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Article ; Online: Enzootic calcinosis in Toggenburg goats in New Zealand.

Brown, S E / Collett, M G / Matthews, Z M / Marshall, J C / Dittmer, K E

2023 Volume 72, Issue 1, Page(s) 45–52

Abstract: ... Concentrations of calcium, phosphorus, 25-hydroxyvitamin D: Vegetation survey: All paddocks on the property ... perpendicularly to form a grid. No known calcinogenic species were identified. Known plant sources of vitamin D ... vitamin D toxicosis of non-plant origin. ...

Abstract	Case history: Necropsies on Toggenburg goats culled from a small farm in the Manawatū district of New Zealand, performed at Massey University (Palmerston North, NZ) over a period of 29 years (1991-2019), revealed soft tissue mineralisation, particularly of cardiovascular tissues. The farm spans 10 acres and runs between 15 and 30 Toggenburg goats. The goats are predominantly on pasture comprising a variety of types. Pathological findings: Necropsies were performed on all adult goats (n = 45) that died or were euthanised. Histopathology was performed on 42 goats (93%), of which 33 (73%) included sufficient tissues diagnostically relevant to soft tissue mineralisation. The most significant gross findings were in various arteries, with the aorta most commonly affected, followed by the heart and lungs. The aortic intima showed prominent, multifocal to coalescing, raised, wrinkled, white plaques. Microscopically there were multiphasic lesions of mineralisation, chondroid, and osseous metaplasia in the elastic arteries, aorta, heart and lungs. A lumbar vertebra from one goat had prominent, basophilic, fibrillar, tangled matrix lining Haversian canals and lamellae. Laboratory findings: Blood samples were collected from 15 adult goats in the affected herd and from 10 adult Toggenburg goats from an unaffected herd. Samples were collected by jugular venipuncture at 2-month intervals for 12 months (April 2018-March 2019). Concentrations of calcium, phosphorus, 25-hydroxyvitamin D Vegetation survey: All paddocks on the property were surveyed every 2 months along evenly spaced line transects, and then further traversed perpendicularly to form a grid. No known calcinogenic species were identified. Known plant sources of vitamin D identified on the farm included mushrooms (species not defined), Diagnosis: Soft tissue mineralisation and enzootic calcinosis. Clinical relevance: Veterinarians are alerted to the possibility of either enzootic calcinosis in goats and the potential occurrence of calcinogenic plants in New Zealand; or chronic vitamin D toxicosis of non-plant origin.
MeSH term(s)	Humans ; Animals ; New Zealand/epidemiology ; Vitamin D ; Calcifediol ; Calcinosis/pathology ; Calcinosis/veterinary ; Goats ; Goat Diseases/epidemiology
Chemical Substances	Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2023-12-10
Publishing country	England
Document type	Journal Article
ZDB-ID	415642-0
ISSN	1176-0710 ; 0048-0169
ISSN (online)	1176-0710
ISSN	0048-0169
DOI	10.1080/00480169.2023.2263399
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Article ; Online: Probing the expression and adhesion of glycans involved in Helicobacter pylori infection.

Sijmons, Daniel / Collett, Simon / Soliman, Caroline / Guy, Andrew J / Scott, Andrew M / Durrant, Lindy G / Elbourne, Aaron / Walduck, Anna K / Ramsland, Paul A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8587

Abstract: Helicobacter pylori infects approximately half the human population and has an unusual infective niche of the human stomach. Helicobacter pylori is a major cause of gastritis and has been classified as a group 1 carcinogen by the WHO. Treatment involves ... ...

