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Article ; Online: Scientific Nomenclature for K

Dupps, William J / Randleman, J Bradley / Kohnen, Thomas / Srinivasan, Sathish / Werner, Liliana

Journal of refractive surgery (Thorofare, N.J. : 1995)

2023 Volume 39, Issue 11, Page(s) 726–727

MeSH term(s)	Humans ; Visual Acuity ; Corneal Stroma/surgery ; Corneal Surgery, Laser ; Lasers, Excimer
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Editorial
ZDB-ID	1264796-2
ISSN	1938-2391 ; 0883-0444 ; 1081-597X ; 1081-0803
ISSN (online)	1938-2391
ISSN	0883-0444 ; 1081-597X ; 1081-0803
DOI	10.3928/1081597X-20231010-0
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Article ; Online: Modulation of K

Sale, Harinath / Roy, Samrat / Warrier, Jayakumar / Thangathirupathy, Srinivasan / Vadari, Yoganand / Gopal, Shruthi K / Krishnamurthy, Prasad / Ramarao, Manjunath

British journal of pharmacology

2017 Volume 174, Issue 15, Page(s) 2484–2500

Abstract: Background and purpose: Activators of K: Experimental approach: Conventional ...

Abstract	Background and purpose: Activators of K Experimental approach: Conventional electrophysiological methods were used to assess the effects of ITP-2 on hERG1a and hERG1a/1b channels expressed heterologously in HEK-293 cells. Key results: ITP-2 selectively increased test pulse currents (EC Conclusions and implications: ITP-2 may serve as another novel lead molecule for designing robust activators of hERG channels. hERG1a/1b gating kinetics were differentially modulated by ITP-2 leading to altered sensitivity. ITP-2 is capable of activating an LQT2 mutant and may be potentially useful in the development of LQT2 therapeutics.
MeSH term(s)	Cells, Cultured ; Dose-Response Relationship, Drug ; ERG1 Potassium Channel/drug effects ; ERG1 Potassium Channel/metabolism ; HEK293 Cells ; Humans ; Ion Channel Gating/drug effects ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship
Chemical Substances	ERG1 Potassium Channel ; Pyrimidines ; Small Molecule Libraries
Language	English
Publishing date	2017-06-18
Publishing country	England
Document type	Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.13859
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Book ; Online: K-TanH

Kundu, Abhisek / Heinecke, Alex / Kalamkar, Dhiraj / Srinivasan, Sudarshan / Qin, Eric C. / Mellempudi, Naveen K. / Das, Dipankar / Banerjee, Kunal / Kaul, Bharat / Dubey, Pradeep

Efficient TanH For Deep Learning

2019

Abstract: We propose K-TanH, a novel, highly accurate, hardware efficient approximation of popular ... activation function TanH for Deep Learning. K-TanH consists of parameterized low-precision integer operations ... look-up tables that can fit in CPU registers. K-TanH can work on various numerical formats ...

Abstract	We propose K-TanH, a novel, highly accurate, hardware efficient approximation of popular activation function TanH for Deep Learning. K-TanH consists of parameterized low-precision integer operations, such as, shift and add/subtract (no floating point operation needed) where parameters are stored in very small look-up tables that can fit in CPU registers. K-TanH can work on various numerical formats, such as, Float32 and BFloat16. High quality approximations to other activation functions, e.g., Sigmoid, Swish and GELU, can be derived from K-TanH. Our AVX512 implementation of K-TanH demonstrates $>5\times$ speed up over Intel SVML, and it is consistently superior in efficiency over other approximations that use floating point arithmetic. Finally, we achieve state-of-the-art Bleu score and convergence results for training language translation model GNMT on WMT16 data sets with approximate TanH obtained via K-TanH on BFloat16 inputs. Comment: 6 pages, 1 figures
Keywords	Computer Science - Machine Learning ; Computer Science - Neural and Evolutionary Computing ; Statistics - Machine Learning
Subject code	006
Publishing date	2019-09-17
Publishing country	us
Document type	Book ; Online
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Article ; Online: Improving reading and comprehension in K-12

Venkat Srinivasan / Hemavathi Murthy

Computers and Education: Artificial Intelligence, Vol 2, Iss , Pp 100019- (2021)

Evidence from a large-scale AI technology intervention in India

2021

Abstract: This paper presents evidence on the impact of technology-aided instruction on literacy using an AI-based multi-sensory technology platform across a large cross-section of government schools in India. The study focused on reading and comprehension in the ... ...

