LIVIVO - Search results -

Search results

Result 1 - 10 of total 29

Search options

Article ; Online: Early computed tomography coronary angiography in adults presenting with suspected acute coronary syndrome: the RAPID-CTCA RCT.

Gray, Alasdair J / Roobottom, Carl / Smith, Jason E / Goodacre, Steve / Oatey, Katherine / O'Brien, Rachel / Storey, Robert F / Curzen, Nick / Keating, Liza / Kardos, Attila / Felmeden, Dirk / Lee, Robert J / Thokala, Praveen / Lewis, Steff C / Newby, David E

Health technology assessment (Winchester, England)

2023 Volume 26, Issue 37, Page(s) 1–114

Abstract: Background: Acute coronary syndrome is a common medical emergency. The optimal strategy to investigate patients who are at intermediate risk of acute coronary syndrome has not been fully determined.: Objective: To investigate the role of early ... ...

Abstract	Background: Acute coronary syndrome is a common medical emergency. The optimal strategy to investigate patients who are at intermediate risk of acute coronary syndrome has not been fully determined. Objective: To investigate the role of early computed tomography coronary angiography in the investigation and treatment of adults presenting with suspected acute coronary syndrome. Design: A prospective, multicentre, open, parallel-group randomised controlled trial with blinded end-point adjudication. Setting: Thirty-seven hospitals in the UK. Participants: Adults (aged ≥ 18 years) presenting to the emergency department, acute medicine services or cardiology department with suspected or provisionally diagnosed acute coronary syndrome and at least one of the following: (1) a prior history of coronary artery disease, (2) a cardiac troponin level > 99th centile and (3) an abnormal 12-lead electrocardiogram. Interventions: Early computed tomography coronary angiography in addition to standard care was compared with standard care alone. Participants were followed up for 1 year. Main outcome measure: One-year all-cause death or subsequent type 1 (spontaneous) or type 4b (stent thrombosis) myocardial infarction, measured as the time to such event adjudicated by two cardiologists blinded to the computerised tomography coronary angiography ( CTCA ) arm. Cost-effectiveness was estimated as the lifetime incremental cost per quality-adjusted life-year gained. Results: Between 23 March 2015 and 27 June 2019, 1748 participants [mean age 62 years (standard deviation 13 years), 64% male, mean Global Registry Of Acute Coronary Events score 115 (standard deviation 35)] were randomised to receive early computed tomography coronary angiography ( Limitations: The principal limitation of the trial was the slower than anticipated recruitment, leading to a revised sample size, and the requirement to compromise and accept a larger relative effect size estimate for the trial intervention. Future work: The potential role of computed tomography coronary angiography in selected patients with a low probability of obstructive coronary artery disease (intermediate or mildly elevated level of troponin) or who have limited access to invasive cardiac catheterisation facilities needs further prospective evaluation. Conclusions: In patients with suspected or provisionally diagnosed acute coronary syndrome, computed tomography coronary angiography did not alter overall coronary therapeutic interventions or 1-year clinical outcomes, but it did increase the length of hospital stay and health-care costs. These findings do not support the routine use of early computed tomography coronary angiography in intermediate-risk patients with acute chest pain. Trial registration: This trial is registered as ISRCTN19102565 and Clinical Trials NCT02284191. Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme and will be published in full in
MeSH term(s)	Acute Coronary Syndrome/diagnostic imaging ; Adult ; Coronary Angiography ; Coronary Artery Disease/therapy ; Cost-Benefit Analysis ; Female ; Humans ; Male ; Middle Aged ; Quality of Life ; Tomography ; Troponin
Chemical Substances	Troponin
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2006765-3
ISSN	2046-4924 ; 1366-5278
ISSN (online)	2046-4924
ISSN	1366-5278
DOI	10.3310/IRWI5180
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5162: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Early computed tomography coronary angiography and preventative treatment in patients with suspected acute coronary syndrome: A secondary analysis of the RAPID-CTCA trial.

