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  1. Article: The Clinical Characteristics of Multiple Myeloma in the Acute Care Setting: Case Presentation and Clinical Recommendations.

    Zetter, Daniel R / Kabir, Tanvir / Reynolds, Samuel B

    Cureus

    2020  Volume 12, Issue 9, Page(s) e10463

    Abstract: The acute complications of multiple myeloma can be varied and devastating, including electrolyte derangements, renal failure, and infections amongst others. The varying pathological mechanisms behind these complications make the management of patients ... ...

    Abstract The acute complications of multiple myeloma can be varied and devastating, including electrolyte derangements, renal failure, and infections amongst others. The varying pathological mechanisms behind these complications make the management of patients presenting with multiple myeloma a complicated and sometimes tenuous process. The patient compliance can further exacerbate these difficulties. The patient discussed in this case initially presented with newly developed altered mental status, fatigue, epistaxis, and an ecchymotic rash. Laboratory testing and imaging would conclude a diagnosis of multiple myeloma, but unfortunately treatment was cut short. Admission at a later date would show rapidly deteriorating condition with new lung consolidations and worsening laboratory findings. Herein the authors discuss the clinical findings of patients with acute manifestations of multiple myeloma, their prognostic value, and the implications of patient compliance and early intervention in the setting of multiple myeloma.
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.10463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hold that line. Angiomotin regulates endothelial cell motility.

    Zetter, B R

    The Journal of cell biology

    2001  Volume 152, Issue 6, Page(s) F35–6

    MeSH term(s) Angiostatins ; Animals ; Carrier Proteins/metabolism ; Cell Movement/physiology ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins ; Membrane Proteins ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Peptide Fragments/metabolism ; Plasminogen/genetics ; Plasminogen/metabolism
    Chemical Substances AMOT protein, human ; Carrier Proteins ; Intercellular Signaling Peptides and Proteins ; Membrane Proteins ; Peptide Fragments ; Angiostatins (86090-08-6) ; Plasminogen (9001-91-6)
    Language English
    Publishing date 2001-03-19
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.152.6.f35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Unbiased Phenotype-Based Screen Identifies Therapeutic Agents Selective for Metastatic Prostate Cancer.

    Chung, Ivy / Zhou, Kun / Barrows, Courtney / Banyard, Jacqueline / Wilson, Arianne / Rummel, Nathan / Mizokami, Atsushi / Basu, Sudipta / Sengupta, Poulomi / Shaikh, Badaruddin / Sengupta, Shiladitya / Bielenberg, Diane R / Zetter, Bruce R

    Frontiers in oncology

    2021  Volume 10, Page(s) 594141

    Abstract: In American men, prostate cancer is the second leading cause of cancer-related death. Dissemination of prostate cancer cells to distant organs significantly worsens patients' prognosis, and currently there are no effective treatment options that can cure ...

    Abstract In American men, prostate cancer is the second leading cause of cancer-related death. Dissemination of prostate cancer cells to distant organs significantly worsens patients' prognosis, and currently there are no effective treatment options that can cure advanced-stage prostate cancer. In an effort to identify compounds selective for metastatic prostate cancer cells over benign prostate cancer cells or normal prostate epithelial cells, we applied a phenotype-based
    Language English
    Publishing date 2021-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.594141
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  4. Article: Involvement of Vasopressin in the Pathogenesis of Pulmonary Tuberculosis: A New Therapeutic Target?

    Zetter, Mario / Barrios-Payán, Jorge / Mata-Espinosa, Dulce / Marquina-Castillo, Brenda / Quintanar-Stephano, Andrés / Hernández-Pando, Rogelio

    Frontiers in endocrinology

    2019  Volume 10, Page(s) 351

    Abstract: Tuberculosis (TB) is a highly complex infectious disease caused by the intracellular ... ...

    Abstract Tuberculosis (TB) is a highly complex infectious disease caused by the intracellular pathogen
    Language English
    Publishing date 2019-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00351
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  5. Article: Angiogenesis and tumor metastasis.

    Zetter, B R

    Annual review of medicine

    1998  Volume 49, Page(s) 407–424

    Abstract: Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation. For many tumors, the vascular ... ...

