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Article ; Online: Semi-supervised learning towards automated segmentation of PET images with limited annotations: application to lymphoma patients.

Yousefirizi, Fereshteh / Shiri, Isaac / O, Joo Hyun / Bloise, Ingrid / Martineau, Patrick / Wilson, Don / Bénard, François / Sehn, Laurie H / Savage, Kerry J / Zaidi, Habib / Uribe, Carlos F / Rahmim, Arman

Physical and engineering sciences in medicine

2024

Abstract: Manual segmentation poses a time-consuming challenge for disease quantification, therapy evaluation, treatment planning, and outcome prediction. Convolutional neural networks (CNNs) hold promise in accurately identifying tumor locations and boundaries in ...

Abstract	Manual segmentation poses a time-consuming challenge for disease quantification, therapy evaluation, treatment planning, and outcome prediction. Convolutional neural networks (CNNs) hold promise in accurately identifying tumor locations and boundaries in PET scans. However, a major hurdle is the extensive amount of supervised and annotated data necessary for training. To overcome this limitation, this study explores semi-supervised approaches utilizing unlabeled data, specifically focusing on PET images of diffuse large B-cell lymphoma (DLBCL) and primary mediastinal large B-cell lymphoma (PMBCL) obtained from two centers. We considered 2-[
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ISSN	2662-4737
ISSN (online)	2662-4737
DOI	10.1007/s13246-024-01408-x
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Article ; Online: Evolution of Systemic Treatment Uptake and Survival in Advanced Non-Small Cell Lung Cancer.

Stock-Martineau, Sophie / Laurie, Katie / McKinnon, Mathieu / Zhang, Tinghua / Wheatley-Price, Paul

Current oncology (Toronto, Ont.)

2020 Volume 28, Issue 1, Page(s) 60–68

Abstract: Background: Non-small cell lung cancer (NSCLC) commonly presents at advanced stage. We previously reported systemic treatment uptake in stage IV NSCLC climbing from 55% (2009-2012) to 62% (2015-2017). Since then, first-line immunotherapy and 2nd/3rd ... ...

Abstract	Background: Non-small cell lung cancer (NSCLC) commonly presents at advanced stage. We previously reported systemic treatment uptake in stage IV NSCLC climbing from 55% (2009-2012) to 62% (2015-2017). Since then, first-line immunotherapy and 2nd/3rd generation tyrosine kinase inhibitors (TKIs) have emerged as standards of care. We explored whether treatment rates continued to rise and studied outcomes. Methods: We reviewed all cases of de novo stage IIIB/IIIC/IV NSCLC seen in out-patient medical oncology consultation at our institution between 2009-2012 (cohort A), 2015-2017 (cohort B), and June-December 2018 (cohort C). We compared rates of systemic treatment, molecular testing, targeted therapy, and immune checkpoint inhibitor (ICI) use. We compared survival in the overall, treated/untreated, younger and elderly population in cohort A vs. cohort B + C (=cohort D). Results: Cohorts A, B, and C included 528, 463, and 93 patients, respectively. Overall, 66% received any systemic therapy in cohort C, compared to 62% in cohort B and 55% in cohort A. Across three time periods, first-line chemotherapy rates fell (93, 76, 46%) while rates of first-line targeted therapy (5, 16, 15%) and ICI (0, 2, 36%) rose. Among molecular subtypes, first-line targeted treatment in EGFR-positive patients (63, 94, 100%) and anaplastic lymphoma kinase (ALK)-positive patients (0, 91, 100%) rose. Survival improved in all subgroups in cohort D vs. cohort A, except for patients ≥ 70 years and the untreated population. Conclusions: Systemic treatment rose across three time periods, reflecting the introduction of rapid diagnostic pathways, reflex molecular testing, ICI, and targeted therapies. Survival outcomes of advanced NSCLC patients have significantly improved.
MeSH term(s)	Aged ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Cohort Studies ; ErbB Receptors ; Humans ; Immunotherapy ; Lung Neoplasms/drug therapy
Chemical Substances	ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2020-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol28010008
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Article ; Online: Generation of two induced pluripotent stem cell lines (UQACi002-A and UQACi005-A) from two patients with KRT14 epidermolysis bullosa simplex mutations.

