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  1. Article ; Online: Pancreatic cysts: can surveillance interval for small low-risk lesions be lengthened?

    Chong, Jingli / Wee, Nicole Kessa / Tan, Cher Heng / Low, Hsien Min / Chew, Wei Da / Vu, Charles Kien Fong / Lee, Chau Hung

    Acta radiologica (Stockholm, Sweden : 1987)

    2024  , Page(s) 2841851231222799

    Abstract: Background: Surveillance of pancreatic cysts are necessary due to risk of malignant transformation. However, reported progression rates to advanced neoplasia are variable and the high frequency of surveillance scans may pose a considerable burden on ... ...

    Abstract Background: Surveillance of pancreatic cysts are necessary due to risk of malignant transformation. However, reported progression rates to advanced neoplasia are variable and the high frequency of surveillance scans may pose a considerable burden on healthcare resources.
    Purpose: To validate the effectiveness of the Fukuoka Guidelines surveillance regime and determine if a longer surveillance interval can be established.
    Material and methods: All magnetic resonance imaging (MRI) studies of the pancreas performed at our institution between January 2014 and December 2016 with at least one pancreatic cystic lesion and follow-up MRI or computed tomography (CT) over at least two years were reviewed for size, worrisome feature (WF), and high-risk stigmata (HRS) at diagnosis and follow-up imaging (up to year 6). Reference standards for advanced neoplasia were based on endoscopic ultrasound, fine needle aspiration cytology, or the presence of ≥2 WF or ≥1 HRS on imaging. Comparison of MRI features of progression and outcomes of diagnostic endpoints between lesions <20 mm and ≥20 mm was performed.
    Results: A total of 270 patients were included (201 cysts <20 mm, 69 cysts ≥20 mm). Compared with cysts <20 mm, cysts ≥20 mm were more likely to be associated with WF or HRS (40.6% vs. 12.4%;
    Conclusion: Pancreatic cysts <20 mm have a low risk of developing WF and HRS and surveillance interval may be lengthened.
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 105-3
    ISSN 1600-0455 ; 0284-1851 ; 0349-652X
    ISSN (online) 1600-0455
    ISSN 0284-1851 ; 0349-652X
    DOI 10.1177/02841851231222799
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  2. Article ; Online: The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.

    Sutanto, Clarinda Nataria / Xia, Xuejuan / Heng, Chin Wee / Tan, Yue Shuian / Lee, Delia Pei Shan / Fam, Johnson / Kim, Jung Eun

    Clinical nutrition (Edinburgh, Scotland)

    2024  Volume 43, Issue 3, Page(s) 593–602

    Abstract: Background & aims: Sleep quality is a pivotal part of health and there is growing evidence on the association between gut microbiota composition and sleep quality. 5-Hydroxytryptophan (5-HTP) is known as a precursor of the sleep regulating ... ...

    Abstract Background & aims: Sleep quality is a pivotal part of health and there is growing evidence on the association between gut microbiota composition and sleep quality. 5-Hydroxytryptophan (5-HTP) is known as a precursor of the sleep regulating neurotransmitter and hormone. However, efficacy of 5-HTP supplementation for improving sleep quality in older adults is unclear. Hence, the aim of this study is to assess the impact of 5-HTP supplementation on sleep quality and gut microbiota composition in older adults.
    Methods: This is a single-blinded, 12-week parallel randomized controlled trial. Thirty older adults (66 ± 3 years) in Singapore were randomly assigned to either consume or not consume 100 mg 5-HTP daily. Every 4 weeks, sleep quality was assessed via both subjective (Pittsburg Sleep Quality Index) and objective (actigraphy watch) measures. A global sleep score (GSS) was obtained from the PSQI, where a GSS>5 defines as poor sleeper while a GSS≤5 defines as good sleeper. Blood serotonin level, urine melatonin concentration, gut microbiota composition and stool short chain fatty acids (SCFA) content were assessed at week 0 and 12. This study was registered in clinicaltrials.gov as NCT04078724 (https://clinicaltrials.gov/ct2/show/NCT04078724).
    Results: 5-HTP supplementation showed an overall favorable effect on certain sleep quality components and an increase in serum serotonin concentration. In particular, at week 12, not good sleepers but poor sleepers with 5-HTP supplementation were able to significantly improve subjective GSS (ΔSL
    Conclusions: 5-HTP supplementation can improve certain sleep quality components in older adults and this benefit was more prominently observed in poor sleepers. 5-HTP was also able to improve the gut microbiota composition in poor sleepers.
    MeSH term(s) Humans ; Aged ; Sleep Quality ; Gastrointestinal Microbiome ; 5-Hydroxytryptophan ; Serotonin ; Dietary Supplements
    Chemical Substances 5-Hydroxytryptophan (C1LJO185Q9) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2024.01.010
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  3. Article ; Online: Exploring the Implementation of Shared Decision-Making Involving Health Coaches for Diabetes and Hypertension Self-Management: Qualitative Study.

