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  1. Book ; Online ; E-Book: Intrusive thinking

    Kalivas, Peter W. / Paulus, Martin P.

    from molecules to free will

    (Strüngmann forum reports)

    2020  

    Author's details edited by Peter W. Kalivas and Martin P. Paulus
    Series title Strüngmann forum reports
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvi, 455 Seiten), Illustrationen, Diagramme
    Publisher The MIT Press
    Publishing place Cambridge, Massachusetts
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020882299
    ISBN 978-0-262-36366-2 ; 9780262542371 ; 0-262-36366-6 ; 0262542374
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom.

    Kalivas, Peter W / Gourley, Shannon L / Paulus, Martin P

    Neuroscience and biobehavioral reviews

    2023  Volume 150, Page(s) 105196

    Abstract: Spontaneous thought is an adaptive cognitive process that can produce novel and insightful thought sequences useful in guiding future behavior. In many psychiatric disorders, spontaneous thinking becomes intrusive and uncontrolled, and can trigger ... ...

    Abstract Spontaneous thought is an adaptive cognitive process that can produce novel and insightful thought sequences useful in guiding future behavior. In many psychiatric disorders, spontaneous thinking becomes intrusive and uncontrolled, and can trigger symptoms such as craving, repetitive negative thinking and trauma-related memories. We link studies using clinical imaging and rodent modeling towards understanding the neurocircuitry and neuroplasticity of intrusive thinking. We propose a framework in which drugs or stress change the homeostatic set point of brain reward circuitry, which then impacts subsequent plasticity induced by drug/stress conditioned cues (metaplastic allostasis). We further argue for the importance of examining not only the canonical pre- and postsynapse, but also the adjacent astroglial protrusions and extracellular matrix that together form the tetrapartite synapse and that plasticity throughout the tetrapartite synapse is necessary for cue-induced drug or stress behaviors. This analysis reveals that drug use or trauma cause long-lasting allostatic brain plasticity that sets the stage for subsequent drug/trauma-associated cues to induce transient plasticity that can lead to intrusive thinking.
    MeSH term(s) Humans ; Mental Disorders ; Brain/diagnostic imaging ; Substance-Related Disorders ; Cues ; Problem Solving ; Stress Disorders, Post-Traumatic/psychology
    Language English
    Publishing date 2023-04-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105196
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  3. Article ; Online: Deconstructing and Reconstructing the Dichotomy That Is Dopamine Receptor-1- and Dopamine Receptor-2-Expressing Neurons.

    Kalivas, Peter W

    Biological psychiatry

    2018  Volume 84, Issue 12, Page(s) 862–864

    MeSH term(s) Cocaine ; Dopaminergic Neurons ; Nucleus Accumbens ; Receptors, Dopamine D1
    Chemical Substances Receptors, Dopamine D1 ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2018.10.007
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  4. Article ; Online: Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats.

    Nall, Rusty W / Chalhoub, Reda M / Kalivas, Peter W

    Journal of the experimental analysis of behavior

    2022  Volume 117, Issue 3, Page(s) 457–471

    Abstract: Substance Use Disorders (SUDs) are an impactful problem characterized by chronic relapse and engagement in drug-related behaviors at the expense of non-drug behaviors. Brain regions implicated in drug and non-drug-related behaviors often overlap, ... ...

    Abstract Substance Use Disorders (SUDs) are an impactful problem characterized by chronic relapse and engagement in drug-related behaviors at the expense of non-drug behaviors. Brain regions implicated in drug and non-drug-related behaviors often overlap, complicating investigations of neurobiological mechanisms underlying SUDs. Here we presented a within-subject model for studying self-administration, reinforcer competition, extinction, and cued reinstatement of cocaine- and food-seeking in rats. Due to differences in cocaine- and food-reinforced behavior, we transformed data to proportions of baseline, revealing increased resistance to extinction and disproportionately greater cued reinstatement of cocaine seeking relative to food seeking. Consistent with previous reports, females showed greater preference for cocaine reinforcement than males, though these findings failed to reach statistical significance. To demonstrate the model's utility for investigating neurobiological mechanisms, we included proof-of-concept calcium imaging data demonstrating the utility of the behavioral model for detecting cellular activity patterns associated with cocaine- and food-seeking behaviors. Future studies utilizing this model should improve understanding of the development and expression of pathological behaviors characteristic of SUDs in humans, sex differences in these behaviors, and their neurobiological correlates. Thus, the model has utility for improving understanding of SUDs, leading to novel treatments to reduce the pathological behaviors associated with SUDs.
    MeSH term(s) Animals ; Cocaine/pharmacology ; Cocaine-Related Disorders ; Cues ; Extinction, Psychological ; Female ; Male ; Pharmaceutical Preparations ; Rats ; Reward ; Sex Characteristics
    Chemical Substances Pharmaceutical Preparations ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 219405-3
    ISSN 1938-3711 ; 0022-5002
    ISSN (online) 1938-3711
    ISSN 0022-5002
    DOI 10.1002/jeab.752
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  5. Article ; Online: Astrocyte regulation of synaptic signaling in psychiatric disorders.