Bchetnia, Mbarka / Martineau, Laurie / Racine, Véronique / Powell, Julie / McCuaig, Catherine / Morin, Charles / Dupérée, Audrey / Gros-Louis, François / Laprise, Catherine

Stem cell research

2022 Volume 61, Page(s) 102750

Abstract: More than 107 pathogenic variations were identified in Keratin 14 gene (KRT14) in patients affected by epidermolysis bullosa simplex (EBS), a rare skin disease with still no curative treatment. Disease models as human induced pluripotent stem cells ( ... ...

Abstract	More than 107 pathogenic variations were identified in Keratin 14 gene (KRT14) in patients affected by epidermolysis bullosa simplex (EBS), a rare skin disease with still no curative treatment. Disease models as human induced pluripotent stem cells (hiPSCs) are promising tool for further advance the knowledge about this disorder and accelerate therapies development. Here, two hiPSC lines were reprogrammed from skin fibroblasts of two EBS patients carrying mutations within KRT14 by using CytoTune®Sendai virus. These iPSCs display pluripotent cell morphology, pluripotent markers expression, and the capability to differentiate into the three germ layers.
MeSH term(s)	Epidermolysis Bullosa Simplex/genetics ; Epidermolysis Bullosa Simplex/pathology ; Humans ; Induced Pluripotent Stem Cells/pathology ; Keratin-14/genetics ; Keratin-5/genetics ; Mutation ; Phenotype
Chemical Substances	KRT14 protein, human ; Keratin-14 ; Keratin-5
Language	English
Publishing date	2022-03-14
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2022.102750
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Article ; Online: Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations.

Bchetnia, Mbarka / Martineau, Laurie / Racine, Véronique / Powell, Julie / McCuaig, Catherine / Morin, Charles / Dupérée, Audrey / Gros-Louis, François / Laprise, Catherine

Stem cell research

2022 Volume 60, Page(s) 102726

Abstract: Heterozygous mutations within Keratin 5 (KRT5) are common genetic causes of epidermolysis bullosa simplex (EBS), a skin fragility disorder characterized by blisters, which appear after minor trauma. Using CytoTune®Sendai virus, we generated three human ... ...

Abstract	Heterozygous mutations within Keratin 5 (KRT5) are common genetic causes of epidermolysis bullosa simplex (EBS), a skin fragility disorder characterized by blisters, which appear after minor trauma. Using CytoTune®Sendai virus, we generated three human induced pluripotent stem cell (iPSC) lines from three EBS patients carrying respectively the single heterozygous mutations in KRT5, c.449 T > C, c.980 T > C, and c.608 T > C. All lines display normal karyotype, expressed high levels of pluripotent markers, and can differentiate into derivatives of the three germ layers. These iPSCs are helpful for a better understanding of the EBS pathogenesis and developing novel therapeutic approaches.
MeSH term(s)	Epidermolysis Bullosa Simplex/genetics ; Epidermolysis Bullosa Simplex/pathology ; Heterozygote ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Keratin-5/genetics ; Mutation/genetics
Chemical Substances	KRT5 protein, human ; Keratin-5
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2022.102726
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Article ; Online: Differentiation of lymphoblastoid-derived iPSCs into functional cardiomyocytes, neurons and myoblasts.

Poulin, Hugo / Martineau, Laurie / Racine, Véronique / Puymirat, Jack / Chahine, Mohamed

Biochemical and biophysical research communications

2019 Volume 516, Issue 1, Page(s) 222–228

Abstract: Human induced pluripotent stem cells (hiPSCs) are a valuable tool for investigating complex cellular and molecular events that occur in several human diseases. Importantly, the ability to differentiate hiPSCs into any human cell type provides a unique ... ...

