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  1. Book: Clinician's manual on axial spondyloarthritis

    Sieper, Joachim / Braun, Jürgen

    2014  

    Author's details Joachim Sieper ; Jürgen Braun
    Keywords Spondyloarthropathies
    Subject code 616.73
    Language English
    Size XI, 96 S. : Ill., graph. Darst., 21 cm
    Publisher Springer Healthcare
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018335804
    ISBN 978-1-907673-84-9 ; 1-907673-84-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2014 A 2886 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis.

    Braun, Juergen / Sieper, Joachim

    RMD open

    2023  Volume 9, Issue 3

    Abstract: The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility. Its prevalence in the mid-European ... ...

    Abstract The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility. Its prevalence in the mid-European population is about 8%. The association of HLA B27 alleles with ankylosing spondylitis (AS), a highly heritable disease, which is part of the spectrum of axial spondyloarthritis (axSpA), was discovered 50 years ago. HLA B27 explains less than 30% of the total genetic load. About 60%-90% of axSpA patients worldwide carry HLA B27. The prevalence of the disease is linked to the frequency of HLA B27 in the population which implies that there are relevant differences. Among the roughly 200 subtypes known there are two which are not disease associated. The function of HLA class I molecules is to present peptides to the immune system to defend the organism against microbes targeted by CD8+T cells. This is much supported by the role of the endoplasmic reticulum aminopeptidase 1 (ERAP 1) in AS, an enzyme that is responsible for the intracellular trimming of peptides, since polymorphisms of this gene are only associated with HLA-B27+ disease. The arthritogenic peptide hypothesis trying to explain the pathogenesis of AS is based on that very immune function assuming that also self peptides can be presented. HLA-B27 also plays an important role in classification, diagnosis and severitiy of axSpA.
    MeSH term(s) Humans ; Alleles ; HLA-B27 Antigen/genetics ; Spondylitis, Ankylosing/genetics ; Anniversaries and Special Events
    Chemical Substances HLA-B27 Antigen
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-003102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Geschichte der Biologikatherapie bei axialer Spondyloarthritis – Teil 1.

    Braun, J / Sieper, J

    Zeitschrift fur Rheumatologie

    2022  Volume 81, Issue 10, Page(s) 888–894

    Title translation History of the treatment of axial spondylarthritis with biologics-Part 1.
    MeSH term(s) Humans ; Biological Products/therapeutic use
    Chemical Substances Biological Products
    Language German
    Publishing date 2022-09-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-022-01262-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Ankylosing Spondylitis

    Sieper, Joachim / Braun, Jürgen

    2011  

    Author's details Joachim Sieper ; Jürgen Braun
    Language English
    Size VIII, 83 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016630573
    ISBN 978-0-85729-179-0 ; 0-85729-179-3 ; 9780857291806 ; 0857291807
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2010 A 6386 order for loan Magazin

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  5. Article ; Online: Geschichte der Biologikatherapie bei axialer Spondyloarthritis – Teil 2.

    Sieper, Joachim / Braun, Jürgen

    Zeitschrift fur Rheumatologie

    2022  Volume 82, Issue 1, Page(s) 56–63

    Title translation History of the biologics treatment of axial spondylarthritis-Part 2.
    MeSH term(s) Humans ; Biological Products/therapeutic use ; Spondylarthritis/drug therapy ; Spondylitis, Ankylosing
    Chemical Substances Biological Products
    Language German
    Publishing date 2022-09-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-022-01264-8
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  6. Article ; Online: HLA-B27 and the role of specific T cell receptors in the pathogenesis of spondyloarthritis.

    Braun, Jürgen / Märker-Hermann, Elisabeth / Rudwaleit, Martin / Sieper, Joachim

    Annals of the rheumatic diseases

    2024  

    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2024-225661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Zur Rolle von HLA-B27 in der Pathogenese und Diagnostik der axialen Spondyloarthritis : 50 Jahre nach Entdeckung der starken genetischen Assoziation.

    Braun, Jürgen / Rudwaleit, Martin / Sieper, Joachim

    Zeitschrift fur Rheumatologie

    2023  Volume 83, Issue 2, Page(s) 125–133

    Abstract: Background: The association of the human lymphocyte antigen B27 (HLA-B27) with ankylosing spondylitis (AS), also now called axial spondylarthritis (axSpA), was first described 50 years ago.: Objective: This article gives an overview of the available ... ...

