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  1. Article ; Online: ROCK (RhoA/Rho Kinase) Activation in Atrial Fibrillation: Molecular Pathways and Clinical Implications.

    Proietti, Riccardo / Giordani, Andrea S / Lorenzo, Calò A

    Current cardiology reviews

    2024  Volume 19, Issue 3, Page(s) e171122210986

    Abstract: Among the complex mechanisms of AF pathogenesis, intracellular calcium overload and oxidative stress play a major role, both triggered by inflammatory processes. The additional basic event taking place in AF is atrial fibrotic remodeling, again triggered ...

    Abstract Among the complex mechanisms of AF pathogenesis, intracellular calcium overload and oxidative stress play a major role, both triggered by inflammatory processes. The additional basic event taking place in AF is atrial fibrotic remodeling, again triggered by oxidative stress, which is determined by connexins rearrangement and differentiation of fibroblasts into active collagensecreting myofibroblasts. RhoA/ROCK system is the final pathway of a wide spectrum of molecular effectors such as Angiotensin II, platelet-derived growth factor, connective tissue growth factor and transforming growth factor β, that overall determine calcium dysregulation and pro-fibrotic remodeling. Both in experimental and clinical studies, RhoA/ROCK activation has been linked to superoxide ion production, fibrotic remodeling and connexins rearrangement, with important consequences for AF pathogenesis. ROCK pathway inhibition may therefore be a therapeutic or preventive target for special AF subgroups of patients.
    MeSH term(s) Humans ; Atrial Fibrillation/pathology ; rho-Associated Kinases/metabolism ; Calcium/metabolism ; Signal Transduction ; Connexins/metabolism ; Fibrosis ; rhoA GTP-Binding Protein/metabolism
    Chemical Substances rho-Associated Kinases (EC 2.7.11.1) ; Calcium (SY7Q814VUP) ; Connexins ; RHOA protein, human (124671-05-2) ; rhoA GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2024-03-19
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/1573403X19666221117092951
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  2. Article ; Online: Far di Necessità Virtù, using rare tubulopathies, Gitelman's and Bartter's syndromes, to inform the fight against COVID-19.

    Calò, Lorenzo A / Davis, Paul A

    Journal of nephrology

    2021  Volume 34, Issue 2, Page(s) 281–283

    MeSH term(s) Bartter Syndrome/epidemiology ; Bartter Syndrome/therapy ; COVID-19/epidemiology ; COVID-19/therapy ; Comorbidity ; Disease Management ; Gitelman Syndrome/epidemiology ; Gitelman Syndrome/therapy ; Humans ; Italy/epidemiology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-01-02
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-020-00951-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: "Every Cloud Has a Silver Lining": How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It.

    Cacciapuoti, Martina / Caputo, Ilaria / Stefanelli, Lucia Federica / Davis, Paul A / Nalesso, Federico / Calò, Lorenzo A

    Clinics and practice

    2024  Volume 14, Issue 2, Page(s) 614–618

    Abstract: The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play ... ...

    Abstract The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman's and Bartter's Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research.
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2605724-4
    ISSN 2039-7283 ; 2039-7275
    ISSN (online) 2039-7283
    ISSN 2039-7275
    DOI 10.3390/clinpract14020048
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  4. Article ; Online: Angiotensin II, RAS Activation, and RAS Blockers in COVID-19: Unambiguous Evidence.

    Calò, Lorenzo A / Stefanelli, Lucia Federica / Nalesso, Federico

    Kidney & blood pressure research

    2022  Volume 47, Issue 10, Page(s) 593–596

    MeSH term(s) Humans ; Angiotensin II ; COVID-19 ; Bartter Syndrome
    Chemical Substances Angiotensin II (11128-99-7)
    Language English
    Publishing date 2022-09-05
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1326018-2
    ISSN 1423-0143 ; 1420-4096
    ISSN (online) 1423-0143
    ISSN 1420-4096
    DOI 10.1159/000526791
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1458: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Systemic anticoagulation and new biocompatible dialyzers in the different kidney replacement techniques: More doubts than certainties.

    Nalesso, Federico / Gobbi, Laura / Calò, Lorenzo A

    Artificial organs

    2022  Volume 46, Issue 3, Page(s) 516–517

    MeSH term(s) Anticoagulants/pharmacology ; Blood Coagulation ; Humans ; Kidney ; Kidney Failure, Chronic ; Membranes, Artificial ; Renal Dialysis
    Chemical Substances Anticoagulants ; Membranes, Artificial
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Letter
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.14168
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1463: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Conservative Management in End-Stage Kidney Disease between the Dialysis Myth and Neglected Evidence-Based Medicine.

    Martino, Francesca K / Novara, Giacomo / Nalesso, Federico / Calò, Lorenzo A

    Journal of clinical medicine

    2023  Volume 13, Issue 1

    Abstract: In the last few decades, the aging of the general population has significantly increased the number of elderly patients with end-stage kidney disease (ESKD) who require renal replacement therapy. ESKD elders are often frail and highly comorbid with ... ...

