LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 108

Search options

  1. Article ; Online: Inflammation and Digestive Cancer.

    Waldum, Helge / Fossmark, Reidar

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, i.e., the stomach, colon, and liver. The mechanism of this effect has, however, only partly been focused on. In this review, we focus on different forms of chronic ... ...

    Abstract Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, i.e., the stomach, colon, and liver. The mechanism of this effect has, however, only partly been focused on. In this review, we focus on different forms of chronic hepatitis, chronic inflammatory bowel disease, and chronic gastritis, conditions predisposing individuals to the development of malignancy. Chronic inflammation may cause malignancy because (1) the cause of the chronic inflammation is itself genotoxic, (2) substances released from the inflammatory cells may be genotoxic, (3) the cell death induced by the inflammation induces a compensatory increase in proliferation with an inherent risk of mutation, (4) changes in cell composition due to inflammation may modify function, resulting in hormonal disturbances affecting cellular proliferation. The present review focuses on chronic gastritis (
    MeSH term(s) Humans ; Gastrointestinal Neoplasms ; Inflammation ; Inflammatory Bowel Diseases ; Liver ; Helicobacter pylori ; Gastritis
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713503
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Thesis: Gastric cancer in Japanese cotton rats

    Fossmark, Reidar

    (Doctoral theses at NTNU ; 2004,125)

    2004  

    Author's details Reidar Fossmark
    Series title Doctoral theses at NTNU ; 2004,125
    Collection
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Norway
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Trondheim, Univ., Diss., 2004
    Note Enth. 4 Sonderabdr. aus verschiedenen Zeitschr.
    HBZ-ID HT014467332
    ISBN 82-471-6474-4 ; 978-82-471-6474-7
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 E 1008 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Reply to "Too Soon to Dismiss Inflammation-Related Differences in the Mucosa-Associated Microbiota in Crohn's Disease Patients".

    Olaisen, Maya / Fossmark, Reidar

    Inflammatory bowel diseases

    2022  Volume 28, Issue 8, Page(s) e121

    MeSH term(s) Crohn Disease/microbiology ; Humans ; Ileum/microbiology ; Inflammation ; Microbiota ; Mucous Membrane
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izac047
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Proton Pump Inhibitors and Mortality.

    Waldum, Helge L / Fossmark, Reidar

    Gastroenterology

    2022  Volume 164, Issue 6, Page(s) 1021

    MeSH term(s) Humans ; Proton Pump Inhibitors/adverse effects ; Histamine H2 Antagonists ; Peptic Ulcer Hemorrhage
    Chemical Substances Proton Pump Inhibitors ; Histamine H2 Antagonists
    Language English
    Publishing date 2022-10-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 572: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Is empiric proton pump inhibition in patients with symptoms of extraesophageal gastroesophageal reflux justified?

    Fossmark, Reidar / Ness-Jensen, Eivind / Sørdal, Øystein

    BMC gastroenterology

    2023  Volume 23, Issue 1, Page(s) 303

    Abstract: Background: The prevalence of gastroesophageal reflux disease (GERD) has had a marked increase in Western countries with a paralleling interest in extraesophageal (EE) manifestations of GERD, including laryngopharyngeal reflux (LPR). There are ... ...

    Abstract Background: The prevalence of gastroesophageal reflux disease (GERD) has had a marked increase in Western countries with a paralleling interest in extraesophageal (EE) manifestations of GERD, including laryngopharyngeal reflux (LPR). There are considerable differences in clinical practice between gastroenterologists, otolaryngologists and pulmonologists.
    Methods: In this narrative review we address some of these controversies concerning EE manifestations of GERD and LPR.
    Results: It is disputed whether there is causal relationship between reflux and the numerous symptoms and conditions suggested to be EE manifestations of GERD. Similarly, the pathophysiology is uncertain and there are disagreements concerning diagnostic criteria. Consequently, it is challenging to provide evidence-based treatment recommendations. A significant number of patients are given a trial course with a proton pump inhibitor (PPI) for several months before symptoms are evaluated. In randomized controlled trials (RCTs) and meta-analyses of RCTs PPI treatment does not seem to be advantageous over placebo, and the evidence supporting that patients without verified GERD have any benefit of PPI treatment is negligible. There is a large increase in both over the counter and prescribed PPI use in several countries and a significant proportion of this use is without any symptomatic benefit for the patients. Whereas short-term treatment has few side effects, there is concern about side-effects after long-term use. Although empiric PPI treatment for suspected EE manifestations of GERD instead of prior esophageal 24-hour pH and impedance monitoring is included in several guidelines by various societies, this practice contributes to overtreatment with PPI.
    Conclusion: We argue that the current knowledge suggests that diagnostic testing with pH and impedance monitoring rather than empiric PPI treatment should be chosen in a higher proportion of patients presenting with symptoms possibly attributable to EE reflux.
    MeSH term(s) Humans ; Laryngopharyngeal Reflux/diagnosis ; Laryngopharyngeal Reflux/drug therapy ; Electric Impedance ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-023-02945-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The impact of proton pump inhibitors on the course of ulcerative colitis: a cohort study of over 10,000 newly diagnosed patients in Norway.

    Fossmark, Reidar / Lirhus, Sandre Svatun / Høivik, Marte Lie

    Scandinavian journal of gastroenterology

    2023  Volume 59, Issue 1, Page(s) 46–51

    Abstract: Background and aims: Proton pump inhibitors (PPI) affect the gastrointestinal microbiota, which is thought to play a role in the pathogenesis of ulcerative colitis (UC). Previous studies suggest an association between PPI use and risk of incident UC as ... ...

