LIVIVO - Search results -

Search results

Result 1 - 10 of total 19

Search options

Article ; Online: Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems.

Dumontel, Bianca / Jiménez-Jiménez, Carla / Vallet-Regí, María / Manzano, Miguel

Materials today. Bio

2023 Volume 23, Page(s) 100850

Abstract: In recent years, there has been a breakthrough in the integration of artificial nanoplatforms with natural biomaterials for the development of more efficient drug delivery systems. The formulation of bioinspired nanosystems, combining the benefits of ... ...

Abstract	In recent years, there has been a breakthrough in the integration of artificial nanoplatforms with natural biomaterials for the development of more efficient drug delivery systems. The formulation of bioinspired nanosystems, combining the benefits of synthetic nanoparticles with the natural features of biological materials, provides an efficient strategy to improve nanoparticle circulation time, biocompatibility and specificity toward targeted tissues. Among others biological materials, extracellular vesicles (EVs), membranous structures secreted by many types of cells composed by a protein rich lipid bilayer, have shown a great potential as drug delivery systems themselves and in combination with artificial nanoparticles. The reason for such interest relays on their natural properties, such as overcoming several biological barriers or migration towards specific tissues. Here, we propose the use of mesoporous silica nanoparticles (MSNs) as efficient and versatile nanocarriers in combination with tumor derived extracellular vesicles (EVs) for the development of selective drug delivery systems. The hybrid nanosystems demonstrated selective cellular internalization in parent cells, indicating that the EV targeting capabilities were efficiently transferred to MSNs by the developed coating strategy. As a result, EVs-coated MSNs provided an enhanced and selective intracellular accumulation of doxorubicin and a specific cytotoxic activity against targeted cancer cells, revealing these hybrid nanosystems as promising candidates for the development of targeted treatments.
Language	English
Publishing date	2023-10-29
Publishing country	England
Document type	Journal Article
ISSN	2590-0064
ISSN (online)	2590-0064
DOI	10.1016/j.mtbio.2023.100850
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Biomimetic camouflaged nanoparticles with selective cellular internalization and migration competences.

Jiménez-Jiménez, Carla / Moreno-Borrallo, Almudena / Dumontel, Bianca / Manzano, Miguel / Vallet-Regí, María

Acta biomaterialia

2022 Volume 157, Page(s) 395–407

Abstract: In the last few years, nanotechnology has revolutionized the potential treatment of different diseases. However, the use of nanoparticles for drug delivery might be limited by their immune clearance, poor biocompatibility and systemic immunotoxicity. ... ...

Abstract	In the last few years, nanotechnology has revolutionized the potential treatment of different diseases. However, the use of nanoparticles for drug delivery might be limited by their immune clearance, poor biocompatibility and systemic immunotoxicity. Hypotheses for overcoming rejection from the body and increasing their biocompatibility include coating nanoparticles with cell membranes. Additionally, source cell-specific targeting has been reported when coating nanoparticles with tumor cells membranes. Here we show that coating mesoporous silica nanoparticles with membranes derived from preosteoblastic cells could be employed to develop potential treatments of certain bone diseases. These nanoparticles were selected because of their well-established drug delivery features. On the other hand MC3T3-E1 cells were selected because of their systemic migration capabilities towards bone defects. The coating process was here optimized ensuring their drug loading and delivery features. More importantly, our results demonstrated how camouflaged nanocarriers presented cellular selectivity and migration capability towards the preosteoblastic source cells, which might constitute the inspiration for future bone disease treatments. STATEMENT OF SIGNIFICANCE: This work presents a new nanoparticle formulation for drug delivery able to selectively target certain cells. This approach is based on Mesoporous Silica Nanoparticles coated with cell membranes to overcome the potential rejection from the body and increase their biocompatibility prolonging their circulation time. We have employed membranes derived from preosteoblastic cells for the potential treatment of certain bone diseases. Those cells have shown systemic migration capabilities towards bone defects. The coating process was optimized and their appropriate drug loading and releasing abilities were confirmed. The important novelty of this work is that the camouflaged nanocarriers presented cellular selectivity and migration capability towards the preosteoblastic source cells, which might constitute the inspiration for future bone disease treatments.
MeSH term(s)	Humans ; Biomimetics ; Drug Delivery Systems ; Nanoparticles/therapeutic use ; Bone Diseases ; Silicon Dioxide
Chemical Substances	Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2022.11.059
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Smart Shockwave Responsive Titania-Based Nanoparticles for Cancer Treatment.

