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  1. Article: Nervonic Acid Inhibits Replicative Senescence of Human Wharton's Jelly-Derived Mesenchymal Stem Cells.

    Kim, Sun Jeong / Kwon, Soojin / Chung, Soobeen / Lee, Eun Joo / Park, Sang Eon / Choi, Suk-Joo / Oh, Soo-Young / Ryu, Gyu Ha / Jeon, Hong Bae / Chang, Jong Wook

    International journal of stem cells

    2023  Volume 17, Issue 1, Page(s) 80–90

    Abstract: Cellular senescence causes cell cycle arrest and promotes permanent cessation of proliferation. Since the senescence of mesenchymal stem cells (MSCs) reduces proliferation and multipotency and increases immunogenicity, aged MSCs are not suitable for cell ...

    Abstract Cellular senescence causes cell cycle arrest and promotes permanent cessation of proliferation. Since the senescence of mesenchymal stem cells (MSCs) reduces proliferation and multipotency and increases immunogenicity, aged MSCs are not suitable for cell therapy. Therefore, it is important to inhibit cellular senescence in MSCs. It has recently been reported that metabolites can control aging diseases. Therefore, we aimed to identify novel metabolites that regulate the replicative senescence in MSCs. Using a fecal metabolites library, we identified nervonic acid (NA) as a candidate metabolite for replicative senescence regulation. In replicative senescent MSCs, NA reduced senescence-associated
    Language English
    Publishing date 2023-10-12
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2914134-5
    ISSN 2005-5447 ; 2005-3606
    ISSN (online) 2005-5447
    ISSN 2005-3606
    DOI 10.15283/ijsc23101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Designing Nonfullerene Acceptors with Oligo(Ethylene Glycol) Side Chains: Unraveling the Origin of Increased Open-Circuit Voltage and Balanced Charge Carrier Mobilities.

    Cui, Junjie / Park, Jung-Hwa / Kim, Dong Won / Choi, Min-Woo / Chung, Hae Yeon / Kwon, Oh Kyu / Kwon, Ji Eon / Park, Soo Young

    Chemistry, an Asian journal

    2021  Volume 16, Issue 17, Page(s) 2481–2488

    Abstract: Despite the recent rapid development of organic solar cells (OSCs), the low dielectric constant ( ... ...

    Abstract Despite the recent rapid development of organic solar cells (OSCs), the low dielectric constant (ϵ
    Language English
    Publishing date 2021-07-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202100660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Public effect of the 2022 Colorectal Cancer Awareness Campaign delivered through a metaverse platform.

    Lee, Tae-Gyun / Song, Gil-Hyeon / Ahn, Hong-Min / Oh, Heung-Kwon / Byun, Moonkyoung / Han, Eon Chul / Kim, Sohyun / Kim, Chang Woo / Kim, Hye Jin / Hong, Samin / Song, Kee-Ho / Kim, Chan Wook / Cho, Yong Beom

    Annals of coloproctology

    2023  

    Abstract: Purpose: The Korean Society of Coloproctology has been conducting Colorectal Cancer Awareness Campaign, also known as the Gold Ribbon Campaign, every September since 2007. The 2022 campaign was held through a metaverse platform targeting the younger age ...

    Abstract Purpose: The Korean Society of Coloproctology has been conducting Colorectal Cancer Awareness Campaign, also known as the Gold Ribbon Campaign, every September since 2007. The 2022 campaign was held through a metaverse platform targeting the younger age group under the slogan of raising awareness of early-onset colorectal cancer (CRC). This study aimed to analyze the impact of the 2022 campaign on a metaverse platform.
    Methods: Anonymized survey data were collected from participants in the metaverse campaign from September 1 to 15, 2022. The satisfaction score of the participants was evaluated by sex, age group, and previous campaign participation status.
    Results: During the campaign, 2,770 people visited the metaverse. Among them, 455 people participated in the survey (response rate, 16.4%). Approximately 95% of the participants reported being satisfied with the information provided by the campaign, understood the necessity of undergoing screening for and prevention of early-onset CRC, and were familiar with the structure of the metaverse. The satisfaction score for campaign information tended to decrease as the participants' age increased. When the participants' overall level of satisfaction with the metaverse platform was assessed, teenagers scored particularly lower than the other age groups. The satisfaction scores for CRC information provided in the metaverse, as well as the scores for recognizing the seriousness and necessity of screening for early-onset CRC, indicated a high positive tendency (P<0.001).
    Conclusion: Most of the 2022 Gold Ribbon Campaign participants were satisfied with the metaverse platform. Medical society should pay attention to increasing participation in and satisfaction with future public campaigns.
    Language English
    Publishing date 2023-04-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2711906-3
    ISSN 2287-9722 ; 2287-9714
    ISSN (online) 2287-9722
    ISSN 2287-9714
    DOI 10.3393/ac.2023.00122.0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exposure of Mesenchymal Stem Cells to an Alzheimer's Disease Environment Enhances Therapeutic Effects.

