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Article ; Online: Latest Knowledge on the Role of Vitamin D in Hypertension.

Jensen, Niklas S / Wehland, Markus / Wise, Petra M / Grimm, Daniela

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: ... available. Vitamin D (vitD) is known best for its role in bone and mineral homeostasis. Studies with vitamin ... D receptor (VDR) knockout mice show an increased renin-angiotensin-aldosterone system (RAAS ...

Abstract	Hypertension is the third leading cause of the global disease burden, and while populations live longer, adopt more sedentary lifestyles, and become less economically concerned, the prevalence of hypertension is expected to increase. Pathologically elevated blood pressure (BP) is the strongest risk factor for cardiovascular disease (CVD) and related disability, thus making it imperative to treat this disease. Effective standard pharmacological treatments, i.e., diuretics, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blocker (ARBs), beta-adrenergic receptor blockers (BARBs), and calcium channel blockers (CCBs), are available. Vitamin D (vitD) is known best for its role in bone and mineral homeostasis. Studies with vitamin D receptor (VDR) knockout mice show an increased renin-angiotensin-aldosterone system (RAAS) activity and increased hypertension, suggesting a key role for vitD as a potential antihypertensive agent. Similar studies in humans displayed ambiguous and mixed results. No direct antihypertensive effect was shown, nor a significant impact on the human RAAS. Interestingly, human studies supplementing vitD with other antihypertensive agents reported more promising results. VitD is considered a safe supplement, proposing its great potential as antihypertensive supplement. The aim of this review is to examine the current knowledge about vitD and its role in the treatment of hypertension.
MeSH term(s)	Animals ; Humans ; Mice ; Adrenergic beta-Antagonists/pharmacology ; Adrenergic beta-Antagonists/therapeutic use ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Hypertension/therapy ; Renin-Angiotensin System ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Receptors, Calcitriol/genetics ; Bone Density Conservation Agents/pharmacology ; Bone Density Conservation Agents/therapeutic use
Chemical Substances	Adrenergic beta-Antagonists ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Calcium Channel Blockers ; Vitamin D (1406-16-2) ; Receptors, Calcitriol ; Bone Density Conservation Agents
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054679
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Determination of 24,25-dihydroxyvitamin D

Wise, Stephen A / Hahm, Grace / Burdette, Carolyn Q / Tai, Susan S-C / Camara, Johanna E / Sempos, Christopher T / Williams, Emma L

The Journal of steroid biochemistry and molecular biology

2023 Volume 231, Page(s) 106318

Abstract: Ninety archived human serum samples from the Vitamin D External Quality Assessment Scheme (DEQAS ... liquid chromatography - tandem mass spectrometry (ID LC-MS/MS) for the determination of 24,25-dihydroxyvitamin D ...

Abstract	Ninety archived human serum samples from the Vitamin D External Quality Assessment Scheme (DEQAS) were analyzed using a reference measurement procedure (RMP) based on isotope dilution liquid chromatography - tandem mass spectrometry (ID LC-MS/MS) for the determination of 24,25-dihydroxyvitamin D
MeSH term(s)	Humans ; Chromatography, Liquid ; Tandem Mass Spectrometry/methods ; Vitamin D ; Vitamins ; Calcifediol ; 24,25-Dihydroxyvitamin D 3
Chemical Substances	24,25-dihydroxyvitamin D ; Vitamin D (1406-16-2) ; Vitamins ; Calcifediol (P6YZ13C99Q) ; 24,25-Dihydroxyvitamin D 3 (40013-87-4)
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2023.106318
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Article ; Online: Variation in Isolate Virulence and Accession Resistance Associated with Diaporthe aspalathi, D. caulivora, and D. longicolla in Soybean

Mohan, Karthika / Kontz, Brian / Okello, Paul / Allen, Tom W. / Bergstrom, Gary C. / Bissonnette, Kaitlyn / Bonkowski, John / Bradley, Carl A. / Buck, James / Chilvers, Martin I. / Dorrance, Anne / Giesler, Loren / Kelly, Heather / Koehler, Alyssa / Lopez-Nicora, Horacio D. / Mangel, Dylan / Markell, Samuel G. / Mueller, Daren / Price III, Paul P. /

Rojas, Alejandro / Shires, Madalyn / Smith, Damon / Spurlock, Terry / Webster, Richard W. / Wise, Kiersten / Yabwalo, Dalitso / Mathew, Febina M.

