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Article ; Online: ECG, July 2015.

Tello-Montoliu, Antonio

Revista espanola de cardiologia (English ed.)

2015 Volume 68, Issue 7, Page(s) 627

Language	English
Publishing date	2015-07
Publishing country	Spain
Document type	Journal Article
ISSN	1885-5857
ISSN (online)	1885-5857
DOI	10.1016/j.rec.2014.08.022
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Article ; Online: Simplified Geleijnse score for identifying chest pain features associated with coronary ischemia.

Ding, Wern Yew / Romero-Aniorte, Ana Isabel / Tello-Montoliu, Antonio / Gil-Pérez, Pablo / López-García, Cecilia / Veliz-Martínez, Andrea / Quintana-Giner, Miriam / Lip, Gregory Y H / Rivera-Caravaca, José Miguel / Marín, Francisco

Heart & lung : the journal of critical care

2023 Volume 59, Page(s) 61–66

Abstract: Background: The Geleijnse score, which was proposed to assess for coronary ischemia, has practical limitations.: Objectives: Our aim was to design and evaluate a simplified version of the Geleijnse score.: Methods: We enrolled patients with ... ...

Abstract	Background: The Geleijnse score, which was proposed to assess for coronary ischemia, has practical limitations. Objectives: Our aim was to design and evaluate a simplified version of the Geleijnse score. Methods: We enrolled patients with suspected coronary heart disease but negative troponin T or absence of enzymatic curve, and a non-diagnostic 12-lead ECG. The initial study was performed in a retrospective derivation cohort and the results were subsequently validated in a prospective cohort. Results: From 109 patients included in the derivation cohort, 33 (30.3%) received a diagnosis of coronary heart disease. Chest pain with both arms radiation (OR 3.54), severe intensity (OR 2.41), improvement by nitroglycerin (OR 1.61), associated dyspnea (OR 1.97) and prior exertional angina history (OR 2.91) were independently associated with an ischemic origin on multivariate logistic regression analysis. ROC curves comparison demonstrated both the original and simplified scores presented modest predictive ability with significant difference when analyzed using dichotomous cut-offs (0.647 [simplified] vs. 0.544 [original], p = 0.042) but not as a continuous variable (0.670 [simplified] vs. 0.621 [original], p = 0.396). In 305 patients from the validation cohort, the simplified score presented extensively increased predictive accuracy than the Geleijnse, in the continuous (c-indexes = 0.735 vs. 0.685, p = 0.040) and the dichotomic (c-indexes = 0.682 vs. 0.514, p<0.001) forms. Conclusions: A simplified version of the Geleijnse score, including some routine clinical manifestations associated with coronary heart disease, presented significantly better predictive ability compared to the original score.
MeSH term(s)	Humans ; Prospective Studies ; Retrospective Studies ; Chest Pain/diagnosis ; Chest Pain/etiology ; Coronary Disease ; Electrocardiography/methods ; Emergency Service, Hospital
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2023.01.010
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Article: Impact of renal function on Ticagrelor-induced antiplatelet effects in coronary artery disease patients.

Porlán, Manuel Veas / Tello-Montoliu, Antonio / López-García, Cecilia / Gil-Pérez, Pablo / Quintana-Giner, Miriam / López-Gálvez, Raquel / Rivera-Caravaca, José Miguel / Marín, Francisco / Figal, Domingo Pascual

International journal of cardiology. Heart & vasculature

2023 Volume 46, Page(s) 101195

Abstract: Background: Chronic renal failure (CKD) is associated with the presence of increased platelet reactivity and lower clinical benefit of clopidogrel. Ticagrelor has a more favorable pharmacodynamic and pharmacokinetic profile compared to clopidogrel, ... ...

