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Book: Social cognition, joint attention, and communicative competence from 9 to 15 months of age

Carpenter, Malinda / Nagell, Katherine / Tomasello, Michael

(Monographs of the Society for Research in Child Development ; Vol. 63, no. 4 = Ser. no. 255)

1998

Author's details	Malinda Carpenter ; Katherine Nagell ; Michael Tomasello
Series title	Monographs of the Society for Research in Child Development ; Vol. 63, no. 4 = Ser. no. 255
Collection
Keywords	Kleinstkind ; Soziale Wahrnehmung ; Aufmerksamkeit ; Kommunikative Kompetenz
Subject	Kommunikationskompetenz ; Kommunikative Fähigkeit ; Achtsamkeit ; Daueraufmerksamkeit ; Dauerbeobachtungsfähigkeit ; Dauerüberwachungsfähigkeit ; Konzentration ; Vigilanz ; Wachsamkeit ; Gesellschaft ; Soziale Kognition ; Soziale Perzeption ; Sozialwahrnehmung ; Öffentliche Wahrnehmung ; Kind
Language	English
Size	VI, 176 S. : graph. Darst.
Publisher	Univ. of Chicago Press
Publishing place	Chicago, Ill
Publishing country	United States
Document type	Book
HBZ-ID	HT009419403
ISBN	0-226-09461-8 ; 978-0-226-09461-8
Database	Catalogue ZB MED Medicine, Health

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Se 300 -63,4-	verfügbar in Königswinter	Königswinter

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Article: In vivo matrigel migration and angiogenesis assay.

Malinda, Katherine M

Methods in molecular biology (Clifton, N.J.)

2009 Volume 467, Page(s) 287–294

Abstract: The search for rapid and reproducible in vivo angiogenesis and antiangiogenesis assays is an area of intense interest. These types of assays are extremely useful in testing putative drugs and biological agents and for the comparison and enhancement of in ...

Abstract	The search for rapid and reproducible in vivo angiogenesis and antiangiogenesis assays is an area of intense interest. These types of assays are extremely useful in testing putative drugs and biological agents and for the comparison and enhancement of in vitro tests. The Matrigel plug assay is one such assay and has proved to be a relatively quick and easy method to evaluate both angiogenic and antiangiogenic compounds in vivo. Initial indications of the levels of activity of strong angiogenic or antiangiogenic compounds can be visually assessed even as the plugs come out of the mouse because there are color differences in the plugs compared to the controls. Further quantitation is then needed to determine levels of angiogenic/antiangiogenic activity, and this can be performed using a variety of methods. This chapter presents an overview of the basic methods used to set up both angiogenic and antiangiogenic assays, discusses factors influencing variability, and discusses the methods for quantitating the plugs obtained. The Matrigel plug assay provides another useful tool in angiogenesis research.
MeSH term(s)	Animals ; Biological Assay/methods ; Collagen/metabolism ; Drug Combinations ; Female ; Laminin/metabolism ; Mice ; Mice, Inbred C57BL ; Neovascularization, Physiologic ; Proteoglycans/metabolism
Chemical Substances	Drug Combinations ; Laminin ; Proteoglycans ; matrigel (119978-18-6) ; Collagen (9007-34-5)
Language	English
Publishing date	2009
Publishing country	United States
Document type	Journal Article
ISSN	1064-3745
ISSN	1064-3745
DOI	10.1007/978-1-59745-241-0_17
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Article: In vivo matrigel migration and angiogenesis assays.

Malinda, Katherine M

Methods in molecular medicine

2003 Volume 78, Page(s) 329–335

MeSH term(s)	Animals ; Cell Movement ; Collagen/pharmacology ; Drug Combinations ; Laminin/pharmacology ; Mice ; Models, Animal ; Neovascularization, Physiologic ; Proteoglycans/pharmacology
Chemical Substances	Drug Combinations ; Laminin ; Proteoglycans ; matrigel (119978-18-6) ; Collagen (9007-34-5)
Language	English
Publishing date	2003
Publishing country	United States
Document type	Journal Article
ISSN	1543-1894
ISSN	1543-1894
DOI	10.1385/1-59259-332-1:329
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Article: Experiencing the SARS-CoV-2 Pandemic Whilst Living With Cancer.