Plant Health Progress. 2023 Dec., v. 24, no. 4 p.482-487

2023

Abstract: ... D. caulivora, and D. longicolla reduce yield in the United States. Sources of resistance ... from the USDA Soybean Germplasm Collection with reported resistance to D. aspalathi, D. caulivora, or D ... to moderately correlated with those of the D. aspalathi-susceptible ‘Bragg’, as well as for ‘PI567473B’ and ...

Abstract	Important stem and grain diseases of soybean (Glycine max [L.] Merr.) caused by Diaporthe aspalathi, D. caulivora, and D. longicolla reduce yield in the United States. Sources of resistance to these pathogens have previously been reported; however, there is limited information regarding their resistance when exposed to geographically distinct isolates of the same species. In this study, four accessions from the USDA Soybean Germplasm Collection with reported resistance to D. aspalathi, D. caulivora, or D. longicolla were evaluated using geographically representative isolates within each species from the United States. For each fungus, a greenhouse experiment was conducted as a completely randomized design with a factorial arrangement (isolate × accession). Plants were inoculated at the second to third trifoliate growth stage using toothpicks infested with isolates of each Diaporthe species. Pathogenicity was assessed 21 days postinoculation as 0 = no lesion, 0.5 = lesion length > 1 cm, and 1 = dead plant. A significant isolate-by-accession interaction (P < 0.05) was observed to affect pathogenicity as analyzed using nonparametric statistics (relative treatment effects [RTEs]), indicating that accessions responded differently to the isolates. Correlation analyses suggested that the RTEs on ‘Tracy-M’, ‘Dowling’, and ‘Crockett’ were weakly to moderately correlated with those of the D. aspalathi-susceptible ‘Bragg’, as well as for ‘PI567473B’ and ‘Century’ (D. caulivora), and ‘PI417507’ (D. longicolla), with the RTEs on ‘Hawkeye’ (P > 0.05) indicating possible genetic variation for resistance within these accessions. Our results provide information related to the resistance of previously identified accessions to develop commercial cultivars with resistance to important pathogens within the genus Diaporthe. Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license.
Keywords	Diaporthe ; Glycine max ; USDA ; cultivars ; developmental stages ; fungi ; genetic variation ; germplasm conservation ; greenhouse experimentation ; plant health ; soybeans ; statistics ; virulence ; pod and stem blight ; stem canker
Language	English
Dates of publication	2023-12
Size	p. 482-487.
Publishing place	The American Phytopathological Society
Document type	Article ; Online
ISSN	1535-1025
DOI	10.1094/PHP-04-23-0041-RS
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evolution and impact of Standard Reference Materials (SRMs) for determining vitamin D metabolites.

Wise, Stephen A / Kuszak, Adam J / Camara, Johanna E

Analytical and bioanalytical chemistry

2024 Volume 416, Issue 9, Page(s) 2335–2358

Abstract: ... Material® (SRM) for determining vitamin D metabolites in 2009 motivated by significant concerns ... about the comparability and accuracy of different assays to assess vitamin D status. After 14 years, a suite of five serum ... matrix SRMs and three calibration solution SRMs are available. Values were also assigned for vitamin D ...

