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  1. Book ; Online: Translational Research for Zoonotic Parasites: New Findings toward Improved Diagnostics, Therapy and Prevention

    Colella, Vito

    2021  

    Keywords Research & information: general ; canine vector-borne disease ; blocking primers ; blood DNA extraction ; next-generation sequencing ; kit contaminant bacteria ; mosquito-borne disease ; pest control ; insecticide resistance ; biological control ; paratransgenesis ; Wolbachia ; Asaia ; Bacillus ; Strongyloides stercoralis ; soil-transmitted helminths ; hookworms ; zoonotic parasites ; Australian remote communities ; One Health ; biting midges ; vector ; mitochondrial cytochrome oxidase subunit I ; C. gornostaevae ; C. griseidorsum ; C. pallidicornis ; onchocerciasis ; Onchocerca volvulus ; antibodies ; diagnosis ; OV16 testing ; microfilariae ; epilepsy ; Dirofilaria immitis ; modified Knott's test ; ELISA ; immune complex dissociation ; serological assays ; bacterial profile ; cox1 ; Haemaphysalis bancrofti ; Ixodes holocyclus ; Ixodes trichosuri ; Ixodes tasmani ; V3-V4 16S rRNA gene ; mosquito virome ; CRESS-DNA viruses ; CyCV-VN ; insect-specific viruses ; ISV ; BatCV ; Leishmania ; protozoan parasite ; epidemiology ; environment ; Toxocara ; multiple sclerosis ; association ; meta-analysis ; Transphlebotomus ; Central Europe ; autoimmunofluorescence ; MALDI-TOF mass spectrometry ; genotyping ; leishmaniasis ; Polygonum salicifolium ; chalcone ; flavanone ; Leishmania mexicana ; Trypanosoma brucei brucei ; Trypanosoma congolense ; Canis lupus ; Vulpes vulpes ; Sarcoptes scabiei ; PCR ; serology ; Iberian Peninsula ; toxoplasmosis ; animals ; native antigens ; recombinant antigens ; Echinococcus ; NaOH ; LAMP ; DNA extraction ; taeniid egg isolation ; schistosomiasis ; Schistosoma japonicum ; right open reading frame protein kinase (riok) genes ; riok-1 ; RIOK-1 ; double-stranded RNA interference (RNAi) ; chemical inhibition ; toyocamycin ; developmental and reproductive biology ; blood filter paper ; Chagas disease ; Nobuto strip ; Trypanosoma cruzi ; mammalian surveillance ; neglected tropical diseases ; Culex pipiens s. l ; Culex torrentium ; Culiseta glaphyroptera ; caves ; subterranean environment ; Luxembourg ; Germany ; n/a
    Size 1 electronic resource (284 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291801
    ISBN 9783036526249 ; 3036526242
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Development and validation of a long-read metabarcoding platform for the detection of filarial worm pathogens of animals and humans.

    Huggins, Lucas G / Atapattu, Ushani / Young, Neil D / Traub, Rebecca J / Colella, Vito

    BMC microbiology

    2024  Volume 24, Issue 1, Page(s) 28

    Abstract: Background: Filarial worms are important vector-borne pathogens of a large range of animal hosts, including humans, and are responsible for numerous debilitating neglected tropical diseases such as, lymphatic filariasis caused by Wuchereria bancrofti ... ...

