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  1. Article: Der Fall aus der Praxis (110). Patientin: Frau P. M., geb. 1965, Sekretärin.

    Schön, H

    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis

    1988  Volume 77, Issue 25, Page(s) 715–717

    Title translation A case from practice (110). Patient: Mrs P. M., born 1965, secretary.
    MeSH term(s) Brain/pathology ; Cranial Nerve Diseases/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Multiple Sclerosis/diagnosis ; Neurologic Examination ; Trigeminal Nerve
    Language German
    Publishing date 1988-06-21
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1013-2058 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1013-2058 ; 1661-8157 ; 0369-8394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The exceptions that prove the rule-a historical view of bedaquiline susceptibility.

    Miotto, Paolo / Cirillo, Daniela M / Schön, Thomas / Köser, Claudio U

    Genome medicine

    2024  Volume 16, Issue 1, Page(s) 39

    Abstract: In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis ... ...

    Abstract In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results.
    MeSH term(s) Humans ; Diarylquinolines/pharmacology ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Mycobacterium tuberculosis/genetics ; Mutation
    Chemical Substances bedaquiline (78846I289Y) ; Diarylquinolines ; Antitubercular Agents
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-024-01311-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction to: The impact of organisational characteristics of staff and facility on infectious disease outbreaks in care homes: a systematic review.

    Liljas, A E M / Morath, L P / Burström, B / Schön, P / Agerholm, J

    BMC health services research

    2022  Volume 22, Issue 1, Page(s) 384

    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-022-07796-8
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  4. Article ; Online: In Gedenken an Prof. Dr. med. Detlef Zillikens, Direktor der Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck.

    Schmidt, Enno / Goebeler, Matthias / Schön, Michael P / Terheyden, Patrick

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2022  Volume 20, Issue 12, Page(s) 1689–1690

    Language English
    Publishing date 2022-12-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14970_g
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  5. Article ; Online: Comorbid acne inversa and Dowling-Degos disease due to a single NCSTN mutation: is there enough evidence?

    Hermasch, M A / Schön, M P / Frank, J

    The British journal of dermatology

    2020  Volume 184, Issue 2, Page(s) 374

    MeSH term(s) Hidradenitis Suppurativa/epidemiology ; Hidradenitis Suppurativa/genetics ; Humans ; Hyperpigmentation ; Mutation/genetics ; Phenotype ; Skin Diseases, Genetic ; Skin Diseases, Papulosquamous
    Keywords covid19
    Language English
    Publishing date 2020-11-08
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.19539
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  6. Article ; Online: The impact of organisational characteristics of staff and facility on infectious disease outbreaks in care homes: a systematic review.

    Liljas, A E M / Morath, L P / Burström, B / Schön, P / Agerholm, J

    BMC health services research

    2022  Volume 22, Issue 1, Page(s) 339

    Abstract: Background: Infectious disease outbreaks are common in care homes, often with substantial impact on the rates of infection and mortality of the residents, who primarily are older people vulnerable to infections. There is growing evidence that ... ...