    Yoon, Sungwon / Tan, Chao Min / Phang, Jie Kie / Liu, Venice Xi / Tan, Wee Boon / Kwan, Yu Heng / Low, Lian Leng

    JMIR formative research

    2024  Volume 8, Page(s) e51848

    Abstract: Background: An emerging focus on person-centered care has prompted the need to understand how shared decision-making (SDM) and health coaching could support self-management of diabetes and hypertension.: Objective: This study aims to explore ... ...

    Abstract Background: An emerging focus on person-centered care has prompted the need to understand how shared decision-making (SDM) and health coaching could support self-management of diabetes and hypertension.
    Objective: This study aims to explore preferences for the scope of involvement of health coaches and health care professionals (HCPs) in SDM and the factors that may influence optimal implementation of SDM from the perspectives of patients and HCPs.
    Methods: We conducted focus group discussions with 39 patients with diabetes and hypertension and 45 HCPs involved in their care. The main topics discussed included the roles of health coaches and HCPs in self-management, views toward health coaching and SDM, and factors that should be considered for optimal implementation of SDM that involves health coaches. All focus group discussions were audio recorded, transcribed verbatim, and analyzed using thematic analysis.
    Results: Participants agreed that the main responsibility of HCPs should be identifying the patient's stage of change and medication education, while health coaches should focus on lifestyle education, monitoring, and motivational conversation. The health coach was seen to be more effective in engaging patients in lifestyle education and designing goal management plans as health coaches have more time available to spend with patients. The importance of a health coach's personal attributes (eg, sufficient knowledge of both medical and psychosocial management of disease conditions) and credentials (eg, openness, patience, and empathy) was commonly emphasized. Participants viewed that addressing the following five elements would be necessary for the optimal implementation of SDM: (1) target population (newly diagnosed and less stable patients), (2) commitment of all stakeholders (discrepancy on targeted times and modality), (3) continuity of care (familiar faces), (4) philosophy of care (person-centered communication), and (5) faces of legitimacy (physician as the ultimate authority).
    Conclusions: The findings shed light on the appropriate roles of health coaches vis-à-vis HCPs in SDM as perceived by patients and HCPs. Findings from this study also contribute to the understanding of SDM on self-management strategies for patients with diabetes and hypertension and highlight potential opportunities for integrating health coaches into the routine care process.
    Language English
    Publishing date 2024-04-04
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/51848
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  4. Article: The effects of community-based exercise modalities and volume on musculoskeletal health and functions in elderly people.

    Lim, Chin Leong / Keong, Nicholas Ling Swee / Yap, Margaret Mei Chan / Tan, Alvin Wai Kit / Tan, Cher Heng / Lim, Wee Shiong

    Frontiers in physiology

    2023  Volume 14, Page(s) 1227502

    Abstract: The effects of different muscle loading exercise (MLEX) modes and volume on musculoskeletal health is not well-studied in older populations. ...

    Abstract The effects of different muscle loading exercise (MLEX) modes and volume on musculoskeletal health is not well-studied in older populations.
    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1227502
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  5. Article ; Online: Low incidence of non-COVID-19 community respiratory viral infections amongst adults with haematological malignancies during the COVID-19 pandemic.

