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  1. Article ; Online: Assessing Pharmacologic Treatment Effect From a Meta-Analysis in Heart Failure.

    Zheng, Haoyi

    JACC. Heart failure

    2022  Volume 10, Issue 7, Page(s) 527

    MeSH term(s) Heart Failure/drug therapy ; Hospitalization ; Humans
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2022.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: It Is Time to Abandon the Use of Body Surface Area Derived From a 100-Year-Old Formula.

    Zheng, Haoyi

    The American journal of medicine

    2022  Volume 135, Issue 9, Page(s) e308–e310

    MeSH term(s) Body Surface Area ; Humans
    Language English
    Publishing date 2022-04-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.03.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.289: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Cardiovascular Benefits of Digoxin and Empagliflozin in Patients with Chronic Heart Failure: The DIG Trial Revisited.

    Zheng, Haoyi

    The American journal of medicine

    2022  Volume 135, Issue 6, Page(s) 670–672

    MeSH term(s) Benzhydryl Compounds/therapeutic use ; Cardiotonic Agents/therapeutic use ; Clinical Trials as Topic ; Digoxin/therapeutic use ; Glucosides/therapeutic use ; Heart Failure/drug therapy ; Humans
    Chemical Substances Benzhydryl Compounds ; Cardiotonic Agents ; Glucosides ; Digoxin (73K4184T59) ; empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2022-02-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.01.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.289: Show issues Location:
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  4. Article ; Online: Cardio-Oncology Guidelines and Strength of the Evidence.

    Zheng, Haoyi / Zhan, Huichun

    JACC. CardioOncology

    2023  Volume 5, Issue 1, Page(s) 149–152

    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Editorial
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2022.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ChatGPT in Scientific Writing: A Cautionary Tale.

    Zheng, Haoyi / Zhan, Huichun

    The American journal of medicine

    2023  Volume 136, Issue 8, Page(s) 725–726.e6

    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Trastuzumab-Induced Cardiotoxicity: When and How Much Should We Worry?

    Zheng, Haoyi / Mahmood, Syed S / Khalique, Omar K / Zhan, Huichun

    JCO oncology practice

    2024  , Page(s) OP2300816

    Abstract: This review critically analyzes the incidence of trastuzumab-induced left ventricular systolic dysfunction and congestive heart failure (CHF), distinguishing between cases with and without prior anthracycline exposure. It highlights the fact that the ... ...

    Abstract This review critically analyzes the incidence of trastuzumab-induced left ventricular systolic dysfunction and congestive heart failure (CHF), distinguishing between cases with and without prior anthracycline exposure. It highlights the fact that the elevated risk of trastuzumab-induced cardiotoxicity is closely associated with prior anthracycline exposure. In the absence of prior anthracycline exposure, the incidence rates of trastuzumab-induced cardiotoxicity, particularly CHF (ranging from 0% to 0.5%), are largely comparable with those reported in the general population, especially when reversibility is taken into account. Current cardiac surveillance recommendations during trastuzumab treatment have not yet adapted to the increasing adoption of nonanthracycline treatment strategies and the associated low risk of cardiotoxicity. We propose a refined monitoring protocol to reduce the frequency of cardiac evaluations for low-risk to moderate-risk patients, especially those receiving nonanthracycline treatments. By focusing on patients at high risk or those with prior anthracycline exposure, this strategy seeks to optimize the cost-effectiveness of cardiac care in oncology.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.23.00816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Limiting Temperature Rise in Cochlear Implantation Bone Drilling: A Novel Approach.

    Liu, Hengjia / Yu, Hongjian / Du, Zhijiang / Yuan, Wenjing / Zheng, Haoyi

    IEEE transactions on bio-medical engineering

    2024  Volume 71, Issue 4, Page(s) 1104–1114

    Abstract: Objective: In the process of cochlear implantation surgery, it is crucial to develop a method to control the temperature during the drilling of the implant channel since high temperatures can result in damage to bone and nerve tissue.: Methods: This ... ...

    Abstract Objective: In the process of cochlear implantation surgery, it is crucial to develop a method to control the temperature during the drilling of the implant channel since high temperatures can result in damage to bone and nerve tissue.
    Methods: This paper simplified the traditional point heat source temperature rise model and proposed a novel extreme peck drilling model to quantitatively calculate the maximum temperature rise value. It is also innovatively introduced a new method for calculating the best peck drilling duty cycle to strictly control the maximum temperature rise value. Besides, the neural network is trained with virtual data to identify two important thermal parameters in the temperature rise model.
    Results: In the experiment of epoxy resin and temporal bone, the difference between predicted maximum temperature and actual maximum temperature was less than 1.5 °C, and the error rate was less than 10%. And the error source was analyzed by variational mode decomposition, along with discussion of potential solutions. In the temperature control experiment, the model successfully controlled the maximum temperature rise within 10 °C.For cochlear implantation surgery, we also divide the implantation channel into different stages based on the bone density in CT images to identify thermal parameters and calculate drilling strategies.
    Conclusion: This method provides a new strategy for accurate and effective control of borehole heat generation.
    Significance: These achievements provide new ideas and directions for research in cochlear implantation surgery and related fields, and are expected to have extensive application in medical practice.
    MeSH term(s) Temperature ; Cochlear Implantation/methods ; Bone and Bones ; Hot Temperature
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2023.3327277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Glioblastoma patients' survival and its relevant risk factors during the pre- and post-COVID-19 pandemic: Real-world cohort study in the USA and China.

