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Article ; Online: APOL1 Nephropathy Risk Variants Through the Life Course: A Review.

Itoku, Ai / Isaac, Jaya / Wilson, Scott / Reidy, Kimberly / Kaskel, Frederick

American journal of kidney diseases : the official journal of the National Kidney Foundation

2024

Abstract: Two variant alleles of the gene apolipoprotein L1 (APOL1), known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The APOL1 protein contributes to innate immunity and may protect against Trypanosoma, ... ...

Abstract	Two variant alleles of the gene apolipoprotein L1 (APOL1), known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The APOL1 protein contributes to innate immunity and may protect against Trypanosoma, HIV, Salmonella, and leishmaniasis. However, the effects of carrying 1 or more RVs contribute to a variety of disease processes starting as early as in utero and can be exacerbated by other factors (or "second hits"). Indeed, these genetic variations interact with environmental exposures, infections, and systemic disease to modify health outcomes across the life span. This review focuses on APOL1-associated diseases through the life-course perspective and discusses how early exposure to second hits can impact long-term outcomes. APOL1-related kidney disease typically presents in adolescents to young adults, and individuals harboring RVs are more likely to progress to kidney failure than are those with kidney disease who lack APOL-1 RVs. Ongoing research is aimed at elucidating the association of APOL1 RV effects with adverse donor and recipient kidney transplant outcomes. Unfortunately, there is currently no established treatment for APOL1-associated nephropathy. Long-term research is needed to evaluate the risk and protective factors associated with APOL1 RVs at different stages of life.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2023.12.014
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 468: Show issues

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Article ; Online: Management of Esophageal Stricture and Perforation Complicated by Undiagnosed Eosinophilic Esophagitis and Pill Impaction.

Reidy, Maeve / Primo, Julia / Alissa, Feras / Sinclair, Elizabeth M

JPGN reports

2023 Volume 4, Issue 4, Page(s) e360

Language	English
Publishing date	2023-08-29
Publishing country	United States
Document type	Case Reports
ISSN	2691-171X
ISSN (online)	2691-171X
DOI	10.1097/PG9.0000000000000360
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Article ; Online: Supratherapeutic dabigatran: a cause of life-threatening haemorrhage.

Hennessy, M / Reidy, B / Ní Ainle, F / Conneely, J / McDermott, C / Scanaill, P Ó

Anaesthesia reports

2023 Volume 11, Issue 1, Page(s) e12208

Abstract: In this case report, we present a rare case of life-threatening gastrointestinal haemorrhage associated with deranged coagulation due to supratherapeutic levels of dabigatran. Dabigatran is a potent, synthetic, reversible non-peptide thrombin inhibitor ... ...

Abstract	In this case report, we present a rare case of life-threatening gastrointestinal haemorrhage associated with deranged coagulation due to supratherapeutic levels of dabigatran. Dabigatran is a potent, synthetic, reversible non-peptide thrombin inhibitor which is increasingly used for stroke prevention in patients with non-valvular atrial fibrillation. It is generally accepted that dabigatran dosing does not require titration or the monitoring of plasma levels due to its predictable pharmacokinetics and pharmacodynamics. However, this case report challenges this viewpoint while identifying an important knowledge gap in relation to the effect of altered gastrointestinal motility on the absorption of direct oral anticoagulants. Furthermore, it demonstrates the successful use of high-dose idarucizumab in a critical care setting. Idarucizumab is a monoclonal antibody fragment that binds specifically to dabigatran and its metabolites, thereby reversing the anticoagulant effect.
Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Case Reports
ISSN	2637-3726
ISSN (online)	2637-3726
DOI	10.1002/anr3.12208
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Article ; Online: Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.

Marmorale, Lucas J / Jin, Huan / Reidy, Thomas G / Palomino-Alonso, Brandon / Zysnarski, Christopher J / Jordan-Javed, Fatima / Lahiri, Sagar / Duncan, Mara C

The Journal of cell biology

2024 Volume 223, Issue 3

Abstract: The highly conserved HEATR5 proteins are best known for their roles in membrane traffic mediated by the adaptor protein complex-1 (AP1). HEATR5 proteins rely on fast-evolving cofactors to bind to AP1. However, how HEATR5 proteins interact with these ... ...