Abstract	This paper presents evidence on the impact of technology-aided instruction on literacy using an AI-based multi-sensory technology platform across a large cross-section of government schools in India. The study focused on reading and comprehension in the English language. The intervention enhances the instructional effectiveness of the teachers and the learning ability of the children within the existing instructional environment without any new instructional design or pedagogy or content. Besides, the intervention is implemented by existing teachers and not outside volunteers.A total of 1 million children and 15,000 teachers across 5000 government schools in the states of Maharashtra, West Bengal, Punjab, Tamil Nadu, Telangana, Gujarat and Karnataka used the technology for the 2016-17 academic year. Using a randomized control-treatment assessment, the study finds a 20–40% overall gain in learning outcomes in the treatment sample. Gains within individual states and grades vary. Learning outcomes rose across the entire range of proficiency levels in a grade. Ongoing self-administered assessments report even higher impact in the 50–60% range. In addition, teachers also reported improving their skills as a result of using the technology, suggesting that the intervention can also alleviate teacher shortage and inadequate teacher training.The paper also reports briefly on the growing adoption of the program in several countries outside India. The results hold significant promise for disrupting the low and stagnating literacy levels across government schools in India and other similar environments.
Keywords	Elementary education ; Distance education and online learning ; Improving classroom teaching ; Cooperative/collaborative learning ; Teaching/learning strategies ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	370
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial.

Hunnali, Charan Raj / Devi, Usha / Kitchanan, Srinivasan / Sethuraman, Giridhar

The Journal of pediatrics

2022 Volume 255, Page(s) 98–104

Abstract: Objective: To study the efficacy of 3 different vitamin K birth prophylaxis regimens in infants ... 0 mg, 0.5 mg, or 0.3 mg intramuscular (IM) vitamin K1 at birth. Protein induced by vitamin K absence ... Results: All the 3 regimens resulted in similar proportion of vitamin K subclinical sufficiency (PIVKA-II ...

Abstract	Objective: To study the efficacy of 3 different vitamin K birth prophylaxis regimens in infants born premature. Study design: This was an open-label, parallel-group, randomized clinical trial conducted in a tertiary neonatal care unit in India. Infants born very preterm (≤32 weeks) and/or with very low birth weight (≤1500 g) were included. In each arm, 25 babies were enrolled. Babies were randomized to receive 1.0 mg, 0.5 mg, or 0.3 mg intramuscular (IM) vitamin K1 at birth. Protein induced by vitamin K absence - II (PIVKA-II) levels were assessed at birth, and on days 5 and 28, along with the frequency of death, bleeding manifestations, intraventricular hemorrhage, necrotizing enterocolitis, bilirubin levels, and duration of phototherapy. The primary outcome was comparison of PIVKA-II levels on day 5 of life. Results: All the 3 regimens resulted in similar proportion of vitamin K subclinical sufficiency (PIVKA-II < 0.028 AU/mL) infants on day 5 (1 mg - 100%; 0.5 mg - 91.7%; 0.3 mg - 91.7%, P = .347), with no significant difference in median (IQR) PIVKA-II levels (AU/mL): 1 mg 0.006 (0.004, 0.009); 0.5 mg 0.008 (0.004, 0.009); 0.3 mg 0.006 (0.003, 0.009), P = .301. However, on day 28, there was a significant decrease in the proportion of vitamin K-sufficient infants in the 0.3-mg IM group (72.7%) compared with the 1.0-mg (100%) or 0.5-mg (91.3) groups. The 1.0-mg group had significantly greater bilirubin levels and duration of phototherapy. None of the other clinical outcomes were statistically different. Conclusions: Both 1-mg and 0.5-mg IM vitamin K birth prophylaxis resulted in high sufficiency on follow-up, compared with 0.3 mg. The current recommendation of 0.5-1 mg IM vitamin K birth prophylaxis for infants born preterm, needs to be continued. Trial registration: CTRI/2022/02/040396.
MeSH term(s)	Infant, Newborn ; Infant ; Humans ; Vitamin K ; Prothrombin ; Protein Precursors/metabolism ; Vitamin K 1/therapeutic use ; Vitamins ; Bilirubin
Chemical Substances	Vitamin K (12001-79-5) ; Prothrombin (9001-26-7) ; Protein Precursors ; Vitamin K 1 (84-80-0) ; Vitamins ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2022.10.031
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Article ; Online: Challenges and Opportunities for Improved Drug-Drug Interaction Predictions for Renal OCT2 and MATE1/2-K Transporters.