    Kruyer, Anna / Kalivas, Peter W / Scofield, Michael D

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2022  Volume 48, Issue 1, Page(s) 21–36

    Abstract: Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical role of astroglia in shaping neuronal synaptic activity and along with the pre- and postsynapse is now considered an equal partner in tripartite synaptic ... ...

    Abstract Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical role of astroglia in shaping neuronal synaptic activity and along with the pre- and postsynapse is now considered an equal partner in tripartite synaptic transmission and plasticity. The relative youth of this recognition and a corresponding deficit in reagents and technologies for quantifying and manipulating astroglia relative to neurons continues to hamper advances in understanding tripartite synaptic physiology. Nonetheless, substantial advances have been made and are reviewed herein. We review the role of astroglia in synaptic function and regulation of behavior with an eye on how tripartite synapses figure into brain pathologies underlying behavioral impairments in psychiatric disorders, both from the perspective of measures in postmortem human brains and more subtle influences on tripartite synaptic regulation of behavior in animal models of psychiatric symptoms. Our goal is to provide the reader a well-referenced state-of-the-art understanding of current knowledge and predict what we may discover with deeper investigation of tripartite synapses using reagents and technologies not yet available.
    MeSH term(s) Animals ; Humans ; Adolescent ; Astrocytes/physiology ; Synaptic Transmission/physiology ; Synapses/physiology ; Neurons/physiology ; Mental Disorders ; Neuronal Plasticity/physiology
    Language English
    Publishing date 2022-05-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-022-01338-w
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  6. Article ; Online: Understanding the Munchies.

    Neuhofer, Daniela / Kalivas, Peter W

    Neuron

    2020  Volume 107, Issue 1, Page(s) 11–13

    Abstract: In this issue of Neuron, Thoeni et al. (2020) demonstrate that both food restriction and a high-fat diet cause an endocannabinoid-dependent inhibition of D1 medium spiny neuron terminals in the lateral hypothalamus that promotes overeating. ...

    Abstract In this issue of Neuron, Thoeni et al. (2020) demonstrate that both food restriction and a high-fat diet cause an endocannabinoid-dependent inhibition of D1 medium spiny neuron terminals in the lateral hypothalamus that promotes overeating.
    MeSH term(s) Humans ; Hyperphagia ; Hypothalamic Area, Lateral ; Neurons ; Synapses
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.06.009
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  7. Article ; Online: Astrocytes as cellular mediators of cue reactivity in addiction.

    Kruyer, Anna / Kalivas, Peter W

    Current opinion in pharmacology

    2020  Volume 56, Page(s) 1–6

    Abstract: Relapse to addictive drug use remains a major medical problem worldwide. In rodents, glutamate release in the nucleus accumbens core triggers reinstated drug seeking in response to stress, and drug-associated cues and contexts. Glutamatergic ... ...

    Abstract Relapse to addictive drug use remains a major medical problem worldwide. In rodents, glutamate release in the nucleus accumbens core triggers reinstated drug seeking in response to stress, and drug-associated cues and contexts. Glutamatergic dysregulation in addiction results in part from long-lasting adaptations in accumbens astroglia, including downregulation of the glutamate transporter GLT-1 and retraction from synapses after withdrawal from psychostimulants and opioids. While their capacity to clear glutamate is disrupted by drug use and withdrawal, accumbens astrocytes undergo rapid, transient plasticity in response to drug-associated cues that reinstate seeking. Cued reinstatement of heroin seeking, for example, restores synaptic proximity of astrocyte processes through ezrin phosphorylation, and enhances GLT-1 surface expression. These adaptations limit drug seeking behavior and largely occur on non-overlapping populations of astroglia. Here we review the growing literature supporting a critical role for accumbens astrocytes in modulating glutamate transmission during drug seeking in rodent models of relapse.
    MeSH term(s) Animals ; Astrocytes ; Cues ; Drug-Seeking Behavior ; Rats ; Rats, Sprague-Dawley ; Self Administration
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2020.07.009
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    Zs.A 5608: Show issues Location:
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  8. Article ; Online: Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date.

    Chalhoub, Reda M / Kalivas, Peter W

    Drugs

    2020  Volume 80, Issue 15, Page(s) 1509–1524

    Abstract: Opioid use disorder (OUD) represents a major public health problem that affects millions of people in the USA and worldwide. The relapsing and recurring aspect of OUD, driven by lasting neurobiological adaptations at different reward centres in the brain, ...