Abstract	The highly conserved HEATR5 proteins are best known for their roles in membrane traffic mediated by the adaptor protein complex-1 (AP1). HEATR5 proteins rely on fast-evolving cofactors to bind to AP1. However, how HEATR5 proteins interact with these cofactors is unknown. Here, we report that the budding yeast HEATR5 protein, Laa1, functions in two biochemically distinct complexes. These complexes are defined by a pair of mutually exclusive Laa1-binding proteins, Laa2 and the previously uncharacterized Lft1/Yml037c. Despite limited sequence similarity, biochemical analysis and structure predictions indicate that Lft1 and Laa2 bind Laa1 via structurally similar mechanisms. Both Laa1 complexes function in intra-Golgi recycling. However, only the Laa2-Laa1 complex binds to AP1 and contributes to its localization. Finally, structure predictions indicate that human HEATR5 proteins bind to a pair of fast-evolving interacting partners via a mechanism similar to that observed in yeast. These results reveal mechanistic insight into how HEATR5 proteins bind their cofactors and indicate that Laa1 performs functions besides recruiting AP1.
MeSH term(s)	Humans ; Adaptor Protein Complex 1/metabolism ; Carrier Proteins/metabolism ; Golgi Apparatus/metabolism ; Saccharomyces cerevisiae/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	Adaptor Protein Complex 1 ; Carrier Proteins ; HEATR5B protein, human ; Laa1 protein, S cerevisiae ; Adaptor Proteins, Signal Transducing ; Saccharomyces cerevisiae Proteins
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202309047
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Article ; Online: Lack of efficacy of aprotinin over tranexamic acid in type A aortic dissection repair.

Reidy, Bryan / Aston, Daniel / Sitaranjan, Daniel / Fazmin, Ibrahim Talal / Muir, Martin / Ali, Jason / De Silva, Ravi / Falter, Florian

Transfusion

2024

Abstract: Background: The role of aprotinin in modern cardiac surgery is not well defined. While licensed for use in isolated coronary artery bypass grafting it is more commonly used for cases deemed to be at an increased risk of bleeding. The relative efficacy, ... ...

Abstract	Background: The role of aprotinin in modern cardiac surgery is not well defined. While licensed for use in isolated coronary artery bypass grafting it is more commonly used for cases deemed to be at an increased risk of bleeding. The relative efficacy, and safety profile, of aprotinin as compared to other antifibrinolytics in these high-risk cases is uncertain. Study design and methods: A retrospective observational study with propensity matching to determine whether aprotinin versus tranexamic acid reduced bleeding or transfusion requirements in patients presenting for surgical repair of type A aortic dissection (TAD). Results: Between 2016 and 2022, 250 patients presented for repair of TAD. A total of 231 patients were included in the final analysis. Bleeding and transfusion were similar between both groups in both propensity matched and unmatched cohorts. Compared to tranexamic acid, aprotinin use did not reduce transfusion requirements for any product. Rates of bleeding in the first 12 h, return to theater and return to intensive care unit with an open packed chest were similar between groups. There was no difference in rates of renal failure, stroke, or death. Conclusion: Aprotinin did not reduce the risk of bleeding or transfusion requirements in patients undergoing repair of type A aortic dissections. Efficacy of aprotinin may vary depending on the type of surgery performed and the underlying pathology.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.17819
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Zs.A 284: Show issues

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Article: Two functionally distinct HEATR5 protein complexes are defined by fast-evolving co-factors in yeast.

Marmorale, Lucas J / Jin, Huan / Reidy, Thomas G / Palomino-Alonso, Brandon / Zysnarski, Christopher / Jordan-Javed, Fatima / Lahiri, Sagar / Duncan, Mara C

bioRxiv : the preprint server for biology

2023

Abstract: The highly conserved HEATR5 proteins are best known for their roles in membrane traffic mediated by the adaptor protein complex-1 (AP1). HEATR5 proteins rely on fast-evolving co-factors to bind to AP1. However, how HEATR5 proteins interact with these co- ... ...

