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  1. Article ; Online: Seven-year Outcomes of Adolescent Forearm Fractures Treated With Plate Fixation.

    Folkman, Matthew J / Ren, Bryan O / Maheshwer, Bhargavi / Klyce, Walter B / Mistovich, R Justin

    Journal of pediatric orthopedics

    2023  Volume 43, Issue 6, Page(s) e446–e450

    Abstract: Background: Pediatric forearm fractures are common injuries and can sometimes require surgical treatment. Few studies have evaluated the long-term outcomes of pediatric forearm fracture plating. We evaluated long-term functional outcomes and ... ...

    Abstract Background: Pediatric forearm fractures are common injuries and can sometimes require surgical treatment. Few studies have evaluated the long-term outcomes of pediatric forearm fracture plating. We evaluated long-term functional outcomes and satisfaction in children with forearm fractures treated with plate fixation.
    Methods: We performed a single-institution case series at a pediatric level 1 trauma center. Inclusion criteria were: patients with radius and/or ulna diaphyseal fractures, index surgery at 18 years of age or younger, plate fixation, and a minimum of 2 years follow-up. We surveyed patients with the QuickDASH outcome measure and supplemented this with functional outcomes and satisfaction questions. Demographics and surgery characteristics were obtained from the electronic medical record.
    Results: A total of 41 patients met the eligibility criteria, of whom 17 completed the survey with a mean follow-up of 7.2 ± 1.4 years. The mean age at index surgery was 13.1 ± 3.6 years (range, 4 to 17), with 65% males. All patients reported at least one symptom, with aching (41%) and pain (35%) occurring most frequently. There were 2 complications (12%), including one infection and one compartment syndrome treated with fasciotomy. Hardware removal occurred in 29% of patients. There were no refractures. The mean QuickDASH score was 7.7 ± 11.9, with an occupation module score of 1.6 ± 3.9 and a sports/performing arts module score of 12.0 ± 19.7. The mean surgery satisfaction was 92% and scar satisfaction was 75%. All patients returned to prior activities and 88% reported a return to their preoperative baseline level of function.
    Conclusions: Plate fixation for pediatric forearm fractures achieves osseous union but not without the potential for long-term sequelae. All patients reported residual symptoms 7 years later. Scar satisfaction and return to baseline function were imperfect. Patient education for long-term outcomes of surgery is essential, especially in the transition to adulthood.
    Level of evidence: Level IV, therapeutic study.
    MeSH term(s) Male ; Humans ; Adolescent ; Child ; Child, Preschool ; Female ; Radius Fractures/surgery ; Cicatrix ; Forearm ; Forearm Injuries/surgery ; Ulna Fractures/surgery ; Fracture Fixation, Internal ; Bone Plates ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604642-3
    ISSN 1539-2570 ; 0271-6798
    ISSN (online) 1539-2570
    ISSN 0271-6798
    DOI 10.1097/BPO.0000000000002412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Carbon-Electrode-Mediated Electrochemical Synthesis of Hypervalent Iodine Reagents Using Water as the O-Atom Source

    Folkman, Scott J. / Finke, Richard G. / Galán-Mascarós, José Ramón / Miyake, Garret M.

    ACS sustainable chemistry & engineering. 2021 July 23, v. 9, no. 31

    2021  

    Abstract: Photoelectrocatalytic water splitting is an important goal of modern chemistry that is hindered by the slow kinetics of anodic water oxidation. Additionally, the O₂ byproduct of water oxidation catalysis is of little economic value. One way to increase ... ...