Page, Alexander / Broom, Alex / Kenny, Katherine / Lwin, Zarnie / Wakefield, Claire E / Itchins, Malinda / Khasraw, Mustafa

Qualitative health research

2022 Volume 32, Issue 3, Page(s) 426–439

Abstract: The SARS-CoV-2 pandemic has resulted in considerable consequences for many cancer patients, exacerbating pre-existing systemic health system limitations as well as creating new challenges. From socially distanced clinics and the widespread introduction ... ...

Abstract	The SARS-CoV-2 pandemic has resulted in considerable consequences for many cancer patients, exacerbating pre-existing systemic health system limitations as well as creating new challenges. From socially distanced clinics and the widespread introduction of telehealth, to the halting of clinical trials and the reassessment of what constitutes "essential" treatment, care in oncology has abruptly changed. There is currently limited analysis of cancer patients' experiences of the pandemic and its impacts on illness, wellness, and everyday life. Through semi-structured interviews with 54 people living with cancer during the 2020 phase of the SARS-CoV-2 pandemic in Australia, we explore how patients experience illness and care in reflecting upon a range of pandemic challenges, including delay, distance, and vulnerability. We find that in some cases, these pandemic conditions redefined the meaning of essential cancer care, reconfigured expectations around clinical trials, constructed new affective distances, and amplified dread and fear for people living with cancer.
MeSH term(s)	COVID-19 ; Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; Pandemics ; SARS-CoV-2 ; Telemedicine
Language	English
Publishing date	2022-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1275716-0
ISSN	1552-7557 ; 1049-7323
ISSN (online)	1552-7557
ISSN	1049-7323
DOI	10.1177/10497323211057082
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Article ; Online: Victorian Specialist Immunisation Services (VicSIS) - bolstering adult clinics for COVID-19 vaccines.

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 5, Page(s) 2052701

Abstract: The Victorian Specialist Immunization Services (VicSIS) was established in Victoria, Australia, in February 2021, aiming to enhance vaccine safety services for Coronavirus disease (COVID-19) vaccines. VicSIS supports practitioners and patients with ... ...

Abstract	The Victorian Specialist Immunization Services (VicSIS) was established in Victoria, Australia, in February 2021, aiming to enhance vaccine safety services for Coronavirus disease (COVID-19) vaccines. VicSIS supports practitioners and patients with complex vaccine safety questions, including those who experience adverse events following immunization (AEFI) after COVID-19 vaccines. VicSIS provides individual vaccination recommendations, allergy testing, vaccine challenges, and vaccination under supervision. VicSIS initially comprised of eight adult COVID-19 specialist vaccination clinics, subsequently, expanding to better support pediatric patients as the Australian vaccine roll-out extended to adolescents and children. Since their establishment to September 2021, the inaugural VicSIS clinics received a total of 26,401 referrals and reviewed 6,079 patients. Consults were initially predominantly for pre-vaccination reviews, later predominantly becoming post-vaccination AEFI reviews as the program progressed. Regardless of the type of consult, the most common consult outcome was a recommendation for routine vaccination (73% and 55% of consult outcomes respectively). VicSIS is an integral component of the COVID-19 vaccination program and supports confidence in COVID-19 vaccine safety by providing consistent advice across the state. VicSIS aims to strengthen the health system through the pandemic, bolstering specialist immunization services beyond COVID-19 vaccines, including training the next generation of vaccinology experts.
MeSH term(s)	Adolescent ; Adult ; Adverse Drug Reaction Reporting Systems ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Child ; Humans ; Immunization/adverse effects ; Population Surveillance ; Vaccination/adverse effects ; Vaccines/adverse effects ; Victoria
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2052701
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Article ; Online: Hope in the era of precision oncology: a qualitative study of informal caregivers' experiences.

Kenny, Katherine / Williams Veazey, Leah / Broom, Alex / Peterie, Michelle / Page, Alexander / Prainsack, Barbara / Wakefield, Claire E / Itchins, Malinda / Khasraw, Mustafa / Lwin, Zarnie

BMJ open

2023 Volume 13, Issue 5, Page(s) e065753

Abstract: Objectives: To explore informal caregivers' perspectives on precision medicine in cancer care.: Design: Semi-structured interviews with the informal caregivers of people living with cancer and receiving targeted/immunotherapies. Interview transcripts ...

