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  1. Book ; Online: Interactions Between Diets, Gut Microbiota and Host Metabolism

    Yin, Jie / Xie, Liwei / Luo, Yuheng / Oz, Helieh S.

    2020  

    Keywords Medicine ; Dietetics & nutrition ; diets ; gut microbiota ; host metabolism ; dysbiosis ; metagenomics ; metabolomics
    Size 1 electronic resource (595 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231544
    ISBN 9782889639984 ; 2889639983
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Nutrients, Infectious and Inflammatory Diseases

    Oz, Helieh S.

    2018  

    Abstract: ... of hospitalization in the U.S. and globally. Gastrointestinal infections alter gut microbiomes and increase ...

    Abstract Foodborne disease like salmonellosis and toxoplasmosis are amongst the most significant causes of hospitalization in the U.S. and globally. Gastrointestinal infections alter gut microbiomes and increase permeability to toxins. Various invasions by microbial, fungal, viral and parasitic agents stimulate inflammation, a defensive mechanism of the body's immune system. Other stimuli include environmental stimuli, oxidative stress, aging and the physiological process. A long-lasting, persistent and excessive inflammatory response is a significant risk factor for developing various chronic inflammatory and infectious diseases.Different nutritional and dietary life styles, whether poor or lacking essential nutritional elements, as well as excess intake, can result in inflammatory complications and loss of function. Nutritional deficiency is linked with several infectious and inflammatory diseases as a cause or consequence.-

    For instance, protein deficiency was reported in orphanages to provoke microbial and fungal complications including Pneumocystis pneumonia. Similarly, protein deficiency is a tell-tale sign of several parasitic diseases. Studies indicate that nutrients, such as amino acids, oligosaccharides, and short-chain fatty acids exert inhibitory and anti-inflammatory functions. These investigations help to understand nutritional contributions to the prevention, treatment and taming of certain inflammatory and infectious diseases. Infectious and inflammatory complications go hand-in-hand with malnutrition.The purpose of this Special Issue is to publish related new, basic and translational findings and clinical trials in this area. Other investigations or review articles were sought to link infectious and inflammatory diseases with nutrients.-

    In addition, novel diagnostic, preventive and therapeutic modalities were invited to aid the development of nutritional strategies for the treatment and/or prevention of inflammation and infection. Original reviews were of particular interest to advance our understanding of signaling pathways, and the molecular and biochemical mechanisms behind the effects of nutrients on inflammatory and infectious diseases
    Keywords Nutritional diseases. Deficiency diseases
    Size 1 electronic resource (CCCXLVIII, 18 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020098342
    ISBN 9783038427919 ; 9783038427926 ; 3038427918 ; 3038427926
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Chagas Disease

    Nissapatorn, Veeranoot / Oz, Helieh S

    Basic Investigations and Challenges

    2018  

    Keywords Infectious & contagious diseases ; immune system, trypanosoma cruzi, inflammation, epidemiology, chemotherapy, drug discovery
    Language English
    Size 1 electronic resource (238 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030647745
    ISBN 9781838813697 ; 1838813691
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Dirt, Saliva and Leprosy: Anti-Inflammatory and Anti-Infectious Effects.

    Oz, Helieh S

    Diseases (Basel, Switzerland)

    2019  Volume 7, Issue 1

    Abstract: Ancient Egyptians smeared a mixture of dark soil on their eyelids and believed it protected eyes from unknown forces (illness). Recent studies have proven that the dark soil across the Nile River is rich in natural compounds including lead sulfide, which ...

    Abstract Ancient Egyptians smeared a mixture of dark soil on their eyelids and believed it protected eyes from unknown forces (illness). Recent studies have proven that the dark soil across the Nile River is rich in natural compounds including lead sulfide, which in low levels, promotes the production of nitric oxide (240-fold) by keratinocytes, with strong immune stimulatory and antimicrobial properties. Current investigations reveal anti-inflammatory and anti-infectious activities-including cytokines and chemokines-in saliva, as well as its friendly microbiota, which lines the surface of the oral cavity, its protection against inflammatory and infectious organisms in the stoma and other organs, such as the cardiovascular and central nervous systems. In fact, saliva may soon become a safe and practical surrogate biomarker for genomic/proteomic evaluations and to replace painful blood drawing and its side effects. Another example is leprosy, or Hansen's disease, a chronic inflammatory syndrome and neglected tropical disease, which affects the skin, and peripheral and trigeminal neurons causing a lack of sensation to heat and cold and loss of extremities. Leprosy has horrified humans for over 2000 years, as lepers were considered unclean sinners and were subsequently drawn out of towns. This communication scrutinizes the past and the present state of saliva and leprosy to encounter possible mystery and/or wisdom in ancient healing as the mixture of "sputum and dirt" as reported in the biblical time.
    Language English
    Publishing date 2019-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases7010031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Fetomaternal and Pediatric Toxoplasmosis.

    Oz, Helieh S

    Journal of pediatric infectious diseases

    2017  Volume 12, Issue 4, Page(s) 202–208

    Abstract: Toxoplasmosis is one of the most important causes of foodborne illnesses and inflammatory complications, as well as congenital disorders. ... ...

    Abstract Toxoplasmosis is one of the most important causes of foodborne illnesses and inflammatory complications, as well as congenital disorders. Promiscuous
    Language English
    Publishing date 2017-12-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2236947-8
    ISSN 1305-7693 ; 1305-7707 ; 1871-0336
    ISSN (online) 1305-7693
    ISSN 1305-7707 ; 1871-0336
    DOI 10.1055/s-0037-1603942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nutrients, Infectious and Inflammatory Diseases.