    Abstract Photoelectrocatalytic water splitting is an important goal of modern chemistry that is hindered by the slow kinetics of anodic water oxidation. Additionally, the O₂ byproduct of water oxidation catalysis is of little economic value. One way to increase the energy efficiency as well as economic feasibility of photoelectrocatalytic water splitting as an industrial process is to couple the oxidation of water to the formation of value-added, oxygenated products such as olefin epoxidation or other selective oxygenation or oxidation reactions—rather than the coupling of two O-atom equivalents to O₂. However, attempts at direct olefin epoxidation at the same anode where water oxidation catalysis is happening suffer from competing one-electron oxidation or overoxidation of the olefin substrate. Hence, an O-atom-transfer mediator is needed. Hypervalent iodine reagents are known to perform olefin epoxidations via O-atom transfer, oxidation reactions, as well as a myriad of other group-transfer reactions. A drawback addressed in the following work is that the synthesis of hypervalent iodine reagents typically requires the use of a powerful oxidant such as IO₄– or KHSO₅ with multiple steps and potentially explosive intermediates or side products. Herein, we report proof-of-principle electrochemical syntheses of a series of hypervalent iodine reagents, including: λ³-o-iodosobenzoic acid (IBA) in up to 58% isolated yield with a Faradaic efficiency 89%; the previously inaccessible λ³-ethyl 2-iodosobenzoate (IBA-ester) with ∼78% Faradaic efficiency; the well-known λ⁵-2-iodoxyphenyl tert-butyl sulfone (IBX-sulfone) with ∼51% Faradaic efficiency; and a mixture of λ³-2-iodosobenzene sulfonic acid (IBA-sulfonic acid) with λ⁵-2-iodoxybenzene sulfonic acid (IBX-sulfonic acid) with an overall Faradaic efficiency of >78%. Mechanistic studies using H₂¹⁸O in the electrochemical synthesis demonstrate that the O-atom in the product is initially transferred from the oxidized, O-atom-containing surface of the glassy carbon electrode, with ¹⁸O from H₂¹⁸O then replacing the O-atom vacancy on the carbon electrode surface. Overall, the present contribution demonstrates the electrochemical, green synthesis of novel and well-known hypervalent iodine reagents using the O-atom from H₂O. The reported studies also provide insights into the electrochemical mechanism needed to optimize the synthesis yields as well as to exploit those syntheses using O-atom equivalents generated via (photo)electrochemical water splitting.
    Keywords anodes ; byproducts ; economic feasibility ; economic valuation ; electrochemistry ; electrosynthesis ; energy efficiency ; epoxidation reactions ; glassy carbon electrode ; green chemistry ; iodine ; olefin ; oxidants ; oxidation ; photocatalysis ; sulfonic acids ; value added
    Language English
    Dates of publication 2021-0723
    Size p. 10453-10467.
    Publishing place American Chemical Society
    Document type Article
    ISSN 2168-0485
    DOI 10.1021/acssuschemeng.1c01315
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Benchmarking Catalysts for Formic Acid/Formate Electrooxidation.

    Folkman, Scott J / González-Cobos, Jesús / Giancola, Stefano / Sánchez-Molina, Irene / Galán-Mascarós, José Ramón

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 16

    Abstract: Energy production and consumption without the use of fossil fuels are amongst the biggest challenges currently facing humankind and the scientific community. Huge efforts have been invested in creating technologies that enable closed carbon or carbon ... ...

    Abstract Energy production and consumption without the use of fossil fuels are amongst the biggest challenges currently facing humankind and the scientific community. Huge efforts have been invested in creating technologies that enable closed carbon or carbon neutral fuel cycles, limiting CO
    Language English
    Publishing date 2021-08-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26164756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: What informal caregivers actually do: the caregiving skills of partners of men with AIDS.

    Wrubel, J / Folkman, S

    AIDS care

    2015  Volume 9, Issue 6, Page(s) 691–706

    Abstract: This study draws on the narrative accounts of caregiving events provided by 100 HIV-negative and HIV-positive partners of men with AIDS during their partners' illness. The narratives contain rich detail about the wide range of skills that these men ... ...

    Abstract This study draws on the narrative accounts of caregiving events provided by 100 HIV-negative and HIV-positive partners of men with AIDS during their partners' illness. The narratives contain rich detail about the wide range of skills that these men developed over the course of their caregiving. These skills, which go beyond the kinds of assistance with daily activities that normally comprise caregiving assessments, pertain to the provision of emotional support, hands-on care, clinical care, high tech nursing and health care advocacy. Because these narratives depict caregiving in its naturally occurring context, it is also possible to describe ways in which the context of caregiving, including the partners' relationship, the clinical course of the illness and changes in the meaning of the illness, influence the development of these caregiving skills. Finally, the narratives provide insight not only into the burdens of care, but also into its often overlooked positive aspects.
    MeSH term(s) Acquired Immunodeficiency Syndrome/nursing ; Adult ; Caregivers ; Female ; Humans ; Male ; Middle Aged ; Self Efficacy ; Sexual Partners
    Language English
    Publishing date 2015-10-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/713613223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is angiogenesis an organizing principle in biology and medicine?