Wang, Kang-Ling / Meah, Mohammed N / Bularga, Anda / Oatey, Katherine / O'Brien, Rachel / Smith, Jason E / Curzen, Nick / Kardos, Attila / Keating, Liza / Felmeden, Dirk / Storey, Robert F / Goodacre, Steve / Roobottom, Carl / Newby, David E / Gray, Alasdair J

American heart journal

2023 Volume 266, Page(s) 138–148

Abstract: Background: Computed tomography coronary angiography (CTCA) offers detailed assessment of the presence of coronary atherosclerosis and helps guide patient management. We investigated influences of early CTCA on the subsequent use of preventative ... ...

Abstract	Background: Computed tomography coronary angiography (CTCA) offers detailed assessment of the presence of coronary atherosclerosis and helps guide patient management. We investigated influences of early CTCA on the subsequent use of preventative treatment in patients with suspected acute coronary syndrome. Methods: In this secondary analysis of a multicenter randomized controlled trial of early CTCA in intermediate-risk patients with suspected acute coronary syndrome, prescription of aspirin, P2Y Results: In 1,743 patients (874 randomized to early CTCA and 869 to standard of care only), prescription of P2Y Conclusions: Prescription patterns of preventative treatment varied during index hospitalization in patients with suspected acute coronary syndrome. Early CTCA facilitated targeted individualization of these therapies based on the extent of coronary artery disease.
MeSH term(s)	Humans ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/prevention & control ; Coronary Artery Disease/complications ; Coronary Angiography/methods ; Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/drug therapy ; Acute Coronary Syndrome/prevention & control ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Tomography, X-Ray Computed/methods ; Computed Tomography Angiography
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/j.ahj.2023.09.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.15: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Distinguishing Type 1 from Type 2 Myocardial Infarction by Using CT Coronary Angiography.

Radiology. Cardiothoracic imaging

2022 Volume 4, Issue 5, Page(s) e220081

Abstract: Purpose: To determine whether quantitative plaque characterization by using CT coronary angiography (CTCA) can discriminate between type 1 and type 2 myocardial infarction.: Materials and methods: This was a secondary analysis of two prospective ... ...

Abstract	Purpose: To determine whether quantitative plaque characterization by using CT coronary angiography (CTCA) can discriminate between type 1 and type 2 myocardial infarction. Materials and methods: This was a secondary analysis of two prospective studies (ClinicalTrials.gov registration nos. NCT03338504 [2014-2019] and NCT02284191 [2018-2020]) that performed blinded quantitative plaque analysis on findings from CTCA in participants with type 1 myocardial infarction, type 2 myocardial infarction, and chest pain without myocardial infarction. Logistic regression analyses were performed to identify predictors of type 1 myocardial infarction. Results: Overall, 155 participants (mean age, 64 years ± 12 [SD]; 114 men) and 36 participants (mean age, 67 years ± 12; 19 men) had type 1 and type 2 myocardial infarction, respectively, and 136 participants (62 years ± 12; 78 men) had chest pain without myocardial infarction. Participants with type 1 myocardial infarction had greater total (median, 44% [IQR: 35%-50%] vs 35% [IQR: 29%-46%]), noncalcified (39% [IQR: 31%-46%] vs 34% [IQR: 29%-40%]), and low-attenuation (4.15% [IQR: 1.88%-5.79%] vs 1.64% [IQR: 0.89%-2.28%]) plaque burdens ( Conclusion: Higher low-attenuation coronary plaque burden in patients with type 1 myocardial infarction may help distinguish these patients from those with type 2 myocardial infarction.
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article
ISSN	2638-6135
ISSN (online)	2638-6135
DOI	10.1148/ryct.220081
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial.

Wang, Kang Ling / Roobottom, Carl / Smith, Jason E / Goodacre, Steve / Oatey, Katherine / O'Brien, Rachel / Storey, Robert F / Curzen, Nick / Keating, Liza / Kardos, Attila / Felmeden, Dirk / Thokala, Praveen / Mills, Nicholas L / Newby, David E / Gray, Alasdair J

European heart journal. Acute cardiovascular care

2022 Volume 11, Issue 7, Page(s) 570–579

Abstract: Aims: To evaluate the potential associations between presentation cardiac troponin and the clinical impact of early computed tomography coronary angiography (CTCA) in intermediate-risk patients with suspected acute coronary syndrome.: Methods and ... ...