Abstract	Helicobacter pylori infects approximately half the human population and has an unusual infective niche of the human stomach. Helicobacter pylori is a major cause of gastritis and has been classified as a group 1 carcinogen by the WHO. Treatment involves triple or quadruple antibiotic therapy, but antibiotic resistance is becoming increasingly prevalent. Helicobacter pylori expresses certain blood group related antigens (Lewis system) as a part of its lipopolysaccharide (LPS), which is thought to assist in immune evasion. Additionally, H. pylori LPS participates in adhesion to host cells alongside several adhesion proteins. This study profiled the carbohydrates of H. pylori reference strains (SS1 and 26695) using monoclonal antibodies (mAbs) and lectins, identifying interactions between two carbohydrate-targeting mAbs and multiple lectins. Atomic force microscopy (AFM) scans were used to probe lectin and antibody interactions with the bacterial surfaces. The selected mAb and lectins displayed an increased adhesive force over the surface of the curved H. pylori rods. Furthermore, this study demonstrates the ability of anti-carbohydrate antibodies to reduce the adhesion of H. pylori 26695 to human gastric adenocarcinoma cells via AFM. Targeting bacterial carbohydrates to disrupt crucial adhesion and immune evasion mechanisms represents a promising strategy for combating H. pylori infection.
MeSH term(s)	Humans ; Lipopolysaccharides ; Helicobacter pylori ; Helicobacter Infections ; Polysaccharides ; Antibodies, Monoclonal ; Blood Group Antigens ; Lectins
Chemical Substances	Lipopolysaccharides ; Polysaccharides ; Antibodies, Monoclonal ; Blood Group Antigens ; Lectins
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59234-w
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Article ; Online: 'Everyone is trying to outcompete each other': a qualitative study of medical student attitudes to a novel peer-assessed undergraduate teamwork module.

Watson, Helen R / Dolley, Mary-Kate / Perwaiz, Mohammad / Saxelby, Jocelyn / Bertone, Gianluca / Burr, Steven / Collett, Tracey / Jeffery, Robert / Zahra, Daniel

FEBS open bio

2022 Volume 12, Issue 5, Page(s) 900–912

Abstract: ... and meaning; (b) insight into skill development; (c) transferability; (d) peer assessment; and (e ...

Abstract	The centrality of teamwork in ensuring the effective functioning of institutions across all sectors is undeniable. However, embedding teamwork into higher education has been hampered due to a range of deeply entrenched practices associated broadly with the foregrounding of knowledge, beliefs about the place of skill training and routines of assessment. As a result, despite an urgent need to address teamwork, little progress has been made with respect to progressing teamwork education. We have designed and evaluated a novel teamwork module delivered to fourth-year undergraduate medical students involving placements, a cocreated piece of work, reflection and summative peer assessment. This paper aimed to investigate whether the module increased students' insight into teamwork, including their own skill development, and whether their perceptions of teamwork changed. Throughout the evaluation, students played a key role, with four final-year medical students working alongside others in the multidisciplinary project team. Five distinct themes emerged from our in-depth, semi-structured interviews: (a) importance and meaning; (b) insight into skill development; (c) transferability; (d) peer assessment; and (e) resistance to teamwork education. Themes had positive and negative components, and student perceptions changed in multiple ways after experiencing a longitudinal educational opportunity to develop their teamwork skills. Before practice, students focused on superficial explanations and on where they might improve. In contrast, after practice, students conveyed deeper insights, contextualisation, focus on how they might improve, and shared structured reflection.
MeSH term(s)	Attitude ; Humans ; Peer Group ; Qualitative Research ; Students, Medical
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13395
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Article ; Online: A feasibility study to determine whether the daily consumption of flavonoid-rich pure cocoa has the potential to reduce fatigue and fatigability in people with Parkinson's (pwP).

Coe, S / Andreoli, D / George, M / Collett, J / Reed, A / Cossington, J / Izadi, H / Dixon, A / Mansoubi, M / Dawes, H

Clinical nutrition ESPEN

2022 Volume 48, Page(s) 68–73

Abstract: ... NCT03288155). During a six day intervention participants consumed a high (10.79 mg/g) or low flavonoid cocoa ... 1.02 mg/g) beverage (18 g Cocoa with 200 ml Rice milk) once daily. Potential effect on fatigue and ...