Krishnan, Srinivasan / Ramsden, Diane / Ferguson, Douglas / Stahl, Simone H / Wang, Joanne / McGinnity, Dermot F / Hariparsad, Niresh

Clinical pharmacology and therapeutics

2022 Volume 112, Issue 3, Page(s) 562–572

Abstract: ... toxin extrusion 1 and 2-K (MATE1/2-K) transporters. Despite this, there are challenges with translating ... K and the lack of translation to clinically significant effects, it is reasonable to question ...

Abstract	Transporters contribute to renal elimination of drugs; therefore drug disposition can be impacted if transporters are inhibited by comedicant drugs. Regulatory agencies have provided guidelines to assess potential drug-drug interaction (DDI) risk for renal organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 and 2-K (MATE1/2-K) transporters. Despite this, there are challenges with translating in vitro data using currently available tools to obtain a quantitative assessment of DDI risk in the clinic. Given the high number of drugs and new molecular entities showing in vitro inhibition toward OCT2 and/or MATE1/2-K and the lack of translation to clinically significant effects, it is reasonable to question whether the current in vitro assay design and modeling practice has led to unnecessary clinical evaluation. The aim of this review is to assess and discuss available in vitro and clinical data along with prediction models intended to provide clinical context of risk, including static models proposed by regulatory agencies and physiologically-based pharmacokinetic models, in order to identify best practices and areas of future opportunity. This analysis highlights that different in vitro assay designs, including substrate and cell systems used, strongly influence the derived concentration of drug producing 50% inhibition values and contribute to high variability observed across laboratories. Furthermore, the lack of sensitive index substrates coupled with specific inhibitors for individual transporters necessitates the use of complex models to evaluate clinical DDI risk.
MeSH term(s)	Drug Interactions ; HEK293 Cells ; Humans ; Kidney/metabolism ; Organic Cation Transport Proteins/metabolism ; Organic Cation Transporter 2/metabolism ; Renal Elimination
Chemical Substances	Organic Cation Transport Proteins ; Organic Cation Transporter 2 ; SLC47A1 protein, human ; SLC47A2 protein, human
Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2666
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Book ; Online: A Pairwise Fair and Community-preserving Approach to k-Center Clustering

Brubach, Brian / Chakrabarti, Darshan / Dickerson, John P. / Khuller, Samir / Srinivasan, Aravind / Tsepenekas, Leonidas

2020

Abstract: ... an approach for extending existing $k$-center algorithms to satisfy these fairness constraints. Analysis ... we compare the effectiveness of our approach to classical $k$-center algorithms/heuristics and explore ...

Abstract	Clustering is a foundational problem in machine learning with numerous applications. As machine learning increases in ubiquity as a backend for automated systems, concerns about fairness arise. Much of the current literature on fairness deals with discrimination against protected classes in supervised learning (group fairness). We define a different notion of fair clustering wherein the probability that two points (or a community of points) become separated is bounded by an increasing function of their pairwise distance (or community diameter). We capture the situation where data points represent people who gain some benefit from being clustered together. Unfairness arises when certain points are deterministically separated, either arbitrarily or by someone who intends to harm them as in the case of gerrymandering election districts. In response, we formally define two new types of fairness in the clustering setting, pairwise fairness and community preservation. To explore the practicality of our fairness goals, we devise an approach for extending existing $k$-center algorithms to satisfy these fairness constraints. Analysis of this approach proves that reasonable approximations can be achieved while maintaining fairness. In experiments, we compare the effectiveness of our approach to classical $k$-center algorithms/heuristics and explore the tradeoff between optimal clustering and fairness.
Keywords	Computer Science - Machine Learning ; Computer Science - Data Structures and Algorithms ; Statistics - Machine Learning
Subject code	004 ; 006
Publishing date	2020-07-14
Publishing country	us
Document type	Book ; Online
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Article ; Online: Relative effects of different non-vitamin K antagonist oral anticoagulants on global thrombotic status in atrial fibrillation.

Farag, Mohamed / Niespialowska-Steuden, Maria / Okafor, Osita / Artman, Benjamin / Srinivasan, Manivannan / Khan, Arif / Sullivan, Keith / Wellsted, David / Gorog, Diana A

Platelets

2016 Volume 27, Issue 7, Page(s) 687–693

Abstract: Non-vitamin K antagonist oral anticoagulants (NOACs) reduce the risk of thromboembolism in patients ...