    Park, Sang Eon / Kim, Hyeong Seop / Kwon, Soo Jin / Kim, Min-Jeong / Choi, Suk-Joo / Oh, Soo-Young / Ryu, Gyu Ha / Jeon, Hong Bae / Na, Duk L / Chang, Jong Wook

    Stem cells international

    2021  Volume 2021, Page(s) 6660186

    Abstract: Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of Alzheimer's disease (AD). Previous studies suggested that the coculture of human MSCs with AD in ... ...

    Abstract Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of Alzheimer's disease (AD). Previous studies suggested that the coculture of human MSCs with AD in an
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2021/6660186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Temporal Trend of the Incidence and Characteristics of Renal Infarction: Korean Nationwide Population Study.

    Kim, Dong-Eon / Moon, Inki / Park, Suyeong / Park, Minae / Park, Sojeong / Kwon, Seong Soon / Kong, Min Gyu / Park, Hyun Woo / Choi, Hyung Oh / Seo, Hye-Sun / Cho, Yoon Haeng / Lee, Nae Hee / Suh, Jon

    Journal of Korean medical science

    2023  Volume 38, Issue 31, Page(s) e239

    Abstract: Background: Large-scale studies about epidemiologic characteristics of renal infarction (RI) are few. In this study, we aimed to analyze the incidence and prevalence of RI with comorbidities in the South Korean population.: Methods: We investigated ... ...

    Abstract Background: Large-scale studies about epidemiologic characteristics of renal infarction (RI) are few. In this study, we aimed to analyze the incidence and prevalence of RI with comorbidities in the South Korean population.
    Methods: We investigated the medical history of the entire South Korean adult population between 2013 and 2019 using the National Health Insurance Service database (n = 51,849,591 in 2019). Diagnosis of RI comorbidities were confirmed with International Classification of Disease, Tenth Revision, Clinical Modification codes. Epidemiologic characteristics, distribution of comorbidities according to etiologic mechanisms, and trend of antithrombotic agents were estimated.
    Results: During the 7-years, 10,496 patients were newly diagnosed with RI. The incidence rate increased from 2.68 to 3.06 per 100,000 person-years during the study period. The incidence rate of RI increased with age peaking in the 70s with 1.41 times male predominance. The most common comorbidity was hypertension, followed by dyslipidemia and diabetes mellitus. Regarding etiologic risk factor distribution, high embolic risk group, renovascular disease group, and hypercoagulable state group accounted for 16.6%, 29.1%, and 13.7% on average, respectively. For the antithrombotic treatment of RI, the prescription of antiplatelet agent gradually decreased from 17.0% to 13.0% while that of anticoagulation agent was maintained around 35%. The proportion of non-vitamin K antagonist oral anticoagulants remarkably increased from only 1.4% to 17.6%.
    Conclusion: Considering the progressively increasing incidence of RI and high prevalence of coexisting risk factors, constant efforts to raise awareness of the disease are necessary. The current epidemiologic investigation of RI would be the stepping-stone to establishing future studies about clinical outcomes and optimal treatment strategies.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Incidence ; Comorbidity ; Kidney Diseases ; Hypertension/epidemiology ; Prevalence ; Infarction/epidemiology ; Republic of Korea/epidemiology
    Language English
    Publishing date 2023-08-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2023.38.e239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Repositioning Trimebutine Maleate as a Cancer Treatment Targeting Ovarian Cancer Stem Cells.

