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  1. Book ; Online ; Thesis: Implementierung der wissenschaftlichen Kriterien zur Diagnostik des Delirs bei Demenz auf einer gerontopsychiatrischen Station

    Eckl, Linda [Verfasser] / Schiekofer, Stephan [Akademischer Betreuer]

    2024  

    Author's details Linda Eckl ; Betreuer: Stephan Schiekofer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Book ; Thesis: Zur Wertigkeit der Bestimmung von Proinsulin bei Typ 1- und Typ 2-Diabetikern

    Schiekofer, Stephan

    2000  

    Author's details vorgelegt von Stephan Schiekofer
    Language German
    Size 62 S., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Regensburg, Univ., Diss., 2000
    HBZ-ID HT013050939
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: The effect of alexithymia and depressive feelings on pain perception in somatoform pain disorder.

    Lankes, Florian / Schiekofer, Stephan / Eichhammer, Peter / Busch, Volker

    Journal of psychosomatic research

    2020  Volume 133, Page(s) 110101

    Abstract: Objective: To investigate the relationship between alexithymia and depression and their influence on the subjective versus experimental pain perception in somatoform pain disorder.: Methods: Three groups consisting of 40 patients with somatoform pain ...

    Abstract Objective: To investigate the relationship between alexithymia and depression and their influence on the subjective versus experimental pain perception in somatoform pain disorder.
    Methods: Three groups consisting of 40 patients with somatoform pain disorder, 40 patients with depression, and 40 healthy controls were matched. They completed questionnaires regarding alexithymia (TAS26) and depressive feelings (BDI-II). In addition, pain patients rated their subjective pain intensity (NRS). Quantitative sensory testings were conducted in all participants examining temperature (CPT, HPT) and mechanical (MPT, PPT) thresholds.
    Results: Analysis of variance showed that alexithymia was significantly increased in both patient groups compared to healthy controls, but with the highest amount in somatoform pain. Regression analyses confirmed that this finding was in part due to a high comorbidity of depressive feelings in both patient groups. We found a discrepancy between increased clinical pain ratings and elevated pressure pain thresholds, indicating a less intense mechanical pain perception in somatoform pain. Correlation analyses demonstrated a significant connection of subjective pain ratings and pressure pain thresholds with depressive feelings.
    Conclusion: Contrary to the results of other experimental pain studies on chronic muskuloskeletal pain syndromes, we could not confirm central sensitization in somatoform pain disorder. Our findings place the somatoform pain disorder more in the direction of affective disorder such as depression. These findings may improve a better understanding of the disease and also have direct therapeutic implications. The high occurrence of alexithymia and depressive feelings in somatoform pain should be considered in diagnostic and therapeutic regimens of these patients.
    MeSH term(s) Adult ; Affective Symptoms/complications ; Affective Symptoms/psychology ; Chronic Disease/psychology ; Comorbidity ; Depression/complications ; Depression/psychology ; Emotions ; Female ; Humans ; Male ; Middle Aged ; Pain/complications ; Pain/psychology ; Pain Perception ; Somatoform Disorders/complications ; Somatoform Disorders/psychology ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2020-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2020.110101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: β3-integrin Leu33Pro gain of function variant does not modulate inflammatory activity in human derived macrophages in diabetes.

    Helmer, Philipp / Damm, Ellen / Schiekofer, Stephan / Roomp, Kirsten / Schneider, Jochen G

    International journal of medical sciences

    2021  Volume 18, Issue 12, Page(s) 2661–2665

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Aged ; Aged, 80 and over ; Diabetic Nephropathies/blood ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/immunology ; Disease Progression ; Female ; Gain of Function Mutation ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Integrin beta3/genetics ; Integrin beta3/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors
    Chemical Substances ITGB3 protein, human ; Integrin beta3
    Language English
    Publishing date 2021-05-13
    Publishing country Australia
    Document type Journal Article ; Observational Study
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.55648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increased Alexithymia But No Profound Emotion Processing Disorder in Burnout Syndrome.

    Augustin, Magdalena / Eichhammer, Peter / Haas, Joachim / Schiekofer, Stephan / Busch, Volker

    The Journal of nervous and mental disease

    2020  Volume 208, Issue 10, Page(s) 794–802

    Abstract: Our objectives were to investigate alexithymia in burnout patients while controlling for depression and anxiety, as well as to evaluate whether alexithymia may be part of a profound emotional processing disorder or of a mentalization deficit. Alexithymia, ...

