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  1. Article ; Online: Re: 'Aneurysmal degeneration of the inflow artery after arteriovenous access for hemodialysis'.

    Kordzadeh, A / Panayiotopoulos, Y P

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2015  Volume 49, Issue 3, Page(s) 354

    MeSH term(s) Aneurysm/surgery ; Arteries/surgery ; Arteriovenous Shunt, Surgical ; Female ; Humans ; Ligation/adverse effects ; Male ; Renal Dialysis
    Language English
    Publishing date 2015-03
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2014.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Impact of Patient Demographics, Anatomy, Comorbidities, and Peri-operative Planning on the Primary Functional Maturation of Autogenous Radiocephalic Arteriovenous Fistula.

    Kordzadeh, A / Askari, A / Hoff, M / Smith, V / Panayiotopoulos, Y

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2017  Volume 53, Issue 5, Page(s) 726–732

    Abstract: ... 8.63, p < .001) (non-augmented) and radial artery diameter > 1.6 mm (OR 12.26, 95% CI, 6.27-23.97, p ...

    Abstract Objectives: The aim of this study was to evaluate the collective and/or independent impact of patient demographics, comorbidities, anatomical factors, and peri-operative parameters on the primary functional maturation of RCAVFs. This study also aimed to identify the range and best cut off value for each variable and evaluate the likelihood, significance and percentage of primary functional maturation of RCAVFs.
    Methods: This was a prospective consecutive single centre cohort study over a 4 year period; it was conducted on patients with the intention-to-treat using a radiocephalic arteriovenous fistula (RCAVF) (Brescia-Cimino). During this period 548 vascular access procedures, inclusive of RCAVF, were performed. Variables included patient demographics (age, gender), anatomical variance (cephalic vein, radial artery diameter, laterality), comorbidities (diabetes mellitus, ischaemic heart disease, congestive cardiac failure, hypertension), aetiology of renal failure, and anaesthesia type (local versus general anaesthesia).
    Results: Of the total, 324 patients, cephalic vein diameter > 1.5 mm (OR 4.57, 95% CI, 2.42-8.63, p < .001) (non-augmented) and radial artery diameter > 1.6 mm (OR 12.26, 95% CI, 6.27-23.97, p < .001) were found to be independently associated with the primary functional maturation of 86% in the RCAVF formation.
    Conclusion: Of all the variables, cephalic vein and radial artery diameter are independently associated with the primary functional maturation of RCAVFs.
    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2017.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Presenting Baseline Coagulation of Infra Renal Ruptured Abdominal Aortic Aneurysm: A Systematic Review and Pooled Analysis.

    Kordzadeh, A / Parsa, A D / Askari, A / Maddison, B / Panayiotopoulos, Y P

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2016  Volume 51, Issue 5, Page(s) 682–689

    Abstract: Background: The incidence of coagulopathy in patients presenting with rAAA is not clear. The lack of high-quality evidence has led to various speculations, reliance on anecdotal experience, and suggestions about their appropriate haemostatic ... ...

    Abstract Background: The incidence of coagulopathy in patients presenting with rAAA is not clear. The lack of high-quality evidence has led to various speculations, reliance on anecdotal experience, and suggestions about their appropriate haemostatic resuscitation. The aim of this systematic review is to establish the baseline coagulation status of infra renal ruptured abdominal aortic aneurysms (rAAA) against defined standards and definitions.
    Methods: An electronic search of literature in Medline, CINHAL, Scopus Embase, and Cochrane library was performed in accordance with the PRISMA guidelines. Quality assessment of articles was performed using the Oxford critical appraisal skills programme (CASP) and their recommendation for practice was examined through National Institute for Health and Care Excellence (NICE). Information on platelet count, international normalisation ratio (INR), activated partial prothrombin time (aPTT), prothrombin time (PT) fibrinogen and D-dimer was extracted, and pooled analysis was performed in accordance with the definition of coagulopathy and its subtypes. Pooled prevalence of coagulopathies and 95% CI were estimated with a variance weighted random effects model.
    Results: Seven studies, comprising 461 patients were included in this systematic review. Overall weighted prevalence of coagulopathy was 12.3% (95% CI 10.7-13.9), 11.7% for INR (95% CI 1-31.6), 10.1% for platelet count (95% CI 1-26.8), and 11.1% for aPTT (95% CI 0.78-31). Fibrinogen serum concentration level was normal in 97%, and 46.2% (n = 55) of patients had elevated D-dimer. Only 6% of the entire population demonstrated significant coagulopathy. DIC was noted in 2.4% of the population.
    Conclusion: This first systematic review of literature on baseline coagulation of rAAAs suggests that the majority of these patients do not present with coagulopathy and only a minor proportion of patients present with significant coagulopathy.
    MeSH term(s) Aortic Aneurysm, Abdominal/blood ; Aortic Rupture/blood ; Fibrinogen ; Humans ; Incidence
    Chemical Substances Fibrinogen (9001-32-5)
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2016.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A paper for debate: vein versus PTFE for critical limb ischaemia--an unfair comparison?