Abstract	Flavonoids, plant compounds found in certain foods, may have the ability to improve fatigue and fatigability. However, to date, no well-designed intervention studies assessing the role of flavonoid consumption for fatigue management in people with Parkinson's (pwP) have been performed. Objectives: To determine the feasibility and estimate potential effect of flavonoid-rich cocoa on fatigue and fatigability in pwP. Methods: This was a randomised (1:1) double-blind placebo controlled feasibility study in which 30 pwP were recruited from the European Parkinson Therapy Centre, Italy (trial registration: NCT03288155). During a six day intervention participants consumed a high (10.79 mg/g) or low flavonoid cocoa (1.02 mg/g) beverage (18 g Cocoa with 200 ml Rice milk) once daily. Potential effect on fatigue and fatigability was measured (baseline to day 6). Feasibility and fidelity were assessed through recruitment and retention, adherence and a process evaluation. Results: From July 2017 to May 2018, 30 pwP were recruited and randomised and allocated to high (n = 15) or low (n = 15) flavonoid groups and included in analysis. Missing data was less than 5% and adherence to intervention of all allocated individuals was 97%. There was a small effect on fatigability (6 min walk test: ES 0.11 (95%CI = -0.11-0.26); Z = 0.81). There were two adverse events (one in the control and one in the intervention group). Conclusion: The consumption of cocoa is feasible and well received in pwP, and further investigation on the effect on fatigability is warranted.
MeSH term(s)	Chocolate ; Fatigue/drug therapy ; Feasibility Studies ; Flavonoids/therapeutic use ; Humans ; Parkinson Disease
Chemical Substances	Flavonoids
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2022.01.023
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Article ; Online: Constraining emissions of volatile organic compounds from western US wildfires with WE-CAN and FIREX-AQ airborne observations

L. Jin / W. Permar / V. Selimovic / D. Ketcherside / R. J. Yokelson / R. S. Hornbrook / E. C. Apel / I.-T. Ku / J. L. Collett Jr. / A. P. Sullivan / D. A. Jaffe / J. R. Pierce / A. Fried / M. M. Coggon / G. I. Gkatzelis / C. Warneke / E. V. Fischer / L. Hu

Atmospheric Chemistry and Physics, Vol 23, Pp 5969-

2023 Volume 5991

Abstract: The impact of biomass burning (BB) on the atmospheric burden of volatile organic compounds (VOCs) is highly uncertain. Here we apply the GEOS-Chem chemical transport model (CTM) to constrain BB emissions in the western USA at ∼ 25 km resolution. Across ... ...

Abstract	The impact of biomass burning (BB) on the atmospheric burden of volatile organic compounds (VOCs) is highly uncertain. Here we apply the GEOS-Chem chemical transport model (CTM) to constrain BB emissions in the western USA at ∼ 25 km resolution. Across three BB emission inventories widely used in CTMs, the inventory–inventory comparison suggests that the totals of 14 modeled BB VOC emissions in the western USA agree with each other within 30 %–40 %. However, emissions for individual VOCs can differ by a factor of 1–5, driven by the regionally averaged emission ratios (ERs, reflecting both assigned ERs for specific biome and vegetation classifications) across the three inventories. We further evaluate GEOS-Chem simulations with aircraft observations made during WE-CAN (Western Wildfire Experiment for Cloud Chemistry, Aerosol Absorption and Nitrogen) and FIREX-AQ (Fire Influence on Regional to Global Environments and Air Quality) field campaigns. Despite being driven by different global BB inventories or applying various injection height assumptions, the model–observation comparison suggests that GEOS-Chem simulations underpredict observed vertical profiles by a factor of 3–7. The model shows small to no bias for most species in low-/no-smoke conditions. We thus attribute the negative model biases mostly to underestimated BB emissions in these inventories. Tripling BB emissions in the model reproduces observed vertical profiles for primary compounds, i.e., CO , propane, benzene, and toluene. However, it shows no to less significant improvements for oxygenated VOCs, particularly for formaldehyde, formic acid, acetic acid, and lumped ≥ C 3 aldehydes, suggesting the model is missing secondary sources of these compounds in BB-impacted environments. The underestimation of primary BB emissions in inventories is likely attributable to underpredicted amounts of effective dry matter burned, rather than errors in fire detection, injection height, or ERs, as constrained by aircraft and ground measurements. We cannot rule out ...
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	550 ; 551
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
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Article: Pathology of Brucella ovis infection in red deer stags (Cervus elaphus).

