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  1. Article ; Online: The Gut-Lung Axis: What's below the Diaphragm Is Also Important.

    Hung, Chi F / Matute-Bello, Gustavo

    American journal of respiratory cell and molecular biology

    2022  Volume 67, Issue 6, Page(s) 617–618

    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Diaphragm ; Lung Injury ; Zinc Oxide ; Lung ; Nanoparticles
    Chemical Substances Zinc Oxide (SOI2LOH54Z) ; propionic acid (JHU490RVYR)
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0365ED
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  2. Article ; Online: Should we shift the paradigm of preclinical models for ARDS therapies?

    Bain, William / Matute-Bello, Gustavo

    Thorax

    2019  Volume 74, Issue 12, Page(s) 1109–1110

    MeSH term(s) Humans ; Respiration ; Respiratory Distress Syndrome, Adult
    Language English
    Publishing date 2019-10-17
    Publishing country England
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2019-213729
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  3. Article ; Online: Liponucleotides: Promises and Unknowns as Novel Therapeutics for Acute Respiratory Distress Syndrome.

    Hung, Chi F / Matute-Bello, Gustavo

    American journal of respiratory cell and molecular biology

    2020  Volume 64, Issue 6, Page(s) 645–646

    MeSH term(s) Humans ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0110ED
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  4. Article ; Online: Reply: Experimental Acute Lung Injury in Animals: With Age Comes Knowledge.

    Kulkarni, Hrishikesh S / Lee, Janet S / Downey, Gregory P / Matute-Bello, Gustavo

    American journal of respiratory cell and molecular biology

    2022  Volume 67, Issue 2, Page(s) 267

    MeSH term(s) Acute Lung Injury ; Animals ; Disease Models, Animal ; Lung
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0091LE
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  5. Article ; Online: The bioactivity of soluble Fas ligand is modulated by key amino acids of its stalk region.

    Kajikawa, Osamu / Herrero, Raquel / Chow, Yu-Hua / Hung, Chi F / Matute-Bello, Gustavo

    PloS one

    2021  Volume 16, Issue 6, Page(s) e0253260

    Abstract: We have previously reported that the 26-amino acid N-terminus stalk region of soluble Fas ligand (sFasL), which is separate from its binding site, is required for its biological function. Here we investigate the mechanisms that link the structure of the ... ...

    Abstract We have previously reported that the 26-amino acid N-terminus stalk region of soluble Fas ligand (sFasL), which is separate from its binding site, is required for its biological function. Here we investigate the mechanisms that link the structure of the sFasL stalk region with its function. Using site-directed mutagenesis we cloned a mutant form of sFasL in which all the charged amino acids of the stalk region were changed to neutral alanines (mut-sFasL). We used the Fas-sensitive Jurkat T-cell line and mouse and human alveolar epithelial cells to test the bioactivity of sFasL complexes, using caspase-3 activity and Annexin-V externalization as readouts. Finally, we tested the effects of mut-sFasL on lipopolysaccharide-induced lung injury in mice. We found that mutation of all the 8 charged amino acids of the stalk region into the non-charged amino acid alanine (mut-sFasL) resulted in reduced apoptotic activity compared to wild type sFasL (WT-sFasL). The mut-sFasL attenuated WT-sFasL function on the Fas-sensitive human T-cell line Jurkat and on primary human small airway epithelial cells. The inhibitory mechanism was associated with the formation of complexes of mut-sFasL with the WT protein. Intratracheal administration of the mut-sFasL to mice 24 hours after intratracheal Escherichia coli lipopolysaccharide resulted in attenuation of the inflammatory response 24 hours later. Therefore, the stalk region of sFasL has a critical role on bioactivity, and changes in the structure of the stalk region can result in mutant variants that interfere with the wild type protein function in vitro and in vivo.
    MeSH term(s) Alveolar Epithelial Cells/metabolism ; Amino Acids/metabolism ; Animals ; Binding Sites/physiology ; Fas Ligand Protein/metabolism ; Humans ; Jurkat Cells ; Mice
    Chemical Substances Amino Acids ; Fas Ligand Protein
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0253260
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  6. Article ; Online: Reply to Dr. Weiskirchen.