Vighetto, Veronica / Racca, Luisa / Canta, Marta / Matos, Joana C / Dumontel, Bianca / Gonçalves, Maria Clara / Cauda, Valentina

Pharmaceutics

2021 Volume 13, Issue 9

Abstract: Nanomedicine is an emerging treatment approach for many cancers, characterized by having high sensitivity and selectivity for tumor cells and minimal toxic effects induced by the conventional chemotherapeutics. In these context, smart nanoparticles (NPs) ...

Abstract	Nanomedicine is an emerging treatment approach for many cancers, characterized by having high sensitivity and selectivity for tumor cells and minimal toxic effects induced by the conventional chemotherapeutics. In these context, smart nanoparticles (NPs) are getting increasingly relevant in the development of new therapies. NPs with specific chemical composition and/or structure and being stimuli-responsive to magnetic, light or ultrasound waves are new promising tools. In the present work, amorphous-titania propyl-amine functionalized (a-TiO
Language	English
Publishing date	2021-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13091423
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Fetal Niemann-Pick disease type C: ultrastructural and lipid findings in liver and spleen.

Dumontel, C / Girod, C / Dijoud, F / Dumez, Y / Vanier, M T

Virchows Archiv. A, Pathological anatomy and histopathology

1993 Volume 422, Issue 3, Page(s) 253–259

Abstract: ... with Niemann-Pick disease type C in correlation with lipid studies of these tissues. The lipid storage pattern was ...

Abstract	We present the first ultrastructural study of liver and spleen from a 20-week fetus with Niemann-Pick disease type C in correlation with lipid studies of these tissues. The lipid storage pattern was characteristic of the disease and although the distribution of the lipid storage was similar to that of affected children, ultrastructural studies emphasized that many inclusions were qualitatively different. These are discussed. Concomitant with this complex lipid storage, ultrastructural evidence of cholestasis was observed and the early hyperplasia of pericanalicular microfilaments leads us to question the presence of a toxic metabolite which might induce cholestasis by acting upon microfilaments.
MeSH term(s)	Fetal Diseases/metabolism ; Fetal Diseases/pathology ; Humans ; Lipids/analysis ; Liver/embryology ; Liver/ultrastructure ; Microscopy, Electron ; Niemann-Pick Diseases/embryology ; Niemann-Pick Diseases/metabolism ; Niemann-Pick Diseases/pathology ; Spleen/embryology ; Spleen/ultrastructure
Chemical Substances	Lipids
Language	English
Publishing date	1993
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	514-9
ISSN	0174-7398 ; 0042-6423
ISSN	0174-7398 ; 0042-6423
DOI	10.1007/bf01621810
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud III Zs.10: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Prenatal diagnosis of Niemann-Pick type C disease: current strategy from an experience of 37 pregnancies at risk.

Vanier, M T / Rodriguez-Lafrasse, C / Rousson, R / Mandon, G / Boué, J / Choiset, A / Peyrat, M F / Dumontel, C / Juge, M C / Pentchev, P G

American journal of human genetics

1992 Volume 51, Issue 1, Page(s) 111–122

Abstract: Thirty-seven pregnancies at risk for Niemann-Pick type C disease were monitored by study ...