Ridler, A L / West, D M / Collett, M G

New Zealand veterinary journal

2012 Volume 60, Issue 2, Page(s) 146–149

Abstract: Aim: To describe the pathology of the reproductive tract of red deer stags with active Brucella ovis infection and in stags in which B. ovis infection had resolved.: Methods: Twenty-three red deer stags of varying history were slaughtered and their ... ...

Abstract	Aim: To describe the pathology of the reproductive tract of red deer stags with active Brucella ovis infection and in stags in which B. ovis infection had resolved. Methods: Twenty-three red deer stags of varying history were slaughtered and their epididymides and accessory sex glands examined grossly and by histopathology. At the time of slaughter five of the stags had an active B. ovis infection of 24-55 days duration following exposure to infected rams, 10 stags had been experimentally infected with B. ovis by intravenous inoculation 649 days previously and had developed an active infection but the bacterial infection had resolved at least 308 days prior to slaughter, and eight stags had not been exposed to B. ovis at any time. Results: Of the five stags with an active infection, one had gross enlargement of the epididymides that could be detected by scrotal palpation. Histological lesions in all five stags included mild to severe, predominantly non-suppurative epididymitis, vesiculitis, prostatitis and ampullitis, with neutrophil exudation in associated glandular ducts. Additional lesions in the epididymides were spermatic granulomas and epithelial hyperplasia with intra-epithelial cyst formation. Of the 10 stags in which the bacterial infection had resolved, two had gross enlargement of the epididymides. The histological lesions were similar to those in stags with active infection but were generally milder, with increased periductal scar tissue in the epididymides. The lesions seen in stags resembled those seen in rams with B. ovis infection but they were usually less florid and had fewer plasma cells. No gross abnormalities or histopathological lesions were detected in the non-infected stags. Conclusions: Only a small percentage of red deer stags infected with B. ovis develop lesions of epididymitis that can be detected by scrotal palpation. Gross and histological lesions of the genital tract of stags associated with B. ovis infection are similar to the lesions seen in rams. Lesions in stags persist for >300 days after the bacterial infection has resolved. Clinical relevance: Brucella ovis infection should be considered when there are gross lesions of epididymitis or histological evidence of inflammation in the epididymides or accessory sex glands of red deer stags. Retrospective diagnosis of B. ovis in stags could be achieved by histological examination of the reproductive organs.
MeSH term(s)	Animals ; Brucella ovis ; Brucellosis/pathology ; Brucellosis/veterinary ; Deer ; Epididymis/pathology ; Male
Language	English
Publishing date	2012-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	415642-0
ISSN	1176-0710 ; 0048-0169
ISSN (online)	1176-0710
ISSN	0048-0169
DOI	10.1080/00480169.2011.638269
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Article ; Online: Thirty-day readmissions and reoperations after total elbow arthroplasty: a national database study.

Cutler, Holt S / Collett, Garen / Farahani, Farzam / Ahn, Juhno / Nakonezny, Paul / Koehler, Daniel / Khazzam, Michael

Journal of shoulder and elbow surgery

2020 Volume 30, Issue 2, Page(s) e41–e49

Abstract: Background: The purpose of this study was to determine the rate of short-term complications after total elbow arthroplasty (TEA) and identify predictors of readmission and reoperation. We hypothesized that TEA performed for acute elbow trauma would have ...