    Abstract Our objectives were to investigate alexithymia in burnout patients while controlling for depression and anxiety, as well as to evaluate whether alexithymia may be part of a profound emotional processing disorder or of a mentalization deficit. Alexithymia, depressive, and anxious feelings were compared in patients with burnout, depression, and healthy controls using an age-, sex-, and education-matched cross-sectional design (n = 60). A facial emotion recognition task and an emotional mentalizing performance test as well as physical and emotional violation experiences were conducted. Alexithymia was significantly increased in burnout patients, mediated by negative affect in this group. No impairment of facial emotion recognition or mental attribution could be shown. Burnout patients demonstrated slightly increased emotional abuse experiences in early childhood. The present results corroborate the supposition that alexithymia in burnout primarily depends on affect and may rise due to current strain and overload experience, rather than based on a profound developmental disorder in emotion processing.
    MeSH term(s) Adult ; Affective Symptoms/physiopathology ; Affective Symptoms/psychology ; Anxiety/physiopathology ; Anxiety/psychology ; Burnout, Psychological/physiopathology ; Burnout, Psychological/psychology ; Case-Control Studies ; Depression/physiopathology ; Depression/psychology ; Depressive Disorder/physiopathology ; Depressive Disorder/psychology ; Facial Recognition ; Female ; Humans ; Male ; Mentalization ; Middle Aged
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3020-x
    ISSN 1539-736X ; 0022-3018
    ISSN (online) 1539-736X
    ISSN 0022-3018
    DOI 10.1097/NMD.0000000000001214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unerwünschte Arzneimittelwirkungen in der Gerontopsychiatrie.

    Seifert, Johanna / Fay, Bianca / Strueven, Nina Theresa / Schiekofer, Stephan / Wenzel-Seifert, Katharina / Haen, Ekkehard

    Psychiatrische Praxis

    2021  Volume 49, Issue 1, Page(s) 37–45

    Abstract: Objective: The purpose of this study was to examine the extent to which "potentially inappropriate drugs" (PID) are associated with an increased risk for adverse drug reactions (ADR).: Methods: Data from 304 geriatric psychiatric inpatients was ... ...

    Title translation Adverse Drug Reactions in Geriatric Psychiatric Patients - Influence of Potentially Inappropriate Drugs.
    Abstract Objective: The purpose of this study was to examine the extent to which "potentially inappropriate drugs" (PID) are associated with an increased risk for adverse drug reactions (ADR).
    Methods: Data from 304 geriatric psychiatric inpatients was collected. Medical documentation was used to find indications of ADRs. Causal relationship between the ADR and the prescribed drugs was assessed by experts.
    Results: Almost 30 % of patients received ≥ 1 PID before admission to hospital, in comparison to 22 % at discharge. Increasing number of total prescriptions and the diagnosis of schizophrenia resulted in an increased risk for receiving ≥ 1 PID. Higher age and dementia were protective factors. Patients receiving ≥ 1 PID had a 5-fold increased risk of experiencing ≥ 1 ADR. Risk for an ADR increased with number of PID prescriptions. Patients treated with ≥ 1 PID had a 4-fold increased risk of experiencing severe ADRs. Risk for severe ADRs was 10-fold higher in patients treated with ≥ 2 PIDs.
    Conclusion: The PRISCUS list predicts significant risk factors for the occurrence of ADRs in the geriatric psychiatric setting.
    MeSH term(s) Aged ; Drug-Related Side Effects and Adverse Reactions ; Germany ; Hospitalization ; Humans ; Inappropriate Prescribing ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language German
    Publishing date 2021-03-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-1394-2412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: „Mild-behavioral-impairment“-Checkliste : Englisch-deutsche Übersetzung und Beurteilung der Anwendbarkeit in klinischer Praxis.

    Dibbern, Pauline / Horsch, Jennifer / Fiegl, Julia / Eckl, Linda / Finger, Tamara / Diermeier, Lisa / Deppe, Markus / Schiekofer, Stephan / Langguth, Berthold / Ismail, Zahinoor / Barinka, Filip

    Zeitschrift fur Gerontologie und Geriatrie

    2023  

    Abstract: Background: The mild behavioral impairment (MBI) syndrome is defined by the emergence in later life of persistent neuropsychiatric symptoms. The MBI checklist (MBI-C) can be used for systematic detection and documentation of such symptoms.: Objective!# ...