    Folkman, Judah

    Journal of pediatric surgery

    2007  Volume 42, Issue 1, Page(s) 1–11

    MeSH term(s) Angiogenesis Inducing Agents/pharmacology ; Angiogenesis Inducing Agents/therapeutic use ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Biological Assay ; Blood Platelets/physiology ; Chick Embryo ; Delayed-Action Preparations ; Fibroblast Growth Factor 2/physiology ; Humans ; Macular Degeneration/drug therapy ; Macular Degeneration/physiopathology ; Mice ; Neoplasms/blood supply ; Neoplasms/physiopathology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/physiopathology ; Neovascularization, Physiologic/drug effects ; Neovascularization, Physiologic/physiology ; Proteome/physiology ; Rabbits
    Chemical Substances Angiogenesis Inducing Agents ; Angiogenesis Inhibitors ; Delayed-Action Preparations ; Proteome ; Fibroblast Growth Factor 2 (103107-01-3)
    Language English
    Publishing date 2007-01
    Publishing country United States
    Document type Addresses
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2006.09.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Angiogenesis: an organizing principle for drug discovery?

    Folkman, Judah

    Nature reviews. Drug discovery

    2007  Volume 6, Issue 4, Page(s) 273–286

    Abstract: Angiogenesis--the process of new blood-vessel growth--has an essential role in development, reproduction and repair. However, pathological angiogenesis occurs not only in tumour formation, but also in a range of non-neoplastic diseases that could be ... ...

    Abstract Angiogenesis--the process of new blood-vessel growth--has an essential role in development, reproduction and repair. However, pathological angiogenesis occurs not only in tumour formation, but also in a range of non-neoplastic diseases that could be classed together as 'angiogenesis-dependent diseases'. By viewing the process of angiogenesis as an 'organizing principle' in biology, intriguing insights into the molecular mechanisms of seemingly unrelated phenomena might be gained. This has important consequences for the clinical use of angiogenesis inhibitors and for drug discovery, not only for optimizing the treatment of cancer, but possibly also for developing therapeutic approaches for various diseases that are otherwise unrelated to each other.
    MeSH term(s) Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Antineoplastic Agents/pharmacology ; Blood Platelets/physiology ; Endothelium/physiology ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Neovascularization, Physiologic/drug effects ; Neovascularization, Physiologic/genetics ; Neovascularization, Physiologic/physiology
    Chemical Substances Angiogenesis Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2007-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/nrd2115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Reliability of the Modified Fels Knee Skeletal Maturity System.

    Furdock, Ryan J / Sun, Kristie J / Ren, Bryan / Folkman, Matthew / Glotzbecker, Michael P / Son-Hing, Jochen P / Gilmore, Allison / Hardesty, Christina K / Mistovich, R Justin / Liu, Raymond W

    Journal of pediatric orthopedics

    2023  Volume 44, Issue 2, Page(s) e192–e196

    Abstract: Background: The recently described Modified Fels knee skeletal maturity system (mFels) has proven utility in prediction of ultimate lower extremity length in modern pediatric patients. mFels users evaluate chronological age, sex, and 7 anteroposterior ... ...