    Title translation The role of HLA-B27 in the pathogenesis and diagnosis of axial spondyloarthritis : 50 years after discovery of the strong genetic association.
    Abstract Background: The association of the human lymphocyte antigen B27 (HLA-B27) with ankylosing spondylitis (AS), also now called axial spondylarthritis (axSpA), was first described 50 years ago.
    Objective: This article gives an overview of the available knowledge on the topic.
    Material and methods: This is a narrative review based on the experience of the authors.
    Results: The HLA-B27 is a member of the HLA class I family of genes of the major histocompatibility complex (MHC). The prevalence of HLA-B27 in the central European population is approximately 8 %, i.e., the vast majority of carriers of HLA-B27+ remain healthy. The frequency of HLA-B27 shows a decline from north to south. The HLA-B27 explains only 30 % of the genetic burden of axSpA. The prevalence of the disease correlates with the frequency of HLA-B27 in the population, i.e., there are geographic differences. Approximately 60-90 % of patients with axSpA worldwide are HLA-B27+. Some 200 subtypes of HLA-B27 can be differentiated using the polymerase chain reaction (PCR). In Thailand and Sardinia two subtypes were found that are not associated with axSpA. The physiological function of HLA class I molecules is the defence of the organism against microbes. Microbial peptides are presented to the immune system, which can be specifically attacked by CD8+ T‑cells. Genetic polymorphisms of the enzyme endoplasmic reticulum aminopeptidase 1 (ERAP1), which breaks down peptides in the endoplasmic reticulum, are associated only with HLA-B27+ diseases.
    Discussion: The pathogenesis of axSpA is unclear but a major hypothesis is that of the arthritogenic peptides. In this it is assumed that potentially pathogenic foreign or autologous peptides can be presented by HLA-B27. If nothing else, HLA-B27 plays an important role in the diagnosis, classification and determination of the severity of axSpA.
    MeSH term(s) Humans ; HLA-B27 Antigen/genetics ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/genetics ; Peptides/genetics ; Polymorphism, Genetic ; Spondylarthritis/diagnosis ; Spondylarthritis/genetics ; Aminopeptidases/genetics ; Minor Histocompatibility Antigens
    Chemical Substances HLA-B27 Antigen ; Peptides ; ERAP1 protein, human (EC 3.4.11.-) ; Aminopeptidases (EC 3.4.11.-) ; Minor Histocompatibility Antigens
    Language German
    Publishing date 2023-12-19
    Publishing country Germany
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-023-01460-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Spondyloarthritis

    Braun, Jürgen / Sieper, Joachim

    (Rheumatic disease clinics of North America ; 38,3)

    2012  

    Author's details guest ed. Jürgen Braun ; Joachim Sieper
    Series title Rheumatic disease clinics of North America ; 38,3
    Collection
    Language English
    Size XXI S., S. 442 - 652 : Ill., graph. Darst.
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT017466534
    ISBN 978-1-4557-5066-5 ; 1-4557-5066-2
    Database Catalogue ZB MED Medicine, Health

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    Se 363 -38-3- verfügbar in Königswinter Königswinter

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  9. Article ; Online: What is the optimal target for a T2T approach in axial spondyloarthritis?

    Sieper, Joachim / Poddubnyy, Denis

    Annals of the rheumatic diseases

    2021  Volume 80, Issue 11, Page(s) 1367–1369

    MeSH term(s) Humans ; Spondylarthritis ; Spondylitis, Ankylosing
    Language English
    Publishing date 2021-06-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-220603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Twenty years of clinical trials in axial spondyloarthritis: what can we learn for the future?

    Sieper, Joachim / Poddubnyy, Denis

    Current opinion in rheumatology

    2021  Volume 33, Issue 4, Page(s) 363–369

    Abstract: Purpose of review: We have now about 20 years of experience with the treatment of axial spondyloarthritis with biologics, which raises the question what we can learn from past experience, and which open questions should be addressed in future ... ...

    Abstract Purpose of review: We have now about 20 years of experience with the treatment of axial spondyloarthritis with biologics, which raises the question what we can learn from past experience, and which open questions should be addressed in future investigations.
    Recent findings: Many studies have shown that axSpA patients - both patients in their nonradiological and radiological stage - respond similarly well to biologic treatment and these patients should be seen as having the same disease at different stages. AxSpA respond best to TNF-blocker - and probably also to other biologics - if the disease duration is short and if objective parameters of inflammation, such as C-reactive protein or MRI are positive. Primary aim of treatment is to reach and maintain clinical remission. Once remission is achieved, it can be maintained by continuing treatment, and in a proportion of yet not well defined patients the drug dose can be reduced without inducing a flare. The recent demonstration of a good efficacy, in addition to TNF blockers, also of IL-17 inhibitors and JAK-inhibitors in axSpA patients raises the question how to select the best patients for the best treatment. Radiographic progression can best be stopped by effectively suppressing inflammation, whether different drugs have here a different effect has still to be defined. More sensitive measurements of radiographic progression are urgently needed.
    Summary: Reaching and maintaining clinical remission and preventing structural bony damage is the primary treatment target in patients with axSpA. How to reach this aim best has to be further explored in the future.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Humans ; Inflammation ; Magnetic Resonance Imaging ; Radiography ; Spondylarthritis/diagnostic imaging ; Spondylarthritis/drug therapy ; Spondylitis, Ankylosing/drug therapy
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2021-06-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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