Abstract	Thirty-seven pregnancies at risk for Niemann-Pick type C disease were monitored by study of cultured amniotic fluid cells (8 cases) or chorionic villus cells (29 cases) in 23 couples over the period 1984-91. An early protocol combined determination of sphingomyelinase activity with electron microscopy. The current strategy, based on the demonstration of specific abnormalities in intracellular processing of exogenous cholesterol, combines the study of the early phase (first 6 h) of LDL-induced cholesteryl ester formation and the histochemical evaluation (filipin staining after 24 h of LDL uptake) of the LDL-induced accumulation of unesterified cholesterol. Thirteen fetuses were predicted to be affected. Confirmation of the diagnosis was made by study of cholesterol processing in fetal skin fibroblast cultures and/or by demonstration of a characteristic lipid storage in fetal liver, already present at 14 w gestation. Definition of the biochemical phenotype (classical, variant, or intermediate) of the index case, with regard to cholesterol-processing abnormalities, is an absolute prerequisite to adequate genetic counseling in a given family. Prenatal diagnosis has now proved a safe procedure in the predominant (approximately 85%) group of families with the classical phenotype.
MeSH term(s)	Cells, Cultured ; Cholesterol/metabolism ; Cholesterol Esters/metabolism ; Female ; Genetic Counseling ; Humans ; Niemann-Pick Diseases/diagnosis ; Niemann-Pick Diseases/genetics ; Niemann-Pick Diseases/metabolism ; Pregnancy ; Prenatal Diagnosis ; Sphingomyelin Phosphodiesterase/metabolism
Chemical Substances	Cholesterol Esters ; Cholesterol (97C5T2UQ7J) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
Language	English
Publishing date	1992-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 107: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Sonophotocatalytic degradation mechanisms of Rhodamine B dye via radicals generation by micro- and nano-particles of ZnO.

Lops, Carmine / Ancona, Andrea / Di Cesare, Katia / Dumontel, Bianca / Garino, Nadia / Canavese, Giancarlo / Hérnandez, Simelys / Cauda, Valentina

Applied catalysis. B, Environmental

2019 Volume 243, Page(s) 629–640

Abstract: In this work, it is proposed an environmental friendly sonophotocatalytic approach to efficiently treat polluted waters from industrial dyes exploiting ZnO micro- and nano-materials. For the first time, we deeply investigated the generation of reactive ... ...

Abstract	In this work, it is proposed an environmental friendly sonophotocatalytic approach to efficiently treat polluted waters from industrial dyes exploiting ZnO micro- and nano-materials. For the first time, we deeply investigated the generation of reactive oxygen species (ROS) under ultrasound stimulation of different ZnO structures by Electron Paramagnetic Resonance Spectroscopy (EPR). Indeed, five zinc oxide (ZnO) micro- and nano-structures,
Language	English
Publishing date	2019-02-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	0926-3373
ISSN	0926-3373
DOI	10.1016/j.apcatb.2018.10.078
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Angulate lysosomes in skin biopsies of patients with degenerative neurological disorders: high frequency in neuronal ceroid lipofuscinosis.

Dumontel, C / Rousselle, C / Guigard, M P / Trouillas, J

Acta neuropathologica

1999 Volume 98, Issue 1, Page(s) 91–96

Abstract: Angulate lysosomes with intralysosomal trilamellar structures were first described in patients with metabolic peroxisomal disorders. In this ultrastructural study of skin biopsies of 139 patients with degenerative neurological disorders and 45 patients ... ...