    Abstract Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation. For many tumors, the vascular density can provide a prognostic indicator of metastatic potential, with the highly vascular primary tumors having a higher incidence of metastasis than poorly vascular tumors. Tumor angiogenesis is regulated by the production of angiogenic stimulators including members of the fibroblast growth factor and vascular endothelial growth factor families. In addition, tumors may activate angiogenic inhibitors such as angiostatin and endostatin that can modulate angiogenesis both at the primary site and at downstream sites of metastasis. The potential use of these and other natural and synthetic angiogenic inhibitors as anticancer drugs is currently under intense investigation. Such agents may have reduced toxicity and be less likely to generate drug resistance than conventional cytotoxic drugs. Clinical trials are now underway to develop optimum treatment strategies for antiangiogenic agents.
    MeSH term(s) Angiostatins ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Blood Vessels/pathology ; Clinical Trials as Topic ; Collagen/adverse effects ; Collagen/physiology ; Collagen/therapeutic use ; Drug Resistance, Neoplasm ; Endostatins ; Endothelial Growth Factors/physiology ; Fibroblast Growth Factors/physiology ; Humans ; Incidence ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/physiopathology ; Neoplasms/blood supply ; Neoplastic Cells, Circulating/pathology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; Peptide Fragments/adverse effects ; Peptide Fragments/physiology ; Peptide Fragments/therapeutic use ; Plasminogen/adverse effects ; Plasminogen/physiology ; Plasminogen/therapeutic use ; Prognosis
    Chemical Substances Antineoplastic Agents ; Endostatins ; Endothelial Growth Factors ; Peptide Fragments ; Fibroblast Growth Factors (62031-54-3) ; Angiostatins (86090-08-6) ; Plasminogen (9001-91-6) ; Collagen (9007-34-5)
    Language English
    Publishing date 1998
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 0066-4219
    ISSN 0066-4219
    DOI 10.1146/annurev.med.49.1.407
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.321: Show issues Location:
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  6. Article: On target with tumor blood vessel markers.

    Zetter, B R

    Nature biotechnology

    1997  Volume 15, Issue 12, Page(s) 1243–1244

    MeSH term(s) Biomarkers ; Cell Adhesion Molecules/metabolism ; Endothelium, Vascular/metabolism ; Humans ; Indicators and Reagents ; Neoplasm Metastasis ; Neoplasms/blood supply ; Neoplasms/pathology ; Neoplasms/therapy ; Neovascularization, Pathologic
    Chemical Substances Biomarkers ; Cell Adhesion Molecules ; Indicators and Reagents
    Language English
    Publishing date 1997-11
    Publishing country United States
    Document type News
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/nbt1197-1243
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
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    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  7. Article: Adhesion molecules in tumor metastasis.

    Zetter, B R

    Seminars in cancer biology

    1993  Volume 4, Issue 4, Page(s) 219–229

    Abstract: It is now clear that adhesive interactions play a critical role in the process of metastatic tumor dissemination. Adhesion molecules act as both positive and negative modulators of the metastatic process. Molecules such as E-cadherin that promote ... ...

    Abstract It is now clear that adhesive interactions play a critical role in the process of metastatic tumor dissemination. Adhesion molecules act as both positive and negative modulators of the metastatic process. Molecules such as E-cadherin that promote homotypic tumor cell adhesion function to maintain intercellular contacts that confine cells to the primary tumor site and are negatively correlated with metastatic potential. Because tumor cells are rapidly eliminated from the circulation, those cells that can quickly arrest in the vasculature at a secondary site and pass through the vessel wall into the surrounding tissue will have a selective advantage toward establishing new metastatic colonies. The first step in this process is specific adhesion to venular endothelial cells in selected organs, a process mediated by tumor cell surface molecules such as Sialyl LewisX or the VLA-4 (alpha 4 beta 1) integrin that mediate binding to endothelial adhesion molecules such as the E-selectin or the vascular cell adhesion molecule, VCAM-1. Site-specific endothelial determinants such as the lung endothelial cell adhesion molecule, LuECAM, may additionally specify particular sites for preferential adhesion and subsequent site-specific metastasis of particular tumor types. After adherence to endothelial cells and subsequent endothelial retraction, metastatic tumor cells must adhere to elements of the subendothelial basement membrane such as laminin and types IV and V collagen, interactions frequently mediated by members of the beta 1 and beta 4 integrin families. Finally, metastatic tumor cell adhesion to connective tissue elements such as fibronectin, type I collagen and hyaluronan, mediated by molecules such as the beta 1 integrins and by the CD44 cell surface adhesion molecule, are required for movement of tumor cells into the subendothelial stroma and subsequent growth at these new sites. Thus, metastatic potential can be influenced both positively and negatively by a variety of cell surface adhesive molecules that act both independently and in concert to direct tumor cells to particular tissues, allowing them to arrest in those tissues, migrate across the vessel wall and grow at the secondary site. In the current review, I discuss the nature of the adhesion molecules that have been implicated in the metastatic process, emphasizing those molecules that have been shown to correlate with metastasis in clinical human tumors or that have been shown to influence metastatic potential in in vivo experimental assays.
    MeSH term(s) Animals ; Cell Adhesion ; Cell Adhesion Molecules/physiology ; Extracellular Matrix/physiology ; Humans ; Mice ; Neoplasm Metastasis/pathology ; Rats ; Receptors, Immunologic
    Chemical Substances Cell Adhesion Molecules ; Receptors, Immunologic
    Language English
    Publishing date 1993-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
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  8. Article: Cell motility in angiogenesis and tumor metastasis.

