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  1. Article ; Online: Letter to the Editor: the effect of folic acid supplementation on oxidative stress is strictly related to serum homocysteine levels.

    Beyazit, Fatma / Pek, Eren / Beyazit, Yavuz

    Archives of gynecology and obstetrics

    2022  Volume 306, Issue 4, Page(s) 1393–1394

    MeSH term(s) Animals ; Dietary Supplements ; Female ; Folic Acid/pharmacology ; Homocysteine ; Humans ; Ischemia ; Ovarian Torsion ; Oxidative Stress/drug effects ; Rats ; Reperfusion Injury
    Chemical Substances Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-01-24
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-021-06363-6
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  2. Article ; Online: A meta-analyses on the role of IL-6 associated JAK/STAT3 signaling pathway modulation in the inflammatory bowel disease complicated colonic cancer development

    Ece Ünal Çetin / Yavuz Beyazıt

    Turkish Journal of Internal Medicine, Vol 3, Iss Supplement 1, Pp 4-

    2021  Volume 6

    Abstract: The signalling pathway of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) is suggested to be involved in various pathophysiological processes, including immune function, cell growth, differentiation, hematopoiesis and more ... ...

    Abstract The signalling pathway of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) is suggested to be involved in various pathophysiological processes, including immune function, cell growth, differentiation, hematopoiesis and more importantly oncogenesis of distinct tumoral conditions. Interleukin (IL) 6 is a proinflammatory cytokine produced by antigen-presenting cells and non-hematopoietic cells in response to external stimuli and considered to be a key player in the development of the microenvironment of malignancy by promoting tumor growth and metastasis by acting as a bridge between chronic inflammation and cancerous tissue. Recent studies suggest that aberrant interleukin IL6/JAK/STAT3 signaling pathway exists in both IBD and inflammation-related gastrointestinal cancers. In the present meta-analysis we aimed to analyze the relationship between IL-6/JAK/STAT3 and IBD associated colorectal carcinogenesis and the effect of the inhibition of this system on disease follow-up and management.In light of the small number of studies able to be included in the meta-analysis evidence strongly proposed that JAK/STAT3 signaling, especially via the IL-6/STAT3 axis is involved in the transition of inflammatory lesions to tumoral diseases and leading to ulcerative colitis associated colorectal cancer. For this reason, based on the evidence presented in this meta-analysis it is reasonable to suggest that targeting components of the IL-6/JAK/STAT3 signalling pathway can inhibit tumour cell growth and relieve immunosuppression in the UC associated colonic tumoral microenvironment.
    Keywords inflammatory bowel disease ; colon cancer ; il-6 ; jak/stat3 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nizameddin KOCA
    Document type Article ; Online
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  3. Article: False-positive results of lupus anticoagulant tests should be kept in mind in pregnant patients receiving low molecular weight heparin

    Beyazit, Fatma / Ünal Çetin, Ece / Beyazit, Yavuz

    Journal of the Turkish German Gynecological Association

    2021  Volume 22, Issue 4, Page(s) 334–335

    Language English
    Publishing date 2021-12-06
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.galenos.2021.2021.0112
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  4. Article ; Online: Evaluation of clinical features, treatment options and complications in patients with inflammatory bowel disease

    Yavuz Beyazıt / Fatih Kamış / Mücahit Ugar

    Family Practice and Palliative Care, Vol 7, Iss 3, Pp 64-

    2022  Volume 70

    Abstract: Introduction: Inflammatory bowel diseases (IBD) form a group of inflammatory diseases occurring in genetically-susceptible people, which are characterized by chronic progression and whose cause is not fully known. The aim of this study is to determine ... ...