    Abstract Background: The recently described Modified Fels knee skeletal maturity system (mFels) has proven utility in prediction of ultimate lower extremity length in modern pediatric patients. mFels users evaluate chronological age, sex, and 7 anteroposterior knee radiographic parameters to produce a skeletal age estimate. We developed a free mobile application to minimize the learning curve of mFels radiographic parameter evaluation. We sought to identify the reliability of mFels for new users.
    Methods: Five pediatric orthopaedic surgeons, 5 orthopaedic surgery residents, 3 pediatric orthopaedic nurse practitioners, and 5 medical students completely naïve to mFels each evaluated a set of 20 pediatric anteroposterior knee radiographs with the assistance of the (What's the Skeletal Maturity?) mobile application. They were not provided any guidance beyond the instructions and examples embedded in the app. The results of their radiographic evaluations and skeletal age estimates were compared with those of the mFels app developers.
    Results: Averaging across participant groups, inter-rater reliability for each mFels parameter ranged from 0.73 to 0.91. Inter-rater reliability of skeletal age estimates was 0.98. Regardless of group, steady proficiency was reached by the seventh radiograph measured.
    Conclusions: mFels is a reliable means of skeletal maturity evaluation. No special instruction is necessary for first time users at any level to utilize the (What's the Skeletal Maturity?) mobile application, and proficiency in skeletal age estimation is obtained by the seventh radiograph.
    Level of evidence: Level II.
    MeSH term(s) Humans ; Child ; Reproducibility of Results ; Knee ; Lower Extremity ; Knee Joint/diagnostic imaging ; Radiography ; Age Determination by Skeleton/methods
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604642-3
    ISSN 1539-2570 ; 0271-6798
    ISSN (online) 1539-2570
    ISSN 0271-6798
    DOI 10.1097/BPO.0000000000002553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Copper Metal-Organic Framework Surface Catalysis: Catalyst Poisoning, IR Spectroscopic, and Kinetic Evidence Addressing the Nature and Number of the Catalytically Active Sites En Route to Improved Applications.

    Tuttle, Robert R / Folkman, Scott J / Rubin, Heather N / Finke, Richard G / Reynolds, Melissa M

    ACS applied materials & interfaces

    2020  Volume 12, Issue 35, Page(s) 39043–39055

    Abstract: The metal-organic framework (MOF) ... ...

    Abstract The metal-organic framework (MOF) H
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c08961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tumor suppression by p53 is mediated in part by the antiangiogenic activity of endostatin and tumstatin.

    Folkman, Judah

    Science's STKE : signal transduction knowledge environment

    2006  Volume 2006, Issue 354, Page(s) pe35

    Abstract: Recent research shows that p53 suppresses tumor angiogenesis by transcriptionally activating the alpha(II) collagen prolyl-4-hydroxylase gene. This results in the extracellular release of the potent endogenous angiogenesis inhibitors endostatin and ... ...

    Abstract Recent research shows that p53 suppresses tumor angiogenesis by transcriptionally activating the alpha(II) collagen prolyl-4-hydroxylase gene. This results in the extracellular release of the potent endogenous angiogenesis inhibitors endostatin and tumstatin from collagens 18 and 4, respectively. The involvement of these inhibitors elucidates a molecular mechanism. By simultaneously repressing a multitude of proangiogenic pathways and by inducing antiangiogenic pathways, a tumor suppressor protein can prevent an incipient tumor from switching to the angiogenic phenotype. Thus, p53 guards the genome from cancer by controlling the three fundamental processes that are critical for growth of a primary tumor and its metastases-tumor cell proliferation, apoptosis, and tumor angiogenesis.
    MeSH term(s) Angiogenesis Inhibitors/metabolism ; Animals ; Autoantigens/metabolism ; Collagen Type IV/metabolism ; Collagen Type XVIII/metabolism ; Endostatins/metabolism ; Humans ; Neoplasms/blood supply ; Neoplasms/metabolism ; Neovascularization, Pathologic ; Procollagen-Proline Dioxygenase/metabolism ; Tumor Suppressor Protein p53/antagonists & inhibitors ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Angiogenesis Inhibitors ; Autoantigens ; Collagen Type IV ; Collagen Type XVIII ; Endostatins ; Tumor Suppressor Protein p53 ; type IV collagen alpha3 chain ; Procollagen-Proline Dioxygenase (EC 1.14.11.2)
    Language English
    Publishing date 2006-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 1525-8882
    ISSN (online) 1525-8882
    DOI 10.1126/stke.3542006pe35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Francis Daniels Moore: August 17, 1913-November 24, 2001.

    Folkman, Judah

    Biographical memoirs. National Academy of Sciences (U.S.)

    2006  Volume 88, Page(s) 268–282

    MeSH term(s) Burns/history ; Burns/mortality ; Burns/therapy ; General Surgery/history ; History, 20th Century ; Isotope Labeling/history ; Massachusetts ; Metabolism ; Physicians/history
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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