Abstract	The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health, Office of Dietary Supplements (NIH ODS), introduced the first Standard Reference Material® (SRM) for determining vitamin D metabolites in 2009 motivated by significant concerns about the comparability and accuracy of different assays to assess vitamin D status. After 14 years, a suite of five serum matrix SRMs and three calibration solution SRMs are available. Values were also assigned for vitamin D metabolites in five additional SRMs intended primarily to support measurements of other clinical diagnostic markers. Both the SRMs and the certification approach have evolved from significant exogenous serum content to primarily endogenous content and from value assignment by combining the results of multiple analytical methods to the use of measurements exclusively from reference measurement procedures (RMPs). The impact of the availability of these SRMs can be assessed by both the distribution information (sales) and by reports in the scientific literature describing their use for method validation, quality control, and research. In this review, we describe the development of these SRMs, the evolution in design and value assignment, the expansion of information reported, and SRM use in validating analytical methods and providing quality assurance within the vitamin D measurement community.
MeSH term(s)	Vitamin D ; Vitamins ; Quality Control ; Reference Standards ; Dietary Supplements/analysis
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2024-01-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-024-05143-w
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Article ; Online: Latest Knowledge on the Role of Vitamin D in Hypertension

Niklas S. Jensen / Markus Wehland / Petra M. Wise / Daniela Grimm

International Journal of Molecular Sciences, Vol 24, Iss 4679, p

2023 Volume 4679

Abstract	Hypertension is the third leading cause of the global disease burden, and while populations live longer, adopt more sedentary lifestyles, and become less economically concerned, the prevalence of hypertension is expected to increase. Pathologically elevated blood pressure (BP) is the strongest risk factor for cardiovascular disease (CVD) and related disability, thus making it imperative to treat this disease. Effective standard pharmacological treatments, i.e., diuretics, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blocker (ARBs), beta-adrenergic receptor blockers (BARBs), and calcium channel blockers (CCBs), are available. Vitamin D (vitD) is known best for its role in bone and mineral homeostasis. Studies with vitamin D receptor (VDR) knockout mice show an increased renin–angiotensin–aldosterone system (RAAS) activity and increased hypertension, suggesting a key role for vitD as a potential antihypertensive agent. Similar studies in humans displayed ambiguous and mixed results. No direct antihypertensive effect was shown, nor a significant impact on the human RAAS. Interestingly, human studies supplementing vitD with other antihypertensive agents reported more promising results. VitD is considered a safe supplement, proposing its great potential as antihypertensive supplement. The aim of this review is to examine the current knowledge about vitD and its role in the treatment of hypertension.
Keywords	vitamin D ; vitamin D deficiency ; hypertension ; antihypertensive treatment ; supplement ; clinical trials ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of serum total 25-hydroxyvitamin D assay commutability of Standard Reference Materials and College of American Pathologists Accuracy-Based Vitamin D (ABVD) Scheme and Vitamin D External Quality Assessment Scheme (DEQAS) materials: Vitamin D Standardization Program (VDSP) Commutability Study 2.

Camara, Johanna E / Wise, Stephen A / Hoofnagle, Andrew N / Williams, Emma L / Carter, Graham D / Jones, Julia / Burdette, Carolyn Q / Hahm, Grace / Nalin, Federica / Kuszak, Adam J / Merkel, Joyce / Durazo-Arvizu, Ramón A / Lukas, Pierre / Cavalier, Étienne / Popp, Christian / Beckert, Christian / Schultess, Jan / Van Slooten, Glen / Tourneur, Carole /

Pease, Camille / Kaul, Ravi / Villarreal, Alfredo / Ivison, Fiona / Fischer, Ralf / van den Ouweland, Jody M W / Ho, Chung S / Law, Emmett W K / Simard, Jean-Nicolas / Gonthier, Renaud / Holmquist, Brett / Batista, Marcelo Cidade / Pham, Heather / Bennett, Alex / Meadows, Sarah / Cox, Lorna / Jansen, Eugene / Khan, Dilshad Ahmed / Robyak, Kimberly / Creer, Michael H / Kilbane, Mark / Twomey, Patrick J / Freeman, James / Parker, Neil / Yuan, Jinyun / Fitzgerald, Robert / Mushtaq, Sohail / Clarke, Michael W / Breen, Norma / Simpson, Christine / Sempos, Christopher T

Analytical and bioanalytical chemistry

2021 Volume 413, Issue 20, Page(s) 5067–5084

Abstract: An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP ... assessment (PT/EQA) samples for determination of serum total 25-hydroxyvitamin D [25(OH)D] using ligand ... serum samples were assigned target values for 25-hydroxyvitamin D ...