    Abstract Introduction: Inflammatory bowel diseases (IBD) form a group of inflammatory diseases occurring in genetically-susceptible people, which are characterized by chronic progression and whose cause is not fully known. The aim of this study is to determine the incidence of IBD in our region and examine the clinical characteristics, sociodemographic features, and treatment results of IBD patients.Methods: Our study retrospectively investigates 211 patients over 18 years of age who were monitored for an IBD diagnosis between January 2, 2013, and December 31, 2019, by the gastroenterology department of Canakkale Onsekiz Mart University’s Faculty of Medicine. The mean age, female-male ratio, smoking habits, disease severity, and localization sites were identified for included patients. Local and systemic complications of administered treatment types and reasons for surgical treatment were also assessed in patients.Results: Of the 211 patients with IBD diagnoses, 158 (74.9%) had Ulcerative Colitis (UC) and 53 (25.1%) had a diagnosis of Crohn’s disease (CD). The mean age at the time of diagnosis was 43.97±16.22 years for UC patients and 42.30±14.73 years for CD cases. The involvement sites for UC were distal colitis for 58.4% of patients, left colon for 24.1% of patients, pancolitis for 16.5% of patients, and backwash ileitis for 7% of patients. According to the treatment results, 152 (72.0%) patients took 5-aminosalicylate (5-ASA) alone, 48 (22.8%) took thiopurine, and 20 (9.5%) took anti-TNF.Conclusion: Knowing the demographic, clinical, and laboratory features of these diseases, which are frequently seen in our region, can support the early identification of probable complications that may occur and the selection of appropriate approaches during diagnosis, treatment, and follow-up monitoring of these diseases.Keywords: Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn’s Disease, Severity of Illness Index, Abdominal Pain, Diarrhea
    Keywords inflammatory bowel diseases ; ulcerative colitis ; crohn's disease ; severity of illness index ; abdominal pain ; diarrhea ; i̇nflamatuvar barsak hastalığı ; ülseratif kolit ; crohn hastalığı ; hastalık şiddet i̇ndeksi ; karın ağrısı ; i̇shal ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher SERNEV
    Document type Article ; Online
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  5. Article: Haemogram indices are as reliable as CURB-65 to assess 30-day mortality in Covid-19 pneumonia.

    Bardakci, Okan / Das, Murat / Akdur, Gökhan / Akman, Canan / Siddikoglu, Duygu / Akdur, Okhan / Beyazit, Yavuz

    The National medical journal of India

    2023  Volume 35, Issue 4, Page(s) 221–228

    Abstract: Background Mortality due to Covid-19 and severe community-acquired pneumonia (CAP) remains high, despite progress in critical care management. We compared the precision of CURB-65 score with monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ... ...

    Abstract Background Mortality due to Covid-19 and severe community-acquired pneumonia (CAP) remains high, despite progress in critical care management. We compared the precision of CURB-65 score with monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) in prediction of mortality among patients with Covid-19 and CAP presenting to the emergency department. Methods We retrospectively analysed two cohorts of patients admitted to the emergency department of Canakkale University Hospital, namely (i) Covid-19 patients with severe acute respiratory symptoms presenting between 23 March 2020 and 31 October 2020, and (ii) all patients with CAP either from bacterial or viral infection within the 36 months preceding the Covid-19 pandemic. Mortality was defined as in-hospital death or death occurring within 30 days after discharge. Results The first study group consisted of 324 Covid-19 patients and the second group of 257 CAP patients. The non-survivor Covid-19 group had significantly higher MLR, NLR and PLR values. In univariate analysis, in Covid-19 patients, a 1-unit increase in NLR and PLR was associated with increased mortality, and in multivariate analysis for Covid-19 patients, age and NLR remained significant in the final step of the model. According to this model, we found that in the Covid-19 group an increase in 1-unit in NLR would result in an increase by 5% and 7% in the probability of mortality, respectively. According to pairwise analysis, NLR and PLR are as reliable as CURB-65 in predicting mortality in Covid-19. Conclusions Our study indicates that NLR and PLR may serve as reliable predictive factors as CURB-65 in Covid-19 pneumonia, which could easily be used to triage and manage severe patients in the emergency department.
    MeSH term(s) Humans ; COVID-19/diagnosis ; Retrospective Studies ; Hospital Mortality ; Pandemics ; Prognosis ; Pneumonia
    Language English
    Publishing date 2023-01-02
    Publishing country India
    Document type Case Reports
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    DOI 10.25259/NMJI_474_21
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    Zs.A 2493: Show issues Location:
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  6. Article ; Online: Diagnostic utility of hematological indices in predicting adverse outcomes and severity of acute pancreatitis based on BISAP and modified Glasgow score.

    Akdur, Gökhan / Bardakçı, Okan / Das, Murat / Akdur, Okhan / Beyazit, Yavuz

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2022  Volume 28, Issue 3, Page(s) 268–275

    Abstract: Background: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte-ratio (PLR), and red blood cell distribution width (RDW) are simple indicators of inflammatory status previously established as a severity indicator in distinct disease states. This ... ...

