Factor/antagonists & inhibitors ; Brain-Derived Neurotrophic Factor/pharmacology ; Calcium Channels/drug effects ; Cells, Cultured ; Embryo, Mammalian/drug effects ; Motor Neurons/drug effects ; Patch-Clamp Techniques ; Protein Synthesis Inhibitors/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor Protein-Tyrosine Kinases/physiology ; Receptor, Ciliary Neurotrophic Factor ; Receptors, Nerve Growth Factor/physiology ; Spinal Cord/cytology ; Spinal Cord/drug effects ; Spinal Cord/embryology ; Up-Regulation
Chemical Substances	Brain-Derived Neurotrophic Factor ; Calcium Channels ; Protein Synthesis Inhibitors ; Receptor, Ciliary Neurotrophic Factor ; Receptors, Nerve Growth Factor ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	1999-04
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1046/j.1460-9568.1999.00523.x
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Article ; Online: Alterazioni della funzionalità tiroidea nel paziente oncologico: un caso di ipotiroidismo in corso di immunoterapia.

Rossini, Giovanni / Zuppi, Paolo / Ramponi, Sara / Garufi, Carlo / Grillo, Lucia Rosalba / Baldelli, Roberto

Recenti progressi in medicina

2023 Volume 114, Issue 12, Page(s) 14e–17e

Abstract: Endocrinopathies, especially hypothyroidism, are very frequent during immunocheckpoint inhibitors treatment. An early diagnosis, through a correct clinical evaluation and the execution of blood tests, and the use of Levothyroxine therapy, allow you to ... ...

Title translation	Alterations of thyroid function in cancer patients: a case of hypothyroidism during immunotherapy.
Abstract	Endocrinopathies, especially hypothyroidism, are very frequent during immunocheckpoint inhibitors treatment. An early diagnosis, through a correct clinical evaluation and the execution of blood tests, and the use of Levothyroxine therapy, allow you to continue the established tretament in most cases.
MeSH term(s)	Humans ; Hypothyroidism/diagnosis ; Immunotherapy/adverse effects ; Neoplasms/therapy
Language	Italian
Publishing date	2023-11-30
Publishing country	Italy
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	138266-4
ISSN	2038-1840 ; 0034-1193
ISSN (online)	2038-1840
ISSN	0034-1193
DOI	10.1701/4142.41403
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Article ; Online: Fluorescent imaging probes for in vivo ovarian cancer targeted detection and surgery.

Solidoro, Roberta / Centonze, Antonella / Miciaccia, Morena / Baldelli, Olga Maria / Armenise, Domenico / Ferorelli, Savina / Perrone, Maria Grazia / Scilimati, Antonio

Medicinal research reviews

2024

Abstract: Ovarian cancer is the most lethal gynecological cancer, with a survival rate of approximately 40% at five years from the diagno. The first-line treatment consists of cytoreductive surgery combined with chemotherapy (platinum- and taxane-based drugs). To ... ...

Abstract	Ovarian cancer is the most lethal gynecological cancer, with a survival rate of approximately 40% at five years from the diagno. The first-line treatment consists of cytoreductive surgery combined with chemotherapy (platinum- and taxane-based drugs). To date, the main prognostic factor is related to the complete surgical resection of tumor lesions, including occult micrometastases. The presence of minimal residual diseases not detected by visual inspection and palpation during surgery significantly increases the risk of disease relapse. Intraoperative fluorescence imaging systems have the potential to improve surgical outcomes. Fluorescent tracers administered to the patient may support surgeons for better real-time visualization of tumor lesions during cytoreductive procedures. In the last decade, consistent with the discovery of an increasing number of ovarian cancer-specific targets, a wide range of fluorescent agents were identified to be employed for intraoperatively detecting ovarian cancer. Here, we present a collection of fluorescent probes designed and developed for fluorescence-guided ovarian cancer surgery. Original articles published between 2011 and November 2022 focusing on fluorescent probes, currently under preclinical and clinical investigation, were searched in PubMed. The keywords used were targeted detection, ovarian cancer, fluorescent probe, near-infrared fluorescence, fluorescence-guided surgery, and intraoperative imaging. All identified papers were English-language full-text papers, and probes were classified based on the location of the biological target: intracellular, membrane, and extracellular.
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603210-2
ISSN	1098-1128 ; 0198-6325
ISSN (online)	1098-1128
ISSN	0198-6325
DOI	10.1002/med.22027
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Article: Kidney disease and appendicitis.