Abstract	Background: Chronic renal failure (CKD) is associated with the presence of increased platelet reactivity and lower clinical benefit of clopidogrel. Ticagrelor has a more favorable pharmacodynamic and pharmacokinetic profile compared to clopidogrel, which has translated into better clinical outcomes in patients with acute coronary syndrome (ACS). We conducted a prospective mechanistic cohort study in order to investigate the impact of renal failure on the pharmacokinetics and pharmacodynamics of ticagrelor in patients with acute ACS. Methods: Patients were divided into two groups based on their estimated renal clearances (eGFR ≥ 60 mL/min and eGFR < 60 mL/min). Platelet function was determined using the VerifyNow system at baseline, after the ticagrelor loading dose and at discharge. In addition, levels of ticagrelor and its active metabolite (AR-C124910XX) were determined in the first hour after loading dose. Results: 48 patients were recruited (eGFR ≥ 60 mL/min: 35 and eGFR < 60 mL/min: 13). There were no significant differences between the groups in terms of platelet inhibition after the loading or after 7 days of treatment (p = 0.219). However, the levels of ticagrelor and its active metabolite were lower in subjects with normal renal function than in CKD, especially at 4 (p = 0.02 and 0.04 respectively) and 6 h of loading (p = 0.042 and 0.08 respectively). Conclusion: No differences in platelet inhibition were observed after treatment with ticagrelor in patients with different renal function, although patients with renal impairment showed higher levels of ticagrelor and AR-C124910XX after 4 h of the loading dose.
Language	English
Publishing date	2023-03-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2023.101195
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Article ; Online: Nuevos antiagregantes plaquetarios en cardiopatía isquémica.

Tello-Montoliu, Antonio / Jover, Eva / Valdés, Mariano

Medicina clinica

2014 Volume 143, Issue 11, Page(s) 508–514

Abstract: The dual antiplatelet therapy with acetylsalicylic acid and clopidogrel has been the mainstay of both acute and chronic phase coronary artery disease, reducing importantly the risk of adverse events. Despite a correct compliance, a non-negligible rate of ...

Title translation	New antiplatelet drugs in coronary artery disease.
Abstract	The dual antiplatelet therapy with acetylsalicylic acid and clopidogrel has been the mainstay of both acute and chronic phase coronary artery disease, reducing importantly the risk of adverse events. Despite a correct compliance, a non-negligible rate of adverse events still happens. New compounds, with improved properties, are now clinically available (such as prasugrel or ticagrelor) or under advanced development. The aim of the present review is the description of these new compounds, particularly prasugrel and ticagrelor.
MeSH term(s)	Adenosine/adverse effects ; Adenosine/analogs & derivatives ; Adenosine/pharmacology ; Adenosine/therapeutic use ; Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Adenosine Monophosphate/therapeutic use ; Clinical Trials, Phase III as Topic ; Coronary Artery Disease/drug therapy ; Double-Blind Method ; Dyspnea/chemically induced ; Hemorrhage/chemically induced ; Humans ; Multicenter Studies as Topic ; Piperazines/adverse effects ; Piperazines/pharmacology ; Piperazines/therapeutic use ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/classification ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Prasugrel Hydrochloride ; Randomized Controlled Trials as Topic ; Receptors, Proteinase-Activated/antagonists & inhibitors ; Thiophenes/adverse effects ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Treatment Outcome
Chemical Substances	Piperazines ; Platelet Aggregation Inhibitors ; Receptors, Proteinase-Activated ; Thiophenes ; Adenosine Monophosphate (415SHH325A) ; cangrelor (6AQ1Y404U7) ; Prasugrel Hydrochloride (G89JQ59I13) ; Ticagrelor (GLH0314RVC) ; Adenosine (K72T3FS567)
Language	Spanish
Publishing date	2014-12-09
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2013.12.006
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Article: Effect of cocoa (

Seecheran, Naveen Anand / Sukha, Darin / Grimaldos, Kathryn / Grimaldos, Gabriella / Richard, Srivane / Ishmael, Aleena / Gomes, Ceylon / Kampradi, Lirmala / Seecheran, Rajeev / Seecheran, Valmiki / Peram, Lakshmipathi / Dookeeram, Darren / Giddings, Stanley / Sandy, Sherry / Ramlackhansingh, Anil / Raza, Sadi / Umaharan, Pathmanathan / Tello-Montoliu, Antonio / Schneider, David

Open heart

2022 Volume 9, Issue 2

Abstract: Introduction: This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (: Methods: Patients with stable coronary artery disease (CAD) (n=20) who were on maintenance dual ... ...