Abstract	Angulate lysosomes with intralysosomal trilamellar structures were first described in patients with metabolic peroxisomal disorders. In this ultrastructural study of skin biopsies of 139 patients with degenerative neurological disorders and 45 patients with static encephalopathies, we observed angulate lysosomes with similar ultrastructure exclusively in degenerative neurological disorders. They were found in only a few cases (8%), but especially in patients with degenerative metabolic disorders (72%). Because they were never observed in patients with static encephalopathies, angulate lysosomes in the skin would seem to be a sign of progressive encephalopathy. The great majority (75%) of angulate lysosomes were associated with neuronal ceroid-lipofuscinosis (NCL). Their presence in skin biopsy could suggest the diagnosis of NCL and eliminate a peroxisomal disorder. In the latter pathology, angulate lysosomes, numerous in the liver and in the brain, were never observed in the skin. As described in pigmentary retinopathy, a conspicuous feature of NCL, we suggest that in this lysosomal storage disorder, the angulate lysosomes in skin biopsies could result from the phagocytosis of melanin.
MeSH term(s)	Age of Onset ; Biopsy ; Diagnosis, Differential ; Fibroblasts/pathology ; Fibroblasts/ultrastructure ; Humans ; Lysosomes/ultrastructure ; Macrophages/pathology ; Macrophages/ultrastructure ; Melanosomes/pathology ; Melanosomes/ultrastructure ; Microscopy, Electron ; Microscopy, Polarization ; Neurodegenerative Diseases/pathology ; Neuronal Ceroid-Lipofuscinoses/pathology ; Skin/pathology ; Skin/ultrastructure
Language	English
Publishing date	1999-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1079-0
ISSN	1432-0533 ; 0001-6322
ISSN (online)	1432-0533
ISSN	0001-6322
DOI	10.1007/s004010051055
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui II Zs.188: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Localization of transforming growth factors, TGFbeta1 and TGFbeta3, in hypothalamic magnocellular neurones and the neurohypophysis.

Fèvre-Montange, M / Dumontel, C / Chevallier, P / Isnard, A K / Guigard, M-P / Trouillas, J

Journal of neuroendocrinology

2004 Volume 16, Issue 7, Page(s) 571–576

Abstract: The distribution of transforming growth factor beta (TGFbeta) in the rat and human hypothalamus and neurohypophysis was investigated by immunocytochemical techniques using rabbit polyclonal antisera against TGFbeta(1) and TGFbeta(3). Colocalization of ... ...

Abstract	The distribution of transforming growth factor beta (TGFbeta) in the rat and human hypothalamus and neurohypophysis was investigated by immunocytochemical techniques using rabbit polyclonal antisera against TGFbeta(1) and TGFbeta(3). Colocalization of TGFbeta(1) or TGFbeta(3) and arginine vasopressin (AVP) in the rat hypothalamus was studied by double immunolabelling in light microscopy, while their subcellular localization in the rat neurohypophysis was investigated by immunoelectron microscopy. TGFbeta(1) and TGFbeta(3) immunoreactivity was demonstrated in the cell bodies and processes of neurones in the supraoptic nucleus (SON) and paraventricular nucleus (PVN). The TGFbeta-immunoreactive cells were more numerous in the SON compared to the PVN. TGFbeta/AVP double-labelled cells were seen in both nuclei, but some neurones in the SON were labelled for TGFbeta(1) or TGFbeta(3), although not for AVP. In the rat and human neurohypophysis, TGFbeta(3) immunolabelling was more diffuse and stronger than TGFbeta(1) immunolabelling. TGFbeta(1) expression was seen in axonal vesicles and in neurosecretory granules of the axonal endings, while TGFbeta(3) was observed in axonal fibres. Colocalization of TGFbeta(3) or TGFbeta(1) and AVP was observed in some neurosecretory granules, but many were either single-labelled for TGFbeta or AVP or unlabelled. Our results demonstrate, for the first time, the colocalization of TGFbeta and neurohypophysial hormones in magnocellular neurones. We suggest that TGFbeta secreted by the neurohypophysis regulates the proliferation and secretion of certain anterior pituitary cells.
MeSH term(s)	Animals ; Arginine Vasopressin/metabolism ; Female ; Humans ; Hypothalamus/cytology ; Hypothalamus/metabolism ; Hypothalamus/ultrastructure ; Immunohistochemistry ; Male ; Neurons/cytology ; Neurons/metabolism ; Neurons/ultrastructure ; Oxytocin/metabolism ; Pituitary Gland, Posterior/cytology ; Pituitary Gland, Posterior/metabolism ; Pituitary Gland, Posterior/ultrastructure ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Tissue Distribution ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta1 ; Transforming Growth Factor beta3
Chemical Substances	TGFB1 protein, human ; Tgfb1 protein, rat ; Tgfb3 protein, rat ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Transforming Growth Factor beta3 ; Arginine Vasopressin (113-79-1) ; Oxytocin (50-56-6)
Language	English
Publishing date	2004-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/j.1365-2826.2004.01203.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2634: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: In vitro toxic effects of certain antibiotics on the fibroblasts of two children with I-cell disease.