Abstract	Background: The purpose of this study was to determine the rate of short-term complications after total elbow arthroplasty (TEA) and identify predictors of readmission and reoperation. We hypothesized that TEA performed for acute elbow trauma would have higher rates of 30-day readmission and reoperation than TEA performed for osteoarthritis (OA). Methods: Using the National Surgical Quality Improvement Program for the years 2011-2017, we identified patients undergoing TEA for fracture, OA, or inflammatory arthritis. Patient demographic characteristics, comorbidities, reoperations, and readmissions within 30 days of surgery were analyzed. Potential predictors of reoperation and readmission in the model included age, sex, race, body mass index (BMI), diabetes, hypertension, chronic obstructive pulmonary disease, congestive heart failure, smoking, bleeding disorders, American Society of Anesthesiologists classification, wound classification, operative time, and indication for surgery. Results: A total of 414 patients underwent TEA from 2011-2017. Of these patients, 40.6% underwent TEA for fracture; 37.0%, for OA; and 22.7%, for inflammatory arthritis. The overall rate of unplanned readmissions was 5.1% (21 patients). The rate of unplanned reoperations was 2.4% (10 patients). Infection was the most common reason for both unplanned readmissions and reoperations. The rates of reoperations and readmissions were not significantly associated with any of the 3 operative indications: fracture, OA, or inflammatory arthritis. Multiple logistic regression analysis found increased BMI to be associated with lower odds of an unplanned readmission (odds ratio [OR], 0.883; 95% confidence interval [CI], 0.798-0.963; P = .0035) and found wound classification ≥ 3 to be associated with increased odds of an unplanned reoperation (OR, 16.531; 95% CI, 1.300-167.960; P = .0144) and total local complications (OR, 17.587; 95% CI, 2.207-132.019; P = .0057). Patients who were not functionally independent were more likely to experience local complications (OR, 4.181; 95% CI, 0.983-15.664; P = .0309) than were functionally independent patients. Conclusions: The 30-day unplanned reoperation rate after TEA was 2.4%, and the unplanned readmission rate was 5.1%. Low BMI was predictive of readmission. Wounds classified as contaminated or dirty were predictive of reoperation. Dependent functional status and contaminated wounds were predictive of local complications. The indication for TEA (fracture vs. OA vs. inflammatory arthritis) was not found to be a risk factor for reoperation or readmission after TEA.
MeSH term(s)	Arthroplasty, Replacement, Elbow/adverse effects ; Elbow ; Humans ; Patient Readmission ; Postoperative Complications/epidemiology ; Reoperation ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2020.06.033
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Article ; Online: Syncytiotrophoblast extracellular vesicles - Circulating biopsies reflecting placental health.

Tannetta, Dionne / Collett, Gavin / Vatish, Manu / Redman, Chris / Sargent, Ian

Placenta

2016 Volume 52, Page(s) 134–138

Abstract: The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. ... ...

Abstract	The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles, released from the surface of the placenta directly into the maternal circulation, in the form of exosomes, microvesicles and apoptotic bodies. They carry many syncytiotrophoblast derived factors such as proteins, lipids, glycans and nucleic acids, which together could dynamically signal to the mother the status of the placenta. We review STBEV research and discuss the potential for STBEV to be used as circulating syncytiotrophoblast biopsies, accessible via a simple blood sample throughout pregnancy, giving a real-time readout of syncytiotrophoblast health. We also highlight advances in the use of extracellular vesicles as circulating tumour derived biopsies in the field of cancer research, which could prove beneficial to obstetric care.
MeSH term(s)	Biopsy ; Extracellular Vesicles/metabolism ; Female ; Health Status ; Humans ; Placenta/metabolism ; Pregnancy ; Trophoblasts/metabolism
Language	English
Publishing date	2016-11-16
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	603951-0
ISSN	1532-3102 ; 0143-4004
ISSN (online)	1532-3102
ISSN	0143-4004
DOI	10.1016/j.placenta.2016.11.008
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Article ; Online: Unified Synthesis of 10-Oxygenated Lycopodium Alkaloids: Impact of C10-Stereochemistry on Reactivity.

Saha, Mrinmoy / Li, Xin / Collett, Nathan D / Carter, Rich G

The Journal of organic chemistry

2016 Volume 81, Issue 14, Page(s) 5963–5980

Abstract: The pronounced impact of the C10 stereochemistry on the successful construction of a polycyclic Lycopodium alkaloid scaffold has been explored. A wide range of reaction conditions and functionality were investigated to control a keto sulfone Michael ... ...

Abstract	The pronounced impact of the C10 stereochemistry on the successful construction of a polycyclic Lycopodium alkaloid scaffold has been explored. A wide range of reaction conditions and functionality were investigated to control a keto sulfone Michael addition to construct the C7-C12 linkage. An unexpected, overriding impact of the C10 stereochemistry in stereoselectivity and reaction rate in the Michael addition was observed. Furthermore, divergent reactivity of a conformationally accelerated, intramolecular Mannich cyclization based on the C10 stereochemistry was discovered. The successful execution of this synthetic route resulted in the total synthesis of all three known 10-oxygenated Lycopodium alkaloids: 10-hydroxylycopodine, paniculine, and deacetylpaniculine.
MeSH term(s)	Alkaloids/chemistry ; Catalysis ; Crystallography, X-Ray ; Cyclization ; Ketones/chemistry ; Lycopodium/chemistry ; Molecular Structure ; Oxygen/chemistry ; Quinolizines/chemistry ; Stereoisomerism ; Sulfones/chemistry
Chemical Substances	10-hydroxylycopodine ; Alkaloids ; Ketones ; Quinolizines ; Sulfones ; deacetylpaniculine ; himeradine A ; paniculine ; Oxygen (S88TT14065)
Language	English
Publishing date	2016-06-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.6b00900
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Article ; Online: The service user experience of SlowMo therapy: A co-produced thematic analysis of service users' subjective experience.

Greenwood, Kathryn E / Gurnani, Megha / Ward, Tom / Vogel, Evelin / Vella, Claire / McGourty, Alison / Robertson, Sam / Sacadura, Catarina / Hardy, Amy / Rus-Calafell, Mar / Collett, Nicola / Emsley, Richard / Freeman, Daniel / Fowler, David / Kuipers, Elizabeth / Bebbington, Paul / Dunn, Graham / Michelson, Daniel / Garety, Philippa

Psychology and psychotherapy

2022 Volume 95, Issue 3, Page(s) 680–700

Abstract: Objectives: SlowMo is the first blended digital therapy for paranoia, showing significant small-moderate reductions in paranoia in a recent large-scale randomized controlled trial (RCT). This study explored the subjective service-user experience of the ... ...

Abstract	Objectives: SlowMo is the first blended digital therapy for paranoia, showing significant small-moderate reductions in paranoia in a recent large-scale randomized controlled trial (RCT). This study explored the subjective service-user experience of the SlowMo therapy content and design; the experience of the blended therapy approach, including the triangle of the therapeutic alliance; and the experience of the digital aspects of the intervention. Design: Qualitative co-produced sub-study of an RCT. Methods: Participants were 22 adult service users with schizophrenia-spectrum psychosis and persistent distressing paranoia, who completed at least one SlowMo therapy session and a 24-week follow-up, at one of 3 sites in Oxford, London, and Sussex, UK. They were interviewed by peer researchers, using a topic guide co-produced by the Patient and Public Involvement (PPI) team. The transcribed data were analysed thematically. Multiple coding and triangulation, and lay peer researcher validation were used to reach a consensus on the final theme structure. Results: Six core themes were identified: (i) starting the SlowMo journey; (ii) the central role of the supportive therapist; (iii) slowing things down; (iv) value and learning from social connections; (v) approaches and challenges of technology; and (vi) improvements in paranoia and well-being. Conclusions: For these service users, slowing down for a moment was helpful, and integrated into thinking over time. Learning from social connections reflected reduced isolation, and enhanced learning through videos, vignettes, and peers. The central role of the supportive therapist and the triangle of alliance between service user, therapist, and digital platform were effective in promoting positive therapeutic outcomes.
MeSH term(s)	Adult ; Humans ; Paranoid Disorders ; Patient Participation ; Research Design ; Schizophrenia/therapy ; Therapeutic Alliance
Language	English
Publishing date	2022-04-20
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2063873-5
ISSN	2044-8341 ; 1476-0835
ISSN (online)	2044-8341
ISSN	1476-0835
DOI	10.1111/papt.12393
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