Abstract	Aims: To evaluate the potential associations between presentation cardiac troponin and the clinical impact of early computed tomography coronary angiography (CTCA) in intermediate-risk patients with suspected acute coronary syndrome. Methods and results: In a large multicentre randomized controlled trial of patients with intermediate-risk chest pain due to suspected acute coronary syndrome, early CTCA had no effect on the primary outcome-death or subsequent Type 1 or 4b myocardial infarction-but reduced the rate of invasive coronary angiography. In this pre-specified secondary analysis, cardiovascular testing and clinical outcomes were compared between those with or without cardiac troponin elevation at presentation. Of 1748 patients, 1004 (57%) had an elevated cardiac troponin concentration and 744 (43%) had a normal concentration. Patients with cardiac troponin elevation had a higher Global Registry of Acute Coronary Events score (132 vs. 91; P < 0.001) and were more likely to have obstructive coronary artery disease (59 vs. 33%; P < 0.001), non-invasive (72 vs. 52%; P < 0.001) and invasive (72 vs. 38%; P < 0.001) testing, coronary revascularization (47 vs. 15%; P < 0.001), and the primary outcome (8 vs. 3%; P = 0.007) at 1 year. However, there was no evidence that presentation cardiac troponin was associated with the relative effects of early CTCA on rates of non-invasive (Pinteraction = 0.33) and invasive (Pinteraction = 0.99) testing, coronary revascularization (Pinteraction = 0.57), or the primary outcome (Pinteraction = 0.41). Conclusion: Presentation cardiac troponin had no demonstrable associations between the effects of early CTCA on reductions in non-invasive and invasive testing, or the lack of effect on coronary revascularization or the primary outcome in intermediate-risk patients with suspected acute coronary syndrome.
MeSH term(s)	Acute Coronary Syndrome/diagnosis ; Computed Tomography Angiography ; Coronary Angiography/methods ; Coronary Artery Disease ; Humans ; Troponin
Chemical Substances	Troponin
Language	English
Publishing date	2022-06-01
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2663340-1
ISSN	2048-8734 ; 2048-8726
ISSN (online)	2048-8734
ISSN	2048-8726
DOI	10.1093/ehjacc/zuac057
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial.

BMJ (Clinical research ed.)

2021 Volume 374, Page(s) n2106

Abstract: Objectives: To establish if the use of early computed tomography (CT) coronary angiography improves one year clinical outcomes in patients presenting to the emergency department with acute chest pain and at intermediate risk of acute coronary syndrome ... ...

Abstract	Objectives: To establish if the use of early computed tomography (CT) coronary angiography improves one year clinical outcomes in patients presenting to the emergency department with acute chest pain and at intermediate risk of acute coronary syndrome and subsequent clinical events. Design: Randomised controlled trial. Setting: 37 hospitals in the UK. Participants: Adults with suspected or a provisional diagnosis of acute coronary syndrome and one or more of previous coronary heart disease, raised levels of cardiac troponin, or abnormal electrocardiogram. Interventions: Early CT coronary angiography and standard of care compared with standard of care only. Main outcome measures: Primary endpoint was all cause death or subsequent type 1 or 4b myocardial infarction at one year. Results: Between 23 March 2015 and 27 June 2019, 1748 participants (mean age 62 years (standard deviation 13), 64% men, mean global registry of acute coronary events (GRACE) score 115 (standard deviation 35)) were randomised to receive early CT coronary angiography (n=877) or standard of care only (n=871). Median time from randomisation to CT coronary angiography was 4.2 (interquartile range 1.6-21.6) hours. The primary endpoint occurred in 51 (5.8%) participants randomised to CT coronary angiography and 53 (6.1%) participants who received standard of care only (adjusted hazard ratio 0.91 (95% confidence interval 0.62 to 1.35), P=0.65). Invasive coronary angiography was performed in 474 (54.0%) participants randomised to CT coronary angiography and 530 (60.8%) participants who received standard of care only (adjusted hazard ratio 0.81 (0.72 to 0.92), P=0.001). There were no overall differences in coronary revascularisation, use of drug treatment for acute coronary syndrome, or subsequent preventive treatments between the two groups. Early CT coronary angiography was associated with a slightly longer time in hospital (median increase 0.21 (95% confidence interval 0.05 to 0.40) days from a median hospital stay of 2.0 to 2.2 days). Conclusions: In intermediate risk patients with acute chest pain and suspected acute coronary syndrome, early CT coronary angiography did not alter overall coronary therapeutic interventions or one year clinical outcomes, but reduced rates of invasive angiography while modestly increasing length of hospital stay. These findings do not support the routine use of early CT coronary angiography in intermediate risk patients with acute chest pain and suspected acute coronary syndrome. Trial registration: ISRCTN19102565, NCT02284191.
MeSH term(s)	Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/etiology ; Acute Coronary Syndrome/mortality ; Acute Disease ; Aged ; Chest Pain/complications ; Chest Pain/diagnostic imaging ; Computed Tomography Angiography/methods ; Early Diagnosis ; Emergency Service, Hospital ; Female ; Heart Disease Risk Factors ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Myocardial Infarction/mortality ; Outcome Assessment, Health Care ; Proportional Hazards Models ; Risk Assessment ; Standard of Care ; Time Factors
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.n2106
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.10: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Hormone replacement therapy and cardiovascular risk: do abnormalities of coagulation and fibrinolysis matter?