    Abstract Background: Filarial worms are important vector-borne pathogens of a large range of animal hosts, including humans, and are responsible for numerous debilitating neglected tropical diseases such as, lymphatic filariasis caused by Wuchereria bancrofti and Brugia spp., as well as loiasis caused by Loa loa. Moreover, some emerging or difficult-to-eliminate filarioid pathogens are zoonotic using animals like canines as reservoir hosts, for example Dirofilaria sp. 'hongkongensis'. Diagnosis of filariasis through commonly available methods, like microscopy, can be challenging as microfilaremia may wane below the limit of detection. In contrast, conventional PCR methods are more sensitive and specific but may show limited ability to detect coinfections as well as emerging and/or novel pathogens. Use of deep-sequencing technologies obviate these challenges, providing sensitive detection of entire parasite communities, whilst also being better suited for the characterisation of rare or novel pathogens. Therefore, we developed a novel long-read metabarcoding assay for deep-sequencing the filarial nematode cytochrome c oxidase subunit I gene on Oxford Nanopore Technologies' (ONT) MinION™ sequencer. We assessed the overall performance of our assay using kappa statistics to compare it to commonly used diagnostic methods for filarial worm detection, such as conventional PCR (cPCR) with Sanger sequencing and the microscopy-based modified Knott's test (MKT).
    Results: We confirmed our metabarcoding assay can characterise filarial parasites from a diverse range of genera, including, Breinlia, Brugia, Cercopithifilaria, Dipetalonema, Dirofilaria, Onchocerca, Setaria, Stephanofilaria and Wuchereria. We demonstrated proof-of-concept for this assay by using blood samples from Sri Lankan dogs, whereby we identified infections with the filarioids Acanthocheilonema reconditum, Brugia sp. Sri Lanka genotype and zoonotic Dirofilaria sp. 'hongkongensis'. When compared to traditionally used diagnostics, such as the MKT and cPCR with Sanger sequencing, we identified an additional filarioid species and over 15% more mono- and coinfections.
    Conclusions: Our developed metabarcoding assay may show broad applicability for the metabarcoding and diagnosis of the full spectrum of filarioids from a wide range of animal hosts, including mammals and vectors, whilst the utilisation of ONT' small and portable MinION™ means that such methods could be deployed for field use.
    MeSH term(s) Humans ; Animals ; Dogs ; Coinfection ; Filarioidea/genetics ; Filariasis/diagnosis ; Filariasis/veterinary ; Filariasis/parasitology ; Brugia/genetics ; Wuchereria bancrofti/genetics ; Mammals
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-03159-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metabarcoding using nanopore long-read sequencing for the unbiased characterization of apicomplexan haemoparasites.

    Huggins, Lucas G / Colella, Vito / Young, Neil D / Traub, Rebecca J

    Molecular ecology resources

    2023  Volume 24, Issue 2, Page(s) e13878

    Abstract: Apicomplexan haemoparasites generate significant morbidity and mortality in humans and other animals, particularly in many low-to-middle income countries. Malaria caused by Plasmodium remains responsible for some of the highest numbers of annual deaths ... ...

    Abstract Apicomplexan haemoparasites generate significant morbidity and mortality in humans and other animals, particularly in many low-to-middle income countries. Malaria caused by Plasmodium remains responsible for some of the highest numbers of annual deaths of any human pathogen, whilst piroplasmids, such as Babesia and Theileria can have immense negative economic effects through livestock loss. Diagnosing haemoparasites via traditional methods like microscopy is challenging due to low-level and transient parasitaemia. PCR-based diagnostics overcome these limitations by being both highly sensitive and specific, but they may be unable to accurately detect coinfections or identify novel species. In contrast, next-generation sequencing (NGS)-based methods can characterize all pathogens from a group of interest concurrently, although, the short-read platforms previously used have been limited in the taxonomic resolution achievable. Here, we used Oxford Nanopore Technologies' (ONT) long-read MinION™ sequencer to conduct apicomplexan haemoparasite metabarcoding via sequencing the near full-length 18S ribosomal RNA gene, demonstrating its ability to detect Babesia, Hepatozoon, Neospora, Plasmodium, Theileria and Toxoplasma species. This method was tested on blood-extracted DNA from 100 dogs and the results benchmarked against qPCR and Illumina-based metabarcoding. For two common haemoparasites, nanopore sequencing performed as well as qPCR (kappa agreement statistics > 0.98), whilst also detecting one pathogen, Hepatozoon felis, missed by the other techniques. The long-reads obtained by nanopore sequencing provide an improved species-level taxonomic resolution whilst the method's broad applicability mean it can be used to explore apicomplexan communities from diverse mammalian hosts, on a portable sequencer that easily permits adaptation to field use.
    MeSH term(s) Animals ; Dogs ; High-Throughput Nucleotide Sequencing ; Malaria ; Mammals ; Nanopore Sequencing ; Nanopores ; Sequence Analysis, DNA/methods
    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2406833-0
    ISSN 1755-0998 ; 1755-098X
    ISSN (online) 1755-0998
    ISSN 1755-098X
    DOI 10.1111/1755-0998.13878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Dogs are reservoir hosts of the zoonotic

    Atapattu, Ushani / Koehler, Anson V / Huggins, Lucas G / Wiethoelter, Anke / Traub, Rebecca J / Colella, Vito

    One health (Amsterdam, Netherlands)

    2023  Volume 17, Page(s) 100625

    Abstract: In 2016, the World Health Organization declared Sri Lanka as having successfully eliminated lymphatic filariasis as a public health concern. However, in recent decades, several infections with subperiodic filarial species suggestive of zoonotic ... ...

