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  1. Article ; Online: Exploring the Optoelectronic Properties of D-A and A-D-A 2,2'-bi[3,2-

    Gabrian, Levi / Giurgi, Gavril-Ionel / Stroia, Ioan / Bogdan, Elena / Crişan, Andreea Petronela / Hădade, Niculina Daniela / Grosu, Ion / Terec, Anamaria

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: The synthesis of some novel donor-acceptor and acceptor-donor-acceptor systems containing a 2,2'-bi[3,2- ...

    Abstract The synthesis of some novel donor-acceptor and acceptor-donor-acceptor systems containing a 2,2'-bi[3,2-
    Language English
    Publishing date 2022-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238463
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    Zs.MO 81: Show issues

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  2. Article ; Online: The Impact of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Review.

    Tapalaga, Gianina / Bumbu, Bogdan Andrei / Reddy, Sandhya Rani / Vutukuru, Sai Diksha / Nalla, Akhila / Bratosin, Felix / Fericean, Roxana Manuela / Dumitru, Catalin / Crisan, Doru Ciprian / Nicolae, Nicoleta / Luca, Magda Mihaela

    Nutrients

    2023  Volume 15, Issue 18

    Abstract: Prenatal Vitamin D has been suggested to be critical for dental health in children, affecting ... to evaluate the potential impact of prenatal Vitamin D levels on these dental health outcomes. A total ... with Vitamin D levels or supplementation practices displaying significant variation among the study populations ...

    Abstract Prenatal Vitamin D has been suggested to be critical for dental health in children, affecting outcomes including the prevalence of enamel defects and tooth erosion. This systematic review aimed to evaluate the potential impact of prenatal Vitamin D levels on these dental health outcomes. A total of seven studies, involving 6978 participants, were included after a comprehensive search of PubMed, Web of Science, and Scopus from 2013 to June 2023. The average age of mothers varied across studies, with Vitamin D levels or supplementation practices displaying significant variation among the study populations. The age of children at examination ranged from 3.6 to 6.6 years. The analysis demonstrated a diverse association between Vitamin D levels and dental outcomes, with enamel defects reported in 21.1% to 64% of the children and opacities ranging from 36% to 79.5% across studies. Maternal Vitamin D insufficiency was identified as a significant risk factor for enamel defects in one study (OR: 3.55), whereas high prenatal Vitamin D levels indicated a protective effect against Hypomineralized Second Primary Molars (OR: 0.84) and Molar Incisor Hypomineralization (OR: 0.95) in another. Conversely, low Vitamin D levels increased the risk of enamel hypoplasia (OR: 1.29) and dental decay. The maternal and child demographics varied greatly across the studies, and the assessment and prevalence of Vitamin D deficiency or insufficiency were heterogenous. This review illuminates the potential influence of prenatal Vitamin D on dental health in children, underscoring the importance of adequate Vitamin D levels during pregnancy. However, more robust research is required to establish the optimal Vitamin D intake during pregnancy to ensure healthy dental outcomes in children.
    MeSH term(s) Child ; Pregnancy ; Female ; Humans ; Child, Preschool ; Vitamin D ; Tooth Erosion ; Tooth Diseases ; Vitamins ; Mothers ; Prevalence ; Dental Enamel
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15183863
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  3. Article ; Online: Exploring the Optoelectronic Properties of D-A and A-D-A 2,2′-bi[3,2- b ]thienothiophene Derivatives

    Levi Gabrian / Gavril-Ionel Giurgi / Ioan Stroia / Elena Bogdan / Andreea Petronela Crişan / Niculina Daniela Hădade / Ion Grosu / Anamaria Terec

    Molecules, Vol 27, Iss 8463, p

    2022  Volume 8463

    Abstract: The synthesis of some novel donor-acceptor and acceptor-donor-acceptor systems containing a 2,2′-bi[3,2- b ]thienothiophene donor block and various electron-accepting units is described alongside their photophysical properties studied using ... ...

    Abstract The synthesis of some novel donor-acceptor and acceptor-donor-acceptor systems containing a 2,2′-bi[3,2- b ]thienothiophene donor block and various electron-accepting units is described alongside their photophysical properties studied using electrochemistry, optical spectroscopy and theoretical calculations. The obtained results show that the energy levels can be modulated by changing the strength of the acceptor unit. Among the three investigated end-groups, 1,1-dicyanomethylene-3-indanone exhibited the largest bathochromic shift and the lowest band gap suggesting the strongest electron-withdrawing character. Moreover, the emissive properties of the investigated systems vary greatly with the nature of the terminal group and are generally lower compared to their precursor aldehyde derivatives.
    Keywords thienothiophene ; fluorescence ; π-conjugated systems ; electron-acceptor groups ; DFT calculations ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  4. Article ; Online: Metabolomics for genomics: the role of vitamin D in nonalcoholic fatty liver disease.

    Crisan, Dana / Radu, Corina / Suciu, Alina / Grigorescu, Mircea D / Stefanescu, Horia / Romanciuc, Florina / Socaciu, Carmen / Grigorescu, Mircea

    Journal of gastrointestinal and liver diseases : JGLD

    2015  Volume 24, Issue 3, Page(s) 394–395

    MeSH term(s) 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Biomarkers/blood ; Calcifediol/blood ; Case-Control Studies ; Chromatography, High Pressure Liquid ; Elasticity Imaging Techniques ; Genomics ; Genotype ; Humans ; Mass Spectrometry ; Metabolomics/methods ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/enzymology ; Non-alcoholic Fatty Liver Disease/genetics ; Pilot Projects ; Polymorphism, Genetic ; Predictive Value of Tests ; Principal Component Analysis ; Prognosis
    Chemical Substances Biomarkers ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.13.13) ; CYP27B1 protein, human (EC 1.14.15.18) ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2015-09-21
    Publishing country Romania
    Document type Letter
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
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    Zs.A 3825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients.

    Caraba, Alexandru / Crişan, Viorica / Romoşan, Ioan / Mozoş, Ioana / Murariu, Marius

    Disease markers

    2017  Volume 2017, Page(s) 5241012

    Abstract: ... of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients ...

    Abstract Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA.
    MeSH term(s) Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/pathology ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/pathology ; Endothelium, Vascular/pathology ; Female ; Humans ; Insulin Resistance ; Male ; Middle Aged ; Vasodilation ; Vitamin D/blood
    Chemical Substances Biomarkers ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2017/5241012
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    Zs.A 1856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Einzelsignatur: Show issues

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  6. Article ; Online: Reviews

    Crișan Andrei

    American, British and Canadian Studies Journal, Vol 38, Iss 1, Pp 252-

    Sir Gawayn and the Grene Knyght – Sir Gawain și Cavalerul cel Verde. Translated by Mircea M. Tomuș. Cluj-Napoca: Editura Școala Ardeleană, 2021. pp. vi, 350. 50 RON (softcover). ISBN: 978-606-797-644-1

    2022  Volume 256

    Keywords History (General) and history of Europe ; D ; English literature ; PR1-9680
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression.

    Buruiană, Alexandra / Gheban, Bogdan-Alexandru / Gheban-Roșca, Ioana-Andreea / Georgiu, Carmen / Crișan, Doința / Crișan, Maria

    Cancers

    2024  Volume 16, Issue 9

    Abstract: The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays a crucial role in driving tumor progression, shaping treatment responses, and influencing metastasis. This narrative review focuses on the ... ...

    Abstract The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays a crucial role in driving tumor progression, shaping treatment responses, and influencing metastasis. This narrative review focuses on the cutaneous squamous cell carcinoma (cSCC) tumor stroma, highlighting its key constituents and their dynamic contributions. We examine how significant changes within the cSCC ECM-specifically, alterations in fibronectin, hyaluronic acid, laminins, proteoglycans, and collagens-promote cancer progression, metastasis, and drug resistance. The cellular composition of the cSCC TME is also explored, detailing the intricate interplay of cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, pericytes, adipocytes, and various immune cell populations. These diverse players modulate tumor development, angiogenesis, and immune responses. Finally, we emphasize the TME's potential as a therapeutic target. Emerging strategies discussed in this review include harnessing the immune system (adoptive cell transfer, checkpoint blockade), hindering tumor angiogenesis, disrupting CAF activity, and manipulating ECM components. These approaches underscore the vital role that deciphering TME interactions plays in advancing cSCC therapy. Further research illuminating these complex relationships will uncover new avenues for developing more effective treatments for cSCC.
    Language English
    Publishing date 2024-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16091727
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  8. Article: Seeing and Sensing the Hepatorenal Syndrome (HRS): The Growing Role of Ultrasound-Based Techniques as Non-Invasive Tools for the Diagnosis of HRS.

    Tăluță, Cornelia / Ștefănescu, Horia / Crișan, Dana

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 9

    Abstract: More than half of patients hospitalized with liver cirrhosis are dealing with an episode of acute kidney injury; the most severe pattern is hepatorenal syndrome due to its negative prognosis. The main physiopathology mechanisms involve renal ... ...

    Abstract More than half of patients hospitalized with liver cirrhosis are dealing with an episode of acute kidney injury; the most severe pattern is hepatorenal syndrome due to its negative prognosis. The main physiopathology mechanisms involve renal vasoconstriction and systemic inflammation. During the last decade, the definition of hepatorenal syndrome changed, but the validated criteria of diagnosis are still based on the serum creatinine level, which is a biomarker with multiple limitations. This is the reason why novel serum and urinary biomarkers have been intensively studied in recent years. Meanwhile, the imaging studies that use shear wave elastography are using renal stiffness as a surrogate for an early diagnosis. In this article, we focus on the physiopathology definition and highlight the novel tools used in the diagnosis of hepatorenal syndrome.
    Language English
    Publishing date 2024-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14090938
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  9. Article ; Online: Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients

    Alexandru Caraba / Viorica Crişan / Ioan Romoşan / Ioana Mozoş / Marius Murariu

    Disease Markers, Vol

    2017  Volume 2017

    Abstract: ... of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients ... determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction ... low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation ...

    Abstract Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction. Statistical analysis were performed using the Student’s t-test and the Pearson’s test. p values of less than 0.05 were considered statistically significant. Results. The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p<0.00001). Significant inverse correlations between the levels of 25(OH) vitamin D and DAS28, respective insulin resistance, and significant positive correlation between 25(OH) vitamin D and endothelial function were demonstrated. Conclusion. In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction.
    Keywords Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
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  10. Article ; Online: High-frequency ultrasound in auricular skin cancer surgery: a precise, in vivo tool for identification of a potential cartilage infiltration and planning the therapeutic approach.

    Badea, Alexandru / Crisan, Diana

    International journal of dermatology

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17173
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    Ui VI Zs.189: Show issues Location:
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