    Lee, Heejin / Kwon, Oh-Bin / Lee, Jae-Eon / Jeon, Yong-Hyun / Lee, Dong-Seok / Min, Sang-Hyun / Kim, Jun-Woo

    Cells

    2021  Volume 10, Issue 4

    Abstract: The overall five-year survival rate for late-stage patients of ovarian cancer is below 29% due to disease recurrence and drug resistance. Cancer stem cells (CSCs) are known as a major contributor to drug resistance and recurrence. Accordingly, therapies ... ...

    Abstract The overall five-year survival rate for late-stage patients of ovarian cancer is below 29% due to disease recurrence and drug resistance. Cancer stem cells (CSCs) are known as a major contributor to drug resistance and recurrence. Accordingly, therapies targeting ovarian CSCs are needed to overcome the limitations of present treatments. This study evaluated the effect of trimebutine maleate (TM) targeting ovarian CSCs, using A2780-SP cells acquired by a sphere culture of A2780 epithelial ovarian cancer cells. TM is indicated as a gastrointestinal motility modulator and is known to as a peripheral opioid receptor agonist and a blocker for various channels. The GI50 of TM was approximately 0.4 µM in A2780-SP cells but over 100 µM in A2780 cells, demonstrating CSCs specific growth inhibition. TM induced G0/G1 arrest and increased the AV
    MeSH term(s) Calcium/metabolism ; Calcium Channels/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Drug Repositioning ; Female ; Humans ; Ion Channel Gating/drug effects ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism ; Models, Biological ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Protein Subunits/metabolism ; Sodium/metabolism ; Sodium Channels/metabolism ; Transcription Factors/metabolism ; Trimebutine/chemistry ; Trimebutine/pharmacology ; Trimebutine/therapeutic use ; Wnt Signaling Pathway/drug effects
    Chemical Substances Calcium Channels ; KCNMA1 protein, human ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits ; Protein Subunits ; Sodium Channels ; Transcription Factors ; Sodium (9NEZ333N27) ; Trimebutine (QZ1OJ92E5R) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-04-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10040918
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  7. Article: ERRATUM: Correction of Figure 1: Outcomes of surgical treatments for rectovaginal fistula and prognostic factors for successful closure: a single-center tertiary hospital experiences.

    Ryoo, Seung-Bum / Oh, Heung-Kwon / Ha, Heon-Kyun / Han, Eon Chul / Kwon, Yoon-Hye / Song, Inho / Moon, Sang Hui / Choe, Eun Kyung / Park, Kyu Joo

    Annals of surgical treatment and research

    2020  Volume 99, Issue 1, Page(s) 63

    Abstract: This corrects the article on p. 149 in vol. 97, PMID: 31508396.]. ...

    Abstract [This corrects the article on p. 149 in vol. 97, PMID: 31508396.].
    Language English
    Publishing date 2020-06-29
    Publishing country Korea (South)
    Document type Published Erratum
    ZDB-ID 3012234-X
    ISSN 2288-6796 ; 2288-6575
    ISSN (online) 2288-6796
    ISSN 2288-6575
    DOI 10.4174/astr.2020.99.1.63
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  8. Article ; Online: Repositioning Trimebutine Maleate as a Cancer Treatment Targeting Ovarian Cancer Stem Cells

    Heejin Lee / Oh-Bin Kwon / Jae-Eon Lee / Yong-Hyun Jeon / Dong-Seok Lee / Sang-Hyun Min / Jun-Woo Kim

    Cells, Vol 10, Iss 918, p

    2021  Volume 918

    Abstract: The overall five-year survival rate for late-stage patients of ovarian cancer is below 29% due to disease recurrence and drug resistance. Cancer stem cells (CSCs) are known as a major contributor to drug resistance and recurrence. Accordingly, therapies ... ...