    Qin, Ling / Li, Haoyi / Zheng, Dao / Lin, Song / Ren, Xiaohui

    International journal of surgery (London, England)

    2024  

    Abstract: Background: Although the coronavirus disease 2019 (COVID-19) pandemic has exerted potential impact on patients with glioblastomas (GBMs), it remains unclear whether the survival and its related risk factors of GBM patients would be altered or not during ...

    Abstract Background: Although the coronavirus disease 2019 (COVID-19) pandemic has exerted potential impact on patients with glioblastomas (GBMs), it remains unclear whether the survival and its related risk factors of GBM patients would be altered or not during the period spanning from pre- to post- COVID-19 pandemic era. This study aimed to clarify the important issues above.
    Methods: Two observational cohorts were utilized, including the nationwide American cohort from the Surveillance, Epidemiology, and End-Results (SEER) and the Chinese glioblastoma cohort (CGC) at our institution during 2018-2020. Demographics, tumor features, treatment regimens and clinical outcomes were collected. Cox regression model, competing risk model, and subgroup and sensitivity analysis were used to dynamically estimate the survival and its relevant risk factors over different diagnosis years from the pre- (2018 and 2019) to post-COVID-19 (2020) pandemic. Causal mediation analysis was further adopted to explore the potential relationship between risk factors and mortality.
    Results: This study included 11321 GBM cases in SEER and 226 GBM patients in CGC, respectively. Instead of the diagnostic years of 2018-2020, the prognostic risk factors, such as advanced age, bilateral tumor and absence of comprehensive therapy (surgery combined with chemoradiotherapy), were identified to persistently affect GBM survival independently during the period from 2018 to 2020 in the SEER cohort (all P < 0.05). In CGC, lack of comprehensive therapy for GBM patients were restated as survival risk factors during the same timeframe. Causal mediation analysis showed that the effect of comprehensive therapy on all-cause mortality played a determinant role (direct effect value -0.227, 95% confidence interval -0.248 to -0.207), which was partially mediated by age (9.11%) rather than tumor laterality.
    Conclusions: As the timeframe shifted from pre- to post-COVID-19 pandemic, survival of GBM patients remained stable, yet advanced age, bilateral tumors, and passive treatment continuingly impacted GBM survival. It is necessary to optimize the comprehensive treatment for GBM patients even in the post-pandemic era.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  9. Article ; Online: Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier

    Wu, Wangling / Pan, Yingying / Zheng, Tianyan / Sun, Haoyi / Li, Xia / Zhu, Haiyan / Wang, Zheng / Zhou, Xin

    Food & function

    2024  Volume 15, Issue 5, Page(s) 2679–2692

    Abstract: High-fat diet (HFD)-induced dyslipidemia is frequently accompanied by gut microbiota dysbiosis and a compromised gut barrier. Enhancing the intestinal barrier function emerges as a potential therapeutic approach for dyslipidemia. The ILC3-IL22-IL22R ... ...

    Abstract High-fat diet (HFD)-induced dyslipidemia is frequently accompanied by gut microbiota dysbiosis and a compromised gut barrier. Enhancing the intestinal barrier function emerges as a potential therapeutic approach for dyslipidemia. The ILC3-IL22-IL22R pathway, which responds to dietary and microbial signals, has not only attracted attention for its crucial role in maintaining the intestinal barrier, but recent reports have also suggested its potential in regulating lipid metabolism. Limonin is derived from the Chinese herb
    MeSH term(s) Male ; Animals ; Mice ; Obesity/metabolism ; Diet, High-Fat/adverse effects ; Dysbiosis/drug therapy ; Dysbiosis/metabolism ; Limonins/pharmacology ; Mice, Inbred C57BL ; Gastrointestinal Microbiome ; Lipids ; Dyslipidemias/drug therapy ; Dyslipidemias/etiology
    Chemical Substances Limonins ; Lipids
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04530g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  10. Article: Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP.

    Zhang, Haotian / Kafeiti, Nicholas / Lee, Sandy / Masarik, Kyla / Zheng, Haoyi / Zhan, Huichun

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Patients with JAK2V617F-positive myeloproliferative neoplasms (MPNs) and clonal hematopoiesis of indeterminate potential (CHIP) are at a significantly higher risk of cardiovascular diseases (CVDs). Endothelial cells (ECs) carrying the JAK2V617F mutation ... ...

    Abstract Patients with JAK2V617F-positive myeloproliferative neoplasms (MPNs) and clonal hematopoiesis of indeterminate potential (CHIP) are at a significantly higher risk of cardiovascular diseases (CVDs). Endothelial cells (ECs) carrying the JAK2V617F mutation can be detected in many MPN patients. Here, we investigated the impact of endothelial JAK2V617F mutation on CVD development using both transgenic murine models and human induced pluripotent stem cell lines. Our findings revealed that JAK2V617F mutant ECs promote CVDs by impairing endothelial function and undergoing endothelial-to-mesenchymal transition (EndMT). Importantly, we found that inhibiting the endothelial thrombopoietin receptor MPL suppressed JAK2V617F-induced EndMT and prevented cardiovascular dysfunction caused by mutant ECs. These findings propose that targeting the endothelial MPL receptor could be a promising therapeutic approach to manage CVD complications in patients with JAK2V617F-positive MPNs and CHIP. Further investigations into the impact of other CHIP-associated mutations on endothelial dysfunction are needed to improve risk stratification for individuals with CHIP.
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.12.548716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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