    Title translation Mild behavioral impairment checklist : English-German translation and feasibility study assessing its use in clinical practice.
    Abstract Background: The mild behavioral impairment (MBI) syndrome is defined by the emergence in later life of persistent neuropsychiatric symptoms. The MBI checklist (MBI-C) can be used for systematic detection and documentation of such symptoms.
    Objective: Development of a German version of the MBI‑C and assessment of its application in a clinical setting.
    Material and methods: The MBI‑C was translated from English into German in collaboration with the main author of the original version, and its practical application was then tested on a study population (n = 21) in a gerontopsychiatric inpatient clinic. Patient compliance, understanding of questions, time effort, evaluation procedure and possible discrepancy between patient and family member evaluations were assessed.
    Results: The German translation of the original MBI‑C obtained certification as an official version and can be downloaded at https://mbitest.org . All 34 questions were fully completed by the study population, the level of understanding of questions was good, with the mean time effort being 16 min. In some cases, significant differences between patients' and family members' responses were found.
    Discussion: The presence of MBI may indicate the development of an otherwise presymptomatic neurodegenerative dementia syndrome. Hence, the MBI‑C could aid in the early detection of neurodegenerative dementia. By means of the translated version of the MBI‑C presented in this study, this hypothesis can now be tested in German-speaking countries.
    Language German
    Publishing date 2023-06-26
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-023-02200-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Thesis: Demenzen – Vorbereitung für die Laboranalyse des Materials (Blut und Liquor) von Patienten mit verschiedenen Demenzformen

    Röder, Melanie [Verfasser] / Schiekofer, Stephan [Akademischer Betreuer]

    2019  

    Author's details Melanie Röder ; Betreuer: Stephan Schiekofer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Unerwünschte Arzneimittelwirkungen in der Gerontopsychiatrie . Einfluss potenziell inadäquater Wirkstoffe

    Seifert, Johanna / Fay, Bianca / Strueven, Nina Theresa / Schiekofer, Stephan / Wenzel-Seifert, Katharina / Haen, Ekkehard

    Psychiatrische Praxis

    2022  Volume 49, Issue 1, Page(s) 37–45

    Abstract: Ziel der Studie war es zu überprüfen, ob die Verordnung "potenziell inadäquater Wirkstoffe" (PIW) mit einem erhöhten Risiko für unerwünschte Arzneimittelwirkungen (UAW) einhergeht. Methodik: 304 stationäre gerontopsychiatrische Patienten wurden in die ... ...

    Title translation Adverse drug reactions in geriatric psychiatric patients. Influence of potentially inappropriate drugs
    Abstract Ziel der Studie war es zu überprüfen, ob die Verordnung "potenziell inadäquater Wirkstoffe" (PIW) mit einem erhöhten Risiko für unerwünschte Arzneimittelwirkungen (UAW) einhergeht. Methodik: 304 stationäre gerontopsychiatrische Patienten wurden in die Studie eingeschlossen. Anhand der klinischen Daten und Verlaufsdokumentationen wurden Hinweise auf UAW identifiziert. Der Kausalzusammenhang der UAW und der verordneten Wirkstoffe wurde von Experten bewertet. Die potenziell inadäquaten Wirkstoffe (PIW) wurden anhand der PRISCUS-Liste in ihrer Version aus dem Jahr 2010 identifiziert. Ergebnisse: Vor der stationären Aufnahme erhielten etwa 30 % aller Patienten >= 1 PIW, bei Entlassung waren es 22 %. Risikofaktoren für die Verordnung >= 1 PIW waren zunehmende Anzahl verordneter Wirkstoffe und Schizophrenie. Protektiv wirkten die Faktoren Demenz und zunehmendes Lebensalter. Die Verordnung von >= 1 PIW führte zu einem fünffach erhöhten Risiko für das Auftreten von >= 1 UAW; das Risiko für UAW stieg mit der Zahl der PIW. Die Verordnung von >= 1 PIW ging mit einem vierfach erhöhten Risiko für das Auftreten schwerwiegender UAW einher. Bei Einnahme von >= 2 PIW war das Risiko hierfür sogar um ein Zehnfaches erhöht. Schlussfolgerungen: Die PRISCUS-Liste bildet wesentliche Risiken für das Auftreten von UAW in der Gerontopsychiatrie ab.
    Keywords Age Differences ; Altersunterschiede ; Arzneimittelwechselwirkungen ; Dementia ; Demenz ; Drug Interactions ; Drug Therapy ; Geriatric Psychiatry ; Geriatrische Psychiatrie ; Medikamentöse Therapie ; Nebenwirkungen (Drogen und Arzneimittel) ; Patient Safety ; Prescription Drugs ; Protective Factors ; Protektive Faktoren ; Risikofaktoren ; Risk Factors ; Sicherheit von Patientinnen und Patienten ; Side Effects (Drug) ; Verschreibungspflichtige Medikamente
    Language German
    Document type Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-1394-2412
    Database PSYNDEX

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  10. Article: Necrotizing Sarcoid Granulomatosis (NSG): A Diagnostic Pitfall to Watch Out For!

    Schiekofer, Stephan / Zirngibl, Christina / Schneider, Jochen G

    Journal of clinical and diagnostic research : JCDR

    2015  Volume 9, Issue 7, Page(s) OJ02

    Language English
    Publishing date 2015-07-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2015/13328.6228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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