Abstract	Objectives: To explore informal caregivers' perspectives on precision medicine in cancer care. Design: Semi-structured interviews with the informal caregivers of people living with cancer and receiving targeted/immunotherapies. Interview transcripts were analysed thematically using a framework approach. Setting: Recruitment was facilitated by two hospitals and five Australian cancer community groups. Participants: Informal caregivers (n=28; 16 men, 12 women; aged 18-80) of people living with cancer and receiving targeted/immunotherapies. Results: Thematic analysis identified three findings, centred largely on the pervasive theme of hope in relation to precision therapies including: (1) precision as a key component of caregivers' hope; (2) hope as a collective practice between patients, caregivers, clinicians and others, which entailed work and obligation for caregivers; and (3) hope as linked to expectations of further scientific progress, even if there may be no personal, immediate benefit. Conclusions: Innovation and change in precision oncology are rapidly reconfiguring the parameters of hope for patients and caregivers, creating new and difficult relational moments and experiences in everyday life and in clinical encounters. In the context of a shifting therapeutic landscape, caregivers' experiences illustrate the need to understand hope as collectively produced, as emotional and moral labour, and as entangled in broader cultural expectations of medical advances. Such understandings may help clinicians as they guide patients and caregivers through the complexities of diagnosis, treatment, emerging evidence and possible futures in the precision era. Developing a better understanding of informal caregivers' experiences of caring for patients receiving precision therapies is important for improving support to patients and their caregivers.
MeSH term(s)	Male ; Humans ; Female ; Caregivers/psychology ; Neoplasms/therapy ; Precision Medicine ; Australia ; Qualitative Research
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-065753
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Article ; Online: A sociology of precision-in-practice: The affective and temporal complexities of everyday clinical care.

Kenny, Katherine / Broom, Alex / Page, Alexander / Prainsack, Barbara / Wakefield, Claire E / Itchins, Malinda / Lwin, Zarnie / Khasraw, Mustafa

Sociology of health & illness

2021 Volume 43, Issue 9, Page(s) 2178–2195

Abstract: The idea of 'precision medicine', which has gained increasing traction since the early 2000s, is now ubiquitous in health and medicine. Though varied in its implementation across fields, precision medicine has raised hopes of revolutionary treatments and ...

Abstract	The idea of 'precision medicine', which has gained increasing traction since the early 2000s, is now ubiquitous in health and medicine. Though varied in its implementation across fields, precision medicine has raised hopes of revolutionary treatments and has spurred the proliferation of novel therapeutics, the alteration of professional trajectories and various reconfigurations of health/care. Nowhere is the promise of precision medicine more apparent, nor further institutionalised, than in the field of oncology. While the transformative potential of precision medicine is widely taken for granted, there remains scant attention to how it is being experienced at the coalface of care. Here, drawing on the perspectives of 54 cancer care professionals gleaned through eight focus group discussions in two hospitals in Australia, we explore clinicians' experiences of the day-to-day dynamics of precision-in-practice. We illustrate some of the affective and temporal complexities, analysed here under the rubrics of enchantment, acceleration and distraction that are emerging alongside the uptake of precision medicine in the field of oncology. We argue that these complexities, and their dis/continuities with earlier iterations of cancer care, demonstrate the need for sociological analyses of precision medicine as it is being implemented in practice and its varied effects on 'routine' care.
MeSH term(s)	Australia ; Delivery of Health Care ; Humans ; Medical Oncology ; Neoplasms/therapy ; Precision Medicine ; Sociology
Language	English
Publishing date	2021-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	795552-2
ISSN	1467-9566 ; 0141-9889
ISSN (online)	1467-9566
ISSN	0141-9889
DOI	10.1111/1467-9566.13389
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Article ; Online: The cost-effectiveness of preimplantation genetic testing for aneuploidy in the United States: an analysis of cost and birth outcomes from 158,665 in vitro fertilization cycles.

Lee, Malinda / Lofgren, Katherine T / Thomas, Ann / Lanes, Andrea / Goldman, Randi / Ginsburg, Elizabeth S / Hornstein, Mark D

American journal of obstetrics and gynecology

2021 Volume 225, Issue 1, Page(s) 55.e1–55.e17

Abstract: Background: A controversial and unresolved question in reproductive medicine is the utility of preimplantation genetic testing for aneuploidy as an adjunct to in vitro fertilization. Infertility is prevalent, but its treatment is notoriously expensive ... ...