Abstract	Introduction: This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) ( Methods: Patients with stable coronary artery disease (CAD) (n=20) who were on maintenance dual antiplatelet therapy of aspirin (ASA) 81 mg/day and clopidogrel 75 mg/day were recruited. Platelet function was evaluated with the VerifyNow P2Y Results: Cocoa augmented the inhibitory effect of clopidogrel, demonstrated by a reduction of 11.9% (95% CI 5.7% to 18.0%, p value 0.001), significantly decreasing the PRU by 26.85 (95% CI 12.22 to 41.48, p value 0.001). The inhibitory effect of ASA was not impacted by cocoa, reflected by a non-significant reduction in ARU of 17.65 (95% CI 21.00 to 56.3, p value 0.351). No patients experienced any serious adverse events. Conclusions: Cocoa augmented the inhibitory effect of clopidogrel but not ASA. This nutraceutical study could be potentially informative and applicable for patients with stable CAD. Further long-term studies are required to confirm these exploratory findings. Trial registration number: NCT04554901.
MeSH term(s)	Aspirin/therapeutic use ; Cacao ; Chocolate ; Clopidogrel ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/drug therapy ; Humans ; Pilot Projects ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Prospective Studies ; Ticlopidine/pharmacology
Chemical Substances	Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-09-13
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2747269-3
ISSN	2053-3624
ISSN	2053-3624
DOI	10.1136/openhrt-2022-002066
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Article ; Online: Reply: The REAC-TAVI Trial: Better Antiplatelet Therapy, Less Haze on the Horizon.

Jimenez Diaz, Victor Alfonso / Tello-Montoliu, Antonio / Moreno, Raul / Cruz Gonzalez, Ignacio / Iñiguez Romo, Andres

JACC. Cardiovascular interventions

2019 Volume 12, Issue 8, Page(s) 803–804

MeSH term(s)	Aortic Valve Stenosis/surgery ; Blood Platelets ; Humans ; Platelet Aggregation Inhibitors ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2019.02.038
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Article ; Online: Antithrombotic Therapy in Patients with Peripheral Artery Disease: A Focused Review on Oral Anticoagulation.

Rivera-Caravaca, José Miguel / Camelo-Castillo, Anny / Ramírez-Macías, Inmaculada / Gil-Pérez, Pablo / López-García, Cecilia / Esteve-Pastor, María Asunción / Orenes-Piñero, Esteban / Tello-Montoliu, Antonio / Marín, Francisco

International journal of molecular sciences

2021 Volume 22, Issue 13

Abstract: Peripheral artery disease (PAD) is a major cause of morbidity and mortality but it is usually underdiagnosed and undertreated. Patients with PAD present dysregulated procoagulant, anticoagulant, and fibrinolytic pathways leading to arterial and venous ... ...

Abstract	Peripheral artery disease (PAD) is a major cause of morbidity and mortality but it is usually underdiagnosed and undertreated. Patients with PAD present dysregulated procoagulant, anticoagulant, and fibrinolytic pathways leading to arterial and venous thrombosis. The risk of several ischemic-related complications could be mitigated with appropriate antithrombotic therapy, which plays a central role in all types of PAD. For years, antiplatelets have been indicated in patients with symptomatic PAD or those who have undergone revascularization. Unfortunately, a non-negligible proportion of patients with PAD will suffer from adverse events during the follow-up, even despite proper medical therapies for the prevention of PAD complications. Thus, there is room for improving clinical outcomes in these patients. Given the implication of both, primary and secondary hemostasis in arterial thrombosis and the pathophysiology of PAD, the combination of antiplatelets and anticoagulants has emerged as a potential antithrombotic alternative to antiplatelets alone. In this narrative review article, we have highlighted the most recent evidence about antithrombotic therapy in PAD patients, with a special focus on oral anticoagulation. Certainly, COMPASS and VOYAGER PAD trials have shown promising results. Thus, rivaroxaban in combination with aspirin seem to reduce cardiovascular outcomes with a similar bleeding risk compared to aspirin alone. Nevertheless, results from real-world studies are needed to confirm these observations, and other trials will provide novel evidence about the safety and efficacy of emerging anticoagulant agents.
MeSH term(s)	Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Blood Coagulation/drug effects ; Drug Therapy, Combination ; Factor Xa Inhibitors/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Humans ; Peripheral Arterial Disease/drug therapy ; Platelet Aggregation Inhibitors/therapeutic use ; Rivaroxaban/therapeutic use ; Thrombolytic Therapy ; Thrombosis/drug therapy
Chemical Substances	Anticoagulants ; Factor Xa Inhibitors ; Fibrinolytic Agents ; Platelet Aggregation Inhibitors ; Rivaroxaban (9NDF7JZ4M3) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2021-07-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22137113
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Article: Biomarcadores en la estratificación del riesgo del síndrome coronario agudo sin elevación del segmento ST: ¿hay algo más después de la troponina?

Tello-Montoliu, Antonio / Marín, Francisco

Medicina clinica

2009 Volume 133, Issue 15, Page(s) 586–588

Title translation	Biomarkers in risk stratification of acute coronary syndrome without ST elevation: is there anything after troponin?.
MeSH term(s)	Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/epidemiology ; Biomarkers/blood ; Humans ; Natriuretic Peptides/blood ; Risk Assessment ; Troponin/blood
Chemical Substances	Biomarkers ; Natriuretic Peptides ; Troponin
Language	Spanish
Publishing date	2009-10-24
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2009.07.015
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Article ; Online: Successful pregnancy and delivery on prasugrel treatment: considerations for the use of dual antiplatelet therapy during pregnancy in clinical practice.

Tello-Montoliu, Antonio / Seecheran, Naveen A / Angiolillo, Dominick J

Journal of thrombosis and thrombolysis

2012 Volume 36, Issue 3, Page(s) 348–351

Abstract: Ischemic heart disease is uncommon during pregnancy, occurring in approximately 1/10,000 pregnancies resulting in live births. However, the increased age and fertility of mothers has suggested that the coexistence of pregnancy and coronary artery disease ...

Abstract	Ischemic heart disease is uncommon during pregnancy, occurring in approximately 1/10,000 pregnancies resulting in live births. However, the increased age and fertility of mothers has suggested that the coexistence of pregnancy and coronary artery disease is likely to increase. A subject of debate is the management of dual antiplatelet therapy among pregnant women. The potential teratogeneous effects, particularly with regards to thienopyridines, on the fetus are not fully established. In addition, the use of dual antiplatelet therapy is associated with an increased risk for bleeding events, raising concerns in the peripartum period with regards to the route of delivery and choice of anesthestic techniques. Limited data and experience is available with clopidogrel, the most commonly used thienopyridine. Prasugrel is third generation thienopyridine recently introduced into clinical practice with ever growing use in the setting of acute coronary syndrome patients undergoing percutaneous coronary interventions. The present manuscript describes the first case report of a pregnancy while on prasugrel therapy.
MeSH term(s)	Adult ; Female ; Humans ; Live Birth ; Myocardial Ischemia/drug therapy ; Piperazines/administration & dosage ; Platelet Aggregation Inhibitors/administration & dosage ; Prasugrel Hydrochloride ; Pregnancy ; Pregnancy Complications, Cardiovascular/drug therapy ; Purinergic P2Y Receptor Antagonists/administration & dosage ; Thiophenes/administration & dosage
Chemical Substances	Piperazines ; Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Thiophenes ; Prasugrel Hydrochloride (G89JQ59I13)
Language	English
Publishing date	2012-11-10
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-012-0830-7
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Article ; Online: Cardiovascular considerations on recreational scuba diving. SEC-Clinical Cardiology Association/SEC-Working Group on Sports Cardiology consensus document.

Tello Montoliu, Antonio / Olea González, Agustín / Pujante Escudero, Ángel / Martínez Del Villar, María / de la Guía Galipienso, Fernando / Díaz González, Leonel / Fernández Olmo, Rosa / Freixa-Pamias, Román / Vivas Balcones, David

Revista espanola de cardiologia (English ed.)

2024

Abstract: The practice of recreational scuba diving has increased worldwide, with millions of people taking part each year. The aquatic environment is a hostile setting that requires human physiology to adapt by undergoing a series of changes that stress the body. ...

Abstract	The practice of recreational scuba diving has increased worldwide, with millions of people taking part each year. The aquatic environment is a hostile setting that requires human physiology to adapt by undergoing a series of changes that stress the body. Therefore, physical fitness and control of cardiovascular risk factors are essential for practicing this sport. Medical assessment is not mandatory before participating in this sport and is only required when recommended by a health questionnaire designed for this purpose. However, due to the significance of cardiovascular disease, cardiology consultations are becoming more frequent. The aim of the present consensus document is to describe the cardiovascular physiological changes that occur during diving, focusing on related cardiovascular diseases, their management, and follow-up recommendations. The assessment and follow-up of individuals who practice diving with previous cardiovascular disease are also discussed. This document, endorsed by the Clinical Cardiology Association of the Spanish Society of Cardiology (SEC) and the SEC Working Group on Sports Cardiology of the Association of Preventive Cardiology, aims to assist both cardiologists in evaluating patients, as well as other specialists responsible for assessing individuals' fitness for diving practice.
Language	Spanish
Publishing date	2024-04-03
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2024.04.001
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