Abstract	The highly conserved HEATR5 proteins are best known for their roles in membrane traffic mediated by the adaptor protein complex-1 (AP1). HEATR5 proteins rely on fast-evolving co-factors to bind to AP1. However, how HEATR5 proteins interact with these co-factors is unknown. Here, we report that the budding yeast HEATR5 protein, Laa1, functions in two biochemically distinct complexes. These complexes are defined by a pair of mutually exclusive Laa1-binding proteins, Laa2 and the previously uncharacterized Lft1/Yml037c. Despite limited sequence similarity, biochemical analysis and structure predictions indicate that Lft1 and Laa2 bind Laa1 via structurally similar mechanisms. Both Laa1 complexes function in intra-Golgi recycling. However, only the Laa2-Laa1 complex binds to AP1 and contributes to its localization. Finally, structure predictions indicate that human HEATR5 proteins bind to a pair of fast-evolving interacting partners via a mechanism similar to that observed in yeast. These results reveal mechanistic insight into how HEATR5 proteins bind their co-factors and indicate that Laa1 performs functions besides recruiting AP1.
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.24.554671
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Article ; Online: N-glycans from serum IgG and total serum glycoproteins specific for endometriosis.

Kovács, Zsuzsanna / Reidy, Fiona / Glover, Louise / McAuliffe, Fionnuala M / Stockmann, Henning / Kilbane, Mark T / Twomey, Patrick J / Peters, Maire / Saare, Merli / Rudd, Pauline M / Utt, Meeme / Wingfield, Mary / Salumets, Andres / Saldova, Radka

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10480

Abstract: ... we investigated N-glycosylation in two clinical cohorts of women with and without endometriosis. PNGase F-digested ...

Abstract	Endometriosis is a chronic inflammatory gynaecological disease characterized by the growth of endometrial tissue outside the uterine cavity. There are currently no definitive non-invasive diagnostic tools. Glycosylation is the most common posttranslational modification of proteins and altered glycosylation has been found in many diseases, including chronic inflammatory conditions and cancer. Sialylation and galactosylation on serum IgG have previously been found to be altered in endometriosis and serum sialylation changed after Zoladex (Goserelin Acetate) therapy. Using IgG and whole serum glycoproteins, we investigated N-glycosylation in two clinical cohorts of women with and without endometriosis. PNGase F-digested serum samples were fluorescently labelled and N-glycans were profiled by ultra-performance liquid chromatography. Clinical data was collected to link glycomic findings with metabolic and hormonal profiles. Total serum glycoprotein and IgG glycosylation differed in patients with endometriosis compared to control cases. The most significantly altered was glycan peak 3 from IgG, containing bisected biantennary glycans, which was decreased in the endometriosis cohorts (p = 0.0000005-0.018). In conclusion, this is the first pilot study to identify changes in N-glycans from whole serum glycoproteins associated with endometriosis. A larger validation study is now warranted and such studies should include the follow-up of surgically and pharmacologically treated patients.
MeSH term(s)	Humans ; Female ; Endometriosis ; Pilot Projects ; Glycoproteins ; Goserelin ; Polysaccharides ; Immunoglobulin G
Chemical Substances	Glycoproteins ; Goserelin (0F65R8P09N) ; Polysaccharides ; Immunoglobulin G
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37421-5
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Article ; Online: Novel diagnostic options for endometriosis - Based on the glycome and microbiome.

Kovács, Zsuzsanna / Glover, Louise / Reidy, Fiona / MacSharry, John / Saldova, Radka

Journal of advanced research

2021 Volume 33, Page(s) 167–181

Abstract: Background: Endometriosis is a chronic gynaecological disease whose aetiology is still unknown. Despite its prevalence among women of reproductive age, the pathology of the disease has not yet been elucidated and only symptomatic treatment is available. ...