    Abstract Background: Infectious disease outbreaks are common in care homes, often with substantial impact on the rates of infection and mortality of the residents, who primarily are older people vulnerable to infections. There is growing evidence that organisational characteristics of staff and facility might play a role in infectious disease outbreaks however such evidence have not previously been systematically reviewed. Therefore, this systematic review aims to examine the impact of facility and staff characteristics on the risk of infectious disease outbreaks in care homes.
    Methods: Five databases (MEDLINE, EMBASE, ProQuest, Web of Science, CINAHL) were searched. Studies considered for inclusion were of any design reporting on an outbreak of any infectious disease in one or more care homes providing care for primarily older people with original data on: facility size, facility location (urban/rural), facility design, use of temporary hired staff, staff compartmentalizing, residence of staff, and/or nursing aides hours per resident. Retrieved studies were screened, assessed for quality using CASP, and analysed employing a narrative synthesis.
    Results: Sixteen studies (8 cohort studies, 6 cross-sectional studies, 2 case-control) were included from the search which generated 10,424 unique records. COVID-19 was the most commonly reported cause of outbreak (n = 11). The other studies focused on influenza, respiratory and gastrointestinal outbreaks. Most studies reported on the impact of facility size (n = 11) followed by facility design (n = 4), use of temporary hired staff (n = 3), facility location (n = 2), staff compartmentalizing (n = 2), nurse aides hours (n = 2) and residence of staff (n = 1). Findings suggest that urban location and larger facility size may be associated with greater risks of an infectious disease outbreak. Additionally, the risk of a larger outbreak seems lower in larger facilities. Whilst staff compartmentalizing may be associated with lower risk of an outbreak, staff residing in highly infected areas may be associated with greater risk of outbreak. The influence of facility design, use of temporary staff, and nurse aides hours remains unclear.
    Conclusions: This systematic review suggests that larger facilities have greater risks of infectious disease outbreaks, yet the risk of a larger outbreak seems lower in larger facilities. Due to lack of robust findings the impact of facility and staff characteristics on infectious disease outbreaks remain largely unknown.
    Prospero: CRD42020213585 .
    MeSH term(s) Aged ; COVID-19 ; Cross-Sectional Studies ; Disease Outbreaks ; Humans ; Influenza, Human/epidemiology ; Nursing Homes
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-022-07481-w
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  7. Article ; Online: Risk factors for infection in older adults who receive home healthcare and/or home help: A protocol for systematic review and meta-analysis.

    Liljas, Ann E M / Agerholm, Janne / Schön, Pär / Burström, Bo

    Medicine

    2022  Volume 101, Issue 45, Page(s) e31772

    Abstract: Background: The shift towards home-based care has resulted in increased provision of home healthcare and home help to older adults. Infections acquired in older adults while receiving home care have increased too, resulting in unplanned yet avoidable ... ...

    Abstract Background: The shift towards home-based care has resulted in increased provision of home healthcare and home help to older adults. Infections acquired in older adults while receiving home care have increased too, resulting in unplanned yet avoidable hospitalizations. In recent years, several studies have reported an array of factors associated with risk of infection; however, no previous systematic review has compiled such evidence, which is important to better protect older adults. Therefore, we have outlined the work of a systematic review that aims to identify risk factors for infection in older adults receiving home healthcare and/or home help.
    Methods: Searches for relevant studies will be conducted in five databases [MEDLINE, EMBASE (Excerpta Medica Database), Web of Science Core Collection, Cinahl (Cumulative Index to Nursing & Allied Health Literature) and Sociological Abstracts]. All types of studies will be included. Exposures considered refer to medical, individual, social/behavioral and environmental risk factors for infection (outcome). Two researchers will independently go through the records generated. Eligible studies will be assessed for risk of biases using the Cochrane risk of bias assessment tool and an overall interpretation of the biases will be provided. If the data allow, a meta-analysis will be conducted. It is possible that both quantitative and qualitative studies will be identified and eligible. Therefore, for the analysis, the Joanna Briggs Institute Reviewers' Manual for mixed methods systematic reviews will be used as it allows for two or more single method reviews (e.g., one quantitative and one qualitative) to be conducted separately and then combined in a joint overarching synthesis.
    Results: The findings of the planned systematic review are of interest to healthcare professionals, caregivers, older adults and their families, and policy- and decisions makers in the health and social care sectors as the review will provide evidence-based data on multiple factors that influence the risk of infection among older adults receiving care in their homes.
    Conclusion: The results could guide future policy on effective infection control in the home care sector.
    MeSH term(s) Humans ; Aged ; Systematic Reviews as Topic ; Meta-Analysis as Topic ; Home Care Services ; Risk Factors ; Delivery of Health Care
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000031772
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  8. Article: Dogs Can Be Reservoirs of

    Damborg, Peter / Pirolo, Mattia / Schøn Poulsen, Laura / Frimodt-Møller, Niels / Guardabassi, Luca

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: This study aimed to investigate the role played by pets as reservoirs ... ...