    Abstract In the last few decades, the aging of the general population has significantly increased the number of elderly patients with end-stage kidney disease (ESKD) who require renal replacement therapy. ESKD elders are often frail and highly comorbid with social issues and seem to not benefit from dialysis in terms of survival and quality of life. Conservative management (CM) could represent a valid treatment option, allowing them to live for months to years with a modest impact on their habits. Despite these possible advantages, CM remains underused due to the myth of dialysis as the only effective treatment option for all ESKD patients regardless of its impact on quality of life and survival. Both CM and dialysis remain valid alternatives in the management of ESKD. However, assessing comorbidities, disabilities, and social context should drive the choice of the best possible treatment for ESKD, while in elderly patients with short life expectancies, referring them to palliative care seems the most reasonable choice.
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010041
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  7. Article ; Online: Are the Clinical Presentations (Phenotypes) of Gitelman's and Bartter's Syndromes Gene Mutations Driven by Their Effects on Intracellular pH, Their "pH" Enotype?

    Calò, Lorenzo A / Davis, Paul A

    International journal of molecular sciences

    2020  Volume 21, Issue 16

    Abstract: Gitelman's syndrome (GS) and Bartter's syndrome (BS) are rare inherited salt-losing tubulopathies whose variations in genotype do not correlate well with either clinical course or electrolyte requirements. Using GS/BS patients as nature's experiments, we ...

    Abstract Gitelman's syndrome (GS) and Bartter's syndrome (BS) are rare inherited salt-losing tubulopathies whose variations in genotype do not correlate well with either clinical course or electrolyte requirements. Using GS/BS patients as nature's experiments, we found them to be a human model of endogenous Ang II antagonism with activated Renin-Angiotensin System (RAS), resulting in high Ang II levels with blunted cardiovascular effects. These patients are also characterized by increased and directly correlated levels of both Angiotensin Converting Enzyme 2 (ACE2) and Ang 1-7. Understanding the myriad of distinctive and frequently overlapping clinical presentations of GS/BS arises remains challenging. Efforts to find a treatment for COVID-19 has fueled a recent surge in interest in chloroquine/hydroxychloroquine and its effects. Of specific interest are chloroquine/hydroxychloroquine's ability to inhibit SARS-CoV infection by impairing ACE2, the SARS-CoV2 entry point, through terminal glycosylation via effects on TGN/post-Golgi pH homeostasis. Several different studies with a GS or a BS phenotype, along with a nonsyndromic form of X-linked intellectual disability linked to a mutated SLC9A7, provide additional evidence that specific gene defects can act via misregulation of TGN/post-Golgi pH homeostasis, which leads to a common mechanistic basis resulting in overlapping phenotypes. We suggest that linkage between the specific gene defects identified in GS and BS and the myriad of distinctive and frequently overlapping clinical findings may be the result of aberrant glycosylation of ACE2 driven by altered TGN/endosome system acidification caused by the metabolic alkalosis brought about by these salt-losing tubulopathies in addition to their altered intracellular calcium signaling due to a blunted second messenger induced intracellular calcium release that is, in turn, amplified by the RAS system.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Bartter Syndrome/genetics ; Bartter Syndrome/metabolism ; Bartter Syndrome/pathology ; COVID-19 ; Coronavirus Infections/drug therapy ; Endosomes/drug effects ; Endosomes/metabolism ; Gitelman Syndrome/genetics ; Gitelman Syndrome/metabolism ; Gitelman Syndrome/pathology ; Humans ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Phenotype ; Pneumonia, Viral/drug therapy
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Hydroxychloroquine (4QWG6N8QKH) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21165660
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  8. Article ; Online: Corrigendum to "Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: are astrocytes the crossroad?" [Eur. J. Pharmacol. 823 (2018) 79-86].

    Micheli, Laura / Lucarini, Elena / Corti, Francesca / Ciccocioppo, Roberto / Calò, Girolamo / Rizzi, Anna / Ghelardini, Carla / Di Cesare Mannelli, Lorenzo

    European journal of pharmacology

    2024  Volume 970, Page(s) 176497

    Language English
    Publishing date 2024-03-17
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2024.176497
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: On the imbalanced protective arm of RAS in COVID-19: Lesson from rare genetic tubulopathies.

    Davis, Paul A / Bertoldi, Giovanni / Calò, Lorenzo A

    International journal of clinical practice

    2021  Volume 75, Issue 5, Page(s) e14075

    MeSH term(s) Angiotensin Receptor Antagonists ; COVID-19 ; Humans ; Renin-Angiotensin System ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Letter
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14075
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    Ua VI Zs.301: Show issues Location:
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  10. Article ; Online: Conservative Management in End-Stage Kidney Disease between the Dialysis Myth and Neglected Evidence-Based Medicine

    Francesca K. Martino / Giacomo Novara / Federico Nalesso / Lorenzo A. Calò

    Journal of Clinical Medicine, Vol 13, Iss 1, p

    2023  Volume 41

    Abstract: In the last few decades, the aging of the general population has significantly increased the number of elderly patients with end-stage kidney disease (ESKD) who require renal replacement therapy. ESKD elders are often frail and highly comorbid with ... ...

    Abstract In the last few decades, the aging of the general population has significantly increased the number of elderly patients with end-stage kidney disease (ESKD) who require renal replacement therapy. ESKD elders are often frail and highly comorbid with social issues and seem to not benefit from dialysis in terms of survival and quality of life. Conservative management (CM) could represent a valid treatment option, allowing them to live for months to years with a modest impact on their habits. Despite these possible advantages, CM remains underused due to the myth of dialysis as the only effective treatment option for all ESKD patients regardless of its impact on quality of life and survival. Both CM and dialysis remain valid alternatives in the management of ESKD. However, assessing comorbidities, disabilities, and social context should drive the choice of the best possible treatment for ESKD, while in elderly patients with short life expectancies, referring them to palliative care seems the most reasonable choice.
    Keywords elders ; comorbid ; end-stage kidney disease ; conservative management ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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