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Article ; Online: Reversal and Remission of T2DM - An Update for Practitioners.

Shibib, Lina / Al-Qaisi, Mo / Ahmed, Ahmed / Miras, Alexander D / Nott, David / Pelling, Marc / Greenwald, Stephen E / Guess, Nicola

Vascular health and risk management

2022 Volume 18, Page(s) 417–443

Abstract: Over the past 50 years, many countries around the world have faced an unchecked pandemic of obesity and type 2 diabetes (T2DM). As best practice treatment of T2DM has done very little to check its growth, the pandemic of diabesity now threatens to make ... ...

Abstract	Over the past 50 years, many countries around the world have faced an unchecked pandemic of obesity and type 2 diabetes (T2DM). As best practice treatment of T2DM has done very little to check its growth, the pandemic of diabesity now threatens to make health-care systems economically more difficult for governments and individuals to manage within their budgets. The conventional view has been that T2DM is irreversible and progressive. However, in 2016, the World Health Organization (WHO) global report on diabetes added for the first time a section on diabetes reversal and acknowledged that it could be achieved through a number of therapeutic approaches. Many studies indicate that diabetes reversal, and possibly even long-term remission, is achievable, belying the conventional view. However, T2DM reversal is not yet a standardized area of practice and some questions remain about long-term outcomes. Diabetes reversal through diet is not articulated or discussed as a first-line target (or even goal) of treatment by any internationally recognized guidelines, which are mostly silent on the topic beyond encouraging lifestyle interventions in general. This review paper examines all the sustainable, practical, and scalable approaches to T2DM reversal, highlighting the evidence base, and serves as an interim update for practitioners looking to fill the practical knowledge gap on this topic in conventional diabetes guidelines.
MeSH term(s)	Bariatric Surgery ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Life Style ; Obesity ; Treatment Outcome
Language	English
Publishing date	2022-06-14
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/VHRM.S345810
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Article ; Online: Monomer Elution from Three Resin Composites at Two Different Time Interval Using High Performance Liquid Chromatography-An In-Vitro Study.

Janani, Krishnamachari / Teja, Kavalipurapu Venkata / Sandhya, Raghu / Alam, Mohammad Khursheed / Al-Qaisi, Ruba K / Shrivastava, Deepti / Alnusayri, Mohammed Odhayd / Alkhalaf, Zainab Ali / Sghaireen, Mohammed G / Srivastava, Kumar Chandan

Polymers

2021 Volume 13, Issue 24

Abstract: Esthetics, improved colour stability and ease of contour have made photo-activated resin based restorative materials being widely used in routine dental clinical practice. Perhaps improper and inadequate polymerization of resin based composite material ... ...

Abstract	Esthetics, improved colour stability and ease of contour have made photo-activated resin based restorative materials being widely used in routine dental clinical practice. Perhaps improper and inadequate polymerization of resin based composite material might lead to elution of monomer. Thus, the aim of the current study was to quantify the monomer elution from three resin composites. The intended analysis was made using high performance liquid chromatography (HPLC) at two different time periods. Three different materials that were investigated in the current study included Swiss Tech resin composite (Group A), Ceram X (Group B) and Beautifil Injectable composite (Group C). Ten cylindrical samples were fabricated in each study group. In 75% wt of ethanol, the samples were ingressed immediately and stored at room temperature. A 0.5 mL of the samples was assessed at pre-defined time intervals at 24 h and 7th day. Later, assessment of the samples was performed with HPLC and the data was analyzed using statistical test. Bisphenol A-glycidyl methacrylate (Bis-GMA), Triethylene glycol dimethacrylate (TEGDMA), 2-hydroxyethyl methacrylate (HEMA) and Urethane dimethacrylate (UDMA) were quantified in the samples. When analyzing the release monomer, it was found that at the end of 24 h Bis-GMA was eluted more in the injectable resin composite whereas, TEGDMA was eluted from Swiss Tech and Ceram X resin composites. At the end of the 7th day it was evident that Bis-GMA was eluted maximum in all the three resin composites. Thus, monomer release was found to be evident among all three resin composites and it is of utmost important to be assessed in routine clinical practice.
Language	English
Publishing date	2021-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym13244395
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Article ; Online: Ankle brachial pressure index (ABPI): An update for practitioners.

Al-Qaisi, Mo / Nott, David M / King, David H / Kaddoura, Sam

Vascular health and risk management

2009 Volume 5, Page(s) 833–841

Abstract: Peripheral vascular disease affects some 12%-14% of the general population, and the majority of people with the disease are asymptomatic. The ankle brachial pressure index (ABPI) test is widely used by a diverse range of practitioners (in the community ... ...