    Oz, Helieh S

    Nutrients

    2017  Volume 9, Issue 10

    Abstract: A balanced diet with sufficient essential nutritional elements is critical for maintaining a healthy body.[ ... ]. ...

    Abstract A balanced diet with sufficient essential nutritional elements is critical for maintaining a healthy body.[...].
    MeSH term(s) Communicable Diseases ; Diet/standards ; Food Analysis ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Nutritional Status ; Obesity ; Trace Elements
    Chemical Substances Trace Elements
    Language English
    Publishing date 2017-09-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu9101085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dirt, Saliva and Leprosy

    Helieh S. Oz

    Diseases, Vol 7, Iss 1, p

    Anti-Inflammatory and Anti-Infectious Effects

    2019  Volume 31

    Abstract: ... is leprosy, or Hansen’s disease, a chronic inflammatory syndrome and neglected tropical disease ...

    Abstract Ancient Egyptians smeared a mixture of dark soil on their eyelids and believed it protected eyes from unknown forces (illness). Recent studies have proven that the dark soil across the Nile River is rich in natural compounds including lead sulfide, which in low levels, promotes the production of nitric oxide (240-fold) by keratinocytes, with strong immune stimulatory and antimicrobial properties. Current investigations reveal anti-inflammatory and anti-infectious activities—including cytokines and chemokines—in saliva, as well as its friendly microbiota, which lines the surface of the oral cavity, its protection against inflammatory and infectious organisms in the stoma and other organs, such as the cardiovascular and central nervous systems. In fact, saliva may soon become a safe and practical surrogate biomarker for genomic/proteomic evaluations and to replace painful blood drawing and its side effects. Another example is leprosy, or Hansen’s disease, a chronic inflammatory syndrome and neglected tropical disease, which affects the skin, and peripheral and trigeminal neurons causing a lack of sensation to heat and cold and loss of extremities. Leprosy has horrified humans for over 2000 years, as lepers were considered unclean sinners and were subsequently drawn out of towns. This communication scrutinizes the past and the present state of saliva and leprosy to encounter possible mystery and/or wisdom in ancient healing as the mixture of “sputum and dirt„ as reported in the biblical time.
    Keywords soil ; saliva ; leprosy ; Hansen’s disease ; biomarkers ; Medicine ; R
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Chronic Inflammatory Diseases and Green Tea Polyphenols.

    Oz, Helieh S

    Nutrients

    2017  Volume 9, Issue 6

    Abstract: Chronic inflammatory diseases affect millions of people globally and the incidence rate is on the rise. While inflammation contributes to the tissue healing process, chronic inflammation can lead to life-long debilitation and loss of tissue function and ... ...

    Abstract Chronic inflammatory diseases affect millions of people globally and the incidence rate is on the rise. While inflammation contributes to the tissue healing process, chronic inflammation can lead to life-long debilitation and loss of tissue function and organ failure. Chronic inflammatory diseases include hepatic, gastrointestinal and neurodegenerative complications which can lead to malignancy. Despite the millennial advancements in diagnostic and therapeutic modalities, there remains no effective cure for patients who suffer from inflammatory diseases. Therefore, patients seek alternatives and complementary agents as adjunct therapies to relieve symptoms and possibly to prevent consequences of inflammation. It is well known that green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways. These comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 and intervention with the surge of inflammatory markers like cytokines and production ofcyclooxygenase-2. This paper concisely reviews relevant investigations regarding protective effects of GrTPs and some reported adverse effects, as well as possible applications for GrTPs in the treatment of chronic and inflammatory complications.
    Language English
    Publishing date 2017-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu9060561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Induced Aberrant Organisms with Novel Ability to Protect Intestinal Integrity from Inflammation in an Animal Model.

    Oz, Helieh S

    Nutrients

    2017  Volume 9, Issue 8

    Abstract: Robust and balanced gut microbiota are required to support health and growth. Overgrowth of gut microbial or pathogens can change ecosystem balance, and compromise gut integrity to initiate gastrointestinal (GI) complications. There is no safe and ... ...

    Abstract Robust and balanced gut microbiota are required to support health and growth. Overgrowth of gut microbial or pathogens can change ecosystem balance, and compromise gut integrity to initiate gastrointestinal (GI) complications. There is no safe and effective modality against coccidiosis. Antibiotic additives routinely fed to food animals to protect against infection, are entered into the food chain, contaminate food products and pass to the consumers.
    Hypothesis: induced aberrant organisms possess distinct ultrastructure and are tolerated by immunodeficient-animals yet are non-pathogenic, but immunogenic in various strains of chicks to act as a preventive (vaccine) and eliminating the needs for antibiotic additives.
    MeSH term(s) Animals ; Chickens ; Coccidia/classification ; Coccidia/genetics ; Coccidia/ultrastructure ; Coccidiosis ; Cyclophosphamide/toxicity ; Immunosuppression Therapy/veterinary ; Inflammation/parasitology ; Inflammation/pathology ; Inflammation/veterinary ; Intestines/parasitology ; Intestines/pathology ; Poultry Diseases/immunology ; Poultry Diseases/parasitology ; Specific Pathogen-Free Organisms
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2017-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu9080864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: Diets, Gut Microbiota, and Host Metabolism.

    Yin, Jie / Xie, Liwei / Luo, Yuheng / Oz, Helieh S

    Frontiers in nutrition

    2020  Volume 7, Page(s) 108

    Language English
    Publishing date 2020-07-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2020.00108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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