    Abstract The overall five-year survival rate for late-stage patients of ovarian cancer is below 29% due to disease recurrence and drug resistance. Cancer stem cells (CSCs) are known as a major contributor to drug resistance and recurrence. Accordingly, therapies targeting ovarian CSCs are needed to overcome the limitations of present treatments. This study evaluated the effect of trimebutine maleate (TM) targeting ovarian CSCs, using A2780-SP cells acquired by a sphere culture of A2780 epithelial ovarian cancer cells. TM is indicated as a gastrointestinal motility modulator and is known to as a peripheral opioid receptor agonist and a blocker for various channels. The GI50 of TM was approximately 0.4 µM in A2780-SP cells but over 100 µM in A2780 cells, demonstrating CSCs specific growth inhibition. TM induced G0/G1 arrest and increased the AV + /PI + dead cell population in the A2780-SP samples. Furthermore, TM treatment significantly reduced tumor growth in A2780-SP xenograft mice. Voltage gated calcium channels (VGCC) and calcium-activated potassium channels (BKCa) were overexpressed on ovarian CSCs and targeted by TM; inhibition of both channels reduced A2780-SP cells viability. TM reduced stemness-related protein expression; this tendency was reproduced by the simultaneous inhibition of VGCC and BKCa compared to single channel inhibition. In addition, TM suppressed the Wnt/β-catenin, Notch, and Hedgehog pathways which contribute to many CSCs characteristics. Specifically, further suppression of the Wnt/β-catenin pathway by simultaneous inhibition of BKCa and VGCC is necessary for the effective and selective action of TM. Taken together, TM is a potential therapeutic drug for preventing ovarian cancer recurrence and drug resistance.
    Keywords trimebutine maleate ; ovarian cancer stem cells ; BKCa channel ; Ca 2+ channel ; wnt/β-catenin signaling ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Changes in bioimpedance analysis components before and after hemodialysis [Volume 37, Issue 4, December 2018, Pages 393-403].

    Kim, Hyunsuk / Choi, Gwang Ho / Shim, Kwang Eon / Lee, Jung Hoon / Heo, Nam Ju / Joo, Kwon-Wook / Yoon, Jong-Woo / Oh, Yun Kyu

    Kidney research and clinical practice

    2019  Volume 38, Issue 1, Page(s) 128–129

    Language English
    Publishing date 2019-02-11
    Publishing country Korea (South)
    Document type Journal Article ; Published Erratum
    ZDB-ID 2656420-8
    ISSN 2211-9132
    ISSN 2211-9132
    DOI 10.23876/j.krcp.18.0035.corr
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  10. Article ; Online: Pressure Stimuli Improve the Proliferation of Wharton's Jelly-Derived Mesenchymal Stem Cells under Hypoxic Culture Conditions.

    Park, Sang Eon / Kim, Hyeongseop / Kwon, Soojin / Choi, Suk-Joo / Oh, Soo-Young / Ryu, Gyu Ha / Jeon, Hong Bae / Chang, Jong Wook

    International journal of molecular sciences

    2020  Volume 21, Issue 19

    Abstract: Mesenchymal stem cells (MSCs) are safe, and they have good therapeutic efficacy through their paracrine action. However, long-term culture to produce sufficient MSCs for clinical use can result in side-effects, such as an inevitable senescence and the ... ...

    Abstract Mesenchymal stem cells (MSCs) are safe, and they have good therapeutic efficacy through their paracrine action. However, long-term culture to produce sufficient MSCs for clinical use can result in side-effects, such as an inevitable senescence and the reduction of the therapeutic efficacy of the MSCs. In order to overcome this, the primary culture conditions of the MSCs can be modified to simulate the stem cells' niche environment, resulting in accelerated proliferation, the achievement of the target production yield at earlier passages, and the improvement of the therapeutic efficacy. We exposed Wharton's jelly-derived MSCs (WJ-MSCs) to pressure stimuli during the primary culture step. In order to evaluate the proliferation, stemness, and therapeutic efficacy of WJ-MSCs, image, genetic, and Western blot analyses were carried out. Compared with standard incubation culture conditions, the cell proliferation was significantly improved when the WJ-MSCs were exposed to pressure stimuli. However, the therapeutic efficacy (the promotion of cell proliferation and anti-apoptotic effects) and the stemness of the WJ-MSCs was maintained, regardless of the culture conditions. Exposure to pressure stimuli is a simple and efficient way to improve WJ-MSC proliferation without causing changes in stemness and therapeutic efficacy. In this way, clinical-grade WJ-MSCs can be produced rapidly and used for therapeutic applications.
    MeSH term(s) Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Paracrine Communication ; Stress, Mechanical
    Language English
    Publishing date 2020-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21197092
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