Abstract	Peripheral vascular disease affects some 12%-14% of the general population, and the majority of people with the disease are asymptomatic. The ankle brachial pressure index (ABPI) test is widely used by a diverse range of practitioners (in the community and hospital setting) in order to screen asymptomatic patients, diagnose patients with clinical symptoms, and to monitor patients who have had radiological or surgical intervention. This paper explains the theoretical basis of the ABPI test, as well as the relevance of the common modifications of the test. It explores the background to the quoted normal ranges for the ABPI test. It reviews the large body of literature that has developed on the association between ABPI and cardiovascular risk, as well as ABPI as a predictor for cardiovascular morbidity and mortality, highlighting the evidence that can inform practice. The review looks critically at the limitations of the ABPI test, providing practitioners with an evidence-based update on the importance and challenges of standardizing ABPI methodology. This paper highlights the influence of the key technical aspects of the ABPI test that all practitioners need to consider in order to be able to make more reliable and informed management decisions based on ABPI findings.
MeSH term(s)	Ankle/blood supply ; Blood Pressure ; Blood Pressure Determination/standards ; Brachial Artery/physiopathology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Evidence-Based Medicine ; Humans ; Peripheral Vascular Diseases/complications ; Peripheral Vascular Diseases/diagnosis ; Peripheral Vascular Diseases/mortality ; Peripheral Vascular Diseases/physiopathology ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Severity of Illness Index
Language	English
Publishing date	2009-10-12
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/vhrm.s6759
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Article ; Online: Ankle Brachial Pressure Index (ABPI)

Mo Al-Qaisi / David M Nott / David H King

Vascular Health and Risk Management, Vol 2009, Iss default, Pp 833-

An update for practitioners

2009 Volume 841

Abstract: Mo Al-Qaisi1, David M Nott1, David H King2, Sam Kaddoura11Imperial College, London, UK; 2Broomfield ...

Abstract	Mo Al-Qaisi1, David M Nott1, David H King2, Sam Kaddoura11Imperial College, London, UK; 2Broomfield Hospital, Chelmsford, Essex, UKAbstract: Peripheral vascular disease affects some 12%–14% of the general population, and the majority of people with the disease are asymptomatic. The Ankle Brachial Pressure Index (ABPI) test is widely used by a diverse range of practitioners (in the community and hospital setting) in order to screen asymptomatic patients, diagnose patients with clinical symptoms, and to monitor patients who have had radiological or surgical intervention. This paper explains the theoretical basis of the ABPI test, as well as the relevance of the common modifications of the test. It explores the background to the quoted normal ranges for the ABPI test. It reviews the large body of literature that has developed on the association between ABPI and cardiovascular risk, as well as ABPI as a predictor for cardiovascular morbidity and mortality, highlighting the evidence that can inform practice. The review looks critically at the limitations of the ABPI test, providing practitioners with an evidence-based update on the importance and challenges of standardizing ABPI methodology. This paper highlights the influence of the key technical aspects of the ABPI test that all practitioners need to consider in order to be able to make more reliable and informed management decisions based on ABPI findings.Keywords: ankle, brachial, pressure, index, ABPI, update
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	796
Language	English
Publishing date	2009-09-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Volume blood flow, static pressure ratio and venous conductance in native arterio-venous fistulae: three surveillance methods compared.

King, David H / Paulson, William D / Al-Qaisi, Mo / Taylor, Michael G / Panayiotopoulos, Yiannis / Abeygunarsekara, Sumith / Chan, Anthony / Ali, Galil / Chemla, Eric S

The journal of vascular access

2015 Volume 16, Issue 3, Page(s) 211–217

Abstract: Purpose: Dialysis venous pressure monitoring has been widely recommended as a surveillance method but has not been shown to improve access outcomes in randomised controlled trials. The method has been impaired by the need to either turn off the blood ... ...

Abstract	Purpose: Dialysis venous pressure monitoring has been widely recommended as a surveillance method but has not been shown to improve access outcomes in randomised controlled trials. The method has been impaired by the need to either turn off the blood pump or to derive the static venous pressure from the venous pressure measured with the dialysis pump running. We have developed a unique algorithm which converts Doppler-shifted spectral information derived from unscaled pulsatile blood flow waveforms into an estimate of mean blood pressure (MBP) at the point of ultrasound insonation. Methods: We have devised the unique expression shown here: MBP = MAP/(1 + Pff/Vff) where MAP is the mean arterial pressure, Pff = (systolic - diastolic)/MAP measured on the contralateral arm and Vff = spectral maximum - minimum/mean. Venous conductance (VC) can be measured by combining this pressure data with Duplex ultrasound blood flow data. A new device BlueDop™ has been used to illustrate the potential clinical value of non-invasive static pressure ratio (SPRn) in a monitoring role. Duplex and BlueDop™ technology were tested in an arterio-venous fistula (AVF) study in which VC, Q and SPRn were compared. Thresholds used for detection of ≥60% venous stenosis were VC <10 mL min-1 mm Hg-1, Q <500 mL min-1, SPRn >0.56. Results: The following accuracy was achieved: VC = 96%, Q = 92%, SPRn = 76% with similar accuracy in predicting premature thrombosis. Conclusions: A new algorithm has been described and its in vivo accuracy in estimating mean 'pressure from flow' has been confirmed. Two new variables and a new dedicated instrument BlueDop™ have been demonstrated in clinical use.
MeSH term(s)	Algorithms ; Animals ; Arterial Pressure ; Arteriovenous Shunt, Surgical/adverse effects ; Blood Flow Velocity ; Blood Pressure Determination/methods ; Dogs ; Graft Occlusion, Vascular/diagnostic imaging ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/physiopathology ; Humans ; Predictive Value of Tests ; Regional Blood Flow ; Renal Dialysis ; Reproducibility of Results ; Risk Factors ; Signal Processing, Computer-Assisted ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Thrombosis/physiopathology ; Time Factors ; Treatment Outcome ; Ultrasonography, Doppler, Color ; Ultrasonography, Doppler, Duplex/methods ; Vascular Patency ; Venous Pressure
Language	English
Publishing date	2015-05
Publishing country	Italy
Document type	Comparative Study ; Journal Article ; Validation Studies
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.5301/jva.5000324
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Measurement of endothelial function and its clinical utility for cardiovascular risk.