Abstract	Non-vitamin K antagonist oral anticoagulants (NOACs) reduce the risk of thromboembolism in patients with atrial fibrillation (AF). There has been no head-to-head comparison of the effect of these agents on ex vivo thrombotic and thrombolytic status. Enhanced platelet reactivity and impaired endogenous thrombolysis are risk factors for recurrent thrombotic events. We aimed to assess the comparative effect of NOACs and warfarin using an ex vivo test of thrombosis and thrombolysis. Eighty patients with newly diagnosed non-valvular AF were tested before, and after being established on apixaban (n = 20), dabigatran (n = 20), rivaroxaban (n = 20), or warfarin (n = 20). Thrombotic status was assessed with the automated, point-of-care Global Thrombosis Test (GTT) that assesses both platelet reactivity and endogenous thrombolysis from native blood. The time taken to form an occlusive thrombus (occlusion time, OT) and the time required to restore flow through endogenous thrombolysis (lysis time, LT) were measured. All anticoagulants caused OT prolongation compared to baseline (apixaban 403 ± 102s vs. 496 ± 125s, p = 0.006; dabigatran 471 ± 106s vs. 656 ± 165s, p < 0.00001; rivaroxaban 381 ± 119s vs. 579 ± 158, p < 0.00001; warfarin 420 ± 145s vs. 604 ± 124s, p < 0.00001). Apixaban reduced LT from baseline (1895[1702-2167]s vs. 1435[347-1990]s; p = 0.006). A trend for LT reduction was seen with other NOACs (dabigatran 1594[1226-2069]s vs. 1539[561-2316]s, p = 0.499; rivaroxaban 2085[1366-2428]s vs. 1885[724-2420]s, p = 0.295) but not with warfarin (1490[1206-1960]s vs. 1776[1545-2334], p = 0.601). Our results suggest that NOACs and warfarin have a similar favorable effect on reducing platelet reactivity. All NOACs exhibited a trend toward enhancing endogenous thrombolytic status, although this was significant only for apixaban. This raises the possibility of using NOACs to enhance impaired endogenous fibrinolysis in patients at high-thrombotic risk.
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/blood ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Blood Coagulation Tests ; Comorbidity ; Female ; Hemostasis/drug effects ; Humans ; Male ; Middle Aged ; Platelet Function Tests ; Risk Factors ; Thromboembolism/diagnosis ; Thromboembolism/etiology ; Thromboembolism/prevention & control ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1034283-7
ISSN	1369-1635 ; 0953-7104
ISSN (online)	1369-1635
ISSN	0953-7104
DOI	10.3109/09537104.2016.1158402
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Article ; Online: The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.

McCloskey, Conor / Rada, Cara / Bailey, Elizabeth / McCavera, Samantha / van den Berg, Hugo A / Atia, Jolene / Rand, David A / Shmygol, Anatoly / Chan, Yi-Wah / Quenby, Siobhan / Brosens, Jan J / Vatish, Manu / Zhang, Jie / Denton, Jerod S / Taggart, Michael J / Kettleborough, Catherine / Tickle, David / Jerman, Jeff / Wright, Paul /

Dale, Timothy / Kanumilli, Srinivasan / Trezise, Derek J / Thornton, Steve / Brown, Pamela / Catalano, Roberto / Lin, Nan / England, Sarah K / Blanks, Andrew M

EMBO molecular medicine

2014 Volume 6, Issue 9, Page(s) 1161–1174

Abstract: Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage. Uterine contractile patterns are controlled by the generation of complex electrical signals ... ...