    Panayiotopoulos, Y P / Taylor, P R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    1997  Volume 14, Issue 3, Page(s) 191–194

    Abstract: ... to PTFE grafts when the whole cohort was included (p = 0.0038); however, there was no significant ...

    Abstract Introduction: There is a widely held view that vein grafts for infrainguinal arterial reconstruction perform much better than prosthetic conduits, the best of which seems to be PTFE. Many randomised studies have been conducted which confirm this opinion, but is the difference as large as it is thought to be? One interesting feature of published trials is that the results for obligatory PTFE (when no vein is available) were much worse than the results for randomised PTFE grafts. The only way to explain this is that these groups of patients were not similar, and there are probably other factors which contribute to the difference in results when vein and PTFE grafts are compared.
    Materials and methods: A consecutive series of 109 femoro-infrapopliteal grafts undertaken for critical limb ischaemia was analysed to see the difference between vein and PTFE with vein cuff grafts.
    Results: Vein grafts were superior to PTFE grafts when the whole cohort was included (p = 0.0038); however, there was no significant difference when the patients were stratified for inflow and runoff status.
    Conclusions: The difference between vein and PTFE has probably been exaggerated in the past, due to differences in risk factors and in the extent of arterial disease between the two groups of patients. The advantage of vein becomes more significant with time.
    MeSH term(s) Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; Cohort Studies ; Graft Occlusion, Vascular/epidemiology ; Humans ; Ischemia/surgery ; Leg/blood supply ; Polytetrafluoroethylene ; Risk Factors ; Treatment Outcome ; Vascular Patency ; Veins/transplantation
    Chemical Substances Polytetrafluoroethylene (9002-84-0)
    Language English
    Publishing date 1997-09
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/s1078-5884(97)80190-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Problems related to the definition of "distal" bypass and "secondary" patency rates. A paper for debate.

    Panayiotopoulos, Y P / Taylor, P R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    1996  Volume 12, Issue 4, Page(s) 464–470

    Abstract: The large variations observed in "distal" bypass patency rates and the abuse of life-table analysis have encouraged most Vascular Committees to develop standards for evaluating results. However, problems continue to persist. Some of these do not relate ... ...

    Abstract The large variations observed in "distal" bypass patency rates and the abuse of life-table analysis have encouraged most Vascular Committees to develop standards for evaluating results. However, problems continue to persist. Some of these do not relate to statistical analysis but to the lack of definition of both secondary patency and "distal" when referring to arterial bypass grafts to the lower limb. We present various problems and propose some strict definitions for each type of infrainguinal reconstruction, based on the inflow and outflow levels, together with a modification of the definitions of primary assisted and secondary patency.
    MeSH term(s) Anastomosis, Surgical ; Arteries/surgery ; Humans ; Leg/blood supply ; Life Tables ; Vascular Patency ; Veins/transplantation
    Language English
    Publishing date 1996-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/s1078-5884(96)80016-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Does the establishment of a Vascular Unit reduce the prevalence of ruptured aortic aneurysms?