Al-Qaisi, Mo / Kharbanda, Rajesh K / Mittal, Tarun K / Donald, Ann E

Vascular health and risk management

2008 Volume 4, Issue 3, Page(s) 647–652

Abstract: Over the past two decades, the central role of the endothelium in the initiation, progression, and clinical sequelae of atherosclerosis has been increasingly recognized. Assessment of the pathobiology of the endothelium and its ability to act as a ... ...

Abstract	Over the past two decades, the central role of the endothelium in the initiation, progression, and clinical sequelae of atherosclerosis has been increasingly recognized. Assessment of the pathobiology of the endothelium and its ability to act as a potential therapeutic target remains an area of active research interest. Whilst endothelial function has been shown to be a marker for risk of cardiovascular events in high-risk groups, there remains considerable debate about the most appropriate way to assess this. We discuss the different clinical methods to assess endothelial function, focusing on flow-mediated dilatation (FMD) of the brachial artery, highlighting the importance of using a standardized methodology, as well as discussing the clinical limitations of using FMD in individuals.
MeSH term(s)	Atherosclerosis/physiopathology ; Brachial Artery/physiopathology ; Cardiovascular Diseases/physiopathology ; Endothelium, Vascular/physiopathology ; Humans ; Laser-Doppler Flowmetry ; Regional Blood Flow/physiology ; Risk Assessment ; Vasodilation/physiology
Language	English
Publishing date	2008-09-19
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/vhrm.s2769
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Imaging of peripheral vascular disease

Mo Al-Qaisi / David M Nott / David H King / Sam Kaddoura / Mo Hamady

Reports in Medical Imaging, Vol 2009, Iss default, Pp 25-

2009 Volume 34

Abstract: Mo Al-Qaisi1, David M Nott1, David H King1, Sam Kaddoura2, Mo Hamady31Charing Cross Hospital ...

Abstract	Mo Al-Qaisi1, David M Nott1, David H King1, Sam Kaddoura2, Mo Hamady31Charing Cross Hospital, London, UK; 2Royal Brompton Hospital, London, UK; 3St. Mary’s Hospital, London, UKAbstract: This illustrated review article gives an evidence-based update on the different modalities used for imaging peripheral vascular disease (duplex ultrasound, computed tomography angiography, magnetic resonance angiography, and digital subtraction angiography). After discussing the latest technological developments for each modality, their limitations are also highlighted. The evidence is presented for the various modalities’ roles in the imaging of peripheral vascular disease, including problem-solving applications. The strengths and weaknesses of each modality are therefore critically appraised, including the salient technological, clinical, and financial aspects. This review allows the general and specialist practitioner to make an informed decision on how best to deploy imaging tests in peripheral vascular disease as part of an evidence-based approach. The article concludes with a rational imaging algorithm for the investigation of peripheral vascular disease.Keywords: imaging, peripheral, vascular, duplex, angiography, arterial
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2009-03-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Measurement of endothelial function and its clinical utility for cardiovascular risk

Mo Al-Qaisi / Rajesh K Kharbanda / Tarun K Mittal / Ann E Donald

Vascular Health and Risk Management, Vol 2008, Iss Issue 3, Pp 647-

2008 Volume 652

Abstract: Mo Al-Qaisi1, Rajesh K Kharbanda1, Tarun K Mittal1, Ann E Donald21Royal Brompton and Harefield NHS ...

Abstract	Mo Al-Qaisi1, Rajesh K Kharbanda1, Tarun K Mittal1, Ann E Donald21Royal Brompton and Harefield NHS Trust, London, UK; 2Institute of Child Health and Great Ormond Street Hospital, NHS Trust, London, UKAbstract: Over the past two decades, the central role of the endothelium in the initiation, progression, and clinical sequelae of atherosclerosis has been increasingly recognized. Assessment of the pathobiology of the endothelium and its ability to act as a potential therapeutic target remains an area of active research interest. Whilst endothelial function has been shown to be a marker for risk of cardiovascular events in high-risk groups, there remains considerable debate about the most appropriate way to assess this. We discuss the different clinical methods to assess endothelial function, focusing on flow-mediated dilatation (FMD) of the brachial artery, highlighting the importance of using a standardized methodology, as well as discussing the clinical limitations of using FMD in individuals.Keywords: endothelial function, flow-mediated dilatation, clinical utility, cardiovascular risk
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2008-06-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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