Abstract	Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage. Uterine contractile patterns are controlled by the generation of complex electrical signals at the myometrial smooth muscle plasma membrane. To identify novel targets to treat conditions associated with uterine dysfunction, we undertook a genome-wide screen of potassium channels that are enriched in myometrial smooth muscle. Computational modelling identified Kir7.1 as potentially important in regulating uterine excitability during pregnancy. We demonstrate Kir7.1 current hyper-polarizes uterine myocytes and promotes quiescence during gestation. Labour is associated with a decline, but not loss, of Kir7.1 expression. Knockdown of Kir7.1 by lentiviral expression of miRNA was sufficient to increase uterine contractile force and duration significantly. Conversely, overexpression of Kir7.1 inhibited uterine contractility. Finally, we demonstrate that the Kir7.1 inhibitor VU590 as well as novel derivative compounds induces profound, long-lasting contractions in mouse and human myometrium; the activity of these inhibitors exceeds that of other uterotonic drugs. We conclude Kir7.1 regulates the transition from quiescence to contractions in the pregnant uterus and may be a target for therapies to control uterine contractility.
MeSH term(s)	Animals ; Cell Line ; Cricetinae ; Cricetulus ; Female ; Gene Knockdown Techniques ; Humans ; Immunohistochemistry ; In Vitro Techniques ; Labor, Obstetric/metabolism ; Membrane Potentials ; Mice ; Mice, Inbred C57BL ; Patch-Clamp Techniques ; Potassium Channels, Inwardly Rectifying/genetics ; Potassium Channels, Inwardly Rectifying/metabolism ; Potassium Channels, Inwardly Rectifying/physiology ; Pregnancy ; Uterine Contraction/genetics ; Uterine Contraction/metabolism
Chemical Substances	Kir7.1 channel ; Potassium Channels, Inwardly Rectifying
Language	English
Publishing date	2014-07-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.15252/emmm.201403944
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Article ; Online: Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene.

Guha, Manti / Srinivasan, Satish / Koenigstein, Alexander / Zaidi, Mone / Avadhani, Narayan G

Annals of the New York Academy of Sciences

2016 Volume 1364, Page(s) 52–61

Abstract: ... ribonucleoprotein A2 (hnRNP A2) is induced by hypoxia in murine macrophages. We demonstrate that the cathepsin K ...

Abstract	Mitochondrial dysfunction has emerged as an important factor in wide ranging human pathologies. We have previously defined a retrograde signaling pathway that originates from dysfunctional mitochondria (Mt-RS) and causes a global nuclear transcriptional reprograming as its end point. Mitochondrial dysfunction causing disruption of mitochondrial membrane potential and consequent increase in cytosolic calcium [Ca(2) ](c) activates calcineurin and the transcription factors NF-κB, NFAT, CREB, and C/EBPδ. In macrophages, this signaling complements receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastic differentiation. Here, we show that the Mt-RS activated transcriptional coactivator heterogeneous ribonucleoprotein A2 (hnRNP A2) is induced by hypoxia in murine macrophages. We demonstrate that the cathepsin K gene (Ctsk), one of the key genes upregulated during osteoclast differentiation, is transcriptionally activated by Mt-RS factors. HnRNP A2 acts as a coactivator with nuclear transcription factors, cRel, and C/EBPδ for Ctsk promoter activation under hypoxic conditions. Notably, our study shows that hypoxia-induced activation of the stress target factors mediates effects similar to that of RANKL with regard to Ctsk activation. We therefore suggest that mitochondrial dysfunction and activation of Mt-RS, induced by various pathophysiologic conditions, is a potential risk factor for osteoclastogenesis and bone loss.
MeSH term(s)	Animals ; CCAAT-Enhancer-Binding Protein-delta/antagonists & inhibitors ; CCAAT-Enhancer-Binding Protein-delta/genetics ; CCAAT-Enhancer-Binding Protein-delta/metabolism ; Cathepsin K/antagonists & inhibitors ; Cathepsin K/chemistry ; Cathepsin K/genetics ; Cathepsin K/metabolism ; Cell Hypoxia ; Cyclic AMP Response Element-Binding Protein/antagonists & inhibitors ; Cyclic AMP Response Element-Binding Protein/genetics ; Cyclic AMP Response Element-Binding Protein/metabolism ; Genes, Reporter ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/antagonists & inhibitors ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/metabolism ; Mice ; Mitochondria/enzymology ; Mitochondria/metabolism ; NFATC Transcription Factors/antagonists & inhibitors ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; Osteoclasts/cytology ; Osteoclasts/enzymology ; Osteoclasts/metabolism ; Osteogenesis ; Promoter Regions, Genetic ; RANK Ligand/metabolism ; RAW 264.7 Cells ; RNA Interference ; RNA, Messenger/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Signal Transduction ; Transcriptional Activation
Chemical Substances	Cebpd protein, mouse ; Creb1 protein, mouse ; Cyclic AMP Response Element-Binding Protein ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B ; NFATC Transcription Factors ; Nfatc1 protein, mouse ; RANK Ligand ; RNA, Messenger ; Recombinant Proteins ; Tnfsf11 protein, mouse ; hnRNP A2 ; CCAAT-Enhancer-Binding Protein-delta (142662-43-9) ; Cathepsin K (EC 3.4.22.38) ; Ctsk protein, mouse (EC 3.4.22.38)
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/nyas.12709
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