    Tan, Jing Yuan / Conceicao, Edwin Philip / Wee, Liang En / Ng, Heng Joo / Venkatachalam, Indumathi

    Journal of internal medicine

    2021  Volume 291, Issue 2, Page(s) 244–246

    MeSH term(s) Adult ; COVID-19 ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/epidemiology ; Humans ; Incidence ; Pandemics ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Virus Diseases/epidemiology
    Language English
    Publishing date 2021-09-26
    Publishing country England
    Document type Letter
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13388
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  6. Article ; Online: Empowering patients with comorbid diabetes and hypertension through a multi-component intervention of mobile app, health coaching and shared decision-making: Protocol for an effectiveness-implementation of randomised controlled trial.

    Kwan, Yu Heng / Yoon, Sungwon / Tai, Bee Choo / Tan, Chuen Seng / Phang, Jie Kie / Tan, Wee Boon / Tan, Ngiap Chuan / Tan, Cynthia Yan Ling / Koot, David / Quah, Yan Ling / Teo, Hock Hai / Low, Lian Leng

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0296338

    Abstract: Introduction: Diabetes and hypertension are prevalent and costly to the health system. We have developed a mobile app (EMPOWER app) which enables remote monitoring and education through personalised nudges. We aim to study the effectiveness of a multi- ... ...

    Abstract Introduction: Diabetes and hypertension are prevalent and costly to the health system. We have developed a mobile app (EMPOWER app) which enables remote monitoring and education through personalised nudges. We aim to study the effectiveness of a multi-component intervention comprising the EMPOWER mobile app with health coaching and shared decision-making for diabetes and hypertension.
    Methods: We will conduct a two-arm, open-label, pragmatic randomised controlled trial (RCT). Participants with comorbid diabetes and hypertension enrolled from public primary care clinics will be randomised to either intervention or control in a 1:1 ratio. The intervention group participants will have access to health coaching with shared decision-making interventions in addition to the EMPOWER app and their usual primary care. The control group participants will continue to receive usual primary care and will neither receive the EMPOWER app nor health coaching and shared decision-making interventions. Our primary outcome is change in HbA1c level over 9 months. Secondary outcomes include change in systolic blood pressure, quality of life, patient activation, medication adherence, physical activity level, diet, and healthcare cost (direct and indirect) over 9 months.
    Discussion: Our trial will provide key insights into clinical- and cost-effectiveness of a multi-component intervention comprising EMPOWER mobile app, health coaching and shared decision-making in diabetes and hypertension management. This trial will also offer evidence on cost-effective and sustainable methods for promoting behavioural changes among patients with comorbid diabetes and hypertension.
    Trial registration: This study was registered on clintrials.gov on August 3, 2022, with the trial registration number: NCT05486390.
    MeSH term(s) Humans ; Mobile Applications ; Mentoring ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Hypertension/complications ; Hypertension/epidemiology ; Hypertension/therapy ; Power, Psychological ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296338
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  7. Article ; Online: Human bronchial-pulmonary proteomics in coronavirus disease 2019 (COVID-19) pandemic: applications and implications.

    Tan, Heng Wee / Xu, Yan-Ming / Lau, Andy T Y

    Expert review of proteomics

    2021  Volume 18, Issue 11, Page(s) 925–938

    Abstract: Introduction: The outbreak of the newly discovered human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has disrupted the normal life of almost every civilization worldwide. Studies have shown that the coronavirus disease ... ...

    Abstract Introduction: The outbreak of the newly discovered human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has disrupted the normal life of almost every civilization worldwide. Studies have shown that the coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 can affect multiple human organs and physiological systems, but the respiratory system remains the primary location for viral infection.
    Areas covered: We summarize how omics technologies are used in SARS-CoV-2 research and specifically review the current knowledge of COVID-19 from the aspect of human bronchial-pulmonary proteomics. Also, knowledge gaps in COVID-19 that can be fulfilled by proteomics are discussed.
    Expert opinion: Overall, human bronchial-pulmonary proteomics plays an important role in revealing the dynamics, functions, tropism, and pathogenicity of SARS-CoV-2, which is crucial for COVID-19 biomarker and therapeutic target discoveries. To more fully understand the impact of COVID-19, research from various angles using multi-omics approaches should also be conducted on the lungs as well as other organs.
    MeSH term(s) Animals ; Bronchi/metabolism ; COVID-19/metabolism ; COVID-19/virology ; Humans ; Lung/metabolism ; Molecular Targeted Therapy ; Pandemics ; Proteomics ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2299100-1
    ISSN 1744-8387 ; 1478-9450
    ISSN (online) 1744-8387
    ISSN 1478-9450
    DOI 10.1080/14789450.2021.2010549
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  8. Article ; Online: Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes.