    Panayiotopoulos, Y P / Liamis, A / Prionidis, I / Mathai, J / Sort, A / McCartney, C

    International angiology : a journal of the International Union of Angiology

    2007  Volume 26, Issue 3, Page(s) 233–238

    MeSH term(s) Aged ; Aged, 80 and over ; Aneurysm, Ruptured/epidemiology ; Aneurysm, Ruptured/surgery ; Aortic Aneurysm, Abdominal/epidemiology ; Aortic Aneurysm, Abdominal/surgery ; England/epidemiology ; Follow-Up Studies ; Humans ; Middle Aged ; Prevalence ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Surgery Department, Hospital/organization & administration ; Survival Rate/trends ; Time Factors ; Vascular Surgical Procedures/trends
    Language English
    Publishing date 2007-09
    Publishing country Italy
    Document type Comparative Study ; Journal Article
    ZDB-ID 604910-2
    ISSN 0392-9590
    ISSN 0392-9590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Inadvertent rupture of a composite vein graft by angioplasty.

    Sandison, A / Panayiotopoulos, Y / Reidy, J / Taylor, P

    Cardiovascular and interventional radiology

    1997  Volume 20, Issue 4, Page(s) 305–307

    Abstract: The superiority of vein over polytetrafluoroethylene (PTFE) as a bypass conduit for grafts ending below the knee makes it the material of choice for this purpose. When insufficient long saphenous vein is available, lengths of arm vein may be used as a ... ...

    Abstract The superiority of vein over polytetrafluoroethylene (PTFE) as a bypass conduit for grafts ending below the knee makes it the material of choice for this purpose. When insufficient long saphenous vein is available, lengths of arm vein may be used as a satisfactory alternative to make a composite graft. This may cause confusion in subsequent graft surveillance programs as the arm vein segment may show different characteristics from the remainder of the graft. We report a case where a stenosis developed in the arm vein segment of a bypass graft which subsequently ruptured during balloon angioplasty with formation of a false aneurysm. This was due to the balloon size being selected on the basis of the size of the long saphenous vein section of the graft instead of the arm vein segment. Full communication between surgeon and radiologist must include complete details of all materials used in bypass grafts in order to avoid potentially disastrous results from angioplasty.
    MeSH term(s) Aged ; Aneurysm, False/etiology ; Angioplasty, Balloon/adverse effects ; Arm/blood supply ; Blood Vessel Prosthesis ; Female ; Graft Occlusion, Vascular/therapy ; Humans ; Leg/blood supply ; Rupture ; Veins/injuries ; Veins/transplantation
    Language English
    Publishing date 1997-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0174-1551 ; 0342-7196
    ISSN (online) 1432-086X
    ISSN 0174-1551 ; 0342-7196
    DOI 10.1007/bf02743539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Venous thromboembolism during pregnancy.

    Sandison, A J / Panayiotopoulos, Y P / Taylor, P R

    The New England journal of medicine

    1996  Volume 335, Issue 24, Page(s) 1846–7; author reply 1847

    MeSH term(s) Bandages ; Female ; Humans ; Postphlebitic Syndrome/therapy ; Pregnancy ; Pregnancy Complications, Cardiovascular ; Puerperal Disorders/therapy ; Thrombophlebitis/complications
    Language English
    Publishing date 1996-12-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The concept of knee salvage: why does a failed femorocrural/pedal arterial bypass not affect the amputation level?

    Panayiotopoulos, Y P / Reidy, J F / Taylor, P R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    1997  Volume 13, Issue 5, Page(s) 477–485

    Abstract: ... p = 0.061). Below- to above-knee amputation ratio was similar in the two groups (0.85 in secondary ... shown to be: the condition of the inflow (81.9% for good vs. 43.1% for impaired, p = 0.000) the state ... of the profunda femoris artery (good 93%, impaired 71%, occluded 37% p = 0.0001) and the graft material (vein 81.8 ...

