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  1. Article ; Online: Ameliorated nailfold capillary morphology of patients with pulmonary arterial hypertension in systemic sclerosis, treated with riociguat.

    Sugimoto, Tomohiro / Dohi, Yoshihiro / Yoshida, Yusuke / Mokuda, Sho / Hirata, Shintaro

    Rheumatology advances in practice

    2023  Volume 7, Issue 1, Page(s) rkad011

    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Case Reports
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkad011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on: Combination of immunosuppressive therapy and nintedanib improves capillaroscopic changes in systemic sclerosis-interstitial lung disease: a case report.

    Sugimoto, Tomohiro / Yoshida, Yusuke / Mokuda, Sho / Hirata, Shintaro

    Rheumatology advances in practice

    2022  Volume 6, Issue 1, Page(s) rkac024

    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkac024
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  3. Article: Association between increased serum IL-23 levels and ACPA positivity in patients with rheumatoid arthritis.

    Kohno, Hiroki / Sugimoto, Tomohiro / Yoshida, Yusuke / Mokuda, Sho / Hirata, Shintaro / Sugiyama, Eiji

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 5, Page(s) 1198–1199

    MeSH term(s) Humans ; Arthritis, Rheumatoid/diagnosis ; Rheumatoid Factor ; Interleukin-23 ; Autoantibodies
    Chemical Substances Rheumatoid Factor (9009-79-4) ; Interleukin-23 ; Autoantibodies
    Language English
    Publishing date 2023-01-31
    Publishing country Italy
    Document type Letter
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/1yfr4z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Methotrexate-associated reversible liver atrophy in a patient with rheumatoid arthritis.

    Sugimoto, Tomohiro / Mokuda, Sho / Sugiyama, Eiji

    Rheumatology advances in practice

    2020  Volume 4, Issue 1, Page(s) rkaa014

    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Case Reports
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkaa014
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  5. Article ; Online: Successful hydroxychloroquine treatment in a patient with systemic lupus erythematosus-associated nailfold capillary abnormalities.

    Sugimoto, Tomohiro / Mokuda, Sho / Sugiyama, Eiji

    Rheumatology advances in practice

    2020  Volume 4, Issue 2, Page(s) rkaa060

    Language English
    Publishing date 2020-11-05
    Publishing country England
    Document type Case Reports
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkaa060
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  6. Article: N

    Mokuda, Sho / Watanabe, Hirofumi / Kohno, Hiroki / Ishitoku, Michinori / Araki, Kei / Hirata, Shintaro / Sugiyama, Eiji

    Cytotechnology

    2022  Volume 74, Issue 4, Page(s) 503–514

    Abstract: Studies conducted using murine arthritis models have indicated that the use of in vitro-transcribed messenger RNA (IVT mRNA) is an effective therapeutic approach for joint diseases. However, the use of IVT mRNA in human synovial cells has not been widely ...

    Abstract Studies conducted using murine arthritis models have indicated that the use of in vitro-transcribed messenger RNA (IVT mRNA) is an effective therapeutic approach for joint diseases. However, the use of IVT mRNA in human synovial cells has not been widely studied. Recently, the outbreak of the novel coronavirus disease has accelerated the development of innovative mRNA vaccines, such as those containing a modified nucleic acid, N
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-022-00540-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2604: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Angiotensin-converting Enzyme 2, a SARS-CoV-2 Receptor, Is Upregulated by Interleukin 6 through STAT3 Signaling in Synovial Tissues.

    Mokuda, Sho / Tokunaga, Tadahiro / Masumoto, Junya / Sugiyama, Eiji

    The Journal of rheumatology

    2020  Volume 47, Issue 10, Page(s) 1593–1595

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/physiopathology ; Biopsy, Needle ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Humans ; Immunohistochemistry ; Interleukin-6/metabolism ; Japan ; Pandemics/prevention & control ; Peptidyl-Dipeptidase A/genetics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; STAT3 Transcription Factor/metabolism ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/physiopathology ; Signal Transduction/genetics ; Synovial Membrane/pathology ; Up-Regulation/genetics
    Chemical Substances Interleukin-6 ; STAT3 Transcription Factor ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country Canada
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.200547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 135: Show issues

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  8. Article ; Online: Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan.

    Mokuda, Sho / Kawanishi, Namiki / Kuroshima, Shintaro / Kono, Junko / Nakayama, Hirofumi / Mieno, Hiroshi / Kawamoto, Masashi

    Vaccine: X

    2022  Volume 11, Page(s) 100173

    Abstract: Background: There are a few reports on antibody responses after a two-dose BNT162b2 vaccination in non-epidemic areas. We evaluated this phenomenon.: Methods: A total of 344 healthcare workers were vaccinated, and the serum anti-receptor-binding ... ...

    Abstract Background: There are a few reports on antibody responses after a two-dose BNT162b2 vaccination in non-epidemic areas. We evaluated this phenomenon.
    Methods: A total of 344 healthcare workers were vaccinated, and the serum anti-receptor-binding domain (RBD) antibody concentrations before and after two weeks following the two-dose BNT162b2 vaccination were measured using electro chemiluminescence immunoassay system.
    Results: Before vaccination, the antibody titers of all participants were less than 0.6 U/mL. After two doses of the BNT162b2 vaccine injection in 342 participants (2 excluded), a high seroconversion rate (99.7%) was observed. The average (±standard deviation) serum anti-RBD antibody titers were 2324 ± 1739 U/mL. Antibody levels in females and males were 2443 ± 1833 U/mL and 1908 ± 1287 U/mL, respectively (p = 0.037).
    Conclusion: In a non-epidemic area, two BNT162b2 doses induced a satisfactory antibody response, and the antibody concentrations in females were higher than in males.
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article
    ISSN 2590-1362
    ISSN (online) 2590-1362
    DOI 10.1016/j.jvacx.2022.100173
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  9. Article ; Online: Appearance of Anti-MDA5 Antibody-Positive Dermatomyositis After COVID-19 Vaccination.

    Sugimoto, Tomohiro / Yorishima, Ai / Oka, Naoya / Masuda, Sho / Nakamoto, Naoki / Kidoguchi, Genki / Watanabe, Hirofumi / Yoshida, Yusuke / Mokuda, Sho / Hirata, Shintaro

    Modern rheumatology case reports

    2022  

    Abstract: The direct causes of dermatomyositis, a common autoimmune disease, have not yet been accurately identified, but several studies have linked this condition to various patient-associated and environmental factors, such as viral infections and area of ... ...

    Abstract The direct causes of dermatomyositis, a common autoimmune disease, have not yet been accurately identified, but several studies have linked this condition to various patient-associated and environmental factors, such as viral infections and area of residence. In the present report, we describe our experience with a patient presenting with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis, which developed after vaccination against coronavirus disease 2019 (COVID-19). This patient was simultaneously diagnosed with anti-glutamic acid decarboxylase (GAD) antibody-positive slowly progressive insulin-dependent diabetes (SPIDDM); her human leukocyte antigen (HLA) test revealed that she expressed the DRB1*04:05 allele. This is important as this genotype is known to increase susceptibility to both anti-MDA5 antibody-positive dermatomyositis and type I diabetes. To the best of our knowledge, this is the first case of dermatomyositis complicated by SPIDDM identified after COVID-19 vaccination against COVID-19 and presenting with an underlying susceptible genotype. The patient's genetic predisposition may also be important for the development of autoimmune disease after COVID-19 vaccination.
    Language English
    Publishing date 2022-08-11
    Publishing country England
    Document type Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1093/mrcr/rxac064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Disseminated Mycobacterium abscessus infection with osteoarticular manifestations as an important differential diagnosis of inflammatory arthritis: A case report and literature review.

    Watanabe, Chihaya / Yoshida, Yusuke / Kidoguchi, Genki / Kitagawa, Hiroki / Shoji, Takeshi / Nakamoto, Naoki / Oka, Naoya / Sugimoto, Tomohiro / Mokuda, Sho / Hirata, Shintaro

    Modern rheumatology case reports

    2023  Volume 8, Issue 1, Page(s) 49–54

    Abstract: This case report describes a 52-year-old immunocompromised man diagnosed with disseminated Mycobacterium abscessus complex (MABC) infection. The patient had a history of malignant lymphoma and presented with fever and polyarthritis that lasted 3 weeks. ... ...

    Abstract This case report describes a 52-year-old immunocompromised man diagnosed with disseminated Mycobacterium abscessus complex (MABC) infection. The patient had a history of malignant lymphoma and presented with fever and polyarthritis that lasted 3 weeks. Upon initial evaluation, blood and synovial fluid cultures from the swollen joints were negative. Reactive arthritis or rheumatoid arthritis was suspected as the cause of inflammatory synovitis in multiple joints. Administration of prednisolone followed by an interleukin-6 inhibitor improved the fever, but polyarthritis persisted, and destruction of the left hip joint was observed. Two months later, M. abscessus was detected in a blood culture and right shoulder joint synovium, leading to a final diagnosis of disseminated MABC infection. The joint symptoms resolved with combined antimicrobial therapy using amikacin, azithromycin, and imipenem/cilastatin. To date, 12 cases of disseminated MABC infection with osteoarticular manifestations have been reported. A total of 13 cases, including the present case, were reviewed. Seven patients had bone involvements, five had joint involvement, and the remaining one had bursa involvement. All the cases with joint involvement, except for our case, presented with monoarthritis. MABC infection is diagnosed based on the demonstration of MABC itself. Clinicians should keep disseminated MABC infection in mind as a possible cause of persistent arthritis. As demonstrated in our case, multiple replicate cultures of blood or specimens from the affected sites may be needed to detect it.
    MeSH term(s) Male ; Humans ; Middle Aged ; Diagnosis, Differential ; Mycobacterium Infections, Nontuberculous/complications ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Arthritis/diagnosis ; Arthritis/etiology ; Mycobacterium abscessus
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1093/mrcr/rxad054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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