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  1. Article: PET Imaging of the Serotonin 1A Receptor in Major Depressive Disorder: Hierarchical Multivariate Analysis of [

    Matheson, Granville J / Zanderigo, Francesca / Miller, Jeffrey M / Bartlett, Elizabeth A / Mann, J John / Ogden, R Todd

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The serotonin 1A receptor has been linked to both the pathophysiology of major depressive disorder (MDD) and the antidepressant action of serotonin reuptake inhibitors. Most PET studies of the serotonin 1A receptor in MDD used the receptor antagonist ... ...

    Abstract The serotonin 1A receptor has been linked to both the pathophysiology of major depressive disorder (MDD) and the antidepressant action of serotonin reuptake inhibitors. Most PET studies of the serotonin 1A receptor in MDD used the receptor antagonist radioligand, [carbonyl-
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.12.584569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dynamic Human Brain Imaging with a Portable PET Camera: Comparison to a Standard Scanner.

    Bartlett, Elizabeth A / Lesanpezeshki, Mohammad / Anishchenko, Sergey / Shkolnik, Ilia / Ogden, R Todd / Mann, J John / Beylin, David / Miller, Jeffrey M / Zanderigo, Francesca

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  Volume 65, Issue 2, Page(s) 320–326

    Abstract: Portable, cost-effective PET cameras can radically expand the applicability of PET. We present here a within-participant comparison of fully quantified [ ...

    Abstract Portable, cost-effective PET cameras can radically expand the applicability of PET. We present here a within-participant comparison of fully quantified [
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Glucose/metabolism ; Neocortex/metabolism ; Positron-Emission Tomography/methods ; Neuroimaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.265309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.

    Schmit, Megan M / Baxley, Ryan M / Wang, Liangjun / Hinderlie, Peter / Kaufman, Marissa / Simon, Emily / Raju, Anjali / Miller, Jeffrey S / Bielinsky, Anja-Katrin

    Open biology

    2024  Volume 14, Issue 1, Page(s) 230407

    Abstract: Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient with NKD was identified carrying compound heterozygous ...

    Abstract Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient with NKD was identified carrying compound heterozygous variants of
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells ; Cell Differentiation ; Genes, Essential ; Genomic Instability ; Killer Cells, Natural ; Minichromosome Maintenance Proteins
    Chemical Substances MCM10 protein, human ; Minichromosome Maintenance Proteins (EC 3.6.4.12)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.230407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A phase II randomized, placebo-controlled, multicenter trial to evaluate the efficacy of cytomegalovirus PepVax vaccine in preventing cytomegalovirus reactivation and disease after allogeneic hematopoietic stem cell transplant.

    Nakamura, Ryotaro / La Rosa, Corinna / Yang, Dongyun / Hill, Joshua A / Rashidi, Armin / Choe, Hannah / Zhou, Qiao / Lingaraju, Chetan Raj / Kaltcheva, Teodora / Longmate, Jeffrey / Drake, Jennifer / Slape, Cynthia / Duarte, Lupe / Al Malki, Monzr M / Pullarkat, Vinod A / Aribi, Ahmed / Devine, Steven / Verneris, Michael R / Miller, Jeffrey S /
    Forman, Stephen J / Aldoss, Ibrahim / Diamond, Don J

    Haematologica

    2024  

    Abstract: Not available. ...

    Abstract Not available.
    Language English
    Publishing date 2024-02-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect.

    Miller, Jeffrey T / Clark, Bryan W / Reid, Noah M / Karchner, Sibel I / Roach, Jennifer L / Hahn, Mark E / Nacci, Diane / Whitehead, Andrew

    Evolutionary applications

    2024  Volume 17, Issue 1, Page(s) e13648

    Abstract: The genetic architecture of phenotypic traits can affect the mode and tempo of trait evolution. Human-altered environments can impose strong natural selection, where successful evolutionary adaptation requires swift and large phenotypic shifts. In these ... ...

    Abstract The genetic architecture of phenotypic traits can affect the mode and tempo of trait evolution. Human-altered environments can impose strong natural selection, where successful evolutionary adaptation requires swift and large phenotypic shifts. In these scenarios, theory predicts that adaptation is due to a few adaptive variants of large effect, but empirical studies that have revealed the genetic architecture of rapidly evolved phenotypes are rare, especially for populations inhabiting polluted environments.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2405496-3
    ISSN 1752-4563 ; 1752-4571
    ISSN (online) 1752-4563
    ISSN 1752-4571
    DOI 10.1111/eva.13648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Malignant Glioma.

    Wang, Linda M / Englander, Zachary K / Miller, Michael L / Bruce, Jeffrey N

    Advances in experimental medicine and biology

    2023  Volume 1405, Page(s) 1–30

    Abstract: This chapter provides a comprehensive overview of malignant gliomas, the most common primary brain tumor in adults. These tumors are varied in their cellular origin, genetic profile, and morphology under the microscope, but together they share some of ... ...

    Abstract This chapter provides a comprehensive overview of malignant gliomas, the most common primary brain tumor in adults. These tumors are varied in their cellular origin, genetic profile, and morphology under the microscope, but together they share some of the most dismal prognoses of all neoplasms in the body. Although there is currently no cure for malignant glioma, persistent efforts to improve outcomes in patients with these tumors have led to modest increases in survival, and researchers worldwide continue to strive toward a deeper understanding of the factors that influence glioma development and response to treatment. In addition to well-established epidemiology, clinical manifestations, and common histopathologic and radiologic features of malignant gliomas, this section considers recent advances in molecular biology that have led to a more nuanced understanding of the genetic changes that characterize the different types of malignant glioma, as well as their implications for treatment. Beyond the traditional classification of malignant gliomas based on histopathological features, this chapter incorporates the World Health Organization's 2016 criteria for the classification of brain tumors, with special focus on disease-defining genetic alterations and newly established subcategories of malignant glioma that were previously unidentifiable based on microscopic examination alone. Traditional therapeutic modalities that form the cornerstone of treatment for malignant glioma, such as aggressive surgical resection followed by adjuvant chemotherapy and radiation therapy, and the studies that support their efficacy are reviewed in detail. This provides a foundation for additional discussion of novel therapeutic methods such as immunotherapy and convection-enhanced delivery, as well as new techniques for enhancing extent of resection such as fluorescence-guided surgery.
    MeSH term(s) Adult ; Humans ; Glioma/diagnosis ; Glioma/genetics ; Glioma/therapy ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Immunotherapy/methods ; Chemotherapy, Adjuvant
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-23705-8_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: MOSCATO: a supervised approach for analyzing multi-Omic single-Cell data.

    Towle-Miller, Lorin M / Miecznikowski, Jeffrey C

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 557

    Abstract: Background: Advancements in genomic sequencing continually improve personalized medicine, and recent breakthroughs generate multimodal data on a cellular level. We introduce MOSCATO, a technique for selecting features across multimodal single-cell ... ...

    Abstract Background: Advancements in genomic sequencing continually improve personalized medicine, and recent breakthroughs generate multimodal data on a cellular level. We introduce MOSCATO, a technique for selecting features across multimodal single-cell datasets that relate to clinical outcomes. We summarize the single-cell data using tensors and perform regularized tensor regression to return clinically-associated variable sets for each 'omic' type.
    Results: Robustness was assessed over simulations based on available single-cell simulation methods, and applicability was assessed through an example using CITE-seq data to detect genes associated with leukemia. We find that MOSCATO performs favorably in selecting network features while also shown to be applicable to real multimodal single-cell data.
    Conclusions: MOSCATO is a useful analytical technique for supervised feature selection in multimodal single-cell data. The flexibility of our approach enables future extensions on distributional assumptions and covariate adjustments.
    MeSH term(s) Precision Medicine ; Single-Cell Analysis
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08759-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Real-World Data Study on the Impact of the ReadRx Cognitive Training and Reading Intervention on Cognition, Basic Reading Ability, and Psychosocial Skills for 3527 Children.