    Zetter, B R

    Cancer investigation

    1990  Volume 8, Issue 6, Page(s) 669–671

    MeSH term(s) Cell Movement ; Elastin/physiology ; Humans ; Neoplasm Metastasis/pathology ; Neovascularization, Pathologic/pathology
    Chemical Substances Elastin (9007-58-3)
    Language English
    Publishing date 1990
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604942-4
    ISSN 0735-7907
    ISSN 0735-7907
    DOI 10.3109/07357909009018942
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1862: Show issues Location:
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  9. Article: The cellular basis of site-specific tumor metastasis.

    Zetter, B R

    The New England journal of medicine

    1990  Volume 322, Issue 9, Page(s) 605–612

    MeSH term(s) Animals ; Neoplasm Metastasis/pathology ; Organ Specificity
    Language English
    Publishing date 1990-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM199003013220907
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  10. Article ; Online: Experimental Pulmonary Tuberculosis in the Absence of Detectable Brain Infection Induces Neuroinflammation and Behavioural Abnormalities in Male BALB/c Mice.

    Lara-Espinosa, Jacqueline V / Santana-Martínez, Ricardo A / Maldonado, Perla D / Zetter, Mario / Becerril-Villanueva, Enrique / Pérez-Sánchez, Gilberto / Pavón, Lenin / Mata-Espinosa, Dulce / Barrios-Payán, Jorge / López-Torres, Manuel O / Marquina-Castillo, Brenda / Hernández-Pando, Rogelio

    International journal of molecular sciences

    2020  Volume 21, Issue 24

    Abstract: Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive ...

    Abstract Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive or behavioural changes; however, the pathogenic substrate of such manifestations have remained unknown. Here, using a mouse model of progressive pulmonary TB, we report that, even in the absence of brain infection, TB is associated with marked increased synthesis of both inflammatory and anti-inflammatory cytokines in discrete brain areas such as the hypothalamus, the hippocampal formation and cerebellum accompanied by substantial changes in the synthesis of neurotransmitters. Moreover, histopathological findings of neurodegeneration and neuronal death were found as infection progressed with activation of p38, JNK and reduction in the BDNF levels. Finally, we perform behavioural analysis in infected mice throughout the infection, and our data show that the cytokine and neurochemical changes were associated with a marked onset of cognitive impairment as well as depressive- and anxiety-like behaviour. Altogether, our results suggest that besides pulmonary damage, TB is accompanied by an extensive neuroinflammatory and neurodegenerative state which explains some of the behavioural abnormalities found in TB patients.
    MeSH term(s) Animals ; Anxiety/metabolism ; Anxiety/microbiology ; Behavioral Symptoms/microbiology ; Blood-Brain Barrier/cytology ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain/cytology ; Brain/enzymology ; Brain/metabolism ; Brain/pathology ; Brain-Derived Neurotrophic Factor/metabolism ; Chromatography, High Pressure Liquid ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/microbiology ; Cytokines/metabolism ; Depression/metabolism ; Depression/microbiology ; Disease Models, Animal ; Down-Regulation ; Hippocampus/cytology ; Hippocampus/immunology ; Hippocampus/metabolism ; Hippocampus/pathology ; Inflammation/metabolism ; Janus Kinases/metabolism ; MAP Kinase Signaling System/genetics ; Male ; Mice, Inbred BALB C ; Mycobacterium tuberculosis/metabolism ; Mycobacterium tuberculosis/pathogenicity ; Neurons/cytology ; Neurons/pathology ; Neurotransmitter Agents/metabolism ; Tuberculosis, Pulmonary/enzymology ; Tuberculosis, Pulmonary/metabolism ; Tuberculosis, Pulmonary/pathology ; Tuberculosis, Pulmonary/psychology ; Up-Regulation ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances Bdnf protein, mouse ; Brain-Derived Neurotrophic Factor ; Cytokines ; Neurotransmitter Agents ; Janus Kinases (EC 2.7.10.2) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2020-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21249483
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