Abstract	Background: Endometriosis is a chronic gynaecological disease whose aetiology is still unknown. Despite its prevalence among women of reproductive age, the pathology of the disease has not yet been elucidated and only symptomatic treatment is available. Endometriosis has high latency and diagnostic methods are both limited and invasive. Aim of review: The aim of this review is to summarise minimally invasive or non-invasive diagnostic methods for endometriosis and their diagnostic efficiencies. Furthermore, we discuss the identification and diagnostic potential of novel disease biomarkers of microbial or glycan origin. Key scientific concepts of review: Great efforts have been made to develop minimally invasive or non-invasive diagnostic methods in endometriosis. The problem with most potential biomarker candidates is that they have high accuracy only in cases of severe disease. Therefore, it is necessary to examine other potential biomarkers more closely. Associations between gastrointestinal and genital tract microbial health and endometriosis have been identified. For instance, irritable bowel syndrome is more common in women with endometriosis, and hormonal imbalance has a negative impact on the microbiome of both the genital tract and the gastrointestinal system. Further interrogation of these associations may have potential diagnostic significance and may identify novel therapeutic avenues. Glycomics may also be a potent source of biomarkers of endometriosis, with a number of glyco-biomarkers already approved by the FDA. Endometriosis-associated microbial and glycomic profiles may represent viable targets for development of innovative diagnostics in this debilitating disease.
MeSH term(s)	Biomarkers ; Endometriosis/diagnosis ; Female ; Humans ; Irritable Bowel Syndrome ; Microbiota
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-02-05
Publishing country	Egypt
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2541849-X
ISSN	2090-1224 ; 2090-1224
ISSN (online)	2090-1224
ISSN	2090-1224
DOI	10.1016/j.jare.2021.01.015
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Article ; Online: Measurements of Hydroxyl Radical Concentrations during Indoor Cooking Events: Evidence of an Unmeasured Photolytic Source of Radicals.

Reidy, Emily / Bottorff, Brandon P / Rosales, Colleen Marciel F / Cardoso-Saldaña, Felipe J / Arata, Caleb / Zhou, Shan / Wang, Chen / Abeleira, Andrew / Hildebrandt Ruiz, Lea / Goldstein, Allen H / Novoselac, Atila / Kahan, Tara F / Abbatt, Jonathan P D / Vance, Marina E / Farmer, Delphine K / Stevens, Philip S

Environmental science & technology

2023 Volume 57, Issue 2, Page(s) 896–908

Abstract: The hydroxyl radical (OH) is the dominant oxidant in the outdoor environment, controlling the lifetimes of volatile organic compounds (VOCs) and contributing to the growth of secondary organic aerosols. Despite its importance outdoors, there have been ... ...

Abstract	The hydroxyl radical (OH) is the dominant oxidant in the outdoor environment, controlling the lifetimes of volatile organic compounds (VOCs) and contributing to the growth of secondary organic aerosols. Despite its importance outdoors, there have been relatively few measurements of the OH radical in indoor environments. During the House Observations of Microbial and Environmental Chemistry (HOMEChem) campaign, elevated concentrations of OH were observed near a window during cooking events, in addition to elevated mixing ratios of nitrous acid (HONO), VOCs, and nitrogen oxides (NO
MeSH term(s)	Hydroxyl Radical/analysis ; Hydroxyl Radical/chemistry ; Photolysis ; Air Pollution, Indoor/analysis ; Nitrogen Oxides/analysis ; Ozone/analysis ; Cooking ; Nitrous Acid/analysis ; Nitrous Acid/chemistry ; Air Pollutants/analysis
Chemical Substances	Hydroxyl Radical (3352-57-6) ; Nitrogen Oxides ; Ozone (66H7ZZK23N) ; Nitrous Acid (T2I5UM75DN) ; Air Pollutants
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.2c05756
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Article ; Online: The effect of viewing angle on observations of foot orientation in forensic gait analysis.

Reidy, Selina / Stephenson, John / Smith, Francine / Otten, Egbert / Wiedemeijer, Mickey / Curran, Mike

Science & justice : journal of the Forensic Science Society

2020 Volume 60, Issue 6, Page(s) 504–511

MeSH term(s)	Biomechanical Phenomena ; Foot/physiology ; Forensic Medicine ; Gait ; Gait Analysis ; Humans
Language	English
Publishing date	2020-07-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1230910-2
ISSN	1876-4452 ; 1355-0306
ISSN (online)	1876-4452
ISSN	1355-0306
DOI	10.1016/j.scijus.2020.06.005
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