    Moore, Amy Lawson / Miller, Terissa M / Moore, Jeffrey J / Ledbetter, Christina

    Psychology research and behavior management

    2023  Volume 16, Page(s) 1195–1220

    Abstract: Background: The state of reading proficiency among children in the United States continues to be a subject of concern among psychologists, teachers, parents, policy makers, and the education community at large. Despite the widespread use of curricular ... ...

    Abstract Background: The state of reading proficiency among children in the United States continues to be a subject of concern among psychologists, teachers, parents, policy makers, and the education community at large. Despite the widespread use of curricular methods that teach basic reading skills, there remains a large percentage of children that struggle to read. Therefore, novel approaches to reading remediation should be explored.
    Purpose: The aims of this study were to examine 1) the effect of a multicomponent cognitive and reading intervention on cognitive and reading skills; 2) the role of ADHD, age, sex, IQ score, and individual cognitive skills on the effectiveness of the ReadRx intervention; and 3) parent-reported behavioral outcomes following the ReadRx intervention.
    Methods: The current study analyzed a large real-world dataset to examine cognitive, reading, and behavioral outcomes for struggling readers (n = 3527) who had completed 24 weeks (120 hours) of intense cognitive training integrated with a structured literacy intervention using ReadRx in a one-on-one clinic setting.
    Results: Analyses of pretest and post-test scores showed statistically significant changes on all cognitive and reading measures including attention, visual processing, processing speed, long-term memory, working memory, reasoning, phonological awareness, Work Attack, phonetic coding, spelling, comprehension, and overall IQ score with medium to very large effect sizes. The results included an average 4.1-year gain in reading skills including a 6-year gain in phonological awareness. No differences were found based on age, sex, or ADHD status, and minimal differences were found based on pre-intervention IQ score and cognitive test scores. The study also included a qualitative thematic analysis of parent-reported behavioral outcomes revealing themes of improved cognition, academic performance, and psychosocial skills including confidence and perseverance.
    Conclusion: Our findings were consistent with previous controlled studies on this intervention and offer an encouraging alternative instructional approach to reading remediation that aligns with the Science of Reading and includes intensive remediation of underlying cognitive skills.
    Language English
    Publishing date 2023-04-17
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495093-2
    ISSN 1179-1578
    ISSN 1179-1578
    DOI 10.2147/PRBM.S397665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Use of Toxicity Identification Evaluation Procedures to Clarify the Relationship Between Ammonium Concentrations and Phytoplankton Blooms in the San Francisco Bay Estuary, California, USA

    Miller, Jeffrey L. / Bailey, Howard C. / Walker, Cecilia M. / Miller, Kimberley K. / Connor, Valerie

    Environmental Toxicology and Chemistry. 2023 Jan., v. 42, no. 1 p.178-190

    2023  

    Abstract: Phytoplankton blooms in the northern San Francisco Bay Estuary have historically supported much of the larval fish production in the estuary. In the past, blooms were limited largely by reduced light intensities and net outflows through the system, as ... ...