    Abstract Background and aims: Proton pump inhibitors (PPI) affect the gastrointestinal microbiota, which is thought to play a role in the pathogenesis of ulcerative colitis (UC). Previous studies suggest an association between PPI use and risk of incident UC as well as disease course. The aim of the study was to examine if PPI exposure is associated with disease course in UC patients.
    Methods: A national cohort consisting of all newly diagnosed UC patients from 2010 to 2020 was defined combining data from Norwegian registries. PPI exposure was included as a time dependent variable with a 30 day time lag from starting the drug. Outcomes were starting advanced therapies including anti-TNF, systemic glucocorticoids, any additional systemic anti-inflammatory medication and undergoing colectomy during follow-up. Time-dependent Cox regressions included the variables PPI use, first systemic glucocorticoid prescription, first UC hospitalization, age-groups and sex.
    Results: The study cohort consisted of 10,149 patients with median age 40 years (IQR 27-56) and 56% males. PPI use independently increased the risk of starting advanced therapies (HR 1.54, 95% CI 1.36-1.73,
    Conclusions: PPI use was associated with unfavorable outcomes including advanced therapy initiation, additional anti-inflammatory medications and undergoing colectomy. Although further studies are needed, the evidence suggests that PPIs could affect the course of UC and should be used cautiously in UC patients.
    MeSH term(s) Male ; Humans ; Adult ; Female ; Colitis, Ulcerative/surgery ; Cohort Studies ; Proton Pump Inhibitors/adverse effects ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Glucocorticoids/adverse effects ; Disease Progression ; Risk Factors ; Colectomy
    Chemical Substances Proton Pump Inhibitors ; Tumor Necrosis Factor Inhibitors ; Anti-Inflammatory Agents ; Glucocorticoids
    Language English
    Publishing date 2023-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2023.2255710
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 567: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Early Gastric Cancers in Central Norway 2001 to 2016-A Population-Based Study.

    Kvamme, Camilla J / Stillingen, Thomas L / Sandø, Alina D / Mjønes, Patricia / Bringeland, Erling A / Fossmark, Reidar

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Early gastric cancers (EGCs) are confined to the gastric mucosa and submucosa irrespective of lymph node metastases and constitute only a minor proportion of gastric cancer in Western countries. We aimed to characterize EGCs and assess the survival of ... ...

    Abstract Early gastric cancers (EGCs) are confined to the gastric mucosa and submucosa irrespective of lymph node metastases and constitute only a minor proportion of gastric cancer in Western countries. We aimed to characterize EGCs and assess the survival of EGC in Central Norway during 2001-2016. A retrospective population-based study on 1205 patients with gastric cancer was performed. At the time, surgical resection was the standard treatment, and 88 (7.3%) EGCs were identified. Histopathological specimens were re-examined, and the eCura score and survival were evaluated. The number of gastric cancers declined (
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Laser lithotripsy for the treatment of a giant fecalith obstructing a colorectal anastomosis.

    Fossmark, Reidar / Dalsbø, Peter Lefstad / Rokseth, Kjell Morten / Hauso, Øyvind

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E568–E569

    MeSH term(s) Humans ; Fecal Impaction/diagnostic imaging ; Fecal Impaction/surgery ; Lithotripsy, Laser ; Intestinal Obstruction/surgery ; Colorectal Neoplasms/surgery ; Anastomosis, Surgical/adverse effects ; Lithotripsy
    Language English
    Publishing date 2023-03-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2040-3868
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 162: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Gastritis, Gastric Polyps and Gastric Cancer.

    Waldum, Helge / Fossmark, Reidar

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction ... ...

    Abstract Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction in
    MeSH term(s) Adenomatous Polyps/etiology ; Adenomatous Polyps/pathology ; Adenomatous Polyps/therapy ; Animals ; Gastritis/complications ; Gastritis/immunology ; Gastritis/microbiology ; Gastritis/pathology ; Helicobacter pylori/pathogenicity ; Humans ; Stomach Neoplasms/etiology ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy
    Language English
    Publishing date 2021-06-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126548
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Do Gastric Signet Ring Cell Carcinomas and ECL-Cell Neuroendocrine Tumours Have a Common Origin?

    Fossmark, Reidar / Johannessen, Rune / Qvigstad, Gunnar / Mjønes, Patricia

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 4

    Abstract: Gastric cancer is a heterogenous group of tumours, and a better understanding of the carcinogenesis and cellular origin of the various sub-types could affect prevention and future treatment. Gastric neuroendocrine tumours (NETs) and adenocarcinomas that ... ...

    Abstract Gastric cancer is a heterogenous group of tumours, and a better understanding of the carcinogenesis and cellular origin of the various sub-types could affect prevention and future treatment. Gastric neuroendocrine tumours (NETs) and adenocarcinomas that develop in the gastric corpus and fundus of patients with chronic atrophic gastritis have atrophic gastritis, hypoacidity, and hypergastrinemia as common risk factors and a shared cellular origin has been suggested. In particular, signet ring cell carcinomas have previously been suggested to be of neuroendocrine origin. We present a case of a combined gastric NET and signet ring cell carcinoma in a patient with hypergastrinemia due to autoimmune chronic atrophic gastritis. The occurrence of such a combined tumour strengthens the evidence that gastric NETs and signet ring cell carcinomas develop from a common origin.
    MeSH term(s) Adenocarcinoma ; Carcinoma, Signet Ring Cell/complications ; Carcinoma, Signet Ring Cell/pathology ; Gastritis, Atrophic/complications ; Humans ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/pathology ; Stomach Neoplasms/complications ; Stomach Neoplasms/pathology
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58040470
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top