Abstract	An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP) to assess commutability of Standard Reference Materials® (SRMs) and proficiency testing/external quality assessment (PT/EQA) samples for determination of serum total 25-hydroxyvitamin D [25(OH)D] using ligand binding assays and liquid chromatography-tandem mass spectrometry (LC-MS/MS). A set of 50 single-donor serum samples were assigned target values for 25-hydroxyvitamin D
MeSH term(s)	Humans ; Reference Standards ; Societies, Medical/standards ; Specimen Handling ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/chemistry
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-06-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-021-03470-w
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Article ; Online: Vitamin D and uterine fibroid growth, incidence, and loss: a prospective ultrasound study.

Harmon, Quaker E / Patchel, Stacy A / Denslow, Sheri / LaPorte, Frankie / Cooper, Tracy / Wise, Lauren A / Wegienka, Ganesa / Baird, Donna D

Fertility and sterility

2022 Volume 118, Issue 6, Page(s) 1127–1136

Abstract: ... priority. We studied the association between serum vitamin D and uterine fibroid growth, incidence, and ... 5 years to conduct standardized ultrasounds, measure 25-hydroxyvitamin D (25(OH)D), and update ... Serum 25(OH)D measured using immunoassay or liquid chromatography-tandem mass spectrometry.: Main ...

Abstract	Objective: Fibroid treatments that have few side-effects and can preserve fertility are a clinical priority. We studied the association between serum vitamin D and uterine fibroid growth, incidence, and loss. Design: A prospective community cohort study (enrollment 2010-2012) with 4 study visits over 5 years to conduct standardized ultrasounds, measure 25-hydroxyvitamin D (25(OH)D), and update covariates. Setting: Detroit, Michigan area. Patients: Self-identified African American or Black women aged 23-35 at enrollment without previous clinical diagnosis of fibroids. Intervention(s): Serum 25(OH)D measured using immunoassay or liquid chromatography-tandem mass spectrometry. Main outcome measure(s): The primary outcomes were fibroid growth, as measured by change in log volume per 18 months, and fibroid incidence (first detection of fibroid in previously fibroid-free uterus). Adjusted growth estimates from linear mixed models were converted to estimated difference in volume for high vs. low 25(OH)D. Incidence differences were estimated as hazard ratios from age-specific Cox regression. A secondary outcome fibroid loss (reduction in fibroid number between visits), was modeled using Poisson regression. Covariates (reproductive and hormonal variables, demographics, body mass index, current smoking) and 25(OH)D were modeled as time-varying factors. Result(s): At enrollment among 1,610 participants with ≥1 follow-up ultrasound, mean age was 29.2 years, 73% had deficient vitamin D (<20ng/mL), and only 7% had sufficient vitamin D (≥30ng/mL). Serum 25(OH)D ≥20ng/mL compared with <20ng/mL was associated with an estimated 9.7% reduction in fibroid growth (95% confidence interval [CI]: -17.3%, -1.3%), similar to the minimally adjusted estimate -8.4% (95% CI: -16.4, 0.3). Serum 25(OH)D ≥30ng/mL compared with <30ng/mL was associated with an imprecise 22% reduction in incidence (adjusted hazard ratio=0.78; 95% CI: 0.47, 1.30), similar to the unadjusted estimate of 0.84 (95% CI: 0.51, 1.39). The >30ng/mL group also had a 32% increase in fibroid loss (adjusted risk ratio=1.32; 95% CI: 0.95, 1.83). Conclusion(s): Our data support the hypothesis that high concentrations of vitamin D decrease fibroid development but are limited by the few participants with serum 25(OH)D ≥30ng/mL. Interventional trials that raise and maintain 25(OH)D concentrations >30ng/mL and then prospectively monitor fibroid development are needed to further assess supplemental vitamin D efficacy and determine optimal treatment protocols.
MeSH term(s)	Humans ; Female ; Adult ; Uterine Neoplasms/diagnostic imaging ; Uterine Neoplasms/epidemiology ; Prospective Studies ; Cohort Studies ; Leiomyoma/diagnostic imaging ; Leiomyoma/epidemiology ; Leiomyoma/drug therapy ; Vitamin D ; Vitamins
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, American Recovery and Reinvestment Act ; Research Support, N.I.H., Intramural
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2022.08.851
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Article ; Online: Assessment of serum total 25-hydroxyvitamin D assays for Vitamin D External Quality Assessment Scheme (DEQAS) materials distributed at ambient and frozen conditions.

