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  1. Article ; Online: Advances in axial spondyloarthritis: Learning from the leaders.

    Ramiro, Sofia / Haroon, Nigil

    Best practice & research. Clinical rheumatology

    2023  Volume 37, Issue 3, Page(s) 101877

    MeSH term(s) Humans ; Spondylarthritis/therapy ; Spondylitis, Ankylosing ; Axial Spondyloarthritis
    Language English
    Publishing date 2023-11-18
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2023.101877
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  2. Article ; Online: ERAP1 and the return of the UPR in ankylosing spondylitis.

    Haroon, Nigil / Inman, Robert D

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 3, Page(s) 134–135

    MeSH term(s) Humans ; Spondylitis, Ankylosing ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; HLA-B27 Antigen ; Aminopeptidases/genetics ; Minor Histocompatibility Antigens
    Chemical Substances HLA-B27 Antigen ; Aminopeptidases (EC 3.4.11.-) ; Minor Histocompatibility Antigens ; ERAP1 protein, human (EC 3.4.11.-)
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-00910-y
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  3. Article ; Online: Management of Metabolic-Associated Fatty Liver Disease.

    Venkatesan, Kirthika / Haroon, Nisha Nigil

    Endocrinology and metabolism clinics of North America

    2023  Volume 52, Issue 3, Page(s) 547–557

    Abstract: Metabolic-associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD), is the most common cause of liver disease in the world. Its prevalence is over 30% and is becoming the most common cause of liver transplants. ...

    Abstract Metabolic-associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD), is the most common cause of liver disease in the world. Its prevalence is over 30% and is becoming the most common cause of liver transplants. Rates are rising along with obesity-related diseases. Risk factors for MAFLD include adverse lifestyles, genetic variations, advancing age, male sex, and alterations in the gut microbiota. Extrahepatic complications include cardiovascular disease, renal dysfunction, and colorectal cancer. As there are no currently approved medications for MAFLD, management mainly focuses on lifestyle modifications.
    MeSH term(s) Humans ; Male ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/therapy ; Risk Factors ; Behavior Therapy ; Cardiovascular Diseases ; Life Style
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2023.02.002
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  4. Article ; Online: Thinking Positive in Spondyloarthritis.

    Haroon, Nigil

    Arthritis & rheumatology (Hoboken, N.J.)

    2019  Volume 71, Issue 6, Page(s) 839–841

    MeSH term(s) Antigens, Bacterial/immunology ; Antigens, Differentiation, B-Lymphocyte/immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology ; HLA-B27 Antigen/immunology ; Histocompatibility Antigens Class II/immunology ; Humans ; Klebsiella/immunology ; Rheumatoid Factor/immunology ; Spondylarthropathies/immunology
    Chemical Substances Antigens, Bacterial ; Antigens, Differentiation, B-Lymphocyte ; Autoantibodies ; HLA-B27 Antigen ; Histocompatibility Antigens Class II ; invariant chain ; Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2019-04-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.40832
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  5. Article ; Online: Sequence of Events in the Pathogenesis of Axial Spondyloarthritis: A Current Review-2023 SPARTAN Meeting Proceedings.

    Srinath, Archita / Nakamura, Akihiro / Haroon, Nigil

    Current rheumatology reports

    2024  Volume 26, Issue 4, Page(s) 133–143

    Abstract: Purpose of review: Over the past two decades, significant progress has been made to untangle the etiology of inflammation and new bone formation (NBF) associated with axial spondyloarthritis (axSpA). However, exact mechanisms as to how the disease ... ...

    Abstract Purpose of review: Over the past two decades, significant progress has been made to untangle the etiology of inflammation and new bone formation (NBF) associated with axial spondyloarthritis (axSpA). However, exact mechanisms as to how the disease initiates and develops remain elusive.
    Recent findings: Type 3 immunity, centered around the IL-23/IL-17 axis, has been recognized as a key player in the pathogenesis of axSpA. Multiple hypotheses associated with HLA-B*27 have been proposed to account for disease onset and progression of axSpA, potentially by driving downstream T cell responses. However, HLA-B*27 alone is not sufficient to fully explain the development of axSpA. Genome-wide association studies (GWAS) identified several genes that are potentially relevant to disease pathogenesis leading to a better understanding of the immune activation seen in axSpA. Furthermore, gut microbiome studies suggest an altered microbiome in axSpA, and animal studies suggest a pathogenic role for immune cells migrating from the gut to the joint. Recent studies focusing on the pathogenesis of new bone formation (NBF) have highlighted the importance of endochondral ossification, mechanical stress, pre-existing inflammation, and activated anabolic signaling pathways during the development of NBF. Despite the complex etiology of axSpA, recent studies have shed light on pivotal pieces that could lead to a better understanding of the pathogenic events in axSpA.
    MeSH term(s) Humans ; Spondylarthritis/genetics ; Genome-Wide Association Study ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/complications ; Axial Spondyloarthritis ; Inflammation/genetics ; Inflammation/complications ; HLA-B Antigens/genetics
    Chemical Substances HLA-B Antigens
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-024-01136-x
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  6. Article ; Online: Recent advances in spondyloarthritis: positive developments in the seronegative domain.