    Grazioli, Serge / Matute-Bello, Gustavo

    American journal of physiology. Lung cellular and molecular physiology

    2015  Volume 309, Issue 7, Page(s) L749

    MeSH term(s) Acute Lung Injury/metabolism ; Animals ; Cysteine-Rich Protein 61/metabolism ; Gene Expression ; Humans ; Male
    Chemical Substances Cysteine-Rich Protein 61
    Language English
    Publishing date 2015-10-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00265.2015
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  7. Article ; Online: How to measure alterations in alveolar barrier function as a marker of lung injury.

    Herrero, Raquel / Matute-Bello, Gustavo

    Current protocols in toxicology

    2015  Volume 63, Page(s) 24.3.1–24.3.15

    Abstract: The alveolar capillary membrane maintains the proper water and solute content of the epithelial lining fluid at the alveolar air-liquid interface, which is critical for adequate gas exchange in the lung. This is possible due to the alveolar fluid ... ...

    Abstract The alveolar capillary membrane maintains the proper water and solute content of the epithelial lining fluid at the alveolar air-liquid interface, which is critical for adequate gas exchange in the lung. This is possible due to the alveolar fluid clearance (AFC) capacity of this membrane that assists in the removal of salt and water from the alveolar air spaces. The alveolar capillary membrane also provides a barrier that restricts the passage of proteins and water from the interstitial and vascular compartments into the alveolar air spaces. This restricted passage is due to the presence of tight junctions between adjacent alveolar epithelial cells. Severe injury to the alveolar epithelial/endothelial membrane results in increased protein permeability and impairment of AFC, which leads to the formation of protein-rich edema with the consequent deterioration of gas exchange. Many animal models of lung injury, focused on damage of the alveolar-capillary membrane, assess the AFC capacity and the barrier function. We describe a simple method to assess the AFC rate in normal and pathological conditions in mice. We also describe two complementary methods to assess the alveolar-capillary barrier function, which require measuring the concentration of endogenous plasma proteins in bronchoalveolar lavage fluid and detection of tight-junction proteins in lung tissue by immunofluorescence.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Blood Proteins/metabolism ; Blood-Air Barrier/metabolism ; Bronchoalveolar Lavage Fluid/chemistry ; Capillary Permeability ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique ; Lung Injury/diagnosis ; Lung Injury/metabolism ; Lung Injury/physiopathology ; Mice ; Pulmonary Alveoli/metabolism ; Pulmonary Alveoli/pathology ; Pulmonary Alveoli/physiopathology ; Tight Junction Proteins/metabolism ; Workflow
    Chemical Substances Biomarkers ; Blood Proteins ; Tight Junction Proteins
    Language English
    Publishing date 2015-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1934-9262
    ISSN (online) 1934-9262
    DOI 10.1002/0471140856.tx2403s63
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  8. Article ; Online: The bioactivity of soluble Fas ligand is modulated by key amino acids of its stalk region.

    Osamu Kajikawa / Raquel Herrero / Yu-Hua Chow / Chi F Hung / Gustavo Matute-Bello

    PLoS ONE, Vol 16, Iss 6, p e

    2021  Volume 0253260

    Abstract: We have previously reported that the 26-amino acid N-terminus stalk region of soluble Fas ligand (sFasL), which is separate from its binding site, is required for its biological function. Here we investigate the mechanisms that link the structure of the ... ...