Abstract	Human induced pluripotent stem cells (hiPSCs) are a valuable tool for investigating complex cellular and molecular events that occur in several human diseases. Importantly, the ability to differentiate hiPSCs into any human cell type provides a unique way for investigating disease mechanisms such as complex mental health diseases. The in vitro transformation of human lymphocytes into lymphoblasts (LCLs) using the Epstein-Barr virus (EBV) has been the main method for generating immortalized human cell lines for half a century. However, the derivation of iPSCs from LCLs has emerged as an alternative source from which these cell lines can be generated. We show that iPSCs derived from LCLs using the Sendai virus procedure can be successfully differentiated into cardiomyocytes, neurons, and myotubes that express neuron- and myocyte-specific markers. We further show that these cardiac and neuronal cells are functional and generate action potentials that are required for cell excitability. We conclude that the ability to differentiate LCLs into neurons and myocytes will increase the use of LCLs in the future as a potential source of cells for modelling a number of diseases.
MeSH term(s)	Cell Differentiation ; Cell Line ; Cellular Reprogramming Techniques ; Humans ; Induced Pluripotent Stem Cells/cytology ; Myoblasts/cytology ; Myocytes, Cardiac/cytology ; Neurons/cytology
Language	English
Publishing date	2019-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2019.05.176
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Zs.A 116: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations

Mbarka Bchetnia / Laurie Martineau / Véronique Racine / Julie Powell / Catherine McCuaig / Charles Morin / Audrey Dupérée / François Gros-Louis / Catherine Laprise

Stem Cell Research, Vol 60, Iss , Pp 102726- (2022)

2022

Abstract	Heterozygous mutations within Keratin 5 (KRT5) are common genetic causes of epidermolysis bullosa simplex (EBS), a skin fragility disorder characterized by blisters, which appear after minor trauma. Using CytoTune®Sendai virus, we generated three human induced pluripotent stem cell (iPSC) lines from three EBS patients carrying respectively the single heterozygous mutations in KRT5, c.449 T > C, c.980 T > C, and c.608 T > C. All lines display normal karyotype, expressed high levels of pluripotent markers, and can differentiate into derivatives of the three germ layers. These iPSCs are helpful for a better understanding of the EBS pathogenesis and developing novel therapeutic approaches.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generation of two induced pluripotent stem cell lines (UQACi002-A and UQACi005-A) from two patients with KRT14 epidermolysis bullosa simplex mutations

Mbarka Bchetnia / Laurie Martineau / Véronique Racine / Julie Powell / Catherine McCuaig / Charles Morin / Audrey Dupérée / François Gros-Louis / Catherine Laprise

Stem Cell Research, Vol 61, Iss , Pp 102750- (2022)

2022

Abstract	More than 107 pathogenic variations were identified in Keratin 14 gene (KRT14) in patients affected by epidermolysis bullosa simplex (EBS), a rare skin disease with still no curative treatment. Disease models as human induced pluripotent stem cells (hiPSCs) are promising tool for further advance the knowledge about this disorder and accelerate therapies development. Here, two hiPSC lines were reprogrammed from skin fibroblasts of two EBS patients carrying mutations within KRT14 by using CytoTune®Sendai virus. These iPSCs display pluripotent cell morphology, pluripotent markers expression, and the capability to differentiate into the three germ layers.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer.

Journal for immunotherapy of cancer

2024 Volume 12, Issue 1

Abstract: Introduction: Triple-negative breast cancer (TNBC) prognosis is poor. Immunotherapies to enhance the antibody-induced natural killer (NK) cell antitumor activity are emerging for TNBC that is frequently immunogenic. The aspartic protease cathepsin D ( ... ...