    Tay, Dillon W P / Tan, Lee Ling / Heng, Elena / Zulkarnain, Nadiah / Ching, Kuan Chieh / Wibowo, Mario / Chin, Elaine Jinfeng / Tan, Zann Yi Qi / Leong, Chung Yan / Ng, Veronica Wee Pin / Yang, Lay Kien / Seow, Deborah C S / Lim, Yi Wee / Koh, Winston / Koduru, Lokanand / Kanagasundaram, Yoganathan / Ng, Siew Bee / Lim, Yee Hwee / Wong, Fong Tian

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 50

    Abstract: Natural products possess significant therapeutic potential but remain underutilized despite advances in genomics and bioinformatics. While there are approaches to activate and upregulate natural product biosynthesis in both native and heterologous ... ...

    Abstract Natural products possess significant therapeutic potential but remain underutilized despite advances in genomics and bioinformatics. While there are approaches to activate and upregulate natural product biosynthesis in both native and heterologous microbial strains, a comprehensive strategy to elicit production of natural products as well as a generalizable and efficient method to interrogate diverse native strains collection, remains lacking. Here, we explore a flexible and robust integrase-mediated multi-pronged activation approach to reliably perturb and globally trigger antibiotics production in actinobacteria. Across 54 actinobacterial strains, our approach yielded 124 distinct activator-strain combinations which consistently outperform wild type. Our approach expands accessible metabolite space by nearly two-fold and increases selected metabolite yields by up to >200-fold, enabling discovery of Gram-negative bioactivity in tetramic acid analogs. We envision these findings as a gateway towards a more streamlined, accelerated, and scalable strategy to unlock the full potential of Nature's chemical repertoire.
    MeSH term(s) Actinobacteria ; Actinomyces ; Anti-Bacterial Agents/pharmacology ; Biological Products/pharmacology ; Computational Biology
    Chemical Substances Anti-Bacterial Agents ; Biological Products
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05648-7
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  9. Article ; Online: Personal Goals, Barriers to Self-Management and Desired mHealth Application Features to Improve Self-Care in Multi-Ethnic Asian Patients with Type 2 Diabetes: A Qualitative Study.

    Yoon, Sungwon / Kwan, Yu Heng / Phang, Jie Kie / Tan, Wee Boon / Low, Lian Leng

    International journal of environmental research and public health

    2022  Volume 19, Issue 22

    Abstract: 1) Introduction: The ubiquity of mobile phones suggests the potential of mobile health applications to reach patients with type 2 diabetes and engage them to improve self-care. This study aimed to explore personal goals, barriers to self-management and ... ...

    Abstract (1) Introduction: The ubiquity of mobile phones suggests the potential of mobile health applications to reach patients with type 2 diabetes and engage them to improve self-care. This study aimed to explore personal goals, barriers to self-management and desired mobile health application features to improve self-care among multi-ethnic Asian patients with type 2 diabetes. (2) Methods: We conducted semi-structured interviews with patients with type 2 diabetes (
    MeSH term(s) Humans ; Self Care ; Self-Management ; Diabetes Mellitus, Type 2/therapy ; Goals ; Artificial Intelligence ; Telemedicine
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192215415
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  10. Article ; Online: Measuring preferences for

    Wee, Juliana Wt / Png, Wan Yu / Wong, Xin Yi / Kwan, Yu Heng / Lin, Ying Ying / Tan, Doreen S-Y / Wee, Hwee Lin

    Future cardiology

    2020  Volume 16, Issue 6, Page(s) 663–674

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Acute Coronary Syndrome/drug therapy ; Acute Coronary Syndrome/genetics ; Clopidogrel ; Cytochrome P-450 CYP2C19/genetics ; Genotype ; Humans ; Percutaneous Coronary Intervention ; Platelet Aggregation Inhibitors ; Ticagrelor
    Chemical Substances Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Ticagrelor (GLH0314RVC)
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2020-0037
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