    Abstract Opioid use disorder (OUD) represents a major public health problem that affects millions of people in the USA and worldwide. The relapsing and recurring aspect of OUD, driven by lasting neurobiological adaptations at different reward centres in the brain, represents a major obstacle towards successful long-term remission from opioid use. Currently, three drugs that modulate the function of the opioidergic receptors, methadone, buprenorphine and naltrexone have been approved by the US Food and Drug Administration (FDA) to treat OUD. In this review, we discuss the limitations and challenges associated with the current maintenance and medication-assisted withdrawal strategies commonly used to treat OUD. We further explore the involvement of glutamatergic, endocannabinoid and orexin signaling systems in the development, maintenance and expression of addiction-like behaviours in animal models of opioid addiction, and as potential and novel targets to expand therapeutic options to treat OUD. Despite a growing preclinical literature highlighting the role of these potential targets in animal models of opioid addiction, clinical and translational studies for novel treatments of OUD remain limited and inconclusive. Further preclinical and clinical investigations are needed to expand the arsenal of primary treatment options and adjuncts to maximise efficacy and prevent relapse.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Animals ; Behavior, Addictive/chemically induced ; Behavior, Addictive/drug therapy ; Behavior, Addictive/physiopathology ; Behavior, Addictive/psychology ; Brain/drug effects ; Brain/physiopathology ; Buprenorphine/pharmacology ; Buprenorphine/therapeutic use ; Disease Models, Animal ; Endocannabinoids/metabolism ; Glutamic Acid/metabolism ; Humans ; Methadone/pharmacology ; Methadone/therapeutic use ; Naltrexone/pharmacology ; Naltrexone/therapeutic use ; Narcotic Antagonists/pharmacology ; Narcotic Antagonists/therapeutic use ; Opiate Substitution Treatment/methods ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/etiology ; Opioid-Related Disorders/physiopathology ; Opioid-Related Disorders/psychology ; Orexins/metabolism ; Reward ; Secondary Prevention/methods ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Treatment Outcome
    Chemical Substances Analgesics, Opioid ; Endocannabinoids ; Narcotic Antagonists ; Orexins ; Glutamic Acid (3KX376GY7L) ; Buprenorphine (40D3SCR4GZ) ; Naltrexone (5S6W795CQM) ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2020-08-09
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-020-01373-1
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    Zs.A 762: Show issues Location:
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  9. Article ; Online: Extrasynaptic therapeutic targets in substance use and stress disorders.

    Hodebourg, Ritchy / Kalivas, Peter W / Kruyer, Anna

    Trends in pharmacological sciences

    2021  Volume 43, Issue 1, Page(s) 56–68

    Abstract: Treatments for substance use and stress disorders are based on ameliorating behavioral symptoms, not on reversing the synaptic pathology that has the potential to cure disorders. This failing arises in part from a research focus on how pre- and ... ...

    Abstract Treatments for substance use and stress disorders are based on ameliorating behavioral symptoms, not on reversing the synaptic pathology that has the potential to cure disorders. This failing arises in part from a research focus on how pre- and postsynaptic physiology is changed even though key neuropathology exists in the perisynaptic neuropil that homeostatically regulates synaptic transmission. We explore recent findings from the substance use and stress disorder literature pointing to a key role for perisynaptic astroglia and signaling in the extracellular matrix (ECM) in regulating synaptic pathology. We conclude that drugs and stress initiate long-lasting changes in brain synapses via enduring neuroadaptations in astroglia and the ECM, and that modulating extrasynaptic regulators may be therapeutically useful.
    MeSH term(s) Astrocytes ; Brain ; Humans ; Substance-Related Disorders/drug therapy ; Synapses/pathology ; Synaptic Transmission/physiology
    Language English
    Publishing date 2021-11-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2021.10.006
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  10. Book ; Conference proceedings: The neurobiology of drug and alcohol addiction

    Kalivas, Peter W.

    [result of a Conference Entitled the Neurobiology of Drug and Alcohol Addiction held by the New York Academy of Sciences on July 23 - 26, 1991 in Spokane, Washington]

    (Annals of the New York Academy of Sciences ; 654)

    1992  

    Institution New York Academy of Sciences
    Event/congress Conference Entitled the Neurobiology of Drug and Alcohol Addiction (1991, SpokaneWash.)
    Author's details ed. by Peter W. Kalivas
    Series title Annals of the New York Academy of Sciences ; 654
    Collection
    Keywords Neurobiology / congresses ; Substance-Related Disorders / genetics / congresses ; Substance-Related Disorders / therapy / congresses ; Drogenabhängigkeit ; Neuropsychologie ; Alkoholismus
    Subject Alkoholabhängigkeit ; Trunksucht ; Alkoholbedingte Krankheit ; Alkoholkrankheit ; Alkoholsucht ; Alkohol ; Drogensucht ; Drogen ; Toxikomanie ; Substanzabhängigkeit
    Language English
    Size XIII, 545 S. : Ill., graph. Darst.
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT004254632
    ISBN 0-89766-711-5 ; 0-89766-712-3 ; 978-0-89766-711-1 ; 978-0-89766-712-8
    Database Catalogue ZB MED Medicine, Health

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    Se 110 -654- verfügbar in Königswinter Königswinter

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