Sempos, Christopher T / Williams, Emma L / Carter, Graham D / Jones, Julia / Camara, Johanna E / Burdette, Carolyn Q / Hahm, Grace / Nalin, Federica / Duewer, David L / Kuszak, Adam J / Merkel, Joyce / Hoofnagle, Andrew N / Lukas, Pierre / Cavalier, Étienne / Durazo-Arvizu, Ramón A / Crump, Peter M / Popp, Christian / Beckert, Christian / Schultess, Jan /

Van Slooten, Glen / Tourneur, Carole / Pease, Camille / Kaul, Ravi / Villarreal, Alfredo / Ivison, Fiona / Fischer, Ralf / van den Ouweland, Jody M W / Ho, Chung S / Law, Emmett W K / Simard, Jean-Nicolas / Gonthier, Renaud / Holmquist, Brett / Batista, Marcelo Cidade / Meadows, Sarah / Cox, Lorna / Jansen, Eugene / Khan, Dilshad Ahmed / Robyak, Kimberly / Creer, Michael H / Kilbane, Mark / Twomey, Patrick J / Freeman, James / Parker, Neil / Yuan, Jinyun / Fitzgerald, Robert / Mushtaq, Sohail / Clarke, Michael W / Breen, Norma / Simpson, Christine / Wise, Stephen A

Analytical and bioanalytical chemistry

2021 Volume 414, Issue 2, Page(s) 1015–1028

Abstract: The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times ... per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25 ... OH)D)]. These samples are stored at -40 °C prior to distribution and the participants are instructed ...

Abstract	The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25(OH)D)]. These samples are stored at -40 °C prior to distribution and the participants are instructed to store the samples frozen at -20 °C or lower after receipt; however, the samples are shipped to participants at ambient conditions (i.e., no temperature control). To address the question of whether shipment at ambient conditions is sufficient for reliable performance of various 25(OH)D assays, the equivalence of DEQAS human serum samples shipped under frozen and ambient conditions was assessed. As part of a Vitamin D Standardization Program (VDSP) commutability study, two sets of the same nine DEQAS samples were shipped to participants at ambient temperature and frozen on dry ice. Twenty-eight laboratories participated in this study and provided 34 sets of results for the measurement of 25(OH)D using 20 ligand binding assays and 14 liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. Equivalence of the assay response for the frozen versus ambient DEQAS samples for each assay was evaluated using multi-level modeling, paired t-tests including a false discovery rate (FDR) approach, and ordinary least squares linear regression analysis of frozen versus ambient results. Using the paired t-test and confirmed by FDR testing, differences in the results for the ambient and frozen samples were found to be statistically significant at p < 0.05 for four assays (DiaSorin, DIAsource, Siemens, and SNIBE prototype). For all 14 LC-MS/MS assays, the differences in the results for the ambient- and frozen-shipped samples were not found to be significant at p < 0.05 indicating that these analytes were stable during shipment at ambient conditions. Even though assay results have been shown to vary considerably among different 25(OH)D assays in other studies, the results of this study also indicate that sample handling/transport conditions may influence 25(OH)D assay response for several assays.
MeSH term(s)	Chromatography, Liquid/methods ; Freezing ; Humans ; Tandem Mass Spectrometry/methods ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-11-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-021-03742-5
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Article ; Online: External Quality Assessment of 24,25-dihydroxyvitamin D

Carter, G D / Ahmed, F / Berry, J / Cavalier, E / Durazo-Arvizu, R / Gunter, E / Jones, G / Jones, J / Phinney, K / Sempos, C T / Twomey, P J / Williams, E L / Wise, S A

The Journal of steroid biochemistry and molecular biology

2018 Volume 187, Page(s) 130–133

Abstract: The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH) ...