BALDELLI, R

Minerva chirurgica

2010 Volume 2, Issue 3, Page(s) 112–115

Title translation	Affezioni renali e appendicite.
MeSH term(s)	Appendicitis/complications ; Humans ; Kidney Diseases
Language	Italian
Publishing date	2010-02-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123603-9
ISSN	1827-1626 ; 0026-4733
ISSN (online)	1827-1626
ISSN	0026-4733
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Article: The Cocci method for the operation of the inguinal hernia.

BALDELLI, R

Giornale italiano di chirurgia

2010 Volume 3, Issue 3, Page(s) 145–165

Title translation	Il metodo Cocci per l'operazione dell'ernia inguinale.
MeSH term(s)	Hernia, Inguinal ; Humans
Language	Italian
Publishing date	2010-02-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	138034-5
ISSN	0017-0453
ISSN	0017-0453
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Article: The cocci method for the treatment of the rural hernia.

BALDELLI, R

Giornale italiano di chirurgia

2010 Volume 3, Issue 4, Page(s) 197–211

Title translation	Il metodo Cocci per la cura dell'ernia crurale.
MeSH term(s)	Hernia, Femoral ; Humans
Language	Italian
Publishing date	2010-02-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	138034-5
ISSN	0017-0453
ISSN	0017-0453
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Article ; Online: Lacosamide effectiveness and tolerability in patients with drug-resistant epilepsy and severe disability under polytherapy: Therapy optimization as emerging from an observational study.

Pozzi, Marco / Zanotta, Nicoletta / Epifanio, Roberta / Baldelli, Sara / Cattaneo, Dario / Clementi, Emilio / Zucca, Claudio

Epilepsy & behavior : E&B

2022 Volume 128, Page(s) 108598

Abstract: ... with the administered dose (R: Conclusion: Lacosamide add-on allowed dose reduction of previous therapies and reduced ...

Abstract	Objective: We explored the efficacy and safety of lacosamide combined with inhibitors of fast-inactivated sodium channels or with other antiepileptic drugs, in patients with drug refractory focal epilepsy associated with intellectual or psychiatric disability. Methods: Observational study of lacosamide including the monitoring of lacosamide trough plasma levels and of electroencephalograms. Results: We followed up 44 patients from the start of lacosamide therapy for up to 3 years, with a clinical, electroencephalogram (EEG), and pharmacological follow-up. Median patients' age was 32.7 years, median age at epilepsy onset was 3.5 years. Intellectual disability was severe in 55.4% of the cohort and drug refractoriness was diagnosed in 88.6% of patients, who had predominantly focal seizures (80%). The severity of their epilepsy was suggested by the use of combined therapies with non-sodium blockers and sodium blockers in 75% of patients. Lacosamide was added to previous therapies and up-titrated to a median of 300 mg/d. Lacosamide add-on led to simplification of the previous drug regimen with a dose reduction in 87.9% of users of sodium blockers and in 66.7% of users of non-sodium blockers, and to withdrawal of previously administered sodium blockers in 48.5% users and non-sodium blockers in 47.6% users. Lacosamide was prescribed at lower doses in the presence of oxcarbazepine (p = 0.029), lamotrigine (p = 0.015), and topiramate (p < 0.001). Mean lacosamide plasma levels were 6.0 ± 2.4 mg/L; they were in linear correlation with the administered dose (R Conclusion: Lacosamide add-on allowed dose reduction of previous therapies and reduced the frequency of seizures, showing good tolerability even at high doses, without exceeding reference plasma levels.
MeSH term(s)	Adult ; Anticonvulsants/adverse effects ; Drug Resistant Epilepsy/chemically induced ; Drug Resistant Epilepsy/drug therapy ; Drug Therapy, Combination ; Epilepsy/drug therapy ; Humans ; Lacosamide/therapeutic use ; Treatment Outcome
Chemical Substances	Anticonvulsants ; Lacosamide (563KS2PQY5)
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2022.108598
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Zs.A 5289: Show issues

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Article: Editorial: Advances in the Endocrine Role of the Skeleton.

Baldelli, Roberto / Coudert, Amelie E / Del Fattore, Andrea

Frontiers in endocrinology

2020 Volume 11, Page(s) 591085

MeSH term(s)	Animals ; Bone and Bones/physiology ; Endocrine System/physiology ; Energy Metabolism ; Homeostasis ; Humans ; Osteocalcin/metabolism ; Osteoclasts/physiology
Chemical Substances	Osteocalcin (104982-03-8)
Language	English
Publishing date	2020-10-15
Publishing country	Switzerland
Document type	Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2020.591085
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