Abstract	Background: A controversial and unresolved question in reproductive medicine is the utility of preimplantation genetic testing for aneuploidy as an adjunct to in vitro fertilization. Infertility is prevalent, but its treatment is notoriously expensive and typically not covered by insurance. Therefore, cost-effectiveness is critical to consider in this context. Objective: This study aimed to analyze the cost-effectiveness of preimplantation genetic testing for aneuploidy for the treatment of infertility in the United States. Study design: As reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System, a national data registry, in vitro fertilization cycles occurring between 2014 and 2016 in the United States were analyzed. A probabilistic decision tree was developed using empirical outputs to simulate the events and outcomes associated with in vitro fertilization with and without preimplantation genetic testing for aneuploidy. The treatment strategies were (1) in vitro fertilization with intended preimplantation genetic testing for aneuploidy and (2) in vitro fertilization with transfers of untested embryos. Patients progressed through the treatment model until they achieved a live birth or 12 months after ovarian stimulation. Clinical costs related to both treatment strategies were extracted from the literature and considered from both the patient and payer perspectives. Outcome metrics included incremental cost (measured in 2018 US dollars), live birth outcomes, incremental cost-effectiveness ratio, and incremental cost per live birth between treatment strategies. Results: The study population included 114,157 first fresh in vitro fertilization stimulations and 44,508 linked frozen embryo transfer cycles. Of the fresh stimulations, 16.2% intended preimplantation genetic testing for aneuploidy and 83.8% did not. In patients younger than 35 years old, preimplantation genetic testing for aneuploidy was associated with worse clinical outcomes and higher costs. At age 35 years and older, preimplantation genetic testing for aneuploidy led to more cumulative births but was associated with higher costs from both perspectives. From a patient perspective, the incremental cost per live birth favored the no preimplantation genetic testing for aneuploidy strategy from the <35 years age group to the 38 years age group and beginning at age 39 years favored preimplantation genetic testing for aneuploidy. From a payer perspective, the incremental cost per live birth favored preimplantation genetic testing for aneuploidy regardless of patient age. Conclusion: The cost-effectiveness of preimplantation genetic testing for aneuploidy is dependent on patient age and perspective. From an economic perspective, routine preimplantation genetic testing for aneuploidy should not be universally adopted; however, it may be cost-effective in certain scenarios.
MeSH term(s)	Adult ; Age Factors ; Aneuploidy ; Cost-Benefit Analysis ; Costs and Cost Analysis ; Embryo Transfer ; Female ; Fertilization in Vitro ; Genetic Testing ; Humans ; Live Birth ; Pregnancy ; Pregnancy Outcome/economics ; Preimplantation Diagnosis/economics ; Preimplantation Diagnosis/methods ; Reproductive Techniques, Assisted/statistics & numerical data ; United States
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2021.01.021
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Article ; Online: Exploring International Views on Key Concepts for Mass-gathering Health through a Delphi Process.

Steenkamp, Malinda / Hutton, Alison E / Ranse, Jamie C / Lund, Adam / Turris, Sheila A / Bowles, Ron / Arbuthnott, Katherine / Arbon, Paul A

Prehospital and disaster medicine

2016 Volume 31, Issue 4, Page(s) 443–453

Abstract: ... regarding an overall conceptual diagram and proposed matrix for organizing data elements. Steenkamp M ...