Lip, G Y / Felmeden, D C

Journal of internal medicine

2001 Volume 249, Issue 3, Page(s) 201–204

MeSH term(s)	Blood Coagulation/physiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Estrogen Replacement Therapy ; Estrogens/physiology ; Female ; Fibrinolysis/physiology ; Humans ; Menopause/physiology
Chemical Substances	Estrogens
Language	English
Publishing date	2001-03
Publishing country	England
Document type	Comment ; Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1046/j.1365-2796.2001.00796.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.44: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Resistant hypertension and the Birmingham Hypertension Square.

Felmeden, D C / Lip, G Y

Current hypertension reports

2001 Volume 3, Issue 3, Page(s) 203–208

Abstract: Recent guidelines for the treatment of hypertension place great emphasis on tighter blood pressure control, especially in the presence of hypertensive target organ damage and diabetes. In order to achieve these treatment targets, more patients will ... ...

Abstract	Recent guidelines for the treatment of hypertension place great emphasis on tighter blood pressure control, especially in the presence of hypertensive target organ damage and diabetes. In order to achieve these treatment targets, more patients will require a combination of antihypertensive medications. However, resistant hypertension may have many possible underlying causes, and clinicians should appreciate how to detect and tackle these potential problems. Effective and synergistic combinations are therefore of vital importance, especially in patients with resistant hypertension. The choice of rational first- and second-line drugs that act in synergy could lead to better blood pressure management as well as significant financial savings for health care resources. The use of the Birmingham Hypertension Square for the optimum choice of add-in drugs for the treatment of resistant hypertension may aid management.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Drug Therapy, Combination ; Humans ; Hypertension/drug therapy ; Vascular Resistance/drug effects
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2001-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057367-4
ISSN	1522-6417
ISSN	1522-6417
DOI	10.1007/s11906-001-0039-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5522: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Hormone replacement therapy and hypertension.

Felmeden, D C / Lip, G Y

Blood pressure

2001 Volume 9, Issue 5, Page(s) 246–249

Abstract: For many years, Hormone Replacement Therapy (HRT) was considered to be contraindicated in postmenopausal women with hypertension and many such women were excluded from HRT because of concerns that HRT may have an adverse effect on blood pressure. This ... ...