Dumontel, C / Constant, H / Souillet, G / Zabot, M T

Cell biology and toxicology

1998 Volume 14, Issue 5, Page(s) 333–343

Abstract: Six antibiotics, pefloxacin (Peflacine), fosfomycin (Fosfocine), teicoplanin (Targocid), vancomycin (Vancocine), ceftazidime (Fortum), piperacillin (Piperilline), that may be used as a systematic coverage during bone marrow transplantation have been ... ...

Abstract	Six antibiotics, pefloxacin (Peflacine), fosfomycin (Fosfocine), teicoplanin (Targocid), vancomycin (Vancocine), ceftazidime (Fortum), piperacillin (Piperilline), that may be used as a systematic coverage during bone marrow transplantation have been tested on dermal fibroblasts of one control subject and two I-cell disease patients, along with five subcultures, corresponding to 5 weeks of culture. The possible toxicity of these molecules was assessed. The evaluation of lysosomal enzyme sphingomyelinase activity, detection of free intracellular cholesterol and the light- and electron-microscopic examination of treated cells were used as measures of metabolic interference and cytotoxicity. Our study shows that despite a lack of any metabolic sign of interference (no modification in enzyme activity, no increase in free intracellular cholesterol), all the antibiotics tested induced a cytotoxic effect which was notably amplified in the I-cell populations. This may be due to the lysosomal lipid storage of these cells which modifies the relationship between the antibiotic and the cell by inducing a different kind of lipid-antibiotic interference.
MeSH term(s)	Anti-Bacterial Agents/toxicity ; Bone Marrow Transplantation ; Cells, Cultured ; Child, Preschool ; Cholesterol/metabolism ; Fibroblasts/drug effects ; Fibroblasts/enzymology ; Fibroblasts/ultrastructure ; Humans ; Male ; Microscopy, Electron ; Mucolipidoses/pathology ; Mucolipidoses/therapy ; Skin/enzymology ; Skin/pathology ; Skin/ultrastructure ; Sphingomyelin Phosphodiesterase/metabolism
Chemical Substances	Anti-Bacterial Agents ; Cholesterol (97C5T2UQ7J) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
Language	English
Publishing date	1998-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	48824-0
ISSN	1573-6822 ; 0742-2091
ISSN (online)	1573-6822
ISSN	0742-2091
DOI	10.1023/a:1007533723782
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 3024: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Farber disease: an ultrastructural study. Report of a case and review of the literature.

Zappatini-Tommasi, L / Dumontel, C / Guibaud, P / Girod, C

Virchows Archiv. A, Pathological anatomy and histopathology

1992 Volume 420, Issue 3, Page(s) 281–290

Abstract: A case of Farber disease is reported and the ultrastructural pathology of the disease is reviewed. The present case showed the typical clinical picture of Farber disease. Acid ceramidase deficiency was demonstrated biochemically. Ultrastructural features ...

Abstract	A case of Farber disease is reported and the ultrastructural pathology of the disease is reviewed. The present case showed the typical clinical picture of Farber disease. Acid ceramidase deficiency was demonstrated biochemically. Ultrastructural features of one subcutaneous nodule and a skin biopsy are described. Three lysosomal inclusions characterize Farber disease: curvilinear tubular bodies observed mainly in the reticuloendothelial system, "banana bodies" recorded only in the peripheral nervous system and zebra-like bodies which are essentially a neuronal storage. The nature of each is discussed and the skin biopsy is emphasized for its important diagnostic interest.
MeSH term(s)	Biopsy ; Humans ; Infant ; Lysosomal Storage Diseases/pathology ; Male ; Microscopy, Electron ; Skin/pathology ; Skin/ultrastructure ; Skin Diseases/pathology
Language	English
Publishing date	1992
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	514-9
ISSN	0174-7398 ; 0042-6423
ISSN	0174-7398 ; 0042-6423
DOI	10.1007/bf01600282
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud III Zs.10: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito