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  1. Article ; Online: Lymphatic vessels and the renin-angiotensin-system.

    Bertoldi, Giovanni / Caputo, Ilaria / Calò, Lorenzo / Rossitto, Giacomo

    American journal of physiology. Heart and circulatory physiology

    2023  Volume 325, Issue 4, Page(s) H837–H855

    Abstract: The lymphatic system is an integral part of the circulatory system and plays an important role in the fluid homeostasis of the human body. Accumulating evidence has recently suggested the involvement of lymphatic dysfunction in the pathogenesis of cardio- ...

    Abstract The lymphatic system is an integral part of the circulatory system and plays an important role in the fluid homeostasis of the human body. Accumulating evidence has recently suggested the involvement of lymphatic dysfunction in the pathogenesis of cardio-reno-vascular (CRV) disease. However, how the sophisticated contractile machinery of lymphatic vessels is modulated and, possibly impaired in CRV disease, remains largely unknown. In particular, little attention has been paid to the effect of the renin-angiotensin-system (RAS) on lymphatics, despite the high concentration of RAS mediators that these tissue-draining vessels are exposed to and the established role of the RAS in the development of classic microvascular dysfunction and overt CRV disease. We herein review recent studies linking RAS to lymphatic function and/or plasticity and further highlight RAS-specific signaling pathways, previously shown to drive adverse arterial remodeling and CRV organ damage that have potential for direct modulation of the lymphatic system.
    MeSH term(s) Humans ; Renin/metabolism ; Renin-Angiotensin System ; Kidney/metabolism ; Angiotensins/metabolism ; Lymphatic Vessels/metabolism
    Chemical Substances Renin (EC 3.4.23.15) ; Angiotensins
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00023.2023
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    Uc I Zs.89: Show issues Location:
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  2. Article: "Every Cloud Has a Silver Lining": How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It.

    Cacciapuoti, Martina / Caputo, Ilaria / Stefanelli, Lucia Federica / Davis, Paul A / Nalesso, Federico / Calò, Lorenzo A

    Clinics and practice

    2024  Volume 14, Issue 2, Page(s) 614–618

    Abstract: The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play ... ...

    Abstract The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman's and Bartter's Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research.
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2605724-4
    ISSN 2039-7283 ; 2039-7275
    ISSN (online) 2039-7283
    ISSN 2039-7275
    DOI 10.3390/clinpract14020048
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  3. Article ; Online: Response to Letter to the Editor: "Remote Placental Sign-Out: What Digital Pathology Can Offer for Pediatric Pathologists".

    Marletta, Stefano / Pantanowitz, Liron / Santonicco, Nicola / Caputo, Alessandro / Bragantini, Emma / Brunelli, Matteo / Girolami, Ilaria / Eccher, Albino

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2024  , Page(s) 10935266231225791

    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Letter
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.1177/10935266231225791
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5063: Show issues Location:
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  4. Article: The RAAS Goodfellas in Cardiovascular System.

    Caputo, Ilaria / Bertoldi, Giovanni / Driussi, Giulia / Cacciapuoti, Martina / Calò, Lorenzo A

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: In the last two decades, the study of the renin-angiotensin-aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the ... ...

    Abstract In the last two decades, the study of the renin-angiotensin-aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the RAAS mediated by ACE/Ang II/AT1R/aldosterone and plays an important role in the prevention of inflammation, oxidative stress, hypertension, and cardiovascular remodeling. A growing body of evidence suggests that enhancement of this counterregulatory arm of RAAS represents an important therapeutic approach to facing cardiovascular comorbidities. In this review, we provide an overview of the beneficial effects of ACE2, Ang 1-7/MasR, and Ang 1-9 in the context of oxidative stress, vascular dysfunction, and organ damage.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216873
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  5. Article ; Online: Challenges and management of childhood noninfectious chronic uveitis.

    Maccora, Ilaria / Marrani, Edoardo / Pagnini, Ilaria / Mastrolia, Maria Vincenza / de Libero, Cinzia / Caputo, Roberto / Simonini, Gabriele

    Expert review of clinical immunology

    2023  Volume 19, Issue 6, Page(s) 599–611

    Abstract: Introduction: Childhood uveitis is a sight-threatening condition, because if not properly recognized and treated can lead to several ocular complications and blindness. It represents a real challenge not only from an etiologic/diagnostic point of view, ... ...

    Abstract Introduction: Childhood uveitis is a sight-threatening condition, because if not properly recognized and treated can lead to several ocular complications and blindness. It represents a real challenge not only from an etiologic/diagnostic point of view, but also for management and therapy.
    Areas covered: In this review we will discuss the main etiologies, the diagnostic approach, risk factors associated to childhood noninfectious uveitis (cNIU), and the difficulties in eye examination in childhood. Moreover, we will discuss the treatment of cNIU in terms of therapeutic choice, timing of initiation, and withdrawal.
    Expert opinion: Identification of specific diagnosis is mandatory to prevent severe complications, thus a thorough differential diagnosis is essential. Pediatric eye examination may be extremely challenging due to the scarce collaboration, but novel techniques and biomarkers will help in identifying low grade of inflammation, eventually modifying long-term outcomes. Once identified the appropriate diagnosis, recognition of children who may benefit of a systemic treatment is crucial. What, When, and how long are the key questions to address in this field. Current evidence and future results of ongoing clinical trials will help in driving treatment. A proper ocular screening, not only in the context of systemic disease, should be discussed by experts.
    MeSH term(s) Child ; Humans ; Arthritis, Juvenile/complications ; Uveitis/therapy ; Uveitis/drug therapy ; Inflammation/drug therapy ; Glucocorticoids/therapeutic use ; Biomarkers
    Chemical Substances Glucocorticoids ; Biomarkers
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2198210
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
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  6. Article ; Online: Endocrine disruptors and arterial hypertension: A developing story.

    Caroccia, Brasilina / Caputo, Ilaria / Rossi, Federico Bernardo / Piazza, Maria / Pallafacchina, Giorgia / Paolo Rossi, Gian

    Steroids

    2023  Volume 199, Page(s) 109292

    Abstract: Endocrine disrupting Chemicals (EDCs) are substances that interfere with hormones by several mechanisms including receptor activation or antagonism, changes in gene and protein expression, modification of signal transduction, and/or epigenetic ... ...

    Abstract Endocrine disrupting Chemicals (EDCs) are substances that interfere with hormones by several mechanisms including receptor activation or antagonism, changes in gene and protein expression, modification of signal transduction, and/or epigenetic modifications in hormone-producing cells. A survey conducted by the European Union in a Northern Italian region led to the discovery of a large environmental contamination of drinking water by perfluoroalkyl substances (PFAS). As the exposed population showed a high prevalence of arterial hypertension and cardiovascular disease, we decided to investigate if PFAS could enhance the biosynthesis of aldosterone. To this aim, we exposed human adrenocortical carcinoma HAC15 cells to PFAS and found that PFAS markedly increased aldosterone synthase (CYP11B2) gene expression and aldosterone secretion. Moreover, we found that they promoted reactive oxygen species (ROS) production in mitochondria, the organelles where aldosterone biosynthesis takes place. PFAS also enhanced the effects of the aldosterone secretagogue angiotensin II (Ang II) on CYP11B2 gene expression and aldosterone secretion. We also found that not only PFAS but also polychlorinated biphenyl 126 (PCB126), a chemical compound belonging to a different category of EDCs, can increase CYP11B2 gene expression and aldosterone secretion in adrenocortical cells. This novel information needs to be considered in the context of a widespread exposure to the most common EDC, that is excess Na
    Language English
    Publishing date 2023-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80312-1
    ISSN 1878-5867 ; 0039-128X
    ISSN (online) 1878-5867
    ISSN 0039-128X
    DOI 10.1016/j.steroids.2023.109292
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 87: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Impaired ACE2 glycosylation and protease activity in Fabry disease protects from COVID-19.

    Caputo, Ilaria / Bertoldi, Giovanni / Driussi, Giulia / Sgarabotto, Luca / Carraro, Gianni / Stefanelli, Lucia Federica / Davis, Paul A / Calò, Lorenzo A

    Journal of internal medicine

    2023  Volume 294, Issue 2, Page(s) 238–240

    MeSH term(s) Humans ; COVID-19 ; Angiotensin-Converting Enzyme 2/metabolism ; Glycosylation ; Fabry Disease ; SARS-CoV-2
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13672
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    Ua VI Zs.44: Show issues Location:
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  8. Article ; Online: Childhood Chronic Idiopathic Uveitis in a Multicentre International Cohort.

    Maccora, Ilaria / Guly, Catherine / de Libero, Cinzia / Caputo, Roberto / Ramanan, Athimalaipet V / Simonini, Gabriele

    Ocular immunology and inflammation

    2023  Volume 32, Issue 3, Page(s) 310–319

    Abstract: Importance: Idiopathic uveitis makes up around 50% of non-infectious uveitis but the clinical characteristics in children are poorly understood.: Objective: To report the demographic, clinical characteristics, and outcomes of children with idiopathic ...

    Abstract Importance: Idiopathic uveitis makes up around 50% of non-infectious uveitis but the clinical characteristics in children are poorly understood.
    Objective: To report the demographic, clinical characteristics, and outcomes of children with idiopathic non-infectious uveitis (iNIU) in a multicentric retrospective study.
    Results: There were 126 (61 female) children with iNIU. The median age at diagnosis was 9.3 years (3-16 years) . Uveitis was bilateral in 106 patients and anterior in 68.At onset,impaired visual acuity and blindness in the worse eye were reported, in 24.4% and 15.1% patients but at 3 years of follow-up, there was a significant improvement in visual acuity (mean 0.11 SD ±0.50 vs 0.42 SD ± 0.59 p < .001).
    Conclusions and relevance: There is a high rate of visual impairment at presentation in children with idiopathic uveitis. The majority of patients have a significant improvement in vision, but 1 in 6 had impaired vision or blindness in their worse eye at 3 years.
    MeSH term(s) Child ; Humans ; Female ; Retrospective Studies ; Uveitis/diagnosis ; Uveitis/epidemiology ; Blindness ; Visual Acuity ; Vision, Low ; Iridocyclitis
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2023.2169715
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    Zs.A 4004: Show issues Location:
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  9. Article ; Online: The RAAS Goodfellas in Cardiovascular System

    Ilaria Caputo / Giovanni Bertoldi / Giulia Driussi / Martina Cacciapuoti / Lorenzo A. Calò

    Journal of Clinical Medicine, Vol 12, Iss 21, p

    2023  Volume 6873

    Abstract: In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the ... ...

    Abstract In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the RAAS mediated by ACE/Ang II/AT1R/aldosterone and plays an important role in the prevention of inflammation, oxidative stress, hypertension, and cardiovascular remodeling. A growing body of evidence suggests that enhancement of this counterregulatory arm of RAAS represents an important therapeutic approach to facing cardiovascular comorbidities. In this review, we provide an overview of the beneficial effects of ACE2, Ang 1-7/MasR, and Ang 1-9 in the context of oxidative stress, vascular dysfunction, and organ damage.
    Keywords RAAS ; Ang 1-7 ; Ang 1-9 ; cardiovascular remodeling ; oxidative stress ; Medicine ; R
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Biochemical Mechanisms beyond Glycosphingolipid Accumulation in Fabry Disease: Might They Provide Additional Therapeutic Treatments?

    Bertoldi, Giovanni / Caputo, Ilaria / Driussi, Giulia / Stefanelli, Lucia Federica / Di Vico, Valentina / Carraro, Gianni / Nalesso, Federico / Calò, Lorenzo A

    Journal of clinical medicine

    2023  Volume 12, Issue 5

    Abstract: Fabry disease is a rare X-linked disease characterized by deficient expression and activity of alpha-galactosidase A (α-GalA) with consequent lysosomal accumulation of glycosphingolipid in various organs. Currently, enzyme replacement therapy is the ... ...

    Abstract Fabry disease is a rare X-linked disease characterized by deficient expression and activity of alpha-galactosidase A (α-GalA) with consequent lysosomal accumulation of glycosphingolipid in various organs. Currently, enzyme replacement therapy is the cornerstone of the treatment of all Fabry patients, although in the long-term it fails to completely halt the disease's progression. This suggests on one hand that the adverse outcomes cannot be justified only by the lysosomal accumulation of glycosphingolipids and on the other that additional therapies targeted at specific secondary mechanisms might contribute to halt the progression of cardiac, cerebrovascular, and renal disease that occur in Fabry patients. Several studies reported how secondary biochemical processes beyond Gb3 and lyso-Gb3 accumulation-such as oxidative stress, compromised energy metabolism, altered membrane lipid, disturbed cellular trafficking, and impaired autophagy-might exacerbate Fabry disease adverse outcomes. This review aims to summarize the current knowledge of these pathogenetic intracellular mechanisms in Fabry disease, which might suggest novel additional strategies for its treatment.
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12052063
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