    Title translation BISAP ve Modifiye Glaskow Skoru'na göre akut pankreatitde hastalık ciddiyetini ve komplikasyonlarını öngörmede hematolojik parametrelerin rolü.
    Abstract Background: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte-ratio (PLR), and red blood cell distribution width (RDW) are simple indicators of inflammatory status previously established as a severity indicator in distinct disease states. This study aimed to determine the impact of these simple hematologic indices with conventional inflammation markers such as C-reactive pro-tein (CRP) and white blood cells in acute pancreatitis (AP) patients and their relationship with AP risk stratification scores including Bedside Index for Severity of Acute Pancreatitis (BISAP) and modified Glaskow Prognostic score (mGPS) scores.
    Methods: This retrospective study was performed in the emergency department of Canakkale Onsekiz Mart University. A total of 171 patients (male/female: 68 [39.8%]/103 [60.3%]) with AP and 59 age and gender matched healthy subjects (male/female: 23 [39%]/36[61%]) as controls were enrolled in the present study. The patients were grouped according to severity and adverse outcomes according to BISAP and mGPS and a comparative analysis was performed to compare the NLR, PLR, and RDW between groups.
    Results: The mean NLR values of AP patients and control group were 9.62±6.34 and 2.04±1.08, respectively (p<0.001), while the mean PLR values of AP patients and control group were 221.83±122.43 and 83.30±38.89, respectively (p<0.001). Except from RDW, all the other hematologic indices were found to be elevated (p<0.05 for WBC; NLR, PLR, and CRP) on both mild and severe disease at disease onset. NLR and PLR showed significant predictive ability for estimating serious complications associated with AP.
    Conclusion: The present study showed that NLR and PLR is increased in AP. Moreover, peripheral blood NLR and PLR values can predict disease severity and adverse outcomes associated with AP and can be used as an adjunctive marker for estimating disease severity.
    MeSH term(s) Acute Disease ; Biomarkers ; Female ; Humans ; Lymphocytes ; Male ; Pancreatitis/diagnosis ; Prognosis ; Retrospective Studies
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-07-13
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2253739-9
    ISSN 1307-7945 ; 1306-696X
    ISSN (online) 1307-7945
    ISSN 1306-696X
    DOI 10.14744/tjtes.2020.26348
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  7. Article ; Online: Letter to the Editor Regarding "Optic Nerve Sheath Measurements by Computed Tomography to Predict Intracranial Pressure and Guide Surgery in Patients with Traumatic Brain Injury".

    Bardakci, Okan / Das, Murat / Beyazit, Yavuz

    World neurosurgery

    2020  Volume 140, Page(s) 421

    MeSH term(s) Brain Injuries, Traumatic/diagnostic imaging ; Central Nervous System ; Humans ; Intracranial Pressure ; Optic Nerve ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.04.176
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  8. Article ; Online: Prediction of mortality with Charlson Comorbidity Index in super-elderly patients admitted to a tertiary referral hospital

    Yavuz Beyazıt / Okhan Akdur / Coşkun Bakar / İmran Kankaya / Gökhan Akdur / Okan Bardakcı / Murat Daş

    Cukurova Medical Journal, Vol 47, Iss 1, Pp 199-

    2022  Volume 207

    Abstract: Purpose: In most countries, there is an ever-increasing admission rate of the elderly population into emergency departments (EDs). In particular, these elderly patients differ from younger patients because they have multiple comorbidities that affect the ... ...

    Abstract Purpose: In most countries, there is an ever-increasing admission rate of the elderly population into emergency departments (EDs). In particular, these elderly patients differ from younger patients because they have multiple comorbidities that affect the functionality and quality of life. The goal of this study is to reveal whether the Charlson comorbidity index (CCI) foresee the short- and long-term prognosis of the super-elderly patient population. Materials and Methods: The study was a descriptive, retrospective analysis of emergency department (ED) admissions by patients over 85 years of age and admitted to the Canakkale Onsekiz Mart University (COMU) Hospital between 2013 and 2018. The demographic data of the patients were analyzed according to CCI. Cox-regression analyses were conducted to determine whether the variables affected mortality. Results: A total of 1142 patients aged 85 and older (507 men, 635 women) with a mean age of 86.96±2.49 were included in the study. According to the multivariable Cox regression analysis male gender, CCI ≥6 and ICU admission were significantly associated with increased mortality rates Conclusion: The CCI predicts short and long-term prognosis in acutely ill, hospitalized super-elderly patients. The CCI could be used to select super-elderly patients at admission as an indicator of improvement at hospital discharge.
    Keywords charlson komorbidite indeksi ; acil servis ; hospitalizasyon ; mortalite ; 80 ve üstü yaş ; charlson comorbidity index ; emergency department ; hospitalization ; mortality ; aged 80 and over ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Cukurova University
    Document type Article ; Online
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  9. Article ; Online: Ankaferd hemostat (ABS) as a potential mucosal topical agent for the management of COVID-19 syndrome based on its PAR-1 inhibitory effect and oestrogen content.