Abstract	The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)
MeSH term(s)	Chromatography, Liquid/methods ; Chromatography, Liquid/standards ; Humans ; Quality Control ; Reference Standards ; Tandem Mass Spectrometry/methods ; Tandem Mass Spectrometry/standards ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamins/blood
Chemical Substances	24,25-dihydroxyvitamin D ; Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2018-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2018.11.010
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Article: Assessment of serum total 25-hydroxyvitamin D assays for Vitamin D External Quality Assessment Scheme (DEQAS) materials distributed at ambient and frozen conditions

Sempos, Christopher T. / Williams, Emma L. / Carter, Graham D. / Jones, Julia / Camara, Johanna E. / Burdette, Carolyn Q. / Hahm, Grace / Nalin, Federica / Duewer, David L. / Kuszak, Adam J. / Merkel, Joyce / Hoofnagle, Andrew N. / Lukas, Pierre / Cavalier, Étienne / Durazo-Arvizu, Ramón A. / Crump, Peter M. / Popp, Christian / Beckert, Christian / Schultess, Jan /

Van Slooten, Glen / Tourneur, Carole / Pease, Camille / Kaul, Ravi / Villarreal, Alfredo / Ivison, Fiona / Fischer, Ralf / van den Ouweland, Jody M. W. / Ho, Chung S. / Law, Emmett W. K. / Simard, Jean-Nicolas / Gonthier, Renaud / Holmquist, Brett / Batista, Marcelo Cidade / Meadows, Sarah / Cox, Lorna / Jansen, Eugene / Khan, Dilshad Ahmed / Robyak, Kimberly / Creer, Michael H. / Kilbane, Mark / Twomey, Patrick J. / Freeman, James / Parker, Neil / Yuan, Jinyun / Fitzgerald, Robert / Mushtaq, Sohail / Clarke, Michael W. / Breen, Norma / Simpson, Christine / Wise, Stephen A.

Analytical and bioanalytical chemistry. 2022 Jan., v. 414, no. 2

2022

Abstract: The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times ... per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25 ... OH)D)]. These samples are stored at −40 °C prior to distribution and the participants are instructed ...

Abstract	The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25(OH)D)]. These samples are stored at −40 °C prior to distribution and the participants are instructed to store the samples frozen at −20 °C or lower after receipt; however, the samples are shipped to participants at ambient conditions (i.e., no temperature control). To address the question of whether shipment at ambient conditions is sufficient for reliable performance of various 25(OH)D assays, the equivalence of DEQAS human serum samples shipped under frozen and ambient conditions was assessed. As part of a Vitamin D Standardization Program (VDSP) commutability study, two sets of the same nine DEQAS samples were shipped to participants at ambient temperature and frozen on dry ice. Twenty-eight laboratories participated in this study and provided 34 sets of results for the measurement of 25(OH)D using 20 ligand binding assays and 14 liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods. Equivalence of the assay response for the frozen versus ambient DEQAS samples for each assay was evaluated using multi-level modeling, paired t-tests including a false discovery rate (FDR) approach, and ordinary least squares linear regression analysis of frozen versus ambient results. Using the paired t-test and confirmed by FDR testing, differences in the results for the ambient and frozen samples were found to be statistically significant at p < 0.05 for four assays (DiaSorin, DIAsource, Siemens, and SNIBE prototype). For all 14 LC–MS/MS assays, the differences in the results for the ambient- and frozen-shipped samples were not found to be significant at p < 0.05 indicating that these analytes were stable during shipment at ambient conditions. Even though assay results have been shown to vary considerably among different 25(OH)D assays in other studies, the results of this study also indicate that sample handling/transport conditions may influence 25(OH)D assay response for several assays.
Keywords	ambient temperature ; analytical chemistry ; blood serum ; chemical species ; dry ice ; humans ; ligands ; liquid chromatography ; prototypes ; t-test ; tandem mass spectrometry
Language	English
Dates of publication	2022-01
Size	p. 1015-1028.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ISSN	1618-2642
DOI	10.1007/s00216-021-03742-5
Database	NAL-Catalogue (AGRICOLA)

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