Abstract	Introduction: Triple-negative breast cancer (TNBC) prognosis is poor. Immunotherapies to enhance the antibody-induced natural killer (NK) cell antitumor activity are emerging for TNBC that is frequently immunogenic. The aspartic protease cathepsin D (cath-D), a tumor cell-associated extracellular protein with protumor activity and a poor prognosis marker in TNBC, is a prime target for antibody-based therapy to induce NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC). This study investigated whether Fc-engineered anti-cath-D antibodies trigger ADCC, their impact on antitumor efficacy and tumor-infiltrating NK cells, and their relevance for combinatory therapy in TNBC. Methods: Cath-D expression and localization in TNBC samples were evaluated by western blotting, immunofluorescence, and immunohistochemistry. The binding of human anti-cath-D F1M1 and Fc-engineered antibody variants, which enhance (F1M1-Fc Results: Cath-D expression on the TNBC cell surface could be exploited to induce ADCC. F1M1 Fc-variants recognized human and mouse cath-D. F1M1-Fc Conclusions: F1M1-Fc
MeSH term(s)	Humans ; Animals ; Mice ; Triple Negative Breast Neoplasms/pathology ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Cathepsin D ; Mice, Nude ; Cell Line, Tumor ; Antibody-Dependent Cell Cytotoxicity ; Antineoplastic Agents/therapeutic use ; Killer Cells, Natural ; Immunoglobulin Fc Fragments ; Benzamides ; Nitriles ; Phenylthiohydantoin
Chemical Substances	enzalutamide (93T0T9GKNU) ; Paclitaxel (P88XT4IS4D) ; Cathepsin D (EC 3.4.23.5) ; Antineoplastic Agents ; Immunoglobulin Fc Fragments ; Benzamides ; Nitriles ; Phenylthiohydantoin (2010-15-3)
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-007135
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Article ; Online: Lymphoblastoids cell lines – Derived iPSC line from a 26-year-old myotonic dystrophy type 1 patient carrying (CTG)200 expansion in the DMPK gene

Laurie Martineau / Véronique Racine / Siham Ait Benichou / Jack Puymirat

Stem Cell Research, Vol 26, Iss , Pp 103-

CHUQi001-A

2018 Volume 106

Abstract: Human immortalized Epstein-Barr virus (EBV) lymphoblastoids cells line (LCLs) from a 26-year- old male affected by an adult form of myotonic dystrophy type 1 (DM1) disease and carrying 200 CTG repeats mutation in the blood was used to generate induced ... ...

Abstract	Human immortalized Epstein-Barr virus (EBV) lymphoblastoids cells line (LCLs) from a 26-year- old male affected by an adult form of myotonic dystrophy type 1 (DM1) disease and carrying 200 CTG repeats mutation in the blood was used to generate induced pluripotent stem cells (iPSCs) using the Sendai virus expressing KLF4, OCT4, SOX2 and C-MYC. The resulting iPSCs were EBV free, expressed the pluripotency markers, could be differentiated into the three germ layers in vitro, had a normal karyotype, and retained the genetic DM1 mutation. This iPSC line could be useful for the investigation of DM1 mechanisms.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lymphoblastoids cell lines - Derived iPSC line from a 26-year-old myotonic dystrophy type 1 patient carrying (CTG)

Martineau, Laurie / Racine, Véronique / Benichou, Siham Ait / Puymirat, Jack

Stem cell research

2017 Volume 26, Page(s) 103–106

Abstract	Human immortalized Epstein-Barr virus (EBV) lymphoblastoids cells line (LCLs) from a 26-year- old male affected by an adult form of myotonic dystrophy type 1 (DM1) disease and carrying 200 CTG repeats mutation in the blood was used to generate induced pluripotent stem cells (iPSCs) using the Sendai virus expressing KLF4, OCT4, SOX2 and C-MYC. The resulting iPSCs were EBV free, expressed the pluripotency markers, could be differentiated into the three germ layers in vitro, had a normal karyotype, and retained the genetic DM1 mutation. This iPSC line could be useful for the investigation of DM1 mechanisms.
MeSH term(s)	Adult ; Biomarkers/metabolism ; Cell Differentiation ; Cell Line ; Cells, Cultured ; Cellular Reprogramming ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Male ; Myotonic Dystrophy/metabolism ; Myotonic Dystrophy/pathology ; Myotonin-Protein Kinase/genetics ; Trinucleotide Repeat Expansion
Chemical Substances	Biomarkers ; DMPK protein, human ; Myotonin-Protein Kinase (EC 2.7.11.1)
Language	English
Publishing date	2017-12-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1876-7753
ISSN (online)	1876-7753
DOI	10.1016/j.scr.2017.12.010
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