    Beyazit, Fatma / Beyazit, Yavuz / Tanoglu, Alpaslan / Haznedaroglu, Ibrahim C

    Medical hypotheses

    2020  Volume 143, Page(s) 110150

    Abstract: COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 ... ...

    Abstract COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 syndrome-associated inflammation. However, currently no specific medicine is present for the absolute pharmacological cure of COVID-19 mucositis. The re-purposing/re-positioning of already existing drugs is a very important strategy for the management of ongoing pandemy since the development of a new drug needs decades. Apart from altering angiotensin signaling pathways, novel drug candidates for re-purposing comprise medications shall target COVID-19 pathobiology, including pharmaceutical formulations that antagonize proteinase-activated receptors (PARs), mainly PAR-1. Activation of the PAR-1, mediators and hormones impact on the hemostasis, endothelial activation, alveolar epithelial cells and mucosal inflammatory responses which are the essentials of the COVID-19 pathophysiology. In this context, Ankaferd hemostat (Ankaferd Blood Stopper, ABS) which is an already approved hemostatic agent affecting via vital erythroid aggregation and fibrinogen gamma could be a potential topical remedy for the mucosal management of COVID-19. ABS is a clinically safe and effective topical hemostatic agent of plant origin capable of exerting pleiotropic effects on the endothelial cells, angiogenesis, cell proliferation and vascular dynamics. ABS had been approved as a topically applied hemostatic agent for the management of post-surgical/dental bleedings and healing of infected inflammatory mucosal wounds. The anti-inflammatory and proteinase-activated receptor axis properties of ABS with a considerable amount of oestrogenic hormone presence highlight this unique topical hemostatic drug regarding the clinical re-positioning for COVID-19-associated mucositis. Topical ABS as a biological response modifier may lessen SARS-CoV-2 associated microthrombosis, endothelial dysfunction, oropharyngeal inflammation and mucosal lung damage. Moreover, PAR-1 inhibition ability of ABS might be helpful for reducing the initial virus propagation and mocasal spread of COVID-19.
    MeSH term(s) Administration, Topical ; Age Distribution ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/physiopathology ; Drug Repositioning ; Endothelium, Vascular/drug effects ; Estrogens/agonists ; Estrogens/physiology ; Hemostatics/administration & dosage ; Hemostatics/therapeutic use ; Humans ; Mucositis/drug therapy ; Mucositis/etiology ; Pandemics ; Phytoestrogens/administration & dosage ; Phytoestrogens/therapeutic use ; Phytotherapy ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/therapeutic use ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Receptor, PAR-1/antagonists & inhibitors ; Receptor, PAR-1/physiology ; SARS-CoV-2 ; Stomatitis/drug therapy ; Stomatitis/etiology ; Thrombophilia/blood ; Thrombophilia/etiology
    Chemical Substances Anti-Inflammatory Agents ; Estrogens ; Hemostatics ; Phytoestrogens ; Plant Extracts ; Receptor, PAR-1 ; ankaferd blood stopper
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110150
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    Zs.A 1132: Show issues Location:
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  10. Article ; Online: Blood hemoglobin values are a strong predictor of serum adiponectin levels.

    Koçak, Erdem / Beyazıt, Yavuz

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2015  Volume 26, Issue 4, Page(s) 356

    MeSH term(s) Adenoma/blood ; Adiponectin/blood ; Colorectal Neoplasms/blood ; Female ; Humans ; Insulin Resistance ; Male ; Resistin/blood
    Chemical Substances Adiponectin ; Resistin
    Language English
    Publishing date 2015-07
    Publishing country Turkey
    Document type Comment ; Letter
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2015.0061
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