Abstract	For many years, Hormone Replacement Therapy (HRT) was considered to be contraindicated in postmenopausal women with hypertension and many such women were excluded from HRT because of concerns that HRT may have an adverse effect on blood pressure. This perception was mainly due to the effects of oral contraceptive drugs, especially the oestrogen component, in increasing blood pressure. Differences exist between the formulation and doses of oestrogen preparations used, either as oral contraceptives in premenopausal women (in whom high-dose synthetic oestrogens are used) or as HRT in postmenopausal women (in whom low "replacement" doses of natural oestrogens are used). This is not inconsequential, as postmenopausal women represent the largest category of women at risk for hypertension. The aim of this review is to give a balanced view on the effects of HRT on blood pressure in postmenopausal women.
MeSH term(s)	Adult ; Aged ; Blood Pressure/drug effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Cohort Studies ; Contraceptives, Oral, Hormonal/adverse effects ; Contraceptives, Oral, Hormonal/pharmacology ; Contraindications ; Cross-Sectional Studies ; Estradiol/administration & dosage ; Estradiol/pharmacology ; Estrogen Replacement Therapy/adverse effects ; Estrogens/adverse effects ; Estrogens/pharmacology ; Estrogens/therapeutic use ; Female ; Hormone Replacement Therapy/adverse effects ; Humans ; Hypertension/chemically induced ; Hypertension/epidemiology ; Hypertension/physiopathology ; Hypertension/prevention & control ; Menopause/physiology ; Middle Aged ; Prevalence ; Progesterone/adverse effects ; Progesterone/pharmacology ; Progesterone/therapeutic use ; Retrospective Studies ; Risk Factors
Chemical Substances	Contraceptives, Oral, Hormonal ; Estrogens ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2001-01-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1170048-8
ISSN	1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
ISSN (online)	1651-1999 ; 1651-2480
ISSN	0803-7051 ; 0803-8023
DOI	10.1080/080370500448614
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3843: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Myocardial bridging.

Felmeden, D C / Lip, G Y

International journal of clinical practice

2000 Volume 54, Issue 8, Page(s) 542–543

Abstract: We present a case of myocardial bridging, which was seen following urgent cardiac catherisation for post-infarction unstable angina in a 55-year-old man who was initially admitted with an acute inferior myocardial infarction. ...

Abstract	We present a case of myocardial bridging, which was seen following urgent cardiac catherisation for post-infarction unstable angina in a 55-year-old man who was initially admitted with an acute inferior myocardial infarction.
MeSH term(s)	Angina, Unstable/pathology ; Angina, Unstable/therapy ; Cardiac Catheterization ; Catheterization ; Coronary Vessels/pathology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy ; Myocardium/pathology ; Stents
Language	English
Publishing date	2000-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.301: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The renin-angiotensin-aldosterone system and fibrinolysis.

Felmeden, D C / Lip, G Y

Journal of the renin-angiotensin-aldosterone system : JRAAS

2000 Volume 1, Issue 3, Page(s) 240–244

Abstract: Activation of the RAAS has been linked with an increased risk of myocardial infarction and stroke,(1,2,37,38) and recently these beneficial effects have, in part, been attributed to the effects of the RAAS on the fibrinolytic system. Indeed, ACE seems to ...

Abstract	Activation of the RAAS has been linked with an increased risk of myocardial infarction and stroke,(1,2,37,38) and recently these beneficial effects have, in part, been attributed to the effects of the RAAS on the fibrinolytic system. Indeed, ACE seems to occupy a central position in modulating the fibrinolytic balance, where an angiotensin II-mediated increase of PAI-1 plays a major role. By contrast, the effect on bradykinin stimulated t-PA release may be of lesser importance, although the data are conflicting. Importantly, the impact of the RAAS on the fibrinolytic balance may also contribute to the favourable effects of ACE inhibition and AT1-receptor antagonists on cardiovascular events, particularly when considering the activation of the RAAS in hypertension and heart failure. More work is clearly required in this area to elucidate potential therapeutic targets.
MeSH term(s)	Aldosterone/physiology ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Fibrinolysis/drug effects ; Fibrinolysis/physiology ; Humans ; Receptor, Angiotensin, Type 1 ; Renin-Angiotensin System/physiology
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Receptor, Angiotensin, Type 1 ; Aldosterone (4964P6T9RB)
Language	English
Publishing date	2000-09
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2086948-4
ISSN	1752-8976 ; 1470-3203
ISSN (online)	1752-8976
ISSN	1470-3203
DOI	10.3317/jraas.2000.036
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5668: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito