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  1. Article ; Online: Evaluating Discriminative Accuracy of Biomarkers in Relation to Binary Study Outcomes: First Validate, Then Celebrate?

    Bourgonje, Arno R

    Journal of Crohn's & colitis

    2022  Volume 17, Issue 1, Page(s) 146

    MeSH term(s) Humans ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjac117
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    Zs.A 6634: Show issues Location:
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  2. Article ; Online: Microbial Riboflavin Biosynthesis Associates With Response to Dietary Fiber Consumption: Time to Personalize Adjunct Therapy in Patients With Inflammatory Bowel Disease?

    Bourgonje, Arno R

    Gastroenterology

    2022  Volume 165, Issue 2, Page(s) 515–516

    MeSH term(s) Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/chemically induced ; Dietary Fiber/adverse effects ; Riboflavin
    Chemical Substances Dietary Fiber ; Riboflavin (TLM2976OFR)
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.10.016
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  3. Article ; Online: Identifying Phenotypic Determinants of Infliximab Target Concentrations in Inflammatory Bowel Disease: Toward Personalized Evidence-Based Dosing Regimens.

    Bourgonje, Arno R / Mian, Paola

    The American journal of gastroenterology

    2023  Volume 118, Issue 12, Page(s) 2308–2309

    MeSH term(s) Humans ; Infliximab/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Gastrointestinal Agents/therapeutic use ; Drug Monitoring
    Chemical Substances Infliximab (B72HH48FLU) ; Gastrointestinal Agents
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002365
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  4. Article ; Online: The Risk of Developing Long COVID in Patients With Inflammatory Bowel Diseases: Do Immunosuppressive Drugs Matter?

    Bourgonje, Arno R / Otten, Antonius T

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 21, Issue 7, Page(s) 1971–1972

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Immunosuppressive Agents/adverse effects ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/chemically induced
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2022.12.030
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    Zs.A 5836: Show issues Location:
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  5. Article ; Online: Interleukin-18 Inhibition in Inflammatory Bowel Disease: A Delicate Balance.

    Geertsema, Sem / Fagundes, Raphael R / Otten, Antonius T / Dijkstra, Gerard / Faber, Klaas Nico / Bourgonje, Arno R

    Inflammatory bowel diseases

    2024  Volume 30, Issue 4, Page(s) 693–694

    MeSH term(s) Animals ; Mice ; Antibodies, Monoclonal ; Interleukin-18 ; Inflammatory Bowel Diseases/immunology ; Colitis
    Chemical Substances Antibodies, Monoclonal ; Interleukin-18
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izae042
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  6. Article ; Online: The Future of Therapeutic Drug Monitoring in Inflammatory Bowel Disease: An Emphasis on the Essential Ingredients.

    Otten, Antonius T / Dijkstra, Gerard / Visschedijk, Marijn C / Bourgonje, Arno R

    Inflammatory bowel diseases

    2023  Volume 30, Issue 2, Page(s) 318–319

    MeSH term(s) Humans ; Drug Monitoring ; Inflammatory Bowel Diseases/drug therapy ; Infliximab/therapeutic use
    Chemical Substances Infliximab (B72HH48FLU)
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izad144
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  7. Article ; Online: Working towards a comprehensive appraisal of vaccine-induced immunity against SARS-CoV-2 in IBD.

    Otten, Antonius T / Bourgonje, Arno R / Visschedijk, Marijn C

    The lancet. Gastroenterology & hepatology

    2022  Volume 8, Issue 2, Page(s) 99–100

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/prevention & control ; Inflammatory Bowel Diseases
    Language English
    Publishing date 2022-12-05
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00404-6
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  8. Article ; Online: Letter: Diet-microbiome interactions in inflammatory bowel disease-Navigating towards individualised dietary strategies.

    Barth, Iris / Stevens, Corien L / Strokap, Colette J / Campmans-Kuijpers, Marjo J E / Bourgonje, Arno R / Dijkstra, Gerard

    Alimentary pharmacology & therapeutics

    2024  Volume 59, Issue 9, Page(s) 1154–1155

    MeSH term(s) Humans ; Inflammatory Bowel Diseases ; Diet ; Microbiota
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Letter
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17927
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  9. Article ; Online: Letter: disentangling the role of redox-active compounds in the development of inflammatory bowel diseases - moving towards causal associations.

    Geertsema, Sem / van Goor, Harry / Dijkstra, Gerard / Faber, Klaas Nico / Bourgonje, Arno R

    Alimentary pharmacology & therapeutics

    2023  Volume 57, Issue 9, Page(s) 1046–1047

    MeSH term(s) Humans ; Inflammatory Bowel Diseases/drug therapy ; Oxidation-Reduction
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17455
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  10. Article ; Online: Clinical Value of Multiomics-Based Biomarker Signatures in Inflammatory Bowel Diseases: Challenges and Opportunities.

    Bourgonje, Arno R / van Goor, Harry / Faber, Klaas Nico / Dijkstra, Gerard

    Clinical and translational gastroenterology

    2023  Volume 14, Issue 7, Page(s) e00579

    Abstract: Inflammatory bowel diseases (IBDs), encompassing Crohn's disease and ulcerative colitis, are complex and heterogeneous diseases characterized by a multifactorial etiology, therefore demanding a multimodal approach to disentangle the main ... ...

    Abstract Inflammatory bowel diseases (IBDs), encompassing Crohn's disease and ulcerative colitis, are complex and heterogeneous diseases characterized by a multifactorial etiology, therefore demanding a multimodal approach to disentangle the main pathophysiological components driving disease onset and progression. Adoption of a systems biology approach is increasingly advocated with the advent of multiomics profiling technologies, aiming to improve disease classification, to identify disease biomarkers, and to accelerate drug discovery for patients with IBD. However, clinical translation of multiomics-derived biomarker signatures is lagging behind because there are several obstacles that need to be addressed to realize clinically useful signatures. Multiomics integration and IBD-specific identification of molecular networks, standardization and clearly defined outcomes, strategies to tackle cohort heterogeneity, and external validation of multiomics-based signatures are critical aspects. While striving for personalized medicine in IBD, careful consideration of these aspects is, however, needed to adequately match biomarker targets (e.g., the gut microbiome, immunity, or oxidative stress) with their corresponding utilities (e.g., early disease detection and endoscopic and clinical outcome). Theory-driven disease classifications and predictions are still governing clinical practice, while this could be improved by adopting an unbiased, data-driven approach relying on molecular data structures integrated with patient and disease characteristics. In the foreseeable future, the main challenge will lie in the complexity and impracticality of implementing multiomics-based signatures into clinical practice. Still, this could be achieved by developing easy-to-use, robust, and cost-effective tools incorporating omics-derived predictive signatures and through the design and execution of prospective, longitudinal, biomarker-stratified clinical trials.
    MeSH term(s) Humans ; Multiomics ; Prospective Studies ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/drug therapy ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Crohn Disease/genetics ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000579
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