    Haroon, Nigil / Inman, Robert D

    Seminars in immunopathology

    2021  Volume 43, Issue 2, Page(s) 159–161

    MeSH term(s) Humans ; Spondylarthritis/diagnosis
    Language English
    Publishing date 2021-03-21
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-021-00839-y
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  7. Article ; Online: Nonspecific Low Back Pain.

    Passalent, Laura / Inman, Robert D / Haroon, Nigil

    The New England journal of medicine

    2022  Volume 387, Issue 5, Page(s) 478–479

    MeSH term(s) Back Pain ; Humans ; Low Back Pain/etiology ; Pain Measurement
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2207597
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  8. Article ; Online: Recent advances in spondyloarthritis.

    Poddubnyy, Denis / Haroon, Nigil

    Best practice & research. Clinical rheumatology

    2019  Volume 32, Issue 3, Page(s) 329–330

    Language English
    Publishing date 2019-04-13
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2019.03.014
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  9. Article ; Online: Recent Updates in the Immunopathology of Type 3 Immunity-Mediated Enthesitis.

    Nakamura, Akihiro / Haroon, Nigil

    Current rheumatology reports

    2021  Volume 23, Issue 5, Page(s) 31

    Abstract: Purpose of review: Enthesitis is a cardinal feature of spondyloarthritis (SpA). Despite increasing available treatments, challenges remain in adequately controlling inflammation and subsequent new bone formation (NBF) in entheses; thus, a better ... ...

    Abstract Purpose of review: Enthesitis is a cardinal feature of spondyloarthritis (SpA). Despite increasing available treatments, challenges remain in adequately controlling inflammation and subsequent new bone formation (NBF) in entheses; thus, a better understanding of the immunopathogenesis is warranted.
    Recent findings: Increasing evidence has identified immune cells playing key roles in enthesitis such as γδ T cells and group 3 innate lymphoid cells (ILC3), possibly with site-specific regulatory systems. The presence of T cells producing interleukin (IL)-17 independent of IL-23 in human spinal entheses was recently reported, which may corroborate the discrepancy between recent clinical trials and pre-clinical studies. In addition, the contribution of myeloid cells has also been focused in both human and pre-clinical SpA models. Moreover, not only the IL-23/IL-17 signaling, but other key type 3 immunity mediators, such as IL-22 and granulocyte-macrophage colony-stimulating factor (GM-CSF), have been reported as pivotal cytokines in inflammation and NBF of entheses. Immune cells demonstrating distinct features orchestrate entheses, leading to the complex landscape of enthesitis. However, recent advances in understanding the immunopathogenesis may provide new therapeutic targets and future research directions.
    MeSH term(s) Enthesopathy/immunology ; Humans ; Immunity, Innate ; Interleukin-17 ; Interleukin-23 ; Lymphocytes/immunology ; Spondylarthritis/immunology
    Chemical Substances Interleukin-17 ; Interleukin-23
    Language English
    Publishing date 2021-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-021-00995-y
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  10. Article ; Online: The gut-enthesis axis and the pathogenesis of Spondyloarthritis.

    Mauro, Daniele / Nakamura, Akihiro / Haroon, Nigil / Ciccia, Francesco

    Seminars in immunology

    2022  Volume 58, Page(s) 101607

    Abstract: Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show features of dysbiosis, altered gut barrier function, and local expansion of innate and innate-like cells involved in type 3 immune response. The recirculation of ... ...

    Abstract Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show features of dysbiosis, altered gut barrier function, and local expansion of innate and innate-like cells involved in type 3 immune response. The recirculation of intestinal primed immune cells into the bloodstream and, in some cases, in the joints and the inflamed bone marrow of SpA patients gave the basis of the gut-joint axis theory. In the light of the critical role of enthesis in the pathogenesis of SpA and the identification of mucosal-derived immune cells residing into the normal human enthesis, a gut-enthesis axis is also likely to exist. This work reviews the current knowledge on enthesis-associated innate immune cells' primary involvement in enthesitis development, questions their origin, and critically discusses the clues supporting the existence of a gut-enthesis axis contributing to SpA development.
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101607
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