    Abstract Phytoplankton blooms in the northern San Francisco Bay Estuary have historically supported much of the larval fish production in the estuary. In the past, blooms were limited largely by reduced light intensities and net outflows through the system, as well as dense populations of introduced clams that continuously filter the water column. Conversely, the estuary is exposed to a wide variety of contaminants that may also impact phytoplankton growth. Interestingly, previous investigations have suggested that relatively low concentrations of ammonium may inhibit development of bloom conditions by interfering with nitrate assimilation. Given the complex dynamics of the system, with multiple factors that could potentially affect algal growth, additional data to validate this hypothesis are important to identify appropriate management options. Consequently, toxicity identification evaluation (TIE) procedures were applied to ambient water samples and monitored for 72–96 h under controlled conditions to evaluate their effects on algal growth and utilization of dissolved inorganic nitrogen. The TIE treatments specifically targeted ammonium, as well as the potential contributions of metals and nonpolar organic contaminants. Notably, all samples exhibited positive growth over the exposure period with no evidence of toxicity, and TIE treatments did not further improve growth. A subsequent 72‐h study evaluated the effect of ammonium up to 12 µM at a fixed concentration of nitrate was monitored at 24‐h intervals and showed no inhibition of the development of bloom conditions. Collectively, there was no evidence that ammonium interfered with growth, even at concentrations well above the range of postulated effect levels. Of additional interest, the lack of increased growth in TIE treatments targeting chelatable metals and nonpolar organics suggested that these contaminant classes were not present at inhibitory concentrations. These results demonstrate the importance of validation of cause in multistressor environments, and further clarify the roles of different factors that may limit development of bloom conditions in the estuary. Environ Toxicol Chem 2023;42:178–190. © 2022 SETAC
    Keywords algae ; ambient water ; ammonium ; dissolved inorganic nitrogen ; ecotoxicology ; estuaries ; exposure duration ; fish larvae ; fish production ; nitrates ; phytoplankton ; toxicity ; California
    Language English
    Dates of publication 2023-01
    Size p. 178-190.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 46234-2
    ISSN 1552-8618 ; 0730-7268
    ISSN (online) 1552-8618
    ISSN 0730-7268
    DOI 10.1002/etc.5510
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Fascial plane approach to anesthetizing the radial, median, and ulnar nerves: an educational review.

    Moody, Alastair E / Miller, Sarah T / Tupinio, Maegan R / Newberry, Cynthia M / Mangleson, John / Swenson, Jeffrey D

    Regional anesthesia and pain medicine

    2024  Volume 49, Issue 4, Page(s) 285–288

    Abstract: Brachial plexus block provides effective anesthesia and analgesia for upper extremity surgery but requires injection of large anesthetic volumes near major vascular structures. Moreover, the extensive motor and sensory loss produced by plexus block often ...

    Abstract Brachial plexus block provides effective anesthesia and analgesia for upper extremity surgery but requires injection of large anesthetic volumes near major vascular structures. Moreover, the extensive motor and sensory loss produced by plexus block often exceeds the neural distribution needed for corresponding surgical procedures.High-resolution ultrasound facilitates selective nerve blocks at nearly every level of the upper extremity. We present fascial plane injection techniques for selective radial, median, and ulnar nerve blocks. These techniques can be used to match sensory distribution with specific surgical procedures. They are performed using low anesthetic volumes and without proximity to nerves or vascular structures. In this article, fresh cadaver dissections with corresponding ultrasound images are used to demonstrate stepwise fascial plane techniques for the radial, median, and ulnar nerves. These techniques are performed using familiar anatomic landmarks.Practical applications of these techniques are demonstrated for commonly performed procedures of the upper extremity. Corresponding injection volumes with duration of postoperative analgesia are presented. Selected injections are described for both surgical anesthesia and postoperative analgesia.Selective fascial plane injections can provide surgical anesthesia and postoperative analgesia in settings that might otherwise require much larger volumes of local anesthetic. These selective nerve blocks can match sensory loss with the anatomic pain distribution in each patient. Reliable techniques for selective nerve blocks of the upper extremity can expand the capabilities for ultrasound-guided regional anesthesia.
    MeSH term(s) Humans ; Anesthetics, Local ; Brachial Plexus/diagnostic imaging ; Brachial Plexus Block/methods ; Ulnar Nerve/diagnostic imaging ; Ultrasonography, Interventional/methods ; Upper Extremity/surgery
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1136/rapm-2023-104794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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