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  1. Article ; Online: Imaging in drug development: will it deliver on the promise of personalised medicine?

    Dzik-Jurasz, A

    The British journal of radiology

    2010  Volume 83, Issue 990, Page(s) 453–455

    MeSH term(s) Clinical Trials as Topic ; Diagnostic Imaging ; Drug Design ; Humans ; Neoplasms/drug therapy ; Pharmaceutical Preparations ; Precision Medicine/methods ; Research ; United States
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2010-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/65491666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Are targeted contrast agents realistically going to reach the clinic? Recent regulatory experience with targeted MRI contrast agents.

    Dzik-Jurasz, A

    The British journal of radiology

    2006  Volume 79, Issue 947, Page(s) 870–872

    MeSH term(s) Contrast Media/chemistry ; Drug Design ; Humans ; Magnetic Resonance Imaging/methods
    Chemical Substances Contrast Media
    Language English
    Publishing date 2006-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/68807002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The development and application of functional nuclear magnetic resonance to in vivo therapeutic anticancer research: 2002 Sir Godfrey Hounsfield lecture delivered at the President's Day, Manchester.

    Dzik-Jurasz, A

    The British journal of radiology

    2004  Volume 77, Issue 916, Page(s) 296–307

    Abstract: A little over 30 years ago, Sir Godfrey Hounsfield and his colleagues revolutionized medical imaging by developing CT scanning. In recent years a combination of improved technology and a deeper understanding of tumour biology have led to the development ... ...

    Abstract A little over 30 years ago, Sir Godfrey Hounsfield and his colleagues revolutionized medical imaging by developing CT scanning. In recent years a combination of improved technology and a deeper understanding of tumour biology have led to the development of imaging based strategies aimed at interrogating tissue structure and function. The prospects of this new technology include the prediction of tumour response and the non-invasive study of conventionally inaccessible yet important pharmacological compartments. This article explores how functional nuclear MRI and spectroscopy have been used in predicting response to anticancer therapy in rectal cancers and to assess the biliary excretion of chemotherapeutics.
    MeSH term(s) Adenocarcinoma/diagnosis ; Adenocarcinoma/metabolism ; Antimetabolites, Antineoplastic/metabolism ; Biliary Tract/metabolism ; Biomarkers ; Fluorouracil/metabolism ; Forecasting ; Humans ; Magnetic Resonance Imaging/trends ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/metabolism
    Chemical Substances Antimetabolites, Antineoplastic ; Biomarkers ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2004-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/95415645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Angiogenesis imaging in man: a personal view from the pharmaceutical industry.

    Dzik-Jurasz, A

    The British journal of radiology

    2003  Volume 76 Spec No 1, Page(s) S81–2

    Abstract: The imaging of angiogenesis in human disease represents an exciting prospect for those involved in the drug development process. With an increasing focus on the therapeutic modulation of angiogenesis in man, the development of technologies capable of ... ...

    Abstract The imaging of angiogenesis in human disease represents an exciting prospect for those involved in the drug development process. With an increasing focus on the therapeutic modulation of angiogenesis in man, the development of technologies capable of monitoring angiogenic drug interventions non-invasively should be welcomed.
    MeSH term(s) Diagnostic Imaging ; Drug Design ; Drug Industry ; Humans ; Neovascularization, Pathologic/diagnosis ; Neovascularization, Pathologic/drug therapy
    Language English
    Publishing date 2003
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/42249357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pelvic malignancy: integrating form and function.

    Dzik-Jurasz, A S K

    The British journal of radiology

    2005  Volume 78 Spec No 2, Page(s) S86–93

    Abstract: Despite the essential role morphological imaging plays in the management of patients with malignancy, anatomical techniques are limited in their ability to report on tumour biology and behaviour. It has therefore been necessary to develop imaging ... ...

    Abstract Despite the essential role morphological imaging plays in the management of patients with malignancy, anatomical techniques are limited in their ability to report on tumour biology and behaviour. It has therefore been necessary to develop imaging techniques that integrate form and function to probe the micro and molecular environments of cancers. The role of clinical functional and molecular magnetic resonance imaging is discussed with an emphasis on pelvic malignancy. It is argued that the radiological sciences need to take a lead in translating molecular and functional imaging techniques into man. Imaging in support of drug development is suggested as a focus for that development.
    MeSH term(s) Biomarkers, Tumor/analysis ; Cell Death ; Female ; Gene Expression ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Pelvic Neoplasms/blood supply ; Pelvic Neoplasms/diagnosis ; Pelvic Neoplasms/metabolism ; Pharmacology ; Positron-Emission Tomography ; Regional Blood Flow ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2005
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/75936537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Molecular imaging in oncology.

    Dzik-Jurasz, A S K

    Cancer imaging : the official publication of the International Cancer Imaging Society

    2004  Volume 4, Issue 2, Page(s) 162–173

    Abstract: Cancer is a genetic disease that manifests in loss of normal cellular homeostatic mechanisms. The biology and therapeutic modulation of neoplasia occurs at the molecular level. An understanding of these molecular processes is therefore required to ... ...

    Abstract Cancer is a genetic disease that manifests in loss of normal cellular homeostatic mechanisms. The biology and therapeutic modulation of neoplasia occurs at the molecular level. An understanding of these molecular processes is therefore required to develop novel prognostic and early biomarkers of response. In addition to clinical applications, increased impetus for the development of such technologies has been catalysed by pharmaceutical companies investing in the development of molecular therapies. The discipline of molecular imaging therefore aims to image these important molecular processes in vivo. Molecular processes, however, operate at short length scales and concentrations typically beyond the resolution of clinical imaging. Solving these issues will be a challenge to imaging research. The successful implementations of molecular imaging in man will only be realised by the close co-operation amongst molecular biologists, chemists and the imaging scientists.
    Language English
    Publishing date 2004-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2104862-9
    ISSN 1470-7330 ; 1470-7330
    ISSN (online) 1470-7330
    ISSN 1470-7330
    DOI 10.1102/1470-7330.2004.0060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Molecular imaging in vivo: an introduction.

    Dzik-Jurasz, A S K

    The British journal of radiology

    2003  Volume 76 Spec No 2, Page(s) S98–109

    MeSH term(s) Animals ; DNA Probes ; Diagnostic Imaging/methods ; Humans ; Magnetic Resonance Imaging/methods ; Molecular Biology/methods ; Neoplasms/blood supply ; Neoplasms/diagnosis ; Nuclear Magnetic Resonance, Biomolecular/methods ; Positron-Emission Tomography/methods ; Tomography/methods ; Tomography, Emission-Computed, Single-Photon/methods ; Ultrasonography/methods
    Chemical Substances DNA Probes
    Language English
    Publishing date 2003
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/25833499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of clinical imaging in oncological drug development.

    Murphy, P S / McCarthy, T J / Dzik-Jurasz, A S K

    The British journal of radiology

    2008  Volume 81, Issue 969, Page(s) 685–692

    Abstract: Clinical imaging has the potential to provide key biomarkers to inform decision-making in drug development. There is considerable optimism that emerging functional imaging techniques will substantially add to the conventional morphological depiction of ... ...

    Abstract Clinical imaging has the potential to provide key biomarkers to inform decision-making in drug development. There is considerable optimism that emerging functional imaging techniques will substantially add to the conventional morphological depiction of disease. The discovery, development and qualification of clinical imaging biomarkers remain a considerable undertaking. Once an imaging biomarker is developed, it must be implemented with a high degree of consistency to ensure the collection of robust clinical trial data. The aim of such a development and implementation process is to deliver sufficient confidence in an imaging biomarker to support "go/no-go" decisions made in a drug development programme. This article outlines the drug development process, with a focus on the current impact of clinical imaging on drug development and its probable future direction.
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Chemistry, Pharmaceutical ; Clinical Trials as Topic/economics ; Clinical Trials as Topic/methods ; Decision Making ; Diagnostic Imaging ; Drug Evaluation, Preclinical/economics ; Drug Evaluation, Preclinical/methods ; Drug Industry ; Humans ; Neoplasms/drug therapy ; Positron-Emission Tomography/methods ; Reproducibility of Results ; Technology, Pharmaceutical
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2008-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/16768437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Perfusion MR imaging of extracranial tumor angiogenesis.

    Padhani, Anwar R / Dzik-Jurasz, Andy

    Topics in magnetic resonance imaging : TMRI

    2004  Volume 15, Issue 1, Page(s) 41–57

    Abstract: Dynamic contrast-enhanced MRI (DCE-MRI) using small molecular weight gadolinium chelates enables noninvasive imaging characterization of tissue vascularity. Depending on the technique used, data reflecting tissue perfusion (blood flow, blood volume, mean ...

    Abstract Dynamic contrast-enhanced MRI (DCE-MRI) using small molecular weight gadolinium chelates enables noninvasive imaging characterization of tissue vascularity. Depending on the technique used, data reflecting tissue perfusion (blood flow, blood volume, mean transit time), microvessel permeability surface area product, and extracellular leakage space can be obtained. Insights into these physiological processes can be obtained from inspection of kinetic enhancement curves or by the application of complex compartmental modeling techniques. Combining morphologic and kinetic features can increase the accuracy of clinical diagnoses. Potential clinical applications include screening for malignant disease, lesion characterization, monitoring lesion response to treatment, and assessment of residual disease. Newer applications include prognostication, pharmacodynamic assessments of antivascular anticancer drugs, and predicting efficacy of treatment. For dynamic MRI to enter into widespread clinical practice, it will be necessary to develop standardized approaches to measurement and robust analysis approaches.
    MeSH term(s) Blood Flow Velocity ; Blood Volume ; Contrast Media ; Drug Screening Assays, Antitumor ; Gadolinium ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging/methods ; Neoplasms/blood supply ; Neoplasms/drug therapy ; Neovascularization, Pathologic/diagnosis
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2004-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1112716-8
    ISSN 0899-3459
    ISSN 0899-3459
    DOI 10.1097/00002142-200402000-00005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Imaging.

    Dzik-Jurasz, Andrzej / Mason, Malcolm / Schipper, Harvey

    Expert review of anticancer therapy

    2004  Volume 4 Suppl 1, Page(s) S29–32

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Radiography
    Language English
    Publishing date 2004-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1586/14737140.4.5.s29
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