    Abstract This study aimed to investigate the role played by pets as reservoirs of
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081269
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  9. Article ; Online: The role of social connections and support in the use of emergency care among older adults.

    Naseer, Mahwish / Dahlberg, Lena / Ehrenberg, Anna / Schön, Pär / Calderón-Larrañaga, Amaia

    Archives of gerontology and geriatrics

    2023  Volume 111, Page(s) 105010

    Abstract: Objectives: Limited and inconsistent findings have been reported on the link between social connections and support and emergency department (ED) visits in older populations. Moreover, the adequacy of informal care for older adults has rarely been ... ...

    Abstract Objectives: Limited and inconsistent findings have been reported on the link between social connections and support and emergency department (ED) visits in older populations. Moreover, the adequacy of informal care for older adults has rarely been considered. This study explored the associations of social connections, social support, and informal care with ED visits in younger-old (<78 years) and oldest-old (≥78 years) adults.
    Methods: This is a prospective cohort study based on community-living adults ≥60 years old participating in the Swedish National Study on Aging and Care in Kungsholmen (N=3066 at wave 1, 2001-2004; N=1885 at wave 3, 2007-2010; N=1208 at wave 5, 2013-2016). Standardised indexes were developed to measure social connections, social support, and informal care. The outcome variable was hospital-based ED visits within 4 years of the SNAC-K interview. Associations between exposure variables and ED visits were assessed through negative binomial regressions using generalised estimating equations.
    Results: Medium (IRR 0.77; 95% CI 0.59-0.99) and high (IRR 0.77; 95% CI 0.56-0.99) levels of social support were negatively associated with ED visits compared to low levels of social support, but only in oldest-old adults. No statistically significant associations were observed between social connections and ED visits. Higher ED visit rates were seen in oldest-old adults with unmet informal care needs, even if the differences did not reach statistical significance.
    Conclusions: ED visits were associated with social support levels among adults aged ≥78 years. Public health interventions to mitigate situations of poor social support may improve health outcomes and reduce avoidable ED visits in oldest-old adults.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Prospective Studies ; Emergency Service, Hospital ; Sweden
    Language English
    Publishing date 2023-03-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2023.105010
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  10. Article ; Online: Revisiting the Nature of Chemical Bonding in Chalcogenides to Explain and Design their Properties.

    Wuttig, Matthias / Schön, Carl-Friedrich / Lötfering, Jakob / Golub, Pavlo / Gatti, Carlo / Raty, Jean-Yves

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 20, Page(s) e2208485

    Abstract: Quantum chemical bonding descriptors have recently been utilized to design materials with tailored properties. Their usage to facilitate a quantitative description of bonding in chalcogenides as well as the transition between different bonding mechanisms ...

    Abstract Quantum chemical bonding descriptors have recently been utilized to design materials with tailored properties. Their usage to facilitate a quantitative description of bonding in chalcogenides as well as the transition between different bonding mechanisms is reviewed. More importantly, these descriptors can also be employed as property predictors for several important material characteristics, including optical and transport properties. Hence, these quantum chemical bonding descriptors can be utilized to tailor material properties of chalcogenides relevant for thermoelectrics, photovoltaics, and phase-change memories. Relating material properties to bonding mechanisms also shows that there is a class of materials, which are characterized by unconventional properties such as a pronounced anharmonicity, a large chemical bond polarizability, and strong optical absorption. This unusual property portfolio is attributed to a novel bonding mechanism, fundamentally different from ionic, metallic, and covalent bonding, which is called "metavalent." In the concluding section, a number of promising research directions are sketched, which explore the nature of the property changes upon changing bonding mechanism and extend the concept of quantum chemical property predictors to more complex compounds.
    Language English
    Publishing date 2023-03-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202208485
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