Abstract	Introduction The science underpinning mass-gathering health (MGH) is developing rapidly. However, MGH terminology and concepts are not yet well defined or used consistently. These variations can complicate comparisons across settings. There is, therefore, a need to develop consensus and standardize concepts and data points to support the development of a robust MGH evidence-base for governments, event planners, responders, and researchers. This project explored the views and sought consensus of international MGH experts on previously published concepts around MGH to inform the development of a transnational minimum data set (MDS) with an accompanying data dictionary (DD). Report A two-round Delphi process was undertaken involving volunteers from the World Health Organization (WHO) Virtual Interdisciplinary Advisory Group (VIAG) on Mass Gatherings (MGs) and the MG section of the World Association for Disaster and Emergency Medicine (WADEM). The first online survey tested agreement on six key concepts: (1) using the term "MG HEALTH;" (2) purposes of the proposed MDS and DD; (3) event phases; (4) two MG population models; (5) a MGH conceptual diagram; and (6) a data matrix for organizing MGH data elements. Consensus was defined as ≥80% agreement. Round 2 presented five refined MGH principles based on Round 1 input that was analyzed using descriptive statistics and content analysis. Thirty-eight participants started Round 1 with 36 completing the survey and 24 (65% of 36) completing Round 2. Agreement was reached on: the term "MGH" (n=35/38; 92%); the stated purposes for the MDS (n=38/38; 100%); the two MG population models (n=31/36; 86% and n=30/36; 83%, respectively); and the event phases (n=34/36; 94%). Consensus was not achieved on the overall conceptual MGH diagram (n=25/37; 67%) and the proposed matrix to organize data elements (n=28/37; 77%). In Round 2, agreement was reached on all the proposed principles and revisions, except on the MGH diagram (n=18/24; 75%). Discussion/Conclusions Event health stakeholders require sound data upon which to build a robust MGH evidence-base. The move towards standardization of data points and/or reporting items of interest will strengthen the development of such an evidence-base from which governments, researchers, clinicians, and event planners could benefit. There is substantial agreement on some broad concepts underlying MGH amongst an international group of MG experts. Refinement is needed regarding an overall conceptual diagram and proposed matrix for organizing data elements. Steenkamp M , Hutton AE , Ranse JC , Lund A , Turris SA , Bowles R , Arbuthnott K , Arbon PA . Exploring international views on key concepts for mass-gathering health through a Delphi process. Prehosp Disaster Med. 2016;31(4):443-453.
MeSH term(s)	Attitude of Health Personnel ; Crowding ; Delphi Technique ; Disaster Planning/methods ; Disaster Planning/organization & administration ; Emergency Medical Services/methods ; Emergency Medical Services/organization & administration ; Global Health ; Humans ; Mass Behavior ; Models, Organizational
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025975-2
ISSN	1945-1938 ; 1049-023X
ISSN (online)	1945-1938
ISSN	1049-023X
DOI	10.1017/S1049023X1600042X
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Article ; Online: Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation.

Caton, Andrew J / Kropf, Elizabeth / Simons, Donald M / Aitken, Malinda / Weissler, Katherine A / Jordan, Martha S

European journal of immunology

2013 Volume 44, Issue 3, Page(s) 785–793

Abstract: Autoreactive CD4(+) CD8(-) (CD4SP) thymocytes can be subjected to deletion when they encounter self-peptide during their development, but they can also undergo selection to become CD4SPFoxp3(+) Treg cells. We have analyzed the relationship between these ... ...

Abstract	Autoreactive CD4(+) CD8(-) (CD4SP) thymocytes can be subjected to deletion when they encounter self-peptide during their development, but they can also undergo selection to become CD4SPFoxp3(+) Treg cells. We have analyzed the relationship between these distinct developmental fates using mice in which signals transmitted by the TCR have been attenuated by mutation of a critical tyrosine residue of the adapter protein SLP-76. In mice containing polyclonal TCR repertoires, the mutation caused increased frequencies of CD4SPFoxp3(+) thymocytes. CD4SP thymocytes expressing TCR Vβ-chains that are subjected to deletion by endogenous retroviral superantigens were also present at increased frequencies, particularly among Foxp3(+) thymocytes. In transgenic mice in which CD4SP thymocytes expressing an autoreactive TCR undergo both deletion and Treg-cell formation in response to a defined self-peptide, SLP-76 mutation abrogated deletion of autoreactive CD4SP thymocytes. Notably, Foxp3(+) Treg-cell formation still occurred, albeit with a reduced efficiency, and the mutation was also associated with decreased Nur77 expression by the autoreactive CD4SP thymocytes. These studies provide evidence that the strength of the TCR signal can play a direct role in directing the extent of both thymocyte deletion and Treg-cell differentiation, and suggest that distinct TCR signaling thresholds and/or pathways can promote CD4SP thymocyte deletion versus Treg-cell formation.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Antigen Presentation ; Autoantigens/chemistry ; Autoantigens/immunology ; Autoimmunity ; Clonal Deletion/genetics ; Clonal Deletion/immunology ; Forkhead Transcription Factors/metabolism ; Gene Expression ; Interleukin-2 Receptor alpha Subunit/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Mutation ; Peptides/chemistry ; Peptides/immunology ; Phenotype ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Thymocytes/immunology ; Thymocytes/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; Autoantigens ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Interleukin-2 Receptor alpha Subunit ; Peptides ; Phosphoproteins ; Receptors, Antigen, T-Cell ; Receptors, Antigen, T-Cell, alpha-beta ; SLP-76 signal Transducing adaptor proteins
Language	English
Publishing date	2013-12-27
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201343767
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