    Abstract We have previously reported that the 26-amino acid N-terminus stalk region of soluble Fas ligand (sFasL), which is separate from its binding site, is required for its biological function. Here we investigate the mechanisms that link the structure of the sFasL stalk region with its function. Using site-directed mutagenesis we cloned a mutant form of sFasL in which all the charged amino acids of the stalk region were changed to neutral alanines (mut-sFasL). We used the Fas-sensitive Jurkat T-cell line and mouse and human alveolar epithelial cells to test the bioactivity of sFasL complexes, using caspase-3 activity and Annexin-V externalization as readouts. Finally, we tested the effects of mut-sFasL on lipopolysaccharide-induced lung injury in mice. We found that mutation of all the 8 charged amino acids of the stalk region into the non-charged amino acid alanine (mut-sFasL) resulted in reduced apoptotic activity compared to wild type sFasL (WT-sFasL). The mut-sFasL attenuated WT-sFasL function on the Fas-sensitive human T-cell line Jurkat and on primary human small airway epithelial cells. The inhibitory mechanism was associated with the formation of complexes of mut-sFasL with the WT protein. Intratracheal administration of the mut-sFasL to mice 24 hours after intratracheal Escherichia coli lipopolysaccharide resulted in attenuation of the inflammatory response 24 hours later. Therefore, the stalk region of sFasL has a critical role on bioactivity, and changes in the structure of the stalk region can result in mutant variants that interfere with the wild type protein function in vitro and in vivo.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A 68-Year-Old Man With Skin Rash and a Pleural Effusion.

    Stiller, Robin H / Gadzhiev, Marat / Schachtel, April K / Chang, Oliver H / Bastawrous, Sarah / Hermes Shantz, Heidi / Matute-Bello, Gustavo / Albert, Tyler J

    Chest

    2020  Volume 158, Issue 1, Page(s) e33–e36

    Abstract: Case presentation: A 68-year-old man developed an erythematous, papular, pruritic rash on his right thigh 1 month prior to presentation. It subsequently spread to his other extremities and trunk. He also endorsed fevers of > 38.3°C, night sweats, ... ...

    Abstract Case presentation: A 68-year-old man developed an erythematous, papular, pruritic rash on his right thigh 1 month prior to presentation. It subsequently spread to his other extremities and trunk. He also endorsed fevers of > 38.3°C, night sweats, fatigue, shortness of breath, and a dry cough. He was prescribed triamcinolone 0.1% cream for his rash and azithromycin for presumed community-acquired pneumonia, with no improvement in symptoms. He had a history of relapsing polychondritis for which he was prescribed infliximab and low-dose prednisone. He had never smoked tobacco, did not use alcohol or illicit substances, and had no significant travel history.
    MeSH term(s) Aged ; Exanthema/diagnosis ; Exanthema/etiology ; Exanthema/therapy ; Humans ; Male ; Pleural Effusion/diagnosis ; Pleural Effusion/etiology ; Pleural Effusion/therapy ; Polychondritis, Relapsing/complications ; Polychondritis, Relapsing/diagnosis ; Polychondritis, Relapsing/therapy ; Sweet Syndrome/complications ; Sweet Syndrome/diagnosis ; Sweet Syndrome/therapy
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.12.013
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  10. Article: Targeting caspase-1 in sepsis: a novel approach to an old problem.

    Matute-Bello, Gustavo

    Intensive care medicine

    2007  Volume 33, Issue 5, Page(s) 755–757

    MeSH term(s) Caspase 1/physiology ; Caspase Inhibitors ; Humans ; Interleukin-1beta/biosynthesis ; Interleukin-1beta/physiology ; Oligopeptides/pharmacology ; Oligopeptides/therapeutic use ; Sepsis/drug therapy ; Sepsis/enzymology
    Chemical Substances Caspase Inhibitors ; Interleukin-1beta ; Oligopeptides ; tyrosyl-valyl-alanyl-aspartal ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0342-4642 ; 0340-0964 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0342-4642 ; 0340-0964 ; 0935-1701
    DOI 10.1007/s00134-007-0589-z
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