    Abstract In 2016, the World Health Organization declared Sri Lanka as having successfully eliminated lymphatic filariasis as a public health concern. However, in recent decades, several infections with subperiodic filarial species suggestive of zoonotic infections have been recorded across the country. The arthropod-borne filarioids
    Language English
    Publishing date 2023-08-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ancylostoma ceylanicum.

    Colella, Vito / Bradbury, Richard / Traub, Rebecca

    Trends in parasitology

    2021  Volume 37, Issue 9, Page(s) 844–845

    MeSH term(s) Ancylostoma/genetics ; Ancylostoma/growth & development ; Ancylostoma/isolation & purification ; Ancylostomiasis/diagnosis ; Ancylostomiasis/parasitology ; Ancylostomiasis/prevention & control ; Ancylostomiasis/transmission ; Animals ; Humans ; Life Cycle Stages
    Language English
    Publishing date 2021-05-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2021.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
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  6. Article: Modeling the effectiveness of One Health interventions against the zoonotic hookworm

    Walker, Martin / Lambert, Sébastien / Neves, M Inês / Worsley, Andrew D / Traub, Rebecca / Colella, Vito

    Frontiers in medicine

    2023  Volume 10, Page(s) 1092030

    Abstract: Hookworm disease is a major global public health concern, annually affecting 500-700 million of the world's poorest people. The World Health Organization is targeting the elimination of hookworm as a public health problem by 2030 using a strategy of mass ...

    Abstract Hookworm disease is a major global public health concern, annually affecting 500-700 million of the world's poorest people. The World Health Organization is targeting the elimination of hookworm as a public health problem by 2030 using a strategy of mass drug administration (MDA) to at-risk human populations. However, in Southeast Asia and the Pacific the zoonotic hookworm species,
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1092030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Challenges in the diagnosis of oral squamous cell carcinoma mimicking medication-related osteonecrosis of the jaws: a multi-hospital-based case series.

    Mauceri, Rodolfo / Coppini, Martina / Pérez-Sayáns, Mario / Toro, Corrado / Vitagliano, Rita / Colella, Giuseppe / Rodolico, Vito / Campisi, Giuseppina

    Oral oncology

    2024  Volume 151, Page(s) 106689

    MeSH term(s) Humans ; Carcinoma, Squamous Cell/diagnosis ; Squamous Cell Carcinoma of Head and Neck ; Mouth Neoplasms/diagnosis ; Osteonecrosis ; Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnosis ; Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Hospitals ; Head and Neck Neoplasms ; Jaw ; Bone Density Conservation Agents ; Diphosphonates
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2024.106689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4869: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Translational Research of Zoonotic Parasites: Toward Improved Tools for Diagnosis, Treatment and Control.

    Colella, Vito / Traub, Rebecca J / Gasser, Robin B

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: A range of factors, including social, demographic and economic transformation and human-induced environmental changes, are influencing the emergence or re-emergence of zoonoses, posing new challenges in how we detect, treat and prevent such diseases [ ... ] ...

    Abstract A range of factors, including social, demographic and economic transformation and human-induced environmental changes, are influencing the emergence or re-emergence of zoonoses, posing new challenges in how we detect, treat and prevent such diseases [...].
    Language English
    Publishing date 2021-11-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10111416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Translational Research of Zoonotic Parasites: Toward Improved Tools for Diagnosis, Treatment and Control

    Colella, Vito / Traub, Rebecca J. / Gasser, Robin B.

    Pathogens. 2021 Nov. 01, v. 10, no. 11

    2021  

    Abstract: A range of factors, including social, demographic and economic transformation and human-induced environmental changes, are influencing the emergence or re-emergence of zoonoses, posing new challenges in how we detect, treat and prevent such diseases [ ... ] ...

    Abstract A range of factors, including social, demographic and economic transformation and human-induced environmental changes, are influencing the emergence or re-emergence of zoonoses, posing new challenges in how we detect, treat and prevent such diseases [...]
    Keywords parasites ; pathogens ; zoonoses
    Language English
    Dates of publication 2021-1101
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10111416
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Translational Research of Zoonotic Parasites

    Vito Colella / Rebecca J. Traub / Robin B. Gasser

    Pathogens, Vol 10, Iss 1416, p

    Toward Improved Tools for Diagnosis, Treatment and Control

    2021  Volume 1416

    Abstract: A range of factors, including social, demographic and economic transformation and human-induced environmental changes, are influencing the emergence or re-emergence of zoonoses, posing new challenges in how we detect, treat and prevent such diseases [.] ...

    Abstract A range of factors, including social, demographic and economic transformation and human-induced environmental changes, are influencing the emergence or re-emergence of zoonoses, posing new challenges in how we detect, treat and prevent such diseases [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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