    Abstract Objectives: There is continued controversy over whether a failed distal bypass influences the level of amputation. This issue is important as the number of arterial bypass grafts undertaken for critical ischaemia is increasing, followed by an increasing number of failed grafts.
    Setting: Teaching hospital. STUDY DESIGN AND MATERIALS: A prospective analysis of 109 consecutive femorocrural/pedal bypass grafts performed between June 1991 and January 1995 on patients presenting with severe critical lower limb ischaemia (CLI) to a single vascular unit. A further 43 amputations for non-reconstructible distal disease were also analysed.
    Chief outcome measures: Mortality, amputation, rehabilitation, survival and knee salvage rates. The Kaplan-Meier method was used for comparison of factors associated with knee preservation.
    Results: Primary amputees had a higher in-hospital mortality (18% vs. 10%) but similar 3 year survival rates (30%) compared with secondary amputees (36.6%). Patients with successful grafts showed a trend towards better survival (61.9% at 3 years) compared to amputees (38.6% at 42 months, p = 0.061). Below- to above-knee amputation ratio was similar in the two groups (0.85 in secondary vs. 0.95 in primary amputees). Factors significantly associated with knee salvage at 3 years were shown to be: the condition of the inflow (81.9% for good vs. 43.1% for impaired, p = 0.000) the state of the profunda femoris artery (good 93%, impaired 71%, occluded 37% p = 0.0001) and the graft material (vein 81.8% vs. PTFE 59.8%, p = 0.033). The presence of tissue loss (p = 0.0523) and secondary procedures (p = 0.0879) showed a trend to become significant. Multivariate and Cox regression analysis showed that the most important factors were the inflow (p = 0.001), the state of the profunda (p = 0.001), the graft material (p = 0.034) and previous revascularisation attempts (p = 0.019).
    Conclusions: The factors which determine knee loss are a compromised inflow state, the presence of an inadequate profunda femoris, previous revascularisation attempts and the use of synthetic graft material. Most of these factors (with the exception of infection related to revascularisation) are present before reconstructive arterial surgery is performed and this study shows that failure of a distal graft does not affect the final amputation level.
    MeSH term(s) Aged ; Aged, 80 and over ; Amputation/rehabilitation ; Amputees ; Blood Vessel Prosthesis ; Female ; Femoral Artery/physiopathology ; Femoral Artery/surgery ; Follow-Up Studies ; Graft Survival ; Hospital Mortality ; Humans ; Ischemia/surgery ; Knee/blood supply ; Knee/surgery ; Leg/blood supply ; Life Tables ; Male ; Middle Aged ; Multivariate Analysis ; Polytetrafluoroethylene ; Prospective Studies ; Regional Blood Flow ; Regression Analysis ; Reoperation ; Survival Rate ; Treatment Outcome ; Vascular Patency ; Veins/transplantation
    Chemical Substances Polytetrafluoroethylene (9002-84-0)
    Language English
    Publishing date 1997-05
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/s1078-5884(97)80176-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Practical management of primary varicose veins.

    Houghton, A D / Panayiotopoulos, Y / Taylor, P R

    The British journal of clinical practice

    1996  Volume 50, Issue 2, Page(s) 103–105

    Abstract: Varicose veins cause a great deal of morbidity in our population today. Despite the large amount of surgical time spent dealing with the problem, there is still a disappointingly high recurrence rate and many patients are investigated inadequately before ...

    Abstract Varicose veins cause a great deal of morbidity in our population today. Despite the large amount of surgical time spent dealing with the problem, there is still a disappointingly high recurrence rate and many patients are investigated inadequately before surgery. This review considers the assessment of 'simple' varicose veins using a combination of tourniquet tests and a hand-held doppler probe. The place of more sophisticated investigative techniques is also discussed, in particular the value of duplex assessment in localising the variably sited sapheno-popliteal junction. Routine stripping of the long saphenous vein to the below-knee level is likely to decrease the recurrence rate of simple, long, saphenous varicose veins.
    MeSH term(s) Female ; Humans ; Tourniquets ; Ultrasonography, Doppler ; Varicose Veins/diagnostic imaging ; Varicose Veins/surgery
    Language English
    Publishing date 1996-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 127432